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Lung Mature B-Cell Neoplasm

MedGen UID:
363555
•Concept ID:
C1881484
•
Neoplastic Process
Synonym: Lung Mature B-Cell Lymphocytic Neoplasm

Definition

A neoplasm that arises from mature B-lymphocytes or plasma cells in the lung. Representative examples include mucosa-associated lymphoid tissue lymphoma, diffuse large B-cell lymphoma, lymphomatoid granulomatosis, and primary pulmonary plasmacytoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Mature B-Cell Neoplasm

Recent clinical studies

Etiology

Tyrosine Kinase Inhibitors Target B Lymphocytes.
Upfold NLE, Petakh P, Kamyshnyi A, Oksenych V
Biomolecules 2023 Feb 25;13(3) doi: 10.3390/biom13030438. PMID: 36979373Free PMC Article
Biological Aging Measures Based on Blood DNA Methylation and Risk of Cancer: A Prospective Study.
Dugué PA, Bassett JK, Wong EM, Joo JE, Li S, Yu C, Schmidt DF, Makalic E, Doo NW, Buchanan DD, Hodge AM, English DR, Hopper JL, Giles GG, Southey MC, Milne RL
JNCI Cancer Spectr 2021 Feb;5(1) Epub 2020 Nov 16 doi: 10.1093/jncics/pkaa109. PMID: 33442664Free PMC Article
Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms.
Gagliardi A, Dugué PA, Nøst TH, Southey MC, Buchanan DD, Schmidt DF, Makalic E, Hodge AM, English DR, Doo NW, Hopper JL, Severi G, Baglietto L, Naccarati A, Tarallo S, Pace L, Krogh V, Palli D, Panico S, Sacerdote C, Tumino R, Lund E, Giles GG, Pardini B, Sandanger TM, Milne RL, Vineis P, Polidoro S, Fiorito G
Cancer Epidemiol Biomarkers Prev 2020 Oct;29(10):2026-2037. Epub 2020 Aug 11 doi: 10.1158/1055-9965.EPI-20-0451. PMID: 32788174
Discovery and characteristics of B cell-like T cells: A potential novel tumor immune marker?
Liu Y, Ye S, Guo X, Li W, Xia Y, Wen X, Yu J, Jia Y, Liu X, Guo Y, Zhao Y
Immunol Lett 2020 Apr;220:44-50. Epub 2020 Jan 31 doi: 10.1016/j.imlet.2020.01.007. PMID: 32014490
BCR pathway inhibition as therapy for chronic lymphocytic leukemia and lymphoplasmacytic lymphoma.
Wiestner A
Hematology Am Soc Hematol Educ Program 2014 Dec 5;2014(1):125-34. Epub 2014 Nov 18 doi: 10.1182/asheducation-2014.1.125. PMID: 25696845

Diagnosis

Post-mortem diagnosis of intravascular large B-cell lymphoma.
Maiese A, La Russa R, De Matteis A, Frati P, Fineschi V
J Int Med Res 2020 Jun;48(6):300060520924262. doi: 10.1177/0300060520924262. PMID: 32485117Free PMC Article
SALL4 is a useful marker for pediatric yolk sac tumors.
Wu P, Luo R, Sun B, Zhao J, Xu Q, Feng S, Chen X, Wang C
Pediatr Surg Int 2020 Jun;36(6):727-734. Epub 2020 Mar 28 doi: 10.1007/s00383-020-04652-w. PMID: 32222813
Intravascular large B cell lymphoma presenting in the lung: the diagnostic value of transbronchial cryobiopsy.
Poletti V, Gurioli C, Piciucchi S, Rossi A, Ravaglia C, Dubini A, Asioli S, Casoni GL
Sarcoidosis Vasc Diffuse Lung Dis 2015 Jan 5;31(4):354-8. PMID: 25591148
B-cell receptor signaling as a driver of lymphoma development and evolution.
Niemann CU, Wiestner A
Semin Cancer Biol 2013 Dec;23(6):410-21. Epub 2013 Sep 20 doi: 10.1016/j.semcancer.2013.09.001. PMID: 24060900Free PMC Article
Tumor microenvironment is multifaceted.
Sautès-Fridman C, Cherfils-Vicini J, Damotte D, Fisson S, Fridman WH, Cremer I, Dieu-Nosjean MC
Cancer Metastasis Rev 2011 Mar;30(1):13-25. doi: 10.1007/s10555-011-9279-y. PMID: 21271351

