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Urethritis

MedGen UID:
52934
•Concept ID:
C0041976
•
Disease or Syndrome
Synonym: Urethritides
SNOMED CT: Inflammation of urethra (31822004); Urethritis (31822004)
 
HPO: HP:0500006
Monarch Initiative: MONDO:0005297

Definition

Inflammation of the urethra. [from HPO]

Professional guidelines

PubMed

Update in Epidemiology and Management of Mycoplasma genitalium Infections.
Wood GE, Bradshaw CS, Manhart LE
Infect Dis Clin North Am 2023 Jun;37(2):311-333. doi: 10.1016/j.idc.2023.02.009. PMID: 37105645
Epidemiology, Natural History, Diagnosis, and Treatment of Trichomonas vaginalis in Men.
Van Gerwen OT, Camino AF, Sharma J, Kissinger PJ, Muzny CA
Clin Infect Dis 2021 Sep 15;73(6):1119-1124. doi: 10.1093/cid/ciab514. PMID: 34079999Free PMC Article
Sexually transmitted diseases treatment guidelines, 2015.
Workowski KA, Bolan GA; Centers for Disease Control and Prevention
MMWR Recomm Rep 2015 Jun 5;64(RR-03):1-137. PMID: 26042815Free PMC Article

Recent clinical studies

Etiology

Idiopathic hemorrhagic urethritis of childhood.
Eyer de Jesus L, Fazecas T, Anderson KM, Dekermacher S
J Pediatr Urol 2020 Oct;16(5):690-699. Epub 2020 Jul 22 doi: 10.1016/j.jpurol.2020.07.021. PMID: 32762951
Mycoplasma genitalium infection.
Pinto-Sander N, Soni S
BMJ 2019 Oct 18;367:l5820. doi: 10.1136/bmj.l5820. PMID: 31628115
Mycoplasma genitalium Infection in Men.
Horner PJ, Martin DH
J Infect Dis 2017 Jul 15;216(suppl_2):S396-S405. doi: 10.1093/infdis/jix145. PMID: 28838074Free PMC Article
Epididymitis.
Taylor SN
Clin Infect Dis 2015 Dec 15;61 Suppl 8:S770-3. doi: 10.1093/cid/civ812. PMID: 26602616
Mycoplasma genitalium: a review.
Daley GM, Russell DB, Tabrizi SN, McBride J
Int J STD AIDS 2014 Jun;25(7):475-87. Epub 2014 Feb 11 doi: 10.1177/0956462413515196. PMID: 24517928

Diagnosis

Nongonococcal tysonitis.
Vallejo-Ruiz MS, Sandoval-Garcés M, Bru-Gorraiz FJ, Martín-Gorgojo A
Int J STD AIDS 2024 Feb;35(2):155-157. Epub 2023 Oct 18 doi: 10.1177/09564624231208241. PMID: 37852285
Urethritis.
Am Fam Physician 2021 May 1;103(9):Online. PMID: 33929176
Urethritis: Rapid Evidence Review.
Sell J, Nasir M, Courchesne C
Am Fam Physician 2021 May 1;103(9):553-558. PMID: 33929174
Adenovirus-associated paraphimosis.
Pollack A, Varma R
Int J STD AIDS 2019 Jul;30(8):825-827. Epub 2019 May 9 doi: 10.1177/0956462419842448. PMID: 31072279
Management of non-gonococcal urethritis.
Moi H, Blee K, Horner PJ
BMC Infect Dis 2015 Jul 29;15:294. doi: 10.1186/s12879-015-1043-4. PMID: 26220178Free PMC Article

Therapy

Urethritis.
Am Fam Physician 2021 May 1;103(9):Online. PMID: 33929176
Mycoplasma genitalium Infection in Men.
Horner PJ, Martin DH
J Infect Dis 2017 Jul 15;216(suppl_2):S396-S405. doi: 10.1093/infdis/jix145. PMID: 28838074Free PMC Article
Efficacy of Antimicrobial Therapy for Mycoplasma genitalium Infections.
Manhart LE, Jensen JS, Bradshaw CS, Golden MR, Martin DH
Clin Infect Dis 2015 Dec 15;61 Suppl 8:S802-17. doi: 10.1093/cid/civ785. PMID: 26602619
Ofloxacin.
Tunkel AR, Scheld WM
Infect Control Hosp Epidemiol 1991 Sep;12(9):549-57. doi: 10.1086/646408. PMID: 1940278
Nongonococcal urethritis.
Kogan BA
Urology 1981 Mar;17(3):219-22. doi: 10.1016/0090-4295(81)90032-7. PMID: 6782735

