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Drug-induced autoimmune hemolytic anemia

MedGen UID:
580980
•Concept ID:
C0391817
•
Pathologic Function
Synonyms: Drug induced autoimmune hemolytic anemia; Drug-induced AIHA; drug-induced AIHA; drug-induced autoimmune hemolytic anemia
SNOMED CT: Drug induced autoimmune hemolytic anemia (309742004); Drug-induced autoimmune hemolytic anemia (309742004)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0019535
Orphanet: ORPHA90037

Definition

Drug-induced autoimmune hemolytic anemia is a type of autoimmune hemolytic anemia (AIHA; see this term) that occurs as a reaction to therapeutic drugs, and can be due to various mechanisms. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDrug-induced autoimmune hemolytic anemia
Follow this link to review classifications for Drug-induced autoimmune hemolytic anemia in Orphanet.

Professional guidelines

PubMed

Autoimmune Hemolytic Anemias: Classifications, Pathophysiology, Diagnoses and Management.
Loriamini M, Cserti-Gazdewich C, Branch DR
Int J Mol Sci 2024 Apr 12;25(8) doi: 10.3390/ijms25084296. PMID: 38673882Free PMC Article
Guidelines on the management of drug-induced immune and secondary autoimmune, haemolytic anaemia.
Hill QA, Stamps R, Massey E, Grainger JD, Provan D, Hill A; British Society for Haematology Guidelines
Br J Haematol 2017 Apr;177(2):208-220. Epub 2017 Apr 3 doi: 10.1111/bjh.14654. PMID: 28369704
Management of immune cytopenias in patients with systemic lupus erythematosus - Old and new.
Newman K, Owlia MB, El-Hemaidi I, Akhtari M
Autoimmun Rev 2013 May;12(7):784-91. Epub 2013 Feb 24 doi: 10.1016/j.autrev.2013.02.001. PMID: 23462431

Recent clinical studies

Etiology

Ceftriaxone-induced hemolysis in a child with Lyme arthritis: a case for antimicrobial stewardship.
Boggs SR, Cunnion KM, Raafat RH
Pediatrics 2011 Nov;128(5):e1289-92. Epub 2011 Oct 3 doi: 10.1542/peds.2010-1570. PMID: 21969285
Lack of Rhesus antigen expression by human committed erythroid progenitors.
Rearden A, Chiu P
Blood 1983 Mar;61(3):525-9. PMID: 6402042

Diagnosis

Possible Trimethoprim-Sulfamethoxazole-Induced Hemolytic Anemia: A Case Report.
Williams MF, Doss EP, Montgomery M
J Pharm Pract 2017 Dec;30(6):653-657. Epub 2016 Dec 14 doi: 10.1177/0897190016683303. PMID: 29121838
Drug-induced autoimmune hemolytic anemia in a 78-year-old African-American man with chronic lymphocytic leukemia.
Sartori A, Staley B, Skipper A
Lab Med 2014 Summer;45(3):e105-8. doi: 10.1309/LMLWQDB2Q6LS7VQG. PMID: 25157090
Ceftriaxone-induced hemolysis in a child with Lyme arthritis: a case for antimicrobial stewardship.
Boggs SR, Cunnion KM, Raafat RH
Pediatrics 2011 Nov;128(5):e1289-92. Epub 2011 Oct 3 doi: 10.1542/peds.2010-1570. PMID: 21969285
Lack of Rhesus antigen expression by human committed erythroid progenitors.
Rearden A, Chiu P
Blood 1983 Mar;61(3):525-9. PMID: 6402042

Therapy

Possible autoimmune hemolytic anemia induced by secukinumab: a case report.
Rahman PA, Kalim H, Prawitasari S, Raharjo FM
Pan Afr Med J 2022;41:41. Epub 2022 Jan 17 doi: 10.11604/pamj.2022.41.41.32191. PMID: 35317476Free PMC Article
Possible Trimethoprim-Sulfamethoxazole-Induced Hemolytic Anemia: A Case Report.
Williams MF, Doss EP, Montgomery M
J Pharm Pract 2017 Dec;30(6):653-657. Epub 2016 Dec 14 doi: 10.1177/0897190016683303. PMID: 29121838
Drug-induced autoimmune hemolytic anemia in a 78-year-old African-American man with chronic lymphocytic leukemia.
Sartori A, Staley B, Skipper A
Lab Med 2014 Summer;45(3):e105-8. doi: 10.1309/LMLWQDB2Q6LS7VQG. PMID: 25157090
Ceftriaxone-induced hemolysis in a child with Lyme arthritis: a case for antimicrobial stewardship.
Boggs SR, Cunnion KM, Raafat RH
Pediatrics 2011 Nov;128(5):e1289-92. Epub 2011 Oct 3 doi: 10.1542/peds.2010-1570. PMID: 21969285
Drug-induced autoimmune hemolytic anemia.
Petz LD
Transfus Med Rev 1993 Oct;7(4):242-54. doi: 10.1016/s0887-7963(93)70144-3. PMID: 8241613

Prognosis

Possible Trimethoprim-Sulfamethoxazole-Induced Hemolytic Anemia: A Case Report.
Williams MF, Doss EP, Montgomery M
J Pharm Pract 2017 Dec;30(6):653-657. Epub 2016 Dec 14 doi: 10.1177/0897190016683303. PMID: 29121838
Ceftriaxone-induced hemolysis in a child with Lyme arthritis: a case for antimicrobial stewardship.
Boggs SR, Cunnion KM, Raafat RH
Pediatrics 2011 Nov;128(5):e1289-92. Epub 2011 Oct 3 doi: 10.1542/peds.2010-1570. PMID: 21969285

Clinical prediction guides

Possible autoimmune hemolytic anemia induced by secukinumab: a case report.
Rahman PA, Kalim H, Prawitasari S, Raharjo FM
Pan Afr Med J 2022;41:41. Epub 2022 Jan 17 doi: 10.11604/pamj.2022.41.41.32191. PMID: 35317476Free PMC Article

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