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Overlap syndrome

MedGen UID:
592755
•Concept ID:
C0410000
•
Disease or Syndrome
Synonym: Overlap Syndrome
SNOMED CT: Overlap syndrome (276657008)

Definition

An autoimmune, connective tissue disorder in which the patient exhibits features from two or more diseases. These typically include systemic sclerosis, dermatomyositis, polymyositis, rheumatoid arthritis, systemic lupus erythematosus, and Sjogren syndrome; in pediatrics the respective pediatric entities are encountered. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOverlap syndrome

Professional guidelines

PubMed

Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Pathophysiology and management of critical illness polyneuropathy and myopathy.
Cheung K, Rathbone A, Melanson M, Trier J, Ritsma BR, Allen MD
J Appl Physiol (1985) 2021 May 1;130(5):1479-1489. Epub 2021 Mar 18 doi: 10.1152/japplphysiol.00019.2021. PMID: 33734888Free PMC Article
Current Classification and Management of Inflammatory Myopathies.
Schmidt J
J Neuromuscul Dis 2018;5(2):109-129. doi: 10.3233/JND-180308. PMID: 29865091Free PMC Article

Recent clinical studies

Etiology

Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Antimitochondrial Antibodies: from Bench to Bedside.
Colapietro F, Lleo A, Generali E
Clin Rev Allergy Immunol 2022 Oct;63(2):166-177. Epub 2021 Sep 29 doi: 10.1007/s12016-021-08904-y. PMID: 34586589Free PMC Article
Pathophysiology and management of critical illness polyneuropathy and myopathy.
Cheung K, Rathbone A, Melanson M, Trier J, Ritsma BR, Allen MD
J Appl Physiol (1985) 2021 May 1;130(5):1479-1489. Epub 2021 Mar 18 doi: 10.1152/japplphysiol.00019.2021. PMID: 33734888Free PMC Article
Understanding COPD-overlap syndromes.
Poh TY, Mac Aogáin M, Chan AK, Yii AC, Yong VF, Tiew PY, Koh MS, Chotirmall SH
Expert Rev Respir Med 2017 Apr;11(4):285-298. Epub 2017 Mar 24 doi: 10.1080/17476348.2017.1305895. PMID: 28282995
Scleroderma overlap syndrome.
Balbir-Gurman A, Braun-Moscovici Y
Isr Med Assoc J 2011 Jan;13(1):14-20. PMID: 21446230

Diagnosis

Asthma in the Elderly.
Braman SS
Clin Geriatr Med 2017 Nov;33(4):523-537. Epub 2017 Jul 29 doi: 10.1016/j.cger.2017.06.005. PMID: 28991648
Understanding COPD-overlap syndromes.
Poh TY, Mac Aogáin M, Chan AK, Yii AC, Yong VF, Tiew PY, Koh MS, Chotirmall SH
Expert Rev Respir Med 2017 Apr;11(4):285-298. Epub 2017 Mar 24 doi: 10.1080/17476348.2017.1305895. PMID: 28282995
The asthma-chronic obstructive pulmonary disease overlap syndrome and its challenge for the allergist-immunologist.
Bellanti JA, Settipane RA
Allergy Asthma Proc 2015 Jan-Feb;36(1):1-3. doi: 10.2500/aap.2015.36.3821. PMID: 25562548Free PMC Article
Diagnosis and management of overlap syndromes.
Bunchorntavakul C, Reddy KR
Clin Liver Dis 2015 Feb;19(1):81-97. Epub 2014 Nov 21 doi: 10.1016/j.cld.2014.09.005. PMID: 25454298
Scleroderma overlap syndrome.
Balbir-Gurman A, Braun-Moscovici Y
Isr Med Assoc J 2011 Jan;13(1):14-20. PMID: 21446230

Therapy

Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Rheumatologic Diseases and the Liver.
Gebreselassie A, Aduli F, Howell CD
Clin Liver Dis 2019 May;23(2):247-261. Epub 2019 Mar 8 doi: 10.1016/j.cld.2018.12.007. PMID: 30947875
Autoimmune Liver Diseases in Children.
Mataya L, Patel N, Azzam RK
Pediatr Ann 2018 Nov 1;47(11):e452-e457. doi: 10.3928/19382359-20181022-02. PMID: 30423188
Relapsing polychondritis.
Chopra R, Chaudhary N, Kay J
Rheum Dis Clin North Am 2013 May;39(2):263-76. doi: 10.1016/j.rdc.2013.03.002. PMID: 23597963
Pulmonary vasculitis.
Leavitt RY, Fauci AS
Am Rev Respir Dis 1986 Jul;134(1):149-66. doi: 10.1164/arrd.1986.134.1.149. PMID: 2873770

