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Spontaneous Abortion

MedGen UID:
39
•Concept ID:
C0000786
•
Finding; Pathologic Function
Synonyms: Abortion, Spontaneous; Abortions, Spontaneous; Spontaneous Abortions

Definition

Fetal loss at less than 20 weeks of gestation. [from NCI]

Professional guidelines

PubMed

Vulvovaginal Candidiasis: A Review of the Evidence for the 2021 Centers for Disease Control and Prevention of Sexually Transmitted Infections Treatment Guidelines.
Nyirjesy P, Brookhart C, Lazenby G, Schwebke J, Sobel JD
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S162-S168. doi: 10.1093/cid/ciab1057. PMID: 35416967
Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus.
Auriti C, De Rose DU, Santisi A, Martini L, Piersigilli F, Bersani I, Ronchetti MP, Caforio L
Biochim Biophys Acta Mol Basis Dis 2021 Oct 1;1867(10):166198. Epub 2021 Jun 10 doi: 10.1016/j.bbadis.2021.166198. PMID: 34118406Free PMC Article
Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027

Recent clinical studies

Etiology

Common mental disorders and risk of spontaneous abortion or recurrent spontaneous abortion: A two-sample Mendelian randomization study.
He Y, Wang L, Tang R, Jin H, Liu B, Chen S, Mu H, Wang X
J Affect Disord 2024 Jun 1;354:258-266. Epub 2024 Mar 13 doi: 10.1016/j.jad.2024.03.026. PMID: 38484879
Association of spontaneous abortion with all cause and cause specific premature mortality: prospective cohort study.
Wang YX, Mínguez-Alarcón L, Gaskins AJ, Missmer SA, Rich-Edwards JW, Manson JE, Pan A, Chavarro JE
BMJ 2021 Mar 24;372:n530. doi: 10.1136/bmj.n530. PMID: 33762255Free PMC Article
Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Maternal age and fetal loss: population based register linkage study.
Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M
BMJ 2000 Jun 24;320(7251):1708-12. doi: 10.1136/bmj.320.7251.1708. PMID: 10864550Free PMC Article
Spontaneous abortion.
McBride WZ
Am Fam Physician 1991 Jan;43(1):175-82. PMID: 1986486

Diagnosis

Ectopic pregnancy.
Levine D
Radiology 2007 Nov;245(2):385-97. doi: 10.1148/radiol.2452061031. PMID: 17940301
Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Spontaneous abortion.
Apgar BS, Churgay CA
Prim Care 1993 Sep;20(3):621-7. PMID: 8378454
Spontaneous abortion.
McBride WZ
Am Fam Physician 1991 Jan;43(1):175-82. PMID: 1986486
Recurrent spontaneous abortion.
McIntyre JA, Coulam CB, Faulk WP
Am J Reprod Immunol 1989 Nov-Dec;21(3-4):100-4. doi: 10.1111/j.1600-0897.1989.tb01011.x. PMID: 2534830

Therapy

Progesterone for women with threatened miscarriage (STOP trial): a placebo-controlled randomized clinical trial.
McLindon LA, James G, Beckmann MM, Bertolone J, Mahomed K, Vane M, Baker T, Gleed M, Grey S, Tettamanzi L, Mol BWJ, Li W
Hum Reprod 2023 Apr 3;38(4):560-568. doi: 10.1093/humrep/dead029. PMID: 36806843Free PMC Article
Progestogens for preventing miscarriage: a network meta-analysis.
Devall AJ, Papadopoulou A, Podesek M, Haas DM, Price MJ, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Apr 19;4(4):CD013792. doi: 10.1002/14651858.CD013792.pub2. PMID: 33872382Free PMC Article
Antioxidants for female subfertility.
Showell MG, Mackenzie-Proctor R, Jordan V, Hart RJ
Cochrane Database Syst Rev 2020 Aug 27;8(8):CD007807. doi: 10.1002/14651858.CD007807.pub4. PMID: 32851663Free PMC Article
Interventions for endometriosis-related infertility: a systematic review and network meta-analysis.
Hodgson RM, Lee HL, Wang R, Mol BW, Johnson N
Fertil Steril 2020 Feb;113(2):374-382.e2. doi: 10.1016/j.fertnstert.2019.09.031. PMID: 32106991
The relationship between stress and infertility.
Rooney KL, Domar AD
Dialogues Clin Neurosci 2018 Mar;20(1):41-47. doi: 10.31887/DCNS.2018.20.1/klrooney. PMID: 29946210Free PMC Article

