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Bile Duct Mucinous Cystic Neoplasm, Low Grade

MedGen UID:
474702
•Concept ID:
C3273069
•
Neoplastic Process
Synonyms: Bile Duct MCN with Low Grade Intraepithelial Neoplasia; Bile Duct Mucinous Cystic Neoplasm with Low Grade Intraepithelial Neoplasia; Bile Duct Mucinous Cystic Neoplasm, Low-Grade

Definition

A non-invasive mucinous cystic neoplasm that arises from the intrahepatic or extrahepatic bile ducts. It is characterized by the presence of mild atypia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBile Duct Mucinous Cystic Neoplasm, Low Grade

Professional guidelines

PubMed

Diagnosis and treatment of biliary mucinous cystic neoplasms: A single-center experience.
Jia JJ, Cheng YF, Feng MB, Liu L, Shuai MQ, Shen XD, Tang XF, Zheng SS
Hepatobiliary Pancreat Dis Int 2024 Oct;23(5):495-501. Epub 2023 Aug 12 doi: 10.1016/j.hbpd.2023.08.011. PMID: 37652799

Recent clinical studies

Etiology

Laparoscopic Duodenum and Spleen-Preserving Subtotal or Total Pancreatectomy: A Parenchyma-Sparing Strategy for Main Duct Intraductal Papillary Mucinous Neoplasms (with Video).
Li Z, Shi Y, Tang W, Chen C, Liu W, Zhuo Q, Ji S, Zhou C, Yu X, Xu X
Ann Surg Oncol 2024 Dec;31(13):8734-8740. Epub 2024 Sep 23 doi: 10.1245/s10434-024-16244-2. PMID: 39312053Free PMC Article
The World Health Organization Reporting System for Pancreaticobiliary Cytopathology: Overview and Summary.
Centeno BA, Saieg M, Siddiqui MT, Perez-Machado M, Layfield LJ, Weynand B, Reid MD, Stelow EB, Lozano MD, Fukushima N, Cree IA, Mehrotra R, Schmitt FC, Field AS, Pitman MB
Cancer Cytopathol 2024 Jul;132(7):396-418. Epub 2024 May 6 doi: 10.1002/cncy.22806. PMID: 38709670
Sixteen cases of laparoscopic central pancreatectomy for benign or low-grade malignant tumours in the pancreatic neck and proximal body.
Xiang J, Zhu J, Wang H, Zhou X, Li H
ANZ J Surg 2024 May;94(5):888-893. Epub 2024 Feb 2 doi: 10.1111/ans.18893. PMID: 38308435
Diagnosis and treatment of biliary mucinous cystic neoplasms: A single-center experience.
Jia JJ, Cheng YF, Feng MB, Liu L, Shuai MQ, Shen XD, Tang XF, Zheng SS
Hepatobiliary Pancreat Dis Int 2024 Oct;23(5):495-501. Epub 2023 Aug 12 doi: 10.1016/j.hbpd.2023.08.011. PMID: 37652799
The clinicopathological spectrum and management of intraductal papillary mucinous neoplasm of the bile duct (IPMN-B).
D'souza MA, Isaksson B, Löhr M, Enochsson L, Swahn F, Lundell L, Arnelo U
Scand J Gastroenterol 2013 Apr;48(4):473-9. Epub 2013 Jan 21 doi: 10.3109/00365521.2012.722672. PMID: 23330596

Diagnosis

The World Health Organization Reporting System for Pancreaticobiliary Cytopathology: Overview and Summary.
Centeno BA, Saieg M, Siddiqui MT, Perez-Machado M, Layfield LJ, Weynand B, Reid MD, Stelow EB, Lozano MD, Fukushima N, Cree IA, Mehrotra R, Schmitt FC, Field AS, Pitman MB
Cancer Cytopathol 2024 Jul;132(7):396-418. Epub 2024 May 6 doi: 10.1002/cncy.22806. PMID: 38709670
Diagnosis and treatment of biliary mucinous cystic neoplasms: A single-center experience.
Jia JJ, Cheng YF, Feng MB, Liu L, Shuai MQ, Shen XD, Tang XF, Zheng SS
Hepatobiliary Pancreat Dis Int 2024 Oct;23(5):495-501. Epub 2023 Aug 12 doi: 10.1016/j.hbpd.2023.08.011. PMID: 37652799
The Evolving Role of Pathology in New Developments, Classification, Terminology, and Diagnosis of Pancreatobiliary Neoplasms.
Reid MD, Lewis MM, Willingham FF, Adsay NV
Arch Pathol Lab Med 2017 Mar;141(3):366-380. Epub 2017 Jan 5 doi: 10.5858/arpa.2016-0262-SA. PMID: 28055239
Mucinous cystic neoplasm of the liver with low grade dysplasia of the liver.
Pirdopska T, Terziev I, Taneva I, Dimitrova V
Khirurgiia (Sofiia) 2014;(3):51-2. PMID: 25799624
The clinicopathological spectrum and management of intraductal papillary mucinous neoplasm of the bile duct (IPMN-B).
D'souza MA, Isaksson B, Löhr M, Enochsson L, Swahn F, Lundell L, Arnelo U
Scand J Gastroenterol 2013 Apr;48(4):473-9. Epub 2013 Jan 21 doi: 10.3109/00365521.2012.722672. PMID: 23330596

