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Meningeal Carcinomatosis

MedGen UID:
65080
•Concept ID:
C0220654
•
Neoplastic Process
Synonyms: Carcinomatoses, Leptomeningeal; Carcinomatoses, Meningeal; Carcinomatosis, Leptomeningeal; Carcinomatosis, Meningeal; Carcinomatous Meningitides; Carcinomatous Meningitis; Leptomeningeal Carcinomatoses; Leptomeningeal Carcinomatosis; Meningeal Carcinomatoses; Meningitides, Carcinomatous; Meningitis, Carcinomatous
SNOMED CT: Malignant meningitis (230156002); Carcinomatous meningitis (230156002); Meningeal carcinomatosis (230156002)

Definition

Diffuse spread of cancer to the meninges. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeningeal Carcinomatosis

Professional guidelines

PubMed

Role of intrathecal chemotherapy in the management of meningeal carcinomatosis in patients with breast cancer.
Meneguetti RT, Cruz FJSM, Del Giglio A
Einstein (Sao Paulo) 2023;21:eAO0481. Epub 2023 Dec 22 doi: 10.31744/einstein_journal/2023AO0481. PMID: 38126659Free PMC Article
Endocrine therapy for the treatment of leptomeningeal carcinomatosis in luminal breast cancer: a comprehensive review.
Fernandes L, de Matos LV, Cardoso D, Saraiva M, Medeiros-Mirra R, Coelho A, Miranda H, Martins A
CNS Oncol 2020 Dec 1;9(4):CNS65. Epub 2020 Oct 20 doi: 10.2217/cns-2020-0023. PMID: 33078616Free PMC Article
Treatment of meningeal carcinomatosis.
Sculier JP
Cancer Treat Rev 1985 Jun;12(2):95-104. doi: 10.1016/0305-7372(85)90002-7. PMID: 3902218

Recent clinical studies

Etiology

Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis.
Yang JT, Wijetunga NA, Pentsova E, Wolden S, Young RJ, Correa D, Zhang Z, Zheng J, Steckler A, Bucwinska W, Bernstein A, Betof Warner A, Yu H, Kris MG, Seidman AD, Wilcox JA, Malani R, Lin A, DeAngelis LM, Lee NY, Powell SN, Boire A
J Clin Oncol 2022 Nov 20;40(33):3858-3867. Epub 2022 Jul 8 doi: 10.1200/JCO.22.01148. PMID: 35802849Free PMC Article
Malignant Meningitis Associated with Hydrocephalus.
Kumar A, Sardhara JC, Singh G, Kanjilal S, Maurya VP, Behari S
Neurol India 2021 Nov-Dec;69(Supplement):S443-S455. doi: 10.4103/0028-3886.332278. PMID: 35103001
Management of neoplastic meningitis.
Roth P, Weller M
Chin Clin Oncol 2015 Jun;4(2):26. doi: 10.3978/j.issn.2304-3865.2015.05.02. PMID: 26112812
Neoplastic meningitis.
Van Horn A, Chamberlain MC
J Support Oncol 2012 Mar-Apr;10(2):45-53. Epub 2011 Sep 23 doi: 10.1016/j.suponc.2011.06.002. PMID: 22005214
Meningeal carcinomatosis.
Theodore WH, Gendelman S
Arch Neurol 1981 Nov;38(11):696-9. doi: 10.1001/archneur.1981.00510110056008. PMID: 6975612

Diagnosis

Leptomeningeal Metastasis: A Review of the Pathophysiology, Diagnostic Methodology, and Therapeutic Landscape.
Nguyen A, Nguyen A, Dada OT, Desai PD, Ricci JC, Godbole NB, Pierre K, Lucke-Wold B
Curr Oncol 2023 Jun 19;30(6):5906-5931. doi: 10.3390/curroncol30060442. PMID: 37366925Free PMC Article
Leptomeningeal Metastasis from Non-Small Cell Lung Cancer and Current Landscape of Treatments.
Ozcan G, Singh M, Vredenburgh JJ
Clin Cancer Res 2023 Jan 4;29(1):11-29. doi: 10.1158/1078-0432.CCR-22-1585. PMID: 35972437
Leptomeningeal metastases in non-small cell lung cancer: Diagnosis and treatment.
Wang Y, Yang X, Li NJ, Xue JX
Lung Cancer 2022 Dec;174:1-13. Epub 2022 Oct 1 doi: 10.1016/j.lungcan.2022.09.013. PMID: 36206679
Cerebrospinal Fluid Analysis.
Shahan B, Choi EY, Nieves G
Am Fam Physician 2021 Apr 1;103(7):422-428. PMID: 33788511
Leptomeningeal disease.
Groves MD
Neurosurg Clin N Am 2011 Jan;22(1):67-78, vii. doi: 10.1016/j.nec.2010.08.006. PMID: 21109151