Therapy

First-in-Human Study with Preclinical Data of BCL-2/BCL-xL Inhibitor Pelcitoclax in Locally Advanced or Metastatic Solid Tumors.
Lakhani NJ, Rasco D, Wang H, Men L, Liang E, Fu T, Collins MC, Min P, Yin Y, Davids MS, Yang D, Zhai Y
Clin Cancer Res 2024 Feb 1;30(3):506-521. doi: 10.1158/1078-0432.CCR-23-1525. PMID: 37971712
Tyrosine Kinase Inhibitors Target B Lymphocytes.
Upfold NLE, Petakh P, Kamyshnyi A, Oksenych V
Biomolecules 2023 Feb 25;13(3) doi: 10.3390/biom13030438. PMID: 36979373Free PMC Article
Treatment of Patients with Relapsed or Refractory Mantle-Cell Lymphoma with Zanubrutinib, a Selective Inhibitor of Bruton's Tyrosine Kinase.
Song Y, Zhou K, Zou D, Zhou J, Hu J, Yang H, Zhang H, Ji J, Xu W, Jin J, Lv F, Feng R, Gao S, Guo H, Zhou L, Elstrom R, Huang J, Novotny W, Wei R, Zhu J
Clin Cancer Res 2020 Aug 15;26(16):4216-4224. Epub 2020 May 27 doi: 10.1158/1078-0432.CCR-19-3703. PMID: 32461234
Prognosis and therapy of chronic lymphocytic leukemia and small lymphocytic lymphoma.
Sun C, Wiestner A
Cancer Treat Res 2015;165:147-75. doi: 10.1007/978-3-319-13150-4_6. PMID: 25655609
BCR pathway inhibition as therapy for chronic lymphocytic leukemia and lymphoplasmacytic lymphoma.
Wiestner A
Hematology Am Soc Hematol Educ Program 2014 Dec 5;2014(1):125-34. Epub 2014 Nov 18 doi: 10.1182/asheducation-2014.1.125. PMID: 25696845

Prognosis

Post-mortem diagnosis of intravascular large B-cell lymphoma.
Maiese A, La Russa R, De Matteis A, Frati P, Fineschi V
J Int Med Res 2020 Jun;48(6):300060520924262. doi: 10.1177/0300060520924262. PMID: 32485117Free PMC Article
Treatment of Patients with Relapsed or Refractory Mantle-Cell Lymphoma with Zanubrutinib, a Selective Inhibitor of Bruton's Tyrosine Kinase.
Song Y, Zhou K, Zou D, Zhou J, Hu J, Yang H, Zhang H, Ji J, Xu W, Jin J, Lv F, Feng R, Gao S, Guo H, Zhou L, Elstrom R, Huang J, Novotny W, Wei R, Zhu J
Clin Cancer Res 2020 Aug 15;26(16):4216-4224. Epub 2020 May 27 doi: 10.1158/1078-0432.CCR-19-3703. PMID: 32461234
Prognosis and therapy of chronic lymphocytic leukemia and small lymphocytic lymphoma.
Sun C, Wiestner A
Cancer Treat Res 2015;165:147-75. doi: 10.1007/978-3-319-13150-4_6. PMID: 25655609
B-cell receptor signaling as a driver of lymphoma development and evolution.
Niemann CU, Wiestner A
Semin Cancer Biol 2013 Dec;23(6):410-21. Epub 2013 Sep 20 doi: 10.1016/j.semcancer.2013.09.001. PMID: 24060900Free PMC Article
Tumor microenvironment is multifaceted.
Sautès-Fridman C, Cherfils-Vicini J, Damotte D, Fisson S, Fridman WH, Cremer I, Dieu-Nosjean MC
Cancer Metastasis Rev 2011 Mar;30(1):13-25. doi: 10.1007/s10555-011-9279-y. PMID: 21271351

Clinical prediction guides

Deciphering the genetic landscape of pulmonary lymphomas.
Vela V, Juskevicius D, Prince SS, Cathomas G, Dertinger S, Diebold J, Bubendorf L, Horcic M, Singer G, Zettl A, Dirnhofer S, Tzankov A, Menter T
Mod Pathol 2021 Feb;34(2):371-379. Epub 2020 Aug 27 doi: 10.1038/s41379-020-00660-2. PMID: 32855441
Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms.
Gagliardi A, Dugué PA, Nøst TH, Southey MC, Buchanan DD, Schmidt DF, Makalic E, Hodge AM, English DR, Doo NW, Hopper JL, Severi G, Baglietto L, Naccarati A, Tarallo S, Pace L, Krogh V, Palli D, Panico S, Sacerdote C, Tumino R, Lund E, Giles GG, Pardini B, Sandanger TM, Milne RL, Vineis P, Polidoro S, Fiorito G
Cancer Epidemiol Biomarkers Prev 2020 Oct;29(10):2026-2037. Epub 2020 Aug 11 doi: 10.1158/1055-9965.EPI-20-0451. PMID: 32788174
Intravascular large B cell lymphoma presenting in the lung: the diagnostic value of transbronchial cryobiopsy.
Poletti V, Gurioli C, Piciucchi S, Rossi A, Ravaglia C, Dubini A, Asioli S, Casoni GL
Sarcoidosis Vasc Diffuse Lung Dis 2015 Jan 5;31(4):354-8. PMID: 25591148
Do mantle cell lymphomas have an 'Achilles heel'?
Saba N, Wiestner A
Curr Opin Hematol 2014 Jul;21(4):350-7. doi: 10.1097/MOH.0000000000000057. PMID: 24857884Free PMC Article
Tumor microenvironment is multifaceted.
Sautès-Fridman C, Cherfils-Vicini J, Damotte D, Fisson S, Fridman WH, Cremer I, Dieu-Nosjean MC
Cancer Metastasis Rev 2011 Mar;30(1):13-25. doi: 10.1007/s10555-011-9279-y. PMID: 21271351

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