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Mesonephric adenocarcinoma

MedGen UID:
44373
•Concept ID:
C0025490
•
Neoplastic Process
Synonyms: Mesonephroma; Mesonephromas
SNOMED CT: Malignant mesonephroma (2221008); Mesonephroma, malignant (2221008); Mesonephric adenocarcinoma (2221008); Wolffian duct carcinoma (2221008)
 
Monarch Initiative: MONDO:0005613

Definition

An adenocarcinoma of the cervix or the vagina that derives from Wolffian duct remnants and shows mesonephric differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMesonephric adenocarcinoma

Professional guidelines

PubMed

Mesonephric and mesonephric-like adenocarcinomas of gynecologic origin: A single-center experience with molecular characterization, treatment, and oncologic outcomes.
Praiss AM, White C, Iasonos A, Selenica P, Zivanovic O, Chi DS, Abu-Rustum NR, Weigelt B, Aghajanian C, Girshman J, Park KJ, Grisham RN
Gynecol Oncol 2024 Mar;182:32-38. Epub 2024 Jan 20 doi: 10.1016/j.ygyno.2024.01.015. PMID: 38246044Free PMC Article
Uncommon Cervical Lesions: A Review and Discussion of the Differential Diagnosis.
Griesinger LM, Szczepanski JM, McMullen ER, Skala SL
Arch Pathol Lab Med 2021 Jul 1;145(7):891-902. doi: 10.5858/arpa.2020-0327-RA. PMID: 33091926

Recent clinical studies

Etiology

Mesonephric and mesonephric-like adenocarcinomas of gynecologic origin: A single-center experience with molecular characterization, treatment, and oncologic outcomes.
Praiss AM, White C, Iasonos A, Selenica P, Zivanovic O, Chi DS, Abu-Rustum NR, Weigelt B, Aghajanian C, Girshman J, Park KJ, Grisham RN
Gynecol Oncol 2024 Mar;182:32-38. Epub 2024 Jan 20 doi: 10.1016/j.ygyno.2024.01.015. PMID: 38246044Free PMC Article
Mesonephric-like adenocarcinoma harbours characteristic copy number variations and a distinct DNA methylation signature closely related to mesonephric adenocarcinoma of the cervix.
Kommoss FK, Lee CH, Tessier-Cloutier B, Gilks CB, Stewart CJ, von Deimling A, Köbel M
J Pathol 2024 Jan;262(1):4-9. Epub 2023 Oct 18 doi: 10.1002/path.6217. PMID: 37850576
Mesonephric adenocarcinomas in female genital tract: A case series.
Xie C, Chen Q, Shen Y
Medicine (Baltimore) 2021 Sep 3;100(35):e27174. doi: 10.1097/MD.0000000000027174. PMID: 34477176Free PMC Article
Clinicopathologic Characteristics of Mesonephric Adenocarcinomas and Mesonephric-like Adenocarcinomas in the Gynecologic Tract: A Multi-institutional Study.
Pors J, Segura S, Chiu DS, Almadani N, Ren H, Fix DJ, Howitt BE, Kolin D, McCluggage WG, Mirkovic J, Gilks B, Park KJ, Hoang L
Am J Surg Pathol 2021 Apr 1;45(4):498-506. doi: 10.1097/PAS.0000000000001612. PMID: 33165093Free PMC Article
Hormone receptor-negative, thyroid transcription factor 1-positive uterine and ovarian adenocarcinomas: report of a series of mesonephric-like adenocarcinomas.
McFarland M, Quick CM, McCluggage WG
Histopathology 2016 Jun;68(7):1013-20. Epub 2016 Jan 4 doi: 10.1111/his.12895. PMID: 26484981

Diagnosis

Mesonephric and mesonephric-like adenocarcinomas of gynecologic origin: A single-center experience with molecular characterization, treatment, and oncologic outcomes.
Praiss AM, White C, Iasonos A, Selenica P, Zivanovic O, Chi DS, Abu-Rustum NR, Weigelt B, Aghajanian C, Girshman J, Park KJ, Grisham RN
Gynecol Oncol 2024 Mar;182:32-38. Epub 2024 Jan 20 doi: 10.1016/j.ygyno.2024.01.015. PMID: 38246044Free PMC Article
Uncommon Cervical Lesions: A Review and Discussion of the Differential Diagnosis.
Griesinger LM, Szczepanski JM, McMullen ER, Skala SL
Arch Pathol Lab Med 2021 Jul 1;145(7):891-902. doi: 10.5858/arpa.2020-0327-RA. PMID: 33091926
Uterine lesions with sex cord-like architectures: a systematic review.
Jia M, Sun PL, Gao H
Diagn Pathol 2019 Nov 18;14(1):129. doi: 10.1186/s13000-019-0909-y. PMID: 31739799Free PMC Article
CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus: CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endometrial stroma.
McCluggage WG, Oliva E, Herrington CS, McBride H, Young RH
Histopathology 2003 Aug;43(2):144-50. doi: 10.1046/j.1365-2559.2003.01684.x. PMID: 12877729
Symposium part II: special types of adenocarcinoma of the uterine cervix.
Hart WR
Int J Gynecol Pathol 2002 Oct;21(4):327-46. doi: 10.1097/00004347-200210000-00003. PMID: 12352182

