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Impaired social interactions

MedGen UID:
57707
•Concept ID:
C0150080
•
Mental or Behavioral Dysfunction
Synonyms: Communication Disorder, Pragmatic; Communication Disorder, Social; Communication Disorders, Pragmatic; Communication Disorders, Social; Disorders, Pragmatic Communication; Pragmatic Communication Disorder; Pragmatic Communication Disorders; Social Communication Disorder; Social Communication Disorders
SNOMED CT: Social interaction disorder (88598008); Social communication disorder (88598008); Impaired social interaction (88598008)

Definition

Persistent difficulties in the social uses of verbal and nonverbal communications. (DSM-V) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Impaired social interactions

Professional guidelines

PubMed

The phenotypic spectrum and genotype-phenotype correlations in 106 patients with variants in major autism gene CHD8.
Dingemans AJM, Truijen KMG, van de Ven S, Bernier R, Bongers EMHF, Bouman A, de Graaff-Herder L, Eichler EE, Gerkes EH, De Geus CM, van Hagen JM, Jansen PR, Kerkhof J, Kievit AJA, Kleefstra T, Maas SM, de Man SA, McConkey H, Patterson WG, Dobson AT, Prijoles EJ, Sadikovic B, Relator R, Stevenson RE, Stumpel CTRM, Heijligers M, Stuurman KE, Löhner K, Zeidler S, Lee JA, Lindy A, Zou F, Tedder ML, Vissers LELM, de Vries BBA
Transl Psychiatry 2022 Oct 1;12(1):421. doi: 10.1038/s41398-022-02189-1. PMID: 36182950Free PMC Article
Apolipoprotein E genotype modifies the risk of behavior problems after infant cardiac surgery.
Gaynor JW, Nord AS, Wernovsky G, Bernbaum J, Solot CB, Burnham N, Zackai E, Heagerty PJ, Clancy RR, Nicolson SC, Jarvik GP, Gerdes M
Pediatrics 2009 Jul;124(1):241-50. doi: 10.1542/peds.2008-2281. PMID: 19564306Free PMC Article
The pathophysiology, medical management, and dental implications of autism.
Friedlander AH, Yagiela JA, Paterno VI, Mahler ME
J Calif Dent Assoc 2003 Sep;31(9):681-2, 684, 686-91. PMID: 14560872

Recent clinical studies

Etiology

Microbiota in Autism Spectrum Disorder: A Systematic Review.
Lewandowska-Pietruszka Z, Figlerowicz M, Mazur-Melewska K
Int J Mol Sci 2023 Nov 23;24(23) doi: 10.3390/ijms242316660. PMID: 38068995Free PMC Article
Appearance-based trust processing in schizophrenia.
Sutherland CAM, Rhodes G, Williams N, Connaughton E, Ewing L, Caruana N, Langdon R
Br J Clin Psychol 2020 Jun;59(2):139-153. Epub 2019 Sep 6 doi: 10.1111/bjc.12234. PMID: 31490567
Behavioral analyses of animal models of intellectual and developmental disabilities.
Crawley JN, Fagiolini M, Harrison FE, Samaco R, Wozniak DF, Robinson MB
Neurobiol Learn Mem 2019 Nov;165:107087. Epub 2019 Sep 6 doi: 10.1016/j.nlm.2019.107087. PMID: 31499164
Effect of stress on learning and motivation-relevance to autism spectrum disorder.
Theoharides TC, Kavalioti M
Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419856760. doi: 10.1177/2058738419856760. PMID: 31220952Free PMC Article
Environmental risk factors for autism spectrum disorders.
Liu L, Zhang D, Rodzinka-Pasko JK, Li YM
Nervenarzt 2016 Dec;87(Suppl 2):55-61. doi: 10.1007/s00115-016-0172-3. PMID: 27531204

Diagnosis

Abnormal Cerebellar Development in Autism Spectrum Disorders.
van der Heijden ME, Gill JS, Sillitoe RV
Dev Neurosci 2021;43(3-4):181-190. Epub 2021 Apr 6 doi: 10.1159/000515189. PMID: 33823515Free PMC Article
The problem of overcontrol: Perfectionism, emotional inhibition, and personality disorders.
Dimaggio G, MacBeth A, Popolo R, Salvatore G, Perrini F, Raouna A, Osam CS, Buonocore L, Bandiera A, Montano A
Compr Psychiatry 2018 May;83:71-78. Epub 2018 Mar 20 doi: 10.1016/j.comppsych.2018.03.005. PMID: 29621675
Environmental risk factors for autism spectrum disorders.
Liu L, Zhang D, Rodzinka-Pasko JK, Li YM
Nervenarzt 2016 Dec;87(Suppl 2):55-61. doi: 10.1007/s00115-016-0172-3. PMID: 27531204
A systematic review of the literature on the chiropractic care of patients with autism spectrum disorder.
Alcantara J, Alcantara JD, Alcantara J
Explore (NY) 2011 Nov-Dec;7(6):384-90. doi: 10.1016/j.explore.2011.08.001. PMID: 22051563
Autistic enterocolitis: fact or fiction?
Galiatsatos P, Gologan A, Lamoureux E
Can J Gastroenterol 2009 Feb;23(2):95-8. doi: 10.1155/2009/394317. PMID: 19214283Free PMC Article

