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Pancreatic squamous cell carcinoma

MedGen UID:
393937
•Concept ID:
C2675993
•
Finding; Neoplastic Process
Synonyms: pancreas squamous cell carcinoma; Pancreatic Squamous Cell Carcinoma; pancreatic squamous cell carcinoma; squamous cell carcinoma of pancreas; Squamous cell carcinoma of pancreas; Squamous cell carcinoma of the pancreas; squamous cell carcinoma of the pancreas
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0012142
Monarch Initiative: MONDO:0018521
Orphanet: ORPHA424039

Definition

A subtype of ductal pancreatic carcinoma that is thought to originate from squamous metaplasia of pancreatic ductal epithelium. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic squamous cell carcinoma

Conditions with this feature

Melanoma-pancreatic cancer syndrome
MedGen UID:
325450
•Concept ID:
C1838547
•
Disease or Syndrome
Melanoma-pancreatic cancer syndrome is an inherited cancer predisposition syndrome in which mutation carriers have an increased risk of developing malignant melanoma and/or pancreatic cancer. Mutation carriers within families may develop either or both types of cancer (summary by Harinck et al., 2012). For background and phenotypic information on malignant melanoma and pancreatic cancer, see 155600 and 260350, respectively.
See: Condition Record
Melanoma-pancreatic cancer syndrome

Professional guidelines

PubMed

Epidemiology, Treatment, and Outcome of Pancreatic Squamous Cell Carcinoma and Pancreatic Adenocarcinoma: A Propensity Score-Matching Analysis Based on SEER-Database.
Wang Y, Zhou Y, Chen Y, Xia R, Liu J
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221106533. doi: 10.1177/15330338221106533. PMID: 35770310Free PMC Article

Recent clinical studies

Etiology

The impact of squamous cell carcinoma histology on outcomes in nonmetastatic pancreatic cancer.
Gruhl JD, Garrido-Laguna I, Francis SR, Affolter K, Tao R, Lloyd S
Cancer Med 2020 Mar;9(5):1703-1711. Epub 2020 Jan 16 doi: 10.1002/cam4.2851. PMID: 31945808Free PMC Article
Pancreatic Squamous Cell Carcinoma: A Population-Based Study of Epidemiology, Clinicopathologic Characteristics and Outcomes.
Makarova-Rusher OV, Ulahannan S, Greten TF, Duffy A
Pancreas 2016 Nov;45(10):1432-1437. doi: 10.1097/MPA.0000000000000658. PMID: 27214394Free PMC Article

Diagnosis

Epidemiology, Treatment, and Outcome of Pancreatic Squamous Cell Carcinoma and Pancreatic Adenocarcinoma: A Propensity Score-Matching Analysis Based on SEER-Database.
Wang Y, Zhou Y, Chen Y, Xia R, Liu J
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221106533. doi: 10.1177/15330338221106533. PMID: 35770310Free PMC Article
The impact of squamous cell carcinoma histology on outcomes in nonmetastatic pancreatic cancer.
Gruhl JD, Garrido-Laguna I, Francis SR, Affolter K, Tao R, Lloyd S
Cancer Med 2020 Mar;9(5):1703-1711. Epub 2020 Jan 16 doi: 10.1002/cam4.2851. PMID: 31945808Free PMC Article
Squamous cell carcinoma of the pancreas: A systematic review and pooled survival analysis.
Ntanasis-Stathopoulos I, Tsilimigras DI, Georgiadou D, Kanavidis P, Riccioni O, Salla C, Psaltopoulou T, Sergentanis TN
Eur J Cancer 2017 Jul;79:193-204. Epub 2017 May 13 doi: 10.1016/j.ejca.2017.04.006. PMID: 28511147
Genomic characteristics of pancreatic squamous cell carcinoma, an investigation by using high throughput sequencing after in-solution hybrid capture.
Xu MD, Liu SL, Feng YZ, Liu Q, Shen M, Zhi Q, Liu Z, Gu DM, Yu J, Shou LM, Gong FR, Zhu Q, Duan W, Chen K, Zhang J, Wu MY, Tao M, Li W
Oncotarget 2017 Feb 28;8(9):14620-14635. doi: 10.18632/oncotarget.14678. PMID: 28099906Free PMC Article
Primary squamous cell carcinoma of the pancreas diagnosed by endoscopic ultrasound-guided fine needle aspiration.
Zacharia G, Levine J, Winstead NS, Antillon MR, Davis NK
J Gastrointestin Liver Dis 2012 Sep;21(3):321-3. PMID: 23012676

