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Neonatal Graves disease

MedGen UID:
543546
•Concept ID:
C0271767
•
Disease or Syndrome
Synonyms: Neonatal Graves Disease; Neonatal Graves' disease
SNOMED CT: Neonatal Graves' disease (59957008)

Definition

Graves disease in the neonate resulting from transplacental passage of thyrotropin receptor antibody. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal Graves disease

Professional guidelines

PubMed

Management of Fetal and Neonatal Graves' Disease.
Léger J
Horm Res Paediatr 2017;87(1):1-6. Epub 2016 Dec 16 doi: 10.1159/000453065. PMID: 27978517
Elevated free thyroxine levels detected by a neonatal screening system.
Tajima T, Jo W, Fujikura K, Fukushi M, Fujieda K
Pediatr Res 2009 Sep;66(3):312-6. doi: 10.1203/PDR.0b013e3181b1bcbd. PMID: 19542904
Iopanoic acid in the management of neonatal Graves' disease.
Earles SM, Gerrits PM, Transue DJ
J Perinatol 2004 Feb;24(2):105-8. doi: 10.1038/sj.jp.7211046. PMID: 14762455

Recent clinical studies

Etiology

Thyroid function and long-term outcomes of children born to mothers with Graves' disease: A 20-year review.
Sakornyutthadej N, Mahachoklertwattana P, Poomthavorn P
J Paediatr Child Health 2023 Mar;59(3):526-532. Epub 2023 Feb 1 doi: 10.1111/jpc.16343. PMID: 36722797
Management of Fetal and Neonatal Graves' Disease.
Léger J
Horm Res Paediatr 2017;87(1):1-6. Epub 2016 Dec 16 doi: 10.1159/000453065. PMID: 27978517
Follow-up of newborns of mothers with Graves' disease.
Levy-Shraga Y, Tamir-Hostovsky L, Boyko V, Lerner-Geva L, Pinhas-Hamiel O
Thyroid 2014 Jun;24(6):1032-9. Epub 2014 Mar 17 doi: 10.1089/thy.2013.0489. PMID: 24472020
Iopanoic acid in the management of neonatal Graves' disease.
Earles SM, Gerrits PM, Transue DJ
J Perinatol 2004 Feb;24(2):105-8. doi: 10.1038/sj.jp.7211046. PMID: 14762455
The use of oral radiographic contrast agents in the management of hyperthyroidism.
Fontanilla JC, Schneider AB, Sarne DH
Thyroid 2001 Jun;11(6):561-7. doi: 10.1089/105072501750302868. PMID: 11442003

Diagnosis

Fetal and Neonatal Thyroid Dysfunction.
Léger J, Delcour C, Carel JC
J Clin Endocrinol Metab 2022 Feb 17;107(3):836-846. doi: 10.1210/clinem/dgab747. PMID: 34636892
Management of Fetal and Neonatal Graves' Disease.
Léger J
Horm Res Paediatr 2017;87(1):1-6. Epub 2016 Dec 16 doi: 10.1159/000453065. PMID: 27978517
Fetal and neonatal hyperthyroidism.
Zimmerman D
Thyroid 1999 Jul;9(7):727-33. doi: 10.1089/thy.1999.9.727. PMID: 10447021
Neonatal Graves' disease.
Shields CL, Nelson LB, Carpenter GC, Shields JA
Br J Ophthalmol 1988 Jun;72(6):424-7. doi: 10.1136/bjo.72.6.424. PMID: 3390416Free PMC Article
NEONATAL GRAVES' DISEASE.
MAHONEY CP, PYNE GE, STAMM SJ, BAKKE JL
Am J Dis Child 1964 May;107:516-22. doi: 10.1001/archpedi.1964.02080060518012. PMID: 14120416

Therapy

Management of Fetal and Neonatal Graves' Disease.
Léger J
Horm Res Paediatr 2017;87(1):1-6. Epub 2016 Dec 16 doi: 10.1159/000453065. PMID: 27978517
Thyroid "vise" in an infant with neonatal Graves' disease.
Regelmann MO, Sullivan CK, Rapaport R
Pediatrics 2013 Oct;132(4):e1048-51. Epub 2013 Sep 16 doi: 10.1542/peds.2012-3000. PMID: 24043280
Hyperthyroidism in children: an Indian experience.
Menon PS, Singh GR
J Pediatr Endocrinol Metab 1996 Jul-Aug;9(4):441-6. doi: 10.1515/jpem.1996.9.4.441. PMID: 8910812
Neonatal Graves disease.
Kumar A, Chopra K, Sethi GR, Mital M, Gaind B
Indian Pediatr 1989 Mar;26(3):281-3. PMID: 2753558
Pathogenesis and therapy of neonatal graves disease.
Fisher DA
Am J Dis Child 1976 Feb;130(2):133-4. doi: 10.1001/archpedi.1976.02120030023003. PMID: 766612

Prognosis

Fetal and Neonatal Thyroid Dysfunction.
Léger J, Delcour C, Carel JC
J Clin Endocrinol Metab 2022 Feb 17;107(3):836-846. doi: 10.1210/clinem/dgab747. PMID: 34636892
Management of Fetal and Neonatal Graves' Disease.
Léger J
Horm Res Paediatr 2017;87(1):1-6. Epub 2016 Dec 16 doi: 10.1159/000453065. PMID: 27978517
Follow-up of newborns of mothers with Graves' disease.
Levy-Shraga Y, Tamir-Hostovsky L, Boyko V, Lerner-Geva L, Pinhas-Hamiel O
Thyroid 2014 Jun;24(6):1032-9. Epub 2014 Mar 17 doi: 10.1089/thy.2013.0489. PMID: 24472020
Fetal and neonatal hyperthyroidism.
Zimmerman D
Thyroid 1999 Jul;9(7):727-33. doi: 10.1089/thy.1999.9.727. PMID: 10447021
The pathogenesis of Graves' disease.
Gossage AA, Munro DS
Clin Endocrinol Metab 1985 May;14(2):299-330. doi: 10.1016/s0300-595x(85)80036-0. PMID: 2866051

Clinical prediction guides

Subacute thyroiditis with highly positive thyrotropin receptor antibodies and high thyroidal radioactive iodine uptake.
Fujii S, Miwa U, Seta T, Ohoka T, Mizukami Y
Intern Med 2003 Aug;42(8):704-9. doi: 10.2169/internalmedicine.42.704. PMID: 12924496
Neonatal Graves' disease.
Shields CL, Nelson LB, Carpenter GC, Shields JA
Br J Ophthalmol 1988 Jun;72(6):424-7. doi: 10.1136/bjo.72.6.424. PMID: 3390416Free PMC Article
The pathogenesis of Graves' disease.
Gossage AA, Munro DS
Clin Endocrinol Metab 1985 May;14(2):299-330. doi: 10.1016/s0300-595x(85)80036-0. PMID: 2866051

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