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Peritoneal Carcinomatosis

MedGen UID:
577752
•Concept ID:
C0346990
•
Neoplastic Process
Synonyms: Carcinomatosis, Peritoneal; Malignancy, Peritoneal Surface; Peritoneal Carcinomatoses; Peritoneal Surface Malignancies; Peritoneal Surface Malignancy; Surface Malignancy, Peritoneal
SNOMED CT: Carcinomatosis of peritoneal cavity (255121007); Carcinomatosis of peritoneum (836274002); Carcinomatosis peritonei (836274002); Peritoneal carcinomatosis (836274002)

Definition

A condition in which a carcinoma has spread extensively throughout the peritoneum. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeritoneal Carcinomatosis

Professional guidelines

PubMed

Evidence-based approach to diagnosis and management of abdominal tuberculosis.
Jha DK, Pathiyil MM, Sharma V
Indian J Gastroenterol 2023 Feb;42(1):17-31. Epub 2023 Mar 11 doi: 10.1007/s12664-023-01343-x. PMID: 36899289Free PMC Article
Comprehensive Diagnosis and Management of Malignant Bowel Obstruction: A Review.
Demarest K, Lavu H, Collins E, Batra V
J Pain Palliat Care Pharmacother 2023 Mar;37(1):91-105. Epub 2022 Nov 15 doi: 10.1080/15360288.2022.2106012. PMID: 36377820
A Palliative Approach to Management of Peritoneal Carcinomatosis and Malignant Ascites.
Bleicher J, Lambert LA
Surg Oncol Clin N Am 2021 Jul;30(3):475-490. doi: 10.1016/j.soc.2021.02.004. PMID: 34053663

Recent clinical studies

Etiology

Prophylaxis and treatment of peritoneal carcinomatosis of gastric origin using hyperthermic intraperitoneal chemotherapy: a systematic review and meta-analysis of randomized trials.
Stefano M, Perrina D, Vallicelli C, Ansaloni L, Fugazzola P, Coccolini F, Agnoletti V, Frassineti GL, Passardi A, Tamberi S, Framarini M, Tassinari D, Matteucci L, Sturaro C, Gallo G, Catena F
J Gastrointest Surg 2024 Jul;28(7):1185-1193. Epub 2024 Apr 8 doi: 10.1016/j.gassur.2024.04.007. PMID: 38599315
Malignant Bowel Obstruction Management Over Time: Are We Doing Anything New? A Current Narrative Review.
Shariff F, Bogach J, Guidolin K, Nadler A
Ann Surg Oncol 2022 Mar;29(3):1995-2005. Epub 2021 Oct 18 doi: 10.1245/s10434-021-10922-1. PMID: 34664143
A Palliative Approach to Management of Peritoneal Carcinomatosis and Malignant Ascites.
Bleicher J, Lambert LA
Surg Oncol Clin N Am 2021 Jul;30(3):475-490. doi: 10.1016/j.soc.2021.02.004. PMID: 34053663
Peritoneal metastases management: Towards the era of prospective randomized trials?
Kepenekian V, Glehen O
Eur J Surg Oncol 2021 Jan;47(1):1-3. Epub 2020 Jun 15 doi: 10.1016/j.ejso.2020.05.011. PMID: 32576480
Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer.
Verwaal VJ, van Ruth S, de Bree E, van Sloothen GW, van Tinteren H, Boot H, Zoetmulder FA
J Clin Oncol 2003 Oct 15;21(20):3737-43. doi: 10.1200/JCO.2003.04.187. PMID: 14551293

Diagnosis

ED diagnosis of peritoneal carcinomatosis.
Scheinfeld D, Schwartz C, Fink AZ
Emerg Radiol 2024 Aug;31(4):475-480. Epub 2024 Jun 5 doi: 10.1007/s10140-024-02238-w. PMID: 38836936Free PMC Article
Benign Fibroids Mimicking Peritoneal Carcinomatosis.
Dakhlallah S, Rivard C, Boulay AC
J Obstet Gynaecol Can 2023 Nov;45(11):101878. doi: 10.1016/j.jogc.2021.12.002. PMID: 37977722
Therapeutic Strategies and Oncological Outcome of Peritoneal Metastases from Lung Cancer: A Systematic Review and Pooled Analysis.
Siragusa L, Di Carlo S, Fassari A, Sensi B, Riccetti C, Izzo L, Cavallaro G, Fiori E, Sapienza P, Mallia L, Pernazza G, Sibio S
Curr Oncol 2023 Mar 1;30(3):2928-2941. doi: 10.3390/curroncol30030224. PMID: 36975437Free PMC Article
Palliation of malignant ascites.
Hodge C, Badgwell BD
J Surg Oncol 2019 Jul;120(1):67-73. Epub 2019 Mar 22 doi: 10.1002/jso.25453. PMID: 30903617
Peritoneal carcinomatosis.
Raptopoulos V, Gourtsoyiannis N
Eur Radiol 2001;11(11):2195-206. doi: 10.1007/s003300100998. PMID: 11702160

