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Meningeal Carcinomatosis

MedGen UID:
65080
•Concept ID:
C0220654
•
Neoplastic Process
Synonyms: Carcinomatoses, Leptomeningeal; Carcinomatoses, Meningeal; Carcinomatosis, Leptomeningeal; Carcinomatosis, Meningeal; Carcinomatous Meningitides; Carcinomatous Meningitis; Leptomeningeal Carcinomatoses; Leptomeningeal Carcinomatosis; Meningeal Carcinomatoses; Meningitides, Carcinomatous; Meningitis, Carcinomatous
SNOMED CT: Malignant meningitis (230156002); Carcinomatous meningitis (230156002); Meningeal carcinomatosis (230156002)

Definition

Diffuse spread of cancer to the meninges. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeningeal Carcinomatosis

Professional guidelines

PubMed

Role of intrathecal chemotherapy in the management of meningeal carcinomatosis in patients with breast cancer.
Meneguetti RT, Cruz FJSM, Del Giglio A
Einstein (Sao Paulo) 2023;21:eAO0481. Epub 2023 Dec 22 doi: 10.31744/einstein_journal/2023AO0481. PMID: 38126659Free PMC Article
Endocrine therapy for the treatment of leptomeningeal carcinomatosis in luminal breast cancer: a comprehensive review.
Fernandes L, de Matos LV, Cardoso D, Saraiva M, Medeiros-Mirra R, Coelho A, Miranda H, Martins A
CNS Oncol 2020 Dec 1;9(4):CNS65. Epub 2020 Oct 20 doi: 10.2217/cns-2020-0023. PMID: 33078616Free PMC Article
Intrathecal administration of trastuzumab for the treatment of meningeal carcinomatosis in HER2-positive metastatic breast cancer: a systematic review and pooled analysis.
Zagouri F, Sergentanis TN, Bartsch R, Berghoff AS, Chrysikos D, de Azambuja E, Dimopoulos MA, Preusser M
Breast Cancer Res Treat 2013 May;139(1):13-22. Epub 2013 Apr 16 doi: 10.1007/s10549-013-2525-y. PMID: 23588955

Recent clinical studies

Etiology

Leveraging Molecular and Immune-Based Therapies in Leptomeningeal Metastases.
Wilcox JA, Boire AA
CNS Drugs 2023 Jan;37(1):45-67. Epub 2022 Dec 6 doi: 10.1007/s40263-022-00975-5. PMID: 36474108Free PMC Article
Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis.
Yang JT, Wijetunga NA, Pentsova E, Wolden S, Young RJ, Correa D, Zhang Z, Zheng J, Steckler A, Bucwinska W, Bernstein A, Betof Warner A, Yu H, Kris MG, Seidman AD, Wilcox JA, Malani R, Lin A, DeAngelis LM, Lee NY, Powell SN, Boire A
J Clin Oncol 2022 Nov 20;40(33):3858-3867. Epub 2022 Jul 8 doi: 10.1200/JCO.22.01148. PMID: 35802849Free PMC Article
Malignant Meningitis Associated with Hydrocephalus.
Kumar A, Sardhara JC, Singh G, Kanjilal S, Maurya VP, Behari S
Neurol India 2021 Nov-Dec;69(Supplement):S443-S455. doi: 10.4103/0028-3886.332278. PMID: 35103001
Management of neoplastic meningitis.
Roth P, Weller M
Chin Clin Oncol 2015 Jun;4(2):26. doi: 10.3978/j.issn.2304-3865.2015.05.02. PMID: 26112812
Spinal cord involvement in tuberculous meningitis.
Garg RK, Malhotra HS, Gupta R
Spinal Cord 2015 Sep;53(9):649-57. Epub 2015 Apr 21 doi: 10.1038/sc.2015.58. PMID: 25896347

Diagnosis

Leptomeningeal Metastasis: A Review of the Pathophysiology, Diagnostic Methodology, and Therapeutic Landscape.
Nguyen A, Nguyen A, Dada OT, Desai PD, Ricci JC, Godbole NB, Pierre K, Lucke-Wold B
Curr Oncol 2023 Jun 19;30(6):5906-5931. doi: 10.3390/curroncol30060442. PMID: 37366925Free PMC Article
Leptomeningeal Metastasis from Non-Small Cell Lung Cancer and Current Landscape of Treatments.
Ozcan G, Singh M, Vredenburgh JJ
Clin Cancer Res 2023 Jan 4;29(1):11-29. doi: 10.1158/1078-0432.CCR-22-1585. PMID: 35972437
Leptomeningeal metastases in non-small cell lung cancer: Diagnosis and treatment.
Wang Y, Yang X, Li NJ, Xue JX
Lung Cancer 2022 Dec;174:1-13. Epub 2022 Oct 1 doi: 10.1016/j.lungcan.2022.09.013. PMID: 36206679
Cerebrospinal Fluid Analysis.
Shahan B, Choi EY, Nieves G
Am Fam Physician 2021 Apr 1;103(7):422-428. PMID: 33788511
Leptomeningeal disease.
Groves MD
Neurosurg Clin N Am 2011 Jan;22(1):67-78, vii. doi: 10.1016/j.nec.2010.08.006. PMID: 21109151