Prognosis

Current Classification and Management of Inflammatory Myopathies.
Schmidt J
J Neuromuscul Dis 2018;5(2):109-129. doi: 10.3233/JND-180308. PMID: 29865091Free PMC Article
COPD-bronchiectasis overlap syndrome.
Hurst JR, Elborn JS, De Soyza A; BRONCH-UK Consortium
Eur Respir J 2015 Feb;45(2):310-3. doi: 10.1183/09031936.00170014. PMID: 25653262
Relapsing polychondritis.
Chopra R, Chaudhary N, Kay J
Rheum Dis Clin North Am 2013 May;39(2):263-76. doi: 10.1016/j.rdc.2013.03.002. PMID: 23597963
Dermatomyositis and drugs.
Dourmishev AL, Dourmishev LA
Adv Exp Med Biol 1999;455:187-91. doi: 10.1007/978-1-4615-4857-7_27. PMID: 10599342
Pulmonary vasculitis.
Leavitt RY, Fauci AS
Am Rev Respir Dis 1986 Jul;134(1):149-66. doi: 10.1164/arrd.1986.134.1.149. PMID: 2873770

Clinical prediction guides

Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Immune Checkpoint Inhibitor-Induced Myocarditis with Myositis/Myasthenia Gravis Overlap Syndrome: A Systematic Review of Cases.
Pathak R, Katel A, Massarelli E, Villaflor VM, Sun V, Salgia R
Oncologist 2021 Dec;26(12):1052-1061. Epub 2021 Aug 25 doi: 10.1002/onco.13931. PMID: 34378270Free PMC Article
Pathophysiology and management of critical illness polyneuropathy and myopathy.
Cheung K, Rathbone A, Melanson M, Trier J, Ritsma BR, Allen MD
J Appl Physiol (1985) 2021 May 1;130(5):1479-1489. Epub 2021 Mar 18 doi: 10.1152/japplphysiol.00019.2021. PMID: 33734888Free PMC Article
Understanding COPD-overlap syndromes.
Poh TY, Mac Aogáin M, Chan AK, Yii AC, Yong VF, Tiew PY, Koh MS, Chotirmall SH
Expert Rev Respir Med 2017 Apr;11(4):285-298. Epub 2017 Mar 24 doi: 10.1080/17476348.2017.1305895. PMID: 28282995
Dermatomyositis and drugs.
Dourmishev AL, Dourmishev LA
Adv Exp Med Biol 1999;455:187-91. doi: 10.1007/978-1-4615-4857-7_27. PMID: 10599342

Recent systematic reviews

Autoimmune liver diseases and diabetes: A propensity score matched analysis and a proportional meta-analysis.
Jensen AH, Winther-Sørensen M, Burisch J, Bergquist A, Ytting H, Gluud LL, Wewer Albrechtsen NJ
Liver Int 2023 Nov;43(11):2479-2491. Epub 2023 Sep 26 doi: 10.1111/liv.15720. PMID: 37752719
Neuropathy, Ataxia, and Retinitis Pigmentosa Syndrome.
Finsterer J
J Clin Neuromuscul Dis 2023 Mar 1;24(3):140-146. doi: 10.1097/CND.0000000000000422. PMID: 36809201
Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Immune Checkpoint Inhibitor-Induced Myocarditis with Myositis/Myasthenia Gravis Overlap Syndrome: A Systematic Review of Cases.
Pathak R, Katel A, Massarelli E, Villaflor VM, Sun V, Salgia R
Oncologist 2021 Dec;26(12):1052-1061. Epub 2021 Aug 25 doi: 10.1002/onco.13931. PMID: 34378270Free PMC Article
Asthma and COPD Overlap Syndrome (ACOS): A Systematic Review and Meta Analysis.
Alshabanat A, Zafari Z, Albanyan O, Dairi M, FitzGerald JM
PLoS One 2015;10(9):e0136065. Epub 2015 Sep 3 doi: 10.1371/journal.pone.0136065. PMID: 26336076Free PMC Article

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