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Neurologic Manifestations

MedGen UID:: 18017
•Concept ID:: C0027854
•: Finding

Synonyms:

Manifestation, Neurologic; Manifestation, Neurological; Manifestations, Neurologic; Manifestations, Neurological; Neurologic Manifestation; Neurologic Signs and Symptoms; Neurological Manifestation; Neurological Manifestations

Definition

Clinical signs and symptoms caused by nervous system injury or dysfunction. [from MeSH]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeurologic Manifestations

Pathological Conditions, Signs and Symptoms
- Clinical finding
  - Neurologic Manifestations

Professional guidelines

PubMed

Diagnosis and management of glycogen storage disease type IV, including adult polyglucosan body disease: A clinical practice resource.

Koch RL, Soler-Alfonso C, Kiely BT, Asai A, Smith AL, Bali DS, Kang PB, Landstrom AP, Akman HO, Burrow TA, Orthmann-Murphy JL, Goldman DS, Pendyal S, El-Gharbawy AH, Austin SL, Case LE, Schiffmann R, Hirano M, Kishnani PS
Mol Genet Metab 2023 Mar;138(3):107525. Epub 2023 Jan 25 doi: 10.1016/j.ymgme.2023.107525. PMID: 36796138

Diagnosing antiphospholipid syndrome: 'extra-criteria' manifestations and technical advances.

Sciascia S, Amigo MC, Roccatello D, Khamashta M
Nat Rev Rheumatol 2017 Sep;13(9):548-560. Epub 2017 Aug 3 doi: 10.1038/nrrheum.2017.124. PMID: 28769114

Serotonin syndrome vs neuroleptic malignant syndrome: a contrast of causes, diagnoses, and management.

Perry PJ, Wilborn CA
Ann Clin Psychiatry 2012 May;24(2):155-62. PMID: 22563571

See all (67)

Recent clinical studies

Etiology

Neurological Manifestations of Myocarditis.

Trifan G, Testai FD
Curr Neurol Neurosci Rep 2022 Jul;22(7):363-374. Epub 2022 May 19 doi: 10.1007/s11910-022-01203-9. PMID: 35588043 Free PMC Article

Neurologic Manifestations of the Antiphospholipid Syndrome - an Update.

Leal Rato M, Bandeira M, Romão VC, Aguiar de Sousa D
Curr Neurol Neurosci Rep 2021 Jun 14;21(8):41. doi: 10.1007/s11910-021-01124-z. PMID: 34125304 Free PMC Article

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.

Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X, Li Y, Hu B
JAMA Neurol 2020 Jun 1;77(6):683-690. doi: 10.1001/jamaneurol.2020.1127. PMID: 32275288 Free PMC Article

Neurocutaneous melanosis.

Islam MP
Handb Clin Neurol 2015;132:111-7. doi: 10.1016/B978-0-444-62702-5.00007-X. PMID: 26564074

Serotonin syndrome vs neuroleptic malignant syndrome: a contrast of causes, diagnoses, and management.

Perry PJ, Wilborn CA
Ann Clin Psychiatry 2012 May;24(2):155-62. PMID: 22563571

See all (828)

Diagnosis

Physical Examination in Human Immunodeficiency Virus Disease.

Knight CL
Med Clin North Am 2022 May;106(3):527-536. Epub 2022 Apr 4 doi: 10.1016/j.mcna.2022.01.001. PMID: 35491072

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.

Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X, Li Y, Hu B
JAMA Neurol 2020 Jun 1;77(6):683-690. doi: 10.1001/jamaneurol.2020.1127. PMID: 32275288 Free PMC Article

Fibromuscular Dysplasia and Its Neurologic Manifestations: A Systematic Review.

Touzé E, Southerland AM, Boulanger M, Labeyrie PE, Azizi M, Bouatia-Naji N, Debette S, Gornik HL, Hussain SM, Jeunemaitre X, Joux J, Kirton A, Le Hello C, Majersik JJ, Mocco J, Persu A, Sharma A, Worrall BB, Olin JW, Plouin PF
JAMA Neurol 2019 Feb 1;76(2):217-226. doi: 10.1001/jamaneurol.2018.2848. PMID: 30285053

Neurologic Manifestations of Rheumatoid Arthritis.

DeQuattro K, Imboden JB
Rheum Dis Clin North Am 2017 Nov;43(4):561-571. Epub 2017 Aug 31 doi: 10.1016/j.rdc.2017.06.005. PMID: 29061242

Neurologic Manifestations of Primary Sjögren Syndrome.

Margaretten M
Rheum Dis Clin North Am 2017 Nov;43(4):519-529. Epub 2017 Aug 23 doi: 10.1016/j.rdc.2017.06.002. PMID: 29061239

See all (1921)

Therapy

Neurologic Manifestations of Gastrointestinal and Nutritional Disorders.

Diesing TS
Continuum (Minneap Minn) 2023 Jun 1;29(3):708-733. doi: 10.1212/CON.0000000000001235. PMID: 37341328

Cervical sympathectomy to treat cerebral vasospasm: a scoping review.