Therapy

Leptomeningeal Metastasis from Non-Small Cell Lung Cancer and Current Landscape of Treatments.
Ozcan G, Singh M, Vredenburgh JJ
Clin Cancer Res 2023 Jan 4;29(1):11-29. doi: 10.1158/1078-0432.CCR-22-1585. PMID: 35972437
A phase I/II study of intrathecal trastuzumab in human epidermal growth factor receptor 2-positive (HER2-positive) cancer with leptomeningeal metastases: Safety, efficacy, and cerebrospinal fluid pharmacokinetics.
Kumthekar PU, Avram MJ, Lassman AB, Lin NU, Lee E, Grimm SA, Schwartz M, Bell Burdett KL, Lukas RV, Dixit K, Perron I, Zhang H, Gradishar WJ, Pentsova EI, Jeyapalan S, Groves MD, Melisko M, Raizer JJ
Neuro Oncol 2023 Mar 14;25(3):557-565. doi: 10.1093/neuonc/noac195. PMID: 35948282Free PMC Article
Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis.
Yang JT, Wijetunga NA, Pentsova E, Wolden S, Young RJ, Correa D, Zhang Z, Zheng J, Steckler A, Bucwinska W, Bernstein A, Betof Warner A, Yu H, Kris MG, Seidman AD, Wilcox JA, Malani R, Lin A, DeAngelis LM, Lee NY, Powell SN, Boire A
J Clin Oncol 2022 Nov 20;40(33):3858-3867. Epub 2022 Jul 8 doi: 10.1200/JCO.22.01148. PMID: 35802849Free PMC Article
Malignant Meningitis Associated with Hydrocephalus.
Kumar A, Sardhara JC, Singh G, Kanjilal S, Maurya VP, Behari S
Neurol India 2021 Nov-Dec;69(Supplement):S443-S455. doi: 10.4103/0028-3886.332278. PMID: 35103001
Osimertinib in Patients With Epidermal Growth Factor Receptor Mutation-Positive Non-Small-Cell Lung Cancer and Leptomeningeal Metastases: The BLOOM Study.
Yang JCH, Kim SW, Kim DW, Lee JS, Cho BC, Ahn JS, Lee DH, Kim TM, Goldman JW, Natale RB, Brown AP, Collins B, Chmielecki J, Vishwanathan K, Mendoza-Naranjo A, Ahn MJ
J Clin Oncol 2020 Feb 20;38(6):538-547. Epub 2019 Dec 6 doi: 10.1200/JCO.19.00457. PMID: 31809241Free PMC Article

Prognosis

Leptomeningeal Metastasis: A Review of the Pathophysiology, Diagnostic Methodology, and Therapeutic Landscape.
Nguyen A, Nguyen A, Dada OT, Desai PD, Ricci JC, Godbole NB, Pierre K, Lucke-Wold B
Curr Oncol 2023 Jun 19;30(6):5906-5931. doi: 10.3390/curroncol30060442. PMID: 37366925Free PMC Article
Leptomeningeal Metastasis from Non-Small Cell Lung Cancer and Current Landscape of Treatments.
Ozcan G, Singh M, Vredenburgh JJ
Clin Cancer Res 2023 Jan 4;29(1):11-29. doi: 10.1158/1078-0432.CCR-22-1585. PMID: 35972437
Leptomeningeal metastases in non-small cell lung cancer: Diagnosis and treatment.
Wang Y, Yang X, Li NJ, Xue JX
Lung Cancer 2022 Dec;174:1-13. Epub 2022 Oct 1 doi: 10.1016/j.lungcan.2022.09.013. PMID: 36206679
Single-cell RNA sequencing reveals the characteristics of cerebrospinal fluid tumour environment in breast cancer and lung cancer leptomeningeal metastases.
Ruan H, Wang Z, Sun Z, Wei J, Zhang L, Ju H, Wang T, Zhang C, Guan M, Pan S
Clin Transl Med 2022 Jun;12(6):e885. doi: 10.1002/ctm2.885. PMID: 35678121Free PMC Article
Cerebrospinal Fluid Analysis.
Shahan B, Choi EY, Nieves G
Am Fam Physician 2021 Apr 1;103(7):422-428. PMID: 33788511