Therapy

Leptomeningeal Metastasis from Non-Small Cell Lung Cancer and Current Landscape of Treatments.
Ozcan G, Singh M, Vredenburgh JJ
Clin Cancer Res 2023 Jan 4;29(1):11-29. doi: 10.1158/1078-0432.CCR-22-1585. PMID: 35972437
Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis.
Yang JT, Wijetunga NA, Pentsova E, Wolden S, Young RJ, Correa D, Zhang Z, Zheng J, Steckler A, Bucwinska W, Bernstein A, Betof Warner A, Yu H, Kris MG, Seidman AD, Wilcox JA, Malani R, Lin A, DeAngelis LM, Lee NY, Powell SN, Boire A
J Clin Oncol 2022 Nov 20;40(33):3858-3867. Epub 2022 Jul 8 doi: 10.1200/JCO.22.01148. PMID: 35802849Free PMC Article
Malignant Meningitis Associated with Hydrocephalus.
Kumar A, Sardhara JC, Singh G, Kanjilal S, Maurya VP, Behari S
Neurol India 2021 Nov-Dec;69(Supplement):S443-S455. doi: 10.4103/0028-3886.332278. PMID: 35103001
Under-recognized toxicities of cranial irradiation.
Le Guyader M, Antoni D
Cancer Radiother 2021 Oct;25(6-7):713-722. Epub 2021 Jul 14 doi: 10.1016/j.canrad.2021.06.019. PMID: 34274224
Osimertinib in Patients With Epidermal Growth Factor Receptor Mutation-Positive Non-Small-Cell Lung Cancer and Leptomeningeal Metastases: The BLOOM Study.
Yang JCH, Kim SW, Kim DW, Lee JS, Cho BC, Ahn JS, Lee DH, Kim TM, Goldman JW, Natale RB, Brown AP, Collins B, Chmielecki J, Vishwanathan K, Mendoza-Naranjo A, Ahn MJ
J Clin Oncol 2020 Feb 20;38(6):538-547. Epub 2019 Dec 6 doi: 10.1200/JCO.19.00457. PMID: 31809241Free PMC Article

Prognosis

Leptomeningeal Metastasis: A Review of the Pathophysiology, Diagnostic Methodology, and Therapeutic Landscape.
Nguyen A, Nguyen A, Dada OT, Desai PD, Ricci JC, Godbole NB, Pierre K, Lucke-Wold B
Curr Oncol 2023 Jun 19;30(6):5906-5931. doi: 10.3390/curroncol30060442. PMID: 37366925Free PMC Article
Leptomeningeal Metastasis from Non-Small Cell Lung Cancer and Current Landscape of Treatments.
Ozcan G, Singh M, Vredenburgh JJ
Clin Cancer Res 2023 Jan 4;29(1):11-29. doi: 10.1158/1078-0432.CCR-22-1585. PMID: 35972437
Leptomeningeal metastases in non-small cell lung cancer: Diagnosis and treatment.
Wang Y, Yang X, Li NJ, Xue JX
Lung Cancer 2022 Dec;174:1-13. Epub 2022 Oct 1 doi: 10.1016/j.lungcan.2022.09.013. PMID: 36206679
Single-cell RNA sequencing reveals the characteristics of cerebrospinal fluid tumour environment in breast cancer and lung cancer leptomeningeal metastases.
Ruan H, Wang Z, Sun Z, Wei J, Zhang L, Ju H, Wang T, Zhang C, Guan M, Pan S
Clin Transl Med 2022 Jun;12(6):e885. doi: 10.1002/ctm2.885. PMID: 35678121Free PMC Article
Cerebrospinal Fluid Analysis.
Shahan B, Choi EY, Nieves G
Am Fam Physician 2021 Apr 1;103(7):422-428. PMID: 33788511