Prognosis

2021 European guideline on the management of Mycoplasma genitalium infections.
Jensen JS, Cusini M, Gomberg M, Moi H, Wilson J, Unemo M
J Eur Acad Dermatol Venereol 2022 May;36(5):641-650. Epub 2022 Feb 19 doi: 10.1111/jdv.17972. PMID: 35182080
Idiopathic hemorrhagic urethritis of childhood.
Eyer de Jesus L, Fazecas T, Anderson KM, Dekermacher S
J Pediatr Urol 2020 Oct;16(5):690-699. Epub 2020 Jul 22 doi: 10.1016/j.jpurol.2020.07.021. PMID: 32762951
Mycoplasma genitalium: Accurate Diagnosis Is Necessary for Adequate Treatment.
Gaydos CA
J Infect Dis 2017 Jul 15;216(suppl_2):S406-S411. doi: 10.1093/infdis/jix104. PMID: 28838072Free PMC Article
2016 European guideline on Mycoplasma genitalium infections.
Jensen JS, Cusini M, Gomberg M, Moi H
J Eur Acad Dermatol Venereol 2016 Oct;30(10):1650-1656. Epub 2016 Aug 9 doi: 10.1111/jdv.13849. PMID: 27505296
Chlamydial infections.
Blanchard TJ, Mabey DC
Br J Clin Pract 1994 Jul-Aug;48(4):201-5. PMID: 7917800

Clinical prediction guides

Clinical performance of four multiplex real-time PCR kits detecting urogenital and sexually transmitted pathogens.
Pereyre S, Caméléna F, Hénin N, Berçot B, Bébéar C
Clin Microbiol Infect 2022 May;28(5):733.e7-733.e13. Epub 2021 Oct 2 doi: 10.1016/j.cmi.2021.09.028. PMID: 34610459
Reactive arthritis: images.
Aitken-Saavedra J, Maturana-Ramirez A, Fernández Moraga J, Doro Dias V, Galdino-Santos L, Pineda Flores D
Dermatol Online J 2021 Jul 15;27(7) doi: 10.5070/D327754373. PMID: 34391335
Applications of genomics to slow the spread of multidrug-resistant Neisseria gonorrhoeae.
Mortimer TD, Grad YH
Ann N Y Acad Sci 2019 Jan;1435(1):93-109. Epub 2018 Jun 6 doi: 10.1111/nyas.13871. PMID: 29876934Free PMC Article
Mycoplasma genitalium: Accurate Diagnosis Is Necessary for Adequate Treatment.
Gaydos CA
J Infect Dis 2017 Jul 15;216(suppl_2):S406-S411. doi: 10.1093/infdis/jix104. PMID: 28838072Free PMC Article
Mycoplasma genitalium: a review.
Daley GM, Russell DB, Tabrizi SN, McBride J
Int J STD AIDS 2014 Jun;25(7):475-87. Epub 2014 Feb 11 doi: 10.1177/0956462413515196. PMID: 24517928

Recent systematic reviews

Management of Urethritis: Is It Still the Time for Empirical Antibiotic Treatments?
Bartoletti R, Wagenlehner FME, Bjerklund Johansen TE, Köves B, Cai T, Tandogdu Z, Bonkat G
Eur Urol Focus 2019 Jan;5(1):29-35. Epub 2018 Oct 11 doi: 10.1016/j.euf.2018.10.006. PMID: 30318465
Prevalence of Mycoplasma genitalium in different population groups: systematic review andmeta-analysis.
Baumann L, Cina M, Egli-Gany D, Goutaki M, Halbeisen FS, Lohrer GR, Ali H, Scott P, Low N
Sex Transm Infect 2018 Jun;94(4):255-262. Epub 2018 Feb 9 doi: 10.1136/sextrans-2017-053384. PMID: 29440466Free PMC Article
Human parasitic protozoan infection to infertility: a systematic review.
Shiadeh MN, Niyyati M, Fallahi S, Rostami A
Parasitol Res 2016 Feb;115(2):469-77. Epub 2015 Nov 16 doi: 10.1007/s00436-015-4827-y. PMID: 26573517
Are Ureaplasma spp. a cause of nongonococcal urethritis? A systematic review and meta-analysis.
Zhang N, Wang R, Li X, Liu X, Tang Z, Liu Y
PLoS One 2014;9(12):e113771. Epub 2014 Dec 2 doi: 10.1371/journal.pone.0113771. PMID: 25463970Free PMC Article
Effect of coinfection with STDs and of STD treatment on HIV shedding in genital-tract secretions: systematic review and data synthesis.
Rotchford K, Strum AW, Wilkinson D
Sex Transm Dis 2000 May;27(5):243-8. doi: 10.1097/00007435-200005000-00001. PMID: 10821594

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