Prognosis

Maternal Mortality in Low and Middle-Income Countries.
Lawrence ER, Klein TJ, Beyuo TK
Obstet Gynecol Clin North Am 2022 Dec;49(4):713-733. doi: 10.1016/j.ogc.2022.07.001. PMID: 36328676
Association of spontaneous abortion with all cause and cause specific premature mortality: prospective cohort study.
Wang YX, Mínguez-Alarcón L, Gaskins AJ, Missmer SA, Rich-Edwards JW, Manson JE, Pan A, Chavarro JE
BMJ 2021 Mar 24;372:n530. doi: 10.1136/bmj.n530. PMID: 33762255Free PMC Article
Air pollution exposure during pregnancy and spontaneous abortion and stillbirth.
Grippo A, Zhang J, Chu L, Guo Y, Qiao L, Zhang J, Myneni AA, Mu L
Rev Environ Health 2018 Sep 25;33(3):247-264. doi: 10.1515/reveh-2017-0033. PMID: 29975668Free PMC Article
Rape-related pregnancy: estimates and descriptive characteristics from a national sample of women.
Holmes MM, Resnick HS, Kilpatrick DG, Best CL
Am J Obstet Gynecol 1996 Aug;175(2):320-4; discussion 324-5. doi: 10.1016/s0002-9378(96)70141-2. PMID: 8765248
Habitual abortion.
BENSON RC
Calif Med 1950 Jun;72(6):442-6. PMID: 15414445Free PMC Article

Clinical prediction guides

Common mental disorders and risk of spontaneous abortion or recurrent spontaneous abortion: A two-sample Mendelian randomization study.
He Y, Wang L, Tang R, Jin H, Liu B, Chen S, Mu H, Wang X
J Affect Disord 2024 Jun 1;354:258-266. Epub 2024 Mar 13 doi: 10.1016/j.jad.2024.03.026. PMID: 38484879
Toxoplasma gondii infection and spontaneous abortion: A systematic review and meta-analysis.
Kalantari N, Gorgani-Firouzjaee T, Moulana Z, Chehrazi M, Ghaffari S
Microb Pathog 2021 Sep;158:105070. Epub 2021 Jun 26 doi: 10.1016/j.micpath.2021.105070. PMID: 34186117
Diagnosis and treatment of luteal phase deficiency: a committee opinion.
Practice Committees of the American Society for Reproductive Medicine and the Society for Reproductive Endocrinology and Infertility
Fertil Steril 2021 Jun;115(6):1416-1423. Epub 2021 Apr 4 doi: 10.1016/j.fertnstert.2021.02.010. PMID: 33827766
Antiphospholipid antibodies.
Houghton DE, Moll S
Vasc Med 2017 Dec;22(6):545-550. Epub 2017 Nov 5 doi: 10.1177/1358863X17737374. PMID: 29103369
Endometriosis and recurrent pregnancy loss.
Vercammen EE, D'Hooghe TM
Semin Reprod Med 2000;18(4):363-8. doi: 10.1055/s-2000-13726. PMID: 11355795

Recent systematic reviews

The Effects of Exercise during Pregnancy on Gestational Diabetes Mellitus, Preeclampsia, and Spontaneous Abortion among Healthy Women-A Systematic Review and Meta-Analysis.
Paulsen CP, Bandak E, Edemann-Callesen H, Juhl CB, Händel MN
Int J Environ Res Public Health 2023 Jun 6;20(12) doi: 10.3390/ijerph20126069. PMID: 37372656Free PMC Article
Decidual macrophages in recurrent spontaneous abortion.
Zhao QY, Li QH, Fu YY, Ren CE, Jiang AF, Meng YH
Front Immunol 2022;13:994888. Epub 2022 Dec 8 doi: 10.3389/fimmu.2022.994888. PMID: 36569856Free PMC Article
The risk factors associated with placenta previa: An umbrella review.
Jenabi E, Salimi Z, Bashirian S, Khazaei S, Ayubi E
Placenta 2022 Jan;117:21-27. Epub 2021 Oct 20 doi: 10.1016/j.placenta.2021.10.009. PMID: 34768164
Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis.
Maraka S, Ospina NM, O'Keeffe DT, Espinosa De Ycaza AE, Gionfriddo MR, Erwin PJ, Coddington CC 3rd, Stan MN, Murad MH, Montori VM
Thyroid 2016 Apr;26(4):580-90. Epub 2016 Mar 3 doi: 10.1089/thy.2015.0418. PMID: 26837268Free PMC Article
Fibroids and infertility: an updated systematic review of the evidence.
Pritts EA, Parker WH, Olive DL
Fertil Steril 2009 Apr;91(4):1215-23. Epub 2008 Mar 12 doi: 10.1016/j.fertnstert.2008.01.051. PMID: 18339376

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