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Pancreatic Well Differentiated Ductal Adenocarcinoma

MedGen UID:
459365
Concept ID:
C2987139
Neoplastic Process
Synonym: Pancreatic Well-Differentiated Ductal Adenocarcinoma

Definition

A pancreatic ductal adenocarcinoma characterized by the presence of duct-like structures and medium-sized malignant glandular structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Well Differentiated Ductal Adenocarcinoma

Professional guidelines

PubMed

Álvarez R, Carrato A, Adeva J, Alés I, Prados S, Valladares M, Macarulla T, Muñoz A, Hidalgo M
Eur J Cancer 2018 May;94:26-36. Epub 2018 Mar 20 doi: 10.1016/j.ejca.2018.01.078. PMID: 29505968
Basturk O, Coban I, Adsay NV
Arch Pathol Lab Med 2009 Mar;133(3):423-38. doi: 10.5858/133.3.423. PMID: 19260748
Klöppel G, Adsay NV
Arch Pathol Lab Med 2009 Mar;133(3):382-7. doi: 10.5858/133.3.382. PMID: 19260744

Recent clinical studies

Etiology

Yu C, Lokan J, Jackett L, Nikfarjam M, Mills C
BMJ Case Rep 2022 Dec 22;15(12) doi: 10.1136/bcr-2021-246398. PMID: 36549752Free PMC Article
Ramkissoon R, Gardner TB
Curr Opin Gastroenterol 2019 Sep;35(5):440-447. doi: 10.1097/MOG.0000000000000566. PMID: 31343416
Le N, Sund M, Vinci A; GEMS collaborating group of Pancreas 2000
Dig Liver Dis 2016 Mar;48(3):223-30. Epub 2015 Nov 14 doi: 10.1016/j.dld.2015.11.001. PMID: 26769569
Izumi S, Nakamura S, Mano S, Akaki S
Pancreas 2015 Apr;44(3):394-400. doi: 10.1097/MPA.0000000000000260. PMID: 25426619
Heinrich S, Clavien PA
Curr Opin Gastroenterol 2010 May;26(3):280-5. doi: 10.1097/MOG.0b013e3283378eb0. PMID: 20168227

Diagnosis

Tang Y, Tang S, Yang W, Zhang Z, Wang T, Wu Y, Xu J, Pilarsky C, Mazzone M, Wang LW, Sun Y, Tian R, Tang Y, Wang Y, Wang C, Xue J
Gut 2024 Nov 11;73(12):1999-2011. doi: 10.1136/gutjnl-2024-332350. PMID: 39216984
Dhillon J
Monogr Clin Cytol 2020;26:34-41. Epub 2020 Sep 28 doi: 10.1159/000455733. PMID: 32987395
Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T
Nature 2019 May;569(7754):131-135. Epub 2019 Apr 17 doi: 10.1038/s41586-019-1130-6. PMID: 30996350Free PMC Article
Storz P
Nat Rev Gastroenterol Hepatol 2017 May;14(5):296-304. Epub 2017 Mar 8 doi: 10.1038/nrgastro.2017.12. PMID: 28270694Free PMC Article
Hruban RH, Klimstra DS
Semin Diagn Pathol 2014 Nov;31(6):443-451. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.004. PMID: 25441308Free PMC Article

Therapy

Tang Y, Tang S, Yang W, Zhang Z, Wang T, Wu Y, Xu J, Pilarsky C, Mazzone M, Wang LW, Sun Y, Tian R, Tang Y, Wang Y, Wang C, Xue J
Gut 2024 Nov 11;73(12):1999-2011. doi: 10.1136/gutjnl-2024-332350. PMID: 39216984
Wu Y, Seufert I, Al-Shaheri FN, Kurilov R, Bauer AS, Manoochehri M, Moskalev EA, Brors B, Tjaden C, Giese NA, Hackert T, Büchler MW, Hoheisel JD
Gut 2023 Nov 24;72(12):2344-2353. doi: 10.1136/gutjnl-2023-330155. PMID: 37709492Free PMC Article
Kinker GS, Vitiello GAF, Diniz AB, Cabral-Piccin MP, Pereira PHB, Carvalho MLR, Ferreira WAS, Chaves AS, Rondinelli A, Gusmão AF, Defelicibus A, Dos Santos GO, Nunes WA, Claro LCL, Bernardo TM, Nishio RT, Pacheco AM, Laus AC, Arantes LMRB, Fleck JL, de Jesus VHF, de Moricz A, Weinlich R, Coimbra FJF, de Lima VCC, Medina TDS
Gut 2023 Oct;72(10):1927-1941. Epub 2023 May 25 doi: 10.1136/gutjnl-2022-328697. PMID: 37230755
Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T
Nature 2019 May;569(7754):131-135. Epub 2019 Apr 17 doi: 10.1038/s41586-019-1130-6. PMID: 30996350Free PMC Article
Heinrich S, Clavien PA
Curr Opin Gastroenterol 2010 May;26(3):280-5. doi: 10.1097/MOG.0b013e3283378eb0. PMID: 20168227