Clinical prediction guides

Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis.
Yang JT, Wijetunga NA, Pentsova E, Wolden S, Young RJ, Correa D, Zhang Z, Zheng J, Steckler A, Bucwinska W, Bernstein A, Betof Warner A, Yu H, Kris MG, Seidman AD, Wilcox JA, Malani R, Lin A, DeAngelis LM, Lee NY, Powell SN, Boire A
J Clin Oncol 2022 Nov 20;40(33):3858-3867. Epub 2022 Jul 8 doi: 10.1200/JCO.22.01148. PMID: 35802849Free PMC Article
Malignant Meningitis Associated with Hydrocephalus.
Kumar A, Sardhara JC, Singh G, Kanjilal S, Maurya VP, Behari S
Neurol India 2021 Nov-Dec;69(Supplement):S443-S455. doi: 10.4103/0028-3886.332278. PMID: 35103001
Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases.
Prakadan SM, Alvarez-Breckenridge CA, Markson SC, Kim AE, Klein RH, Nayyar N, Navia AW, Kuter BM, Kolb KE, Bihun I, Mora JL, Bertalan MS, Shaw B, White M, Kaplan A, Stocking JH, Wadsworth MH 2nd, Lee EQ, Chukwueke U, Wang N, Subramanian M, Rotem D, Cahill DP, Adalsteinsson VA, Miller JW, Sullivan RJ, Carter SL, Brastianos PK, Shalek AK
Nat Commun 2021 Oct 12;12(1):5955. doi: 10.1038/s41467-021-25860-5. PMID: 34642316Free PMC Article
Management of neoplastic meningitis.
Roth P, Weller M
Chin Clin Oncol 2015 Jun;4(2):26. doi: 10.3978/j.issn.2304-3865.2015.05.02. PMID: 26112812
Meningeal carcinomatosis in solid tumors.
Martins SJ, Azevedo CR, Chinen LT, Cruz MR, Peterlevitz MA, Gimenes DL
Arq Neuropsiquiatr 2011 Dec;69(6):973-80. doi: 10.1590/s0004-282x2011000700024. PMID: 22297890

Recent systematic reviews

Liquid biopsy in the setting of leptomeningeal metastases: a systematic review and meta-analysis.
Wijaya JH, Patel UD, Quintero-Consuegra MD, Aguilera-Peña MP, Madriñán-Navia HJ, Putra AW, July J, Kataria S
J Neurooncol 2023 Dec;165(3):431-438. Epub 2023 Nov 29 doi: 10.1007/s11060-023-04519-9. PMID: 38019327
Predictors of mortality and tumor recurrence in desmoplastic infantile ganglioglioma and astrocytoma-and individual participant data meta-analysis (IPDMA).
Wang S, Sun MZ, Abecassis IJ, Weil AG, Ibrahim GM, Fallah A, Ene C, Leary SES, Cole BL, Lockwood CM, Olson JM, Geyer JR, Ellenbogen RG, Ojemann JG, Wang AC
J Neurooncol 2021 Nov;155(2):155-163. Epub 2021 Oct 6 doi: 10.1007/s11060-021-03860-1. PMID: 34613581Free PMC Article
The necessity of intrathecal chemotherapy for the treatment of breast cancer patients with leptomeningeal metastasis: A systematic review and pooled analysis.
Lee YC, Hsieh CC, Chuang JP, Li CY
Curr Probl Cancer 2017 Sep-Oct;41(5):355-370. Epub 2017 Jul 12 doi: 10.1016/j.currproblcancer.2017.07.001. PMID: 28779849
Optimal Management of Leptomeningeal Carcinomatosis in Breast Cancer Patients-A Systematic Review.
Dudani S, Mazzarello S, Hilton J, Hutton B, Vandermeer L, Fernandes R, Ibrahim MF, Smith S, Majeed H, Al-Baimani K, Caudrelier JM, Shorr R, Clemons M
Clin Breast Cancer 2016 Dec;16(6):456-470. Epub 2016 Jul 28 doi: 10.1016/j.clbc.2016.07.014. PMID: 27553811
Leptomeningeal carcinomatosis in esophageal cancer: a case series and systematic review of the literature.
Lukas RV, Mata-Machado NA, Nicholas MK, Salgia R, Antic T, Villaflor VM
Dis Esophagus 2015 Nov-Dec;28(8):772-81. Epub 2014 Aug 21 doi: 10.1111/dote.12276. PMID: 25142531

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