Bombardieri AM, Heifets BD, Treggiari M, Albers GW, Steinberg GK, Heit JJ
Reg Anesth Pain Med 2023 Oct;48(10):513-519. Epub 2022 Nov 24 doi: 10.1136/rapm-2022-103999. PMID: 36424089

Autoantibody-Associated Central Nervous System Neurologic Disorders.

Linnoila J, Pittock SJ
Semin Neurol 2016 Aug;36(4):382-96. Epub 2016 Sep 19 doi: 10.1055/s-0036-1585453. PMID: 27643908

Bacterial meningitis.

Hyslop NE Jr, Swartz MN
Postgrad Med 1975 Sep;58(3):120-8. doi: 10.1080/00325481.1975.11714145. PMID: 1161654

Neurosarcoidosis.

James DG, Sharma OP
Proc R Soc Med 1967 Nov 1;60(11 Part 1):1169-70. PMID: 6060718 Free PMC Article

See all (1029)

Prognosis

Sarcoidosis.

Cooper D, Suau S
Immunol Allergy Clin North Am 2023 Aug;43(3):583-591. doi: 10.1016/j.iac.2022.10.011. PMID: 37394261

Sarcoidosis.

Cooper D, Suau S
Emerg Med Clin North Am 2022 Feb;40(1):149-157. Epub 2021 Oct 29 doi: 10.1016/j.emc.2021.08.012. PMID: 34782085

Neuroborreliosis.

Halperin JJ
Neurol Clin 2018 Nov;36(4):821-830. doi: 10.1016/j.ncl.2018.06.006. PMID: 30366557

Overview and diagnosis of multiple sclerosis.

Hunter SF
Am J Manag Care 2016 Jun;22(6 Suppl):s141-50. PMID: 27356023

Sydenham's chorea.

Kulkarni ML, Anees S
Indian Pediatr 1996 Feb;33(2):112-5. PMID: 8772928

See all (715)

Clinical prediction guides

Clinical Presentation, Risk Factors, and Outcomes of Immune Effector Cell-Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T Cell Therapy: A Systematic Review.

Grant SJ, Grimshaw AA, Silberstein J, Murdaugh D, Wildes TM, Rosko AE, Giri S
Transplant Cell Ther 2022 Jun;28(6):294-302. Epub 2022 Mar 11 doi: 10.1016/j.jtct.2022.03.006. PMID: 35288347 Free PMC Article

Persistent neurologic symptoms and cognitive dysfunction in non-hospitalized Covid-19 "long haulers".

Graham EL, Clark JR, Orban ZS, Lim PH, Szymanski AL, Taylor C, DiBiase RM, Jia DT, Balabanov R, Ho SU, Batra A, Liotta EM, Koralnik IJ
Ann Clin Transl Neurol 2021 May;8(5):1073-1085. Epub 2021 Mar 30 doi: 10.1002/acn3.51350. PMID: 33755344 Free PMC Article

Neurological Involvement in COVID-19 and Potential Mechanisms: A Review.

Aghagoli G, Gallo Marin B, Katchur NJ, Chaves-Sell F, Asaad WF, Murphy SA
Neurocrit Care 2021 Jun;34(3):1062-1071. doi: 10.1007/s12028-020-01049-4. PMID: 32661794 Free PMC Article

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.

Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X, Li Y, Hu B
JAMA Neurol 2020 Jun 1;77(6):683-690. doi: 10.1001/jamaneurol.2020.1127. PMID: 32275288 Free PMC Article

Neuroborreliosis.

Halperin JJ
Neurol Clin 2018 Nov;36(4):821-830. doi: 10.1016/j.ncl.2018.06.006. PMID: 30366557

See all (423)

Recent systematic reviews

Whipple's disease-associated infective endocarditis: a systematic review.

Ioannou P, Kourtidis M, Mytilinis DO, Psyllaki A, Baliou S, Kofteridis D
Infect Dis (Lond) 2023 Jul;55(7):447-457. Epub 2023 May 17 doi: 10.1080/23744235.2023.2214610. PMID: 37198913

Cervical sympathectomy to treat cerebral vasospasm: a scoping review.

Bombardieri AM, Heifets BD, Treggiari M, Albers GW, Steinberg GK, Heit JJ
Reg Anesth Pain Med 2023 Oct;48(10):513-519. Epub 2022 Nov 24 doi: 10.1136/rapm-2022-103999. PMID: 36424089

Encephalitis in Patients with COVID-19: A Systematic Evidence-Based Analysis.

Islam MA, Cavestro C, Alam SS, Kundu S, Kamal MA, Reza F
Cells 2022 Aug 18;11(16) doi: 10.3390/cells11162575. PMID: 36010650 Free PMC Article

Clinical Presentation, Risk Factors, and Outcomes of Immune Effector Cell-Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T Cell Therapy: A Systematic Review.

Fibromuscular Dysplasia and Its Neurologic Manifestations: A Systematic Review.

See all (28)