Therapy

Intraperitoneal drug delivery systems for peritoneal carcinomatosis: Bridging the gap between research and clinical implementation.
Perelló-Trias MT, Serrano-Muñoz AJ, Rodríguez-Fernández A, Segura-Sampedro JJ, Ramis JM, Monjo M
J Control Release 2024 Sep;373:70-92. Epub 2024 Jul 14 doi: 10.1016/j.jconrel.2024.07.017. PMID: 38986910
Prophylaxis and treatment of peritoneal carcinomatosis of gastric origin using hyperthermic intraperitoneal chemotherapy: a systematic review and meta-analysis of randomized trials.
Stefano M, Perrina D, Vallicelli C, Ansaloni L, Fugazzola P, Coccolini F, Agnoletti V, Frassineti GL, Passardi A, Tamberi S, Framarini M, Tassinari D, Matteucci L, Sturaro C, Gallo G, Catena F
J Gastrointest Surg 2024 Jul;28(7):1185-1193. Epub 2024 Apr 8 doi: 10.1016/j.gassur.2024.04.007. PMID: 38599315
Peritoneal carcinomatosis with intraperitoneal immunotherapy: current treatment options and perspectives.
Wei GX, Du Y, Zhou YW, Li LJ, Qiu M
Expert Rev Gastroenterol Hepatol 2022 Sep;16(9):851-861. Epub 2022 Sep 19 doi: 10.1080/17474124.2022.2125866. PMID: 36107723
Peritoneal metastases management: Towards the era of prospective randomized trials?
Kepenekian V, Glehen O
Eur J Surg Oncol 2021 Jan;47(1):1-3. Epub 2020 Jun 15 doi: 10.1016/j.ejso.2020.05.011. PMID: 32576480
Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer.
Verwaal VJ, van Ruth S, de Bree E, van Sloothen GW, van Tinteren H, Boot H, Zoetmulder FA
J Clin Oncol 2003 Oct 15;21(20):3737-43. doi: 10.1200/JCO.2003.04.187. PMID: 14551293

Prognosis

Cytoreduction and HIPEC for Gastric Carcinomatosis: Multi-institutional Analysis of Two Phase II Clinical Trials.
Green BL, Blumenthaler AN, Gamble LA, McDonald JD, Robinson K, Connolly M, Epstein M, Hernandez JM, Blakely AM, Badgwell BD, Davis JL
Ann Surg Oncol 2023 Mar;30(3):1852-1860. Epub 2022 Nov 8 doi: 10.1245/s10434-022-12761-0. PMID: 36348206Free PMC Article
Management of Peritoneal Disease in Colorectal Cancer.
Welten VM, Melnitchouk N
Hematol Oncol Clin North Am 2022 Jun;36(3):569-582. Epub 2022 May 13 doi: 10.1016/j.hoc.2022.02.008. PMID: 35577709
Peritoneal sarcoidosis mimicking peritoneal carcinomatosis.
Panaccio P, Bellobono M, Esposito L, Ricciardiello M, Cinalli S, Cotellese R
Ann Ital Chir 2019 Jan 10;8 PMID: 30938712
Palliative Management of Peritoneal Metastases.
Lambert LA, Wiseman J
Ann Surg Oncol 2018 Aug;25(8):2165-2171. Epub 2018 Jan 30 doi: 10.1245/s10434-018-6335-7. PMID: 29383612
Peritoneal carcinomatosis of colorectal origin: Incidence, prognosis and treatment options.
Klaver YL, Lemmens VE, Nienhuijs SW, Luyer MD, de Hingh IH
World J Gastroenterol 2012 Oct 21;18(39):5489-94. doi: 10.3748/wjg.v18.i39.5489. PMID: 23112540Free PMC Article