Therapy

Understanding taste dysfunction in patients with cancer.
McLaughlin L, Mahon SM
Clin J Oncol Nurs 2012 Apr;16(2):171-8. doi: 10.1188/12.CJON.171-178. PMID: 22459526
Care of the patient with an autism spectrum disorder by the general physician.
Venkat A, Jauch E, Russell WS, Crist CR, Farrell R
Postgrad Med J 2012 Aug;88(1042):472-81. Epub 2012 Mar 16 doi: 10.1136/postgradmedj-2011-130727. PMID: 22427366
A systematic review of the literature on the chiropractic care of patients with autism spectrum disorder.
Alcantara J, Alcantara JD, Alcantara J
Explore (NY) 2011 Nov-Dec;7(6):384-90. doi: 10.1016/j.explore.2011.08.001. PMID: 22051563
Autistic enterocolitis: fact or fiction?
Galiatsatos P, Gologan A, Lamoureux E
Can J Gastroenterol 2009 Feb;23(2):95-8. doi: 10.1155/2009/394317. PMID: 19214283Free PMC Article
The pathophysiology, medical management, and dental implications of autism.
Friedlander AH, Yagiela JA, Paterno VI, Mahler ME
J Calif Dent Assoc 2003 Sep;31(9):681-2, 684, 686-91. PMID: 14560872

Prognosis

An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes.
Yardeni T, Cristancho AG, McCoy AJ, Schaefer PM, McManus MJ, Marsh ED, Wallace DC
Proc Natl Acad Sci U S A 2021 Feb 9;118(6) doi: 10.1073/pnas.2021429118. PMID: 33536343Free PMC Article
Predicting Core Characteristics of ASD Through Facial Emotion Recognition and Eye Tracking in Youth.
Jiang M, Francis SM, Tseng A, Srishyla D, DuBois M, Beard K, Conelea C, Zhao Q, Jacob S
Annu Int Conf IEEE Eng Med Biol Soc 2020 Jul;2020:871-875. doi: 10.1109/EMBC44109.2020.9176843. PMID: 33018123
Genomics of Autism.
Fakhro KA
Adv Neurobiol 2020;24:83-96. doi: 10.1007/978-3-030-30402-7_3. PMID: 32006357
Environmental risk factors for autism spectrum disorders.
Liu L, Zhang D, Rodzinka-Pasko JK, Li YM
Nervenarzt 2016 Dec;87(Suppl 2):55-61. doi: 10.1007/s00115-016-0172-3. PMID: 27531204
Preschool neurobehavioral outcome following fetal myelomeningocele surgery.
Danzer E, Gerdes M, Bebbington MW, Koh J, Adzick NS, Johnson MP
Fetal Diagn Ther 2011;30(3):174-9. Epub 2011 Sep 8 doi: 10.1159/000330048. PMID: 21912086

Clinical prediction guides

Loneliness and the Social Brain: How Perceived Social Isolation Impairs Human Interactions.
Lieberz J, Shamay-Tsoory SG, Saporta N, Esser T, Kuskova E, Stoffel-Wagner B, Hurlemann R, Scheele D
Adv Sci (Weinh) 2021 Nov;8(21):e2102076. Epub 2021 Sep 20 doi: 10.1002/advs.202102076. PMID: 34541813Free PMC Article
An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes.
Yardeni T, Cristancho AG, McCoy AJ, Schaefer PM, McManus MJ, Marsh ED, Wallace DC
Proc Natl Acad Sci U S A 2021 Feb 9;118(6) doi: 10.1073/pnas.2021429118. PMID: 33536343Free PMC Article
Genomics of Autism.
Fakhro KA
Adv Neurobiol 2020;24:83-96. doi: 10.1007/978-3-030-30402-7_3. PMID: 32006357
Behavioral analyses of animal models of intellectual and developmental disabilities.
Crawley JN, Fagiolini M, Harrison FE, Samaco R, Wozniak DF, Robinson MB
Neurobiol Learn Mem 2019 Nov;165:107087. Epub 2019 Sep 6 doi: 10.1016/j.nlm.2019.107087. PMID: 31499164
Preschool neurobehavioral outcome following fetal myelomeningocele surgery.
Danzer E, Gerdes M, Bebbington MW, Koh J, Adzick NS, Johnson MP
Fetal Diagn Ther 2011;30(3):174-9. Epub 2011 Sep 8 doi: 10.1159/000330048. PMID: 21912086

Recent systematic reviews

Microbiota in Autism Spectrum Disorder: A Systematic Review.
Lewandowska-Pietruszka Z, Figlerowicz M, Mazur-Melewska K
Int J Mol Sci 2023 Nov 23;24(23) doi: 10.3390/ijms242316660. PMID: 38068995Free PMC Article
A systematic review of the literature on the chiropractic care of patients with autism spectrum disorder.
Alcantara J, Alcantara JD, Alcantara J
Explore (NY) 2011 Nov-Dec;7(6):384-90. doi: 10.1016/j.explore.2011.08.001. PMID: 22051563

Supplemental Content

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    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
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      Related information in PubMed Central Links
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      Related literature resources in PubMed

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