Prognosis

Tang Y, Tang S, Yang W, Zhang Z, Wang T, Wu Y, Xu J, Pilarsky C, Mazzone M, Wang LW, Sun Y, Tian R, Tang Y, Wang Y, Wang C, Xue J
Gut 2024 Nov 11;73(12):1999-2011. doi: 10.1136/gutjnl-2024-332350. PMID: 39216984
Yousuf S, Qiu M, Voith von Voithenberg L, Hulkkonen J, Macinkovic I, Schulz AR, Hartmann D, Mueller F, Mijatovic M, Ibberson D, AlHalabi KT, Hetzer J, Anders S, Brüne B, Mei HE, Imbusch CD, Brors B, Heikenwälder M, Gaida MM, Büchler MW, Weigert A, Hackert T, Roth S
Gastroenterology 2023 Oct;165(4):891-908.e14. Epub 2023 May 30 doi: 10.1053/j.gastro.2023.05.036. PMID: 37263303
Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T
Nature 2019 May;569(7754):131-135. Epub 2019 Apr 17 doi: 10.1038/s41586-019-1130-6. PMID: 30996350Free PMC Article
Le N, Sund M, Vinci A; GEMS collaborating group of Pancreas 2000
Dig Liver Dis 2016 Mar;48(3):223-30. Epub 2015 Nov 14 doi: 10.1016/j.dld.2015.11.001. PMID: 26769569
Heinrich S, Clavien PA
Curr Opin Gastroenterol 2010 May;26(3):280-5. doi: 10.1097/MOG.0b013e3283378eb0. PMID: 20168227

Clinical prediction guides

Zhou Y, Jin J, Ji Y, Zhang J, Fu N, Chen M, Wang J, Qin K, Jiang Y, Cheng D, Deng X, Shen B
J Transl Med 2023 Dec 1;21(1):872. doi: 10.1186/s12967-023-04742-y. PMID: 38037073Free PMC Article
Purushothaman A, Oliva-Ramírez J, Treekitkarnmongkol W, Sankaran D, Hurd MW, Putluri N, Maitra A, Haymaker C, Sen S
Int J Mol Sci 2023 Sep 27;24(19) doi: 10.3390/ijms241914652. PMID: 37834100Free PMC Article
Hayashi A, Yavas A, McIntyre CA, Ho YJ, Erakky A, Wong W, Varghese AM, Melchor JP, Overholtzer M, O'Reilly EM, Klimstra DS, Basturk O, Iacobuzio-Donahue CA
Mod Pathol 2020 Sep;33(9):1822-1831. Epub 2020 Apr 29 doi: 10.1038/s41379-020-0549-5. PMID: 32350415Free PMC Article
Thompson ED, Wood LD
Arch Pathol Lab Med 2020 Jul 1;144(7):808-815. doi: 10.5858/arpa.2019-0472-RA. PMID: 31869246
Le N, Sund M, Vinci A; GEMS collaborating group of Pancreas 2000
Dig Liver Dis 2016 Mar;48(3):223-30. Epub 2015 Nov 14 doi: 10.1016/j.dld.2015.11.001. PMID: 26769569

Recent systematic reviews

Li R, Liu Z, Chen Y, Hu X, Peng X
Medicine (Baltimore) 2020 Jun 26;99(26):e20950. doi: 10.1097/MD.0000000000020950. PMID: 32590806Free PMC Article
Garcea G, Dennison AR, Pattenden CJ, Neal CP, Sutton CD, Berry DP
JOP 2008 Mar 8;9(2):99-132. PMID: 18326920
Belyaev O, Seelig MH, Muller CA, Tannapfel A, Schmidt WE, Uhl W
J Clin Gastroenterol 2008 Mar;42(3):284-94. doi: 10.1097/MCG.0b013e3180500761. PMID: 18223495

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