Clinical prediction guides

ED diagnosis of peritoneal carcinomatosis.
Scheinfeld D, Schwartz C, Fink AZ
Emerg Radiol 2024 Aug;31(4):475-480. Epub 2024 Jun 5 doi: 10.1007/s10140-024-02238-w. PMID: 38836936Free PMC Article
Cytoreduction and HIPEC for Gastric Carcinomatosis: Multi-institutional Analysis of Two Phase II Clinical Trials.
Green BL, Blumenthaler AN, Gamble LA, McDonald JD, Robinson K, Connolly M, Epstein M, Hernandez JM, Blakely AM, Badgwell BD, Davis JL
Ann Surg Oncol 2023 Mar;30(3):1852-1860. Epub 2022 Nov 8 doi: 10.1245/s10434-022-12761-0. PMID: 36348206Free PMC Article
Molecular Imaging of Peritoneal Carcinomatosis in Ovarian Carcinoma.
Lee EYP, An H, Tse KY, Khong PL
AJR Am J Roentgenol 2020 Aug;215(2):305-312. Epub 2020 Jun 17 doi: 10.2214/AJR.19.22621. PMID: 32551907
Development of Peritoneal Carcinomatosis in Epithelial Ovarian Cancer: A Review.
van Baal JOAM, van Noorden CJF, Nieuwland R, Van de Vijver KK, Sturk A, van Driel WJ, Kenter GG, Lok CAR
J Histochem Cytochem 2018 Feb;66(2):67-83. Epub 2017 Nov 22 doi: 10.1369/0022155417742897. PMID: 29164988Free PMC Article
Strategies to prevent peritoneal carcinomatosis arising from colorectal cancer.
Gelli M, Huguenin JF, Cerebelli C, Benhaim L, Honoré C, Elias D, Goéré D
Future Oncol 2017 Apr;13(10):907-918. Epub 2017 Jan 5 doi: 10.2217/fon-2016-0389. PMID: 28052691

Recent systematic reviews

Prophylaxis and treatment of peritoneal carcinomatosis of gastric origin using hyperthermic intraperitoneal chemotherapy: a systematic review and meta-analysis of randomized trials.
Stefano M, Perrina D, Vallicelli C, Ansaloni L, Fugazzola P, Coccolini F, Agnoletti V, Frassineti GL, Passardi A, Tamberi S, Framarini M, Tassinari D, Matteucci L, Sturaro C, Gallo G, Catena F
J Gastrointest Surg 2024 Jul;28(7):1185-1193. Epub 2024 Apr 8 doi: 10.1016/j.gassur.2024.04.007. PMID: 38599315
A Systematic Review of Surgical Management Strategies in the Treatment of Peritoneal Carcinomatosis of Neuroendocrine Origin.
Fallows M, Samant A, Wilson H, Mirnezami R
Curr Oncol 2023 Jul 1;30(7):6316-6329. doi: 10.3390/curroncol30070466. PMID: 37504326Free PMC Article
Therapeutic Strategies and Oncological Outcome of Peritoneal Metastases from Lung Cancer: A Systematic Review and Pooled Analysis.
Siragusa L, Di Carlo S, Fassari A, Sensi B, Riccetti C, Izzo L, Cavallaro G, Fiori E, Sapienza P, Mallia L, Pernazza G, Sibio S
Curr Oncol 2023 Mar 1;30(3):2928-2941. doi: 10.3390/curroncol30030224. PMID: 36975437Free PMC Article
Risk of Peritoneal Carcinomatosis After Risk-Reducing Salpingo-Oophorectomy: A Systematic Review and Individual Patient Data Meta-Analysis.
Steenbeek MP, van Bommel MHD, Bulten J, Hulsmann JA, Bogaerts J, Garcia C, Cun HT, Lu KH, van Beekhuizen HJ, Minig L, Gaarenstroom KN, Nobbenhuis M, Krajc M, Rudaitis V, Norquist BM, Swisher EM, Mourits MJE, Massuger LFAG, Hoogerbrugge N, Hermens RPMG, IntHout J, de Hullu JA
J Clin Oncol 2022 Jun 10;40(17):1879-1891. Epub 2022 Mar 18 doi: 10.1200/JCO.21.02016. PMID: 35302882Free PMC Article
Bowel obstruction and peritoneal carcinomatosis in the elderly. A systematic review.
Santangelo ML, Grifasi C, Criscitiello C, Giuliano M, Calogero A, Dodaro C, Incollingo P, Rupealta N, Candida M, Chiacchio G, Riccio E, Pisani A, Tammaro V, Carlomagno N
Aging Clin Exp Res 2017 Feb;29(Suppl 1):73-78. Epub 2016 Nov 11 doi: 10.1007/s40520-016-0656-9. PMID: 27837464

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