Prognosis

Laparoscopic Duodenum and Spleen-Preserving Subtotal or Total Pancreatectomy: A Parenchyma-Sparing Strategy for Main Duct Intraductal Papillary Mucinous Neoplasms (with Video).
Li Z, Shi Y, Tang W, Chen C, Liu W, Zhuo Q, Ji S, Zhou C, Yu X, Xu X
Ann Surg Oncol 2024 Dec;31(13):8734-8740. Epub 2024 Sep 23 doi: 10.1245/s10434-024-16244-2. PMID: 39312053Free PMC Article
Diagnosis and treatment of biliary mucinous cystic neoplasms: A single-center experience.
Jia JJ, Cheng YF, Feng MB, Liu L, Shuai MQ, Shen XD, Tang XF, Zheng SS
Hepatobiliary Pancreat Dis Int 2024 Oct;23(5):495-501. Epub 2023 Aug 12 doi: 10.1016/j.hbpd.2023.08.011. PMID: 37652799
Cystadenomas of the liver and extrahepatic bile ducts: Morphologic and immunohistochemical characterization of the biliary and intestinal variants.
Albores-Saavedra J, Córdova-Ramón JC, Chablé-Montero F, Dorantes-Heredia R, Henson DE
Ann Diagn Pathol 2015 Jun;19(3):124-9. Epub 2015 Mar 6 doi: 10.1016/j.anndiagpath.2015.03.001. PMID: 25792461
Clinicopathological features and prognosis of mucin-producing bile duct tumor and mucinous cystic tumor of the liver: a multi-institutional study by the Japan Biliary Association.
Kubota K, Nakanuma Y, Kondo F, Hachiya H, Miyazaki M, Nagino M, Yamamoto M, Isayama H, Tabata M, Kinoshita H, Kamisawa T, Inui K
J Hepatobiliary Pancreat Sci 2014 Mar;21(3):176-85. Epub 2013 Aug 1 doi: 10.1002/jhbp.23. PMID: 23908126
The clinicopathological spectrum and management of intraductal papillary mucinous neoplasm of the bile duct (IPMN-B).
D'souza MA, Isaksson B, Löhr M, Enochsson L, Swahn F, Lundell L, Arnelo U
Scand J Gastroenterol 2013 Apr;48(4):473-9. Epub 2013 Jan 21 doi: 10.3109/00365521.2012.722672. PMID: 23330596

Clinical prediction guides

Laparoscopic Duodenum and Spleen-Preserving Subtotal or Total Pancreatectomy: A Parenchyma-Sparing Strategy for Main Duct Intraductal Papillary Mucinous Neoplasms (with Video).
Li Z, Shi Y, Tang W, Chen C, Liu W, Zhuo Q, Ji S, Zhou C, Yu X, Xu X
Ann Surg Oncol 2024 Dec;31(13):8734-8740. Epub 2024 Sep 23 doi: 10.1245/s10434-024-16244-2. PMID: 39312053Free PMC Article
Clinicopathological features and prognosis of mucin-producing bile duct tumor and mucinous cystic tumor of the liver: a multi-institutional study by the Japan Biliary Association.
Kubota K, Nakanuma Y, Kondo F, Hachiya H, Miyazaki M, Nagino M, Yamamoto M, Isayama H, Tabata M, Kinoshita H, Kamisawa T, Inui K
J Hepatobiliary Pancreat Sci 2014 Mar;21(3):176-85. Epub 2013 Aug 1 doi: 10.1002/jhbp.23. PMID: 23908126
Outcome of duodenum-preserving resection of the head of the pancreas for intraductal papillary-mucinous neoplasm.
Hirano S, Kondo S, Ambo Y, Tanaka E, Morikawa T, Okushiba S, Katoh H
Dig Surg 2004;21(3):242-5. Epub 2004 Jun 30 doi: 10.1159/000079494. PMID: 15237258
Almost all infiltrating colloid carcinomas of the pancreas and periampullary region arise from in situ papillary neoplasms: a study of 39 cases.
Seidel G, Zahurak M, Iacobuzio-Donahue C, Sohn TA, Adsay NV, Yeo CJ, Lillemoe KD, Cameron JL, Hruban RH, Wilentz RE
Am J Surg Pathol 2002 Jan;26(1):56-63. doi: 10.1097/00000478-200201000-00006. PMID: 11756769

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