Therapy

A case report: pancreatic squamous cell carcinoma with effective response by S-1 therapy.
Ikeda A, Okuno T, Miki I, Yokozaki H, Kutsumi H, Azuma T
Clin J Gastroenterol 2014 Feb;7(1):79-83. Epub 2014 Jan 1 doi: 10.1007/s12328-013-0449-z. PMID: 26183513

Prognosis

Epidemiology, Treatment, and Outcome of Pancreatic Squamous Cell Carcinoma and Pancreatic Adenocarcinoma: A Propensity Score-Matching Analysis Based on SEER-Database.
Wang Y, Zhou Y, Chen Y, Xia R, Liu J
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221106533. doi: 10.1177/15330338221106533. PMID: 35770310Free PMC Article
The impact of squamous cell carcinoma histology on outcomes in nonmetastatic pancreatic cancer.
Gruhl JD, Garrido-Laguna I, Francis SR, Affolter K, Tao R, Lloyd S
Cancer Med 2020 Mar;9(5):1703-1711. Epub 2020 Jan 16 doi: 10.1002/cam4.2851. PMID: 31945808Free PMC Article
Survival and prognostic factors in patients with pancreatic squamous cell carcinoma.
Tella SH, Kommalapati A, Yadav S, Bergquist JR, Truty MJ, Durgin L, Ma WW, Cleary SP, McWilliams RR, Mahipal A
Eur J Surg Oncol 2019 Sep;45(9):1700-1705. Epub 2019 May 15 doi: 10.1016/j.ejso.2019.05.011. PMID: 31118133
Squamous cell carcinoma of the pancreas: A systematic review and pooled survival analysis.
Ntanasis-Stathopoulos I, Tsilimigras DI, Georgiadou D, Kanavidis P, Riccioni O, Salla C, Psaltopoulou T, Sergentanis TN
Eur J Cancer 2017 Jul;79:193-204. Epub 2017 May 13 doi: 10.1016/j.ejca.2017.04.006. PMID: 28511147
Pancreatic Squamous Cell Carcinoma: A Population-Based Study of Epidemiology, Clinicopathologic Characteristics and Outcomes.
Makarova-Rusher OV, Ulahannan S, Greten TF, Duffy A
Pancreas 2016 Nov;45(10):1432-1437. doi: 10.1097/MPA.0000000000000658. PMID: 27214394Free PMC Article

Clinical prediction guides

Epidemiology, Treatment, and Outcome of Pancreatic Squamous Cell Carcinoma and Pancreatic Adenocarcinoma: A Propensity Score-Matching Analysis Based on SEER-Database.
Wang Y, Zhou Y, Chen Y, Xia R, Liu J
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221106533. doi: 10.1177/15330338221106533. PMID: 35770310Free PMC Article
Pancreatic Squamous Cell Carcinoma: A Population-Based Study of Epidemiology, Clinicopathologic Characteristics and Outcomes.
Makarova-Rusher OV, Ulahannan S, Greten TF, Duffy A
Pancreas 2016 Nov;45(10):1432-1437. doi: 10.1097/MPA.0000000000000658. PMID: 27214394Free PMC Article

Recent systematic reviews

Squamous cell carcinoma of the pancreas: A systematic review and pooled survival analysis.
Ntanasis-Stathopoulos I, Tsilimigras DI, Georgiadou D, Kanavidis P, Riccioni O, Salla C, Psaltopoulou T, Sergentanis TN
Eur J Cancer 2017 Jul;79:193-204. Epub 2017 May 13 doi: 10.1016/j.ejca.2017.04.006. PMID: 28511147

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