Therapy

Mesonephric adenocarcinoma in the uterine corpus: A case report and review of the literature.
Tang X, Li L, He Y
Indian J Pathol Microbiol 2021 Oct-Dec;64(4):806-809. doi: 10.4103/IJPM.IJPM_298_20. PMID: 34673610
Activity of chemotherapy with carboplatin plus paclitaxel in a recurrent mesonephric adenocarcinoma of the uterine corpus.
Montagut C, Mármol M, Rey V, Ordi J, Pahissa J, Rovirosa A, Gascón P, Mellado B
Gynecol Oncol 2003 Aug;90(2):458-61. doi: 10.1016/s0090-8258(03)00228-2. PMID: 12893219
Clear cell (mesonephric) adenocarcinoma of the vagina. A case report.
Rosati LA, Jarzynski DJ
Acta Cytol 1973 Nov-Dec;17(6):493-7. PMID: 4127770

Prognosis

Uncommon Cervical Lesions: A Review and Discussion of the Differential Diagnosis.
Griesinger LM, Szczepanski JM, McMullen ER, Skala SL
Arch Pathol Lab Med 2021 Jul 1;145(7):891-902. doi: 10.5858/arpa.2020-0327-RA. PMID: 33091926
Gastric-type Adenocarcinoma of the Cervix: Tumor With Wide Range of Histologic Appearances.
Pirog EC, Park KJ, Kiyokawa T, Zhang X, Chen W, Jenkins D, Quint W
Adv Anat Pathol 2019 Jan;26(1):1-12. doi: 10.1097/PAP.0000000000000216. PMID: 30234500
Clinicopathologic and Molecular Characteristics of Mesonephric Adenocarcinoma Arising From the Uterine Body.
Na K, Kim HS
Am J Surg Pathol 2019 Jan;43(1):12-25. doi: 10.1097/PAS.0000000000000991. PMID: 29189288Free PMC Article
Hormone receptor-negative, thyroid transcription factor 1-positive uterine and ovarian adenocarcinomas: report of a series of mesonephric-like adenocarcinomas.
McFarland M, Quick CM, McCluggage WG
Histopathology 2016 Jun;68(7):1013-20. Epub 2016 Jan 4 doi: 10.1111/his.12895. PMID: 26484981
Tumor rupture as an initial manifestation of malignant mesonephric mixed tumor: a case report and review of the literature.
Tseng CE, Chen CH, Chen SJ, Chi CL
Int J Clin Exp Pathol 2014;7(3):1212-7. Epub 2014 Feb 15 PMID: 24696739Free PMC Article

Clinical prediction guides

Mesonephric adenocarcinoma in the uterine corpus: A case report and review of the literature.
Tang X, Li L, He Y
Indian J Pathol Microbiol 2021 Oct-Dec;64(4):806-809. doi: 10.4103/IJPM.IJPM_298_20. PMID: 34673610
Uterine lesions with sex cord-like architectures: a systematic review.
Jia M, Sun PL, Gao H
Diagn Pathol 2019 Nov 18;14(1):129. doi: 10.1186/s13000-019-0909-y. PMID: 31739799Free PMC Article
Clinicopathologic and Molecular Characteristics of Mesonephric Adenocarcinoma Arising From the Uterine Body.
Na K, Kim HS
Am J Surg Pathol 2019 Jan;43(1):12-25. doi: 10.1097/PAS.0000000000000991. PMID: 29189288Free PMC Article
Mesonephric Adenocarcinoma of the Uterine Corpus: A Case Report and Diagnostic Pitfall.
Kim SS, Nam JH, Kim GE, Choi YD, Choi C, Park CS
Int J Surg Pathol 2016 Apr;24(2):153-8. Epub 2015 Oct 27 doi: 10.1177/1066896915611489. PMID: 26510860
Mesonephric adenocarcinoma of the uterine corpus.
Wu H, Zhang L, Cao W, Hu Y, Liu Y
Int J Clin Exp Pathol 2014;7(10):7012-9. Epub 2014 Sep 15 PMID: 25400789Free PMC Article

Recent systematic reviews

Uterine lesions with sex cord-like architectures: a systematic review.
Jia M, Sun PL, Gao H
Diagn Pathol 2019 Nov 18;14(1):129. doi: 10.1186/s13000-019-0909-y. PMID: 31739799Free PMC Article

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