Clinical prediction guides

A phase I/II study of intrathecal trastuzumab in human epidermal growth factor receptor 2-positive (HER2-positive) cancer with leptomeningeal metastases: Safety, efficacy, and cerebrospinal fluid pharmacokinetics.
Kumthekar PU, Avram MJ, Lassman AB, Lin NU, Lee E, Grimm SA, Schwartz M, Bell Burdett KL, Lukas RV, Dixit K, Perron I, Zhang H, Gradishar WJ, Pentsova EI, Jeyapalan S, Groves MD, Melisko M, Raizer JJ
Neuro Oncol 2023 Mar 14;25(3):557-565. doi: 10.1093/neuonc/noac195. PMID: 35948282Free PMC Article
Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis.
Yang JT, Wijetunga NA, Pentsova E, Wolden S, Young RJ, Correa D, Zhang Z, Zheng J, Steckler A, Bucwinska W, Bernstein A, Betof Warner A, Yu H, Kris MG, Seidman AD, Wilcox JA, Malani R, Lin A, DeAngelis LM, Lee NY, Powell SN, Boire A
J Clin Oncol 2022 Nov 20;40(33):3858-3867. Epub 2022 Jul 8 doi: 10.1200/JCO.22.01148. PMID: 35802849Free PMC Article
Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases.
Prakadan SM, Alvarez-Breckenridge CA, Markson SC, Kim AE, Klein RH, Nayyar N, Navia AW, Kuter BM, Kolb KE, Bihun I, Mora JL, Bertalan MS, Shaw B, White M, Kaplan A, Stocking JH, Wadsworth MH 2nd, Lee EQ, Chukwueke U, Wang N, Subramanian M, Rotem D, Cahill DP, Adalsteinsson VA, Miller JW, Sullivan RJ, Carter SL, Brastianos PK, Shalek AK
Nat Commun 2021 Oct 12;12(1):5955. doi: 10.1038/s41467-021-25860-5. PMID: 34642316Free PMC Article
Management of neoplastic meningitis.
Roth P, Weller M
Chin Clin Oncol 2015 Jun;4(2):26. doi: 10.3978/j.issn.2304-3865.2015.05.02. PMID: 26112812
Spinal cord involvement in tuberculous meningitis.
Garg RK, Malhotra HS, Gupta R
Spinal Cord 2015 Sep;53(9):649-57. Epub 2015 Apr 21 doi: 10.1038/sc.2015.58. PMID: 25896347

Recent systematic reviews

Sequencing of cerebrospinal fluid in non-small-cell lung cancer patients with leptomeningeal metastasis: A systematic review.
Gao T, Chen F, Li M
Cancer Med 2023 Feb;12(3):2248-2261. Epub 2022 Aug 24 doi: 10.1002/cam4.5163. PMID: 36000927Free PMC Article
Predictors of mortality and tumor recurrence in desmoplastic infantile ganglioglioma and astrocytoma-and individual participant data meta-analysis (IPDMA).
Wang S, Sun MZ, Abecassis IJ, Weil AG, Ibrahim GM, Fallah A, Ene C, Leary SES, Cole BL, Lockwood CM, Olson JM, Geyer JR, Ellenbogen RG, Ojemann JG, Wang AC
J Neurooncol 2021 Nov;155(2):155-163. Epub 2021 Oct 6 doi: 10.1007/s11060-021-03860-1. PMID: 34613581Free PMC Article
Clinical outcomes of non-small cell lung cancer patients with leptomeningeal metastases after immune checkpoint inhibitor treatments.
Zheng MM, Tu HY, Yang JJ, Zhang XC, Zhou Q, Xu CR, Jiang BY, Yang XN, Yang XR, Deng JY, Yang MY, Xu BF, Chen XM, Li YS, Wu YL
Eur J Cancer 2021 Jun;150:23-30. Epub 2021 Apr 18 doi: 10.1016/j.ejca.2021.03.037. PMID: 33882375
Optimal Management of Leptomeningeal Carcinomatosis in Breast Cancer Patients-A Systematic Review.
Dudani S, Mazzarello S, Hilton J, Hutton B, Vandermeer L, Fernandes R, Ibrahim MF, Smith S, Majeed H, Al-Baimani K, Caudrelier JM, Shorr R, Clemons M
Clin Breast Cancer 2016 Dec;16(6):456-470. Epub 2016 Jul 28 doi: 10.1016/j.clbc.2016.07.014. PMID: 27553811
Intrathecal administration of trastuzumab for the treatment of meningeal carcinomatosis in HER2-positive metastatic breast cancer: a systematic review and pooled analysis.
Zagouri F, Sergentanis TN, Bartsch R, Berghoff AS, Chrysikos D, de Azambuja E, Dimopoulos MA, Preusser M
Breast Cancer Res Treat 2013 May;139(1):13-22. Epub 2013 Apr 16 doi: 10.1007/s10549-013-2525-y. PMID: 23588955

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