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Lymphangitic Carcinomatosis

MedGen UID:
65954
•Concept ID:
C0238258
•
Neoplastic Process
Synonym: Lymphangitis carcinomatosa
SNOMED CT: Lymphangitis carcinomatosa (255119002)

Definition

Extensive infiltration of the lymphatic vessels by cancer cells, resulting in widespread cancer dissemination. The lymphatic vessels appear as palpable, cord-like structures, especially in skin areas overlying the carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphangitic Carcinomatosis

Professional guidelines

PubMed

Micronodular lung disease on high-resolution CT: patterns and differential diagnosis.
Kim J, Dabiri B, Hammer MM
Clin Radiol 2021 Jun;76(6):399-406. Epub 2021 Feb 7 doi: 10.1016/j.crad.2020.12.025. PMID: 33563413
Pulmonary toxicity related to systemic treatment of nonsmall cell lung cancer.
De Sanctis A, Taillade L, Vignot S, Novello S, Conforti R, Spano JP, Scagliotti GV, Khayat D
Cancer 2011 Jul 15;117(14):3069-80. Epub 2011 Jan 31 doi: 10.1002/cncr.25894. PMID: 21283982
Effects of radiation therapy on the lung: radiologic appearances and differential diagnosis.
Choi YW, Munden RF, Erasmus JJ, Park KJ, Chung WK, Jeon SC, Park CK
Radiographics 2004 Jul-Aug;24(4):985-97; discussion 998. doi: 10.1148/rg.244035160. PMID: 15256622

Recent clinical studies

Etiology

The role of corticosteroids in the palliation of dyspnea in cancer patients: an evidence-based review.
Hui D, Yennurajalingam S
Curr Opin Support Palliat Care 2023 Dec 1;17(4):270-276. Epub 2023 Sep 29 doi: 10.1097/SPC.0000000000000677. PMID: 37773042
Clinical outcome of pulmonary lymphangitic carcinomatosis in gynecologic malignancy: A single-institution experience.
Kim MS, Jeong SY, Lee YY, Choi CH, Kim TJ, Kim BG, Bae DS, Lee JW
Taiwan J Obstet Gynecol 2022 Mar;61(2):333-338. doi: 10.1016/j.tjog.2022.02.024. PMID: 35361397
Pulmonary Lymphangitic Carcinomatosis: Diagnostic Performance of High-Resolution CT and (18)F-FDG PET/CT in Correlation with Clinical Pathologic Outcome.
Jreige M, Dunet V, Letovanec I, Prior JO, Meuli RA, Beigelman-Aubry C, Schaefer N
J Nucl Med 2020 Jan;61(1):26-32. Epub 2019 Jun 21 doi: 10.2967/jnumed.119.229575. PMID: 31227574
Fluorodeoxyglucose Uptake in Advanced Non-small Cell Lung Cancer With and Without Pulmonary Lymphangitic Carcinomatosis.
Ooi H, Chen CY, Hsiao YC, Huang WS, Hsieh BT
Anticancer Res 2016 Aug;36(8):4313-20. PMID: 27466550
Management of malignant pleural effusions.
Sahn SA
Monaldi Arch Chest Dis 2001 Oct;56(5):394-9. PMID: 11887496

Diagnosis

Clinical outcome of pulmonary lymphangitic carcinomatosis in gynecologic malignancy: A single-institution experience.
Kim MS, Jeong SY, Lee YY, Choi CH, Kim TJ, Kim BG, Bae DS, Lee JW
Taiwan J Obstet Gynecol 2022 Mar;61(2):333-338. doi: 10.1016/j.tjog.2022.02.024. PMID: 35361397
Micronodular lung disease on high-resolution CT: patterns and differential diagnosis.
Kim J, Dabiri B, Hammer MM
Clin Radiol 2021 Jun;76(6):399-406. Epub 2021 Feb 7 doi: 10.1016/j.crad.2020.12.025. PMID: 33563413
Pulmonary lymphangitic carcinomatosis.
Lin WR, Lai RS
QJM 2014 Nov;107(11):935-6. Epub 2014 Apr 8 doi: 10.1093/qjmed/hcu076. PMID: 24713225
Lung metastases.
Herold CJ, Bankier AA, Fleischmann D
Eur Radiol 1996;6(5):596-606. doi: 10.1007/BF00187656. PMID: 8934121
Tropical pulmonary eosinophilia.
Enzenauer RJ, Underwood GH Jr, Ribbing J
South Med J 1990 Jan;83(1):69-72. doi: 10.1097/00007611-199001000-00022. PMID: 2405502

Therapy

Corticosteroids for pulmonary lymphangitic carcinomatosis.
Takimoto T
BMJ Support Palliat Care 2024 Jan 8;13(e3):e951-e952. doi: 10.1136/spcare-2022-003983. PMID: 36302614
The role of corticosteroids in the palliation of dyspnea in cancer patients: an evidence-based review.
Hui D, Yennurajalingam S
Curr Opin Support Palliat Care 2023 Dec 1;17(4):270-276. Epub 2023 Sep 29 doi: 10.1097/SPC.0000000000000677. PMID: 37773042
Micronodular lung disease on high-resolution CT: patterns and differential diagnosis.
Kim J, Dabiri B, Hammer MM
Clin Radiol 2021 Jun;76(6):399-406. Epub 2021 Feb 7 doi: 10.1016/j.crad.2020.12.025. PMID: 33563413
Pulmonary lymphangitic carcinomatosis in liver carcinoma: a rare case report and literature review.
Zhuang L, Liu X, Hu C, Zhang L, Jiang G, Wu J, Zheng S
World J Surg Oncol 2014 Mar 27;12:66. doi: 10.1186/1477-7819-12-66. PMID: 24669948Free PMC Article
Effects of radiation therapy on the lung: radiologic appearances and differential diagnosis.
Choi YW, Munden RF, Erasmus JJ, Park KJ, Chung WK, Jeon SC, Park CK
Radiographics 2004 Jul-Aug;24(4):985-97; discussion 998. doi: 10.1148/rg.244035160. PMID: 15256622

Prognosis

Pulmonary Lymphangitic Carcinomatosis From Renal Cell Carcinoma.
Riley L, Verma N, Mohammed TL, Ataya A
Curr Probl Diagn Radiol 2021 Jan-Feb;50(1):104-107. Epub 2018 Jul 23 doi: 10.1067/j.cpradiol.2018.07.008. PMID: 30120017
Fluorodeoxyglucose Uptake in Advanced Non-small Cell Lung Cancer With and Without Pulmonary Lymphangitic Carcinomatosis.
Ooi H, Chen CY, Hsiao YC, Huang WS, Hsieh BT
Anticancer Res 2016 Aug;36(8):4313-20. PMID: 27466550
Pulmonary lymphangitic carcinomatosis.
Lin WR, Lai RS
QJM 2014 Nov;107(11):935-6. Epub 2014 Apr 8 doi: 10.1093/qjmed/hcu076. PMID: 24713225
Prognostic implication of the lymphangitic carcinomatosis pattern on perfusion lung scan.
Charest M, Armanious S
Can Assoc Radiol J 2012 Nov;63(4):294-303. Epub 2011 Dec 14 doi: 10.1016/j.carj.2011.04.004. PMID: 22172684
Pulmonary medicine and palliative care.
Tucakovic M, Bascom R, Bascom PB
Best Pract Res Clin Obstet Gynaecol 2001 Apr;15(2):291-304. doi: 10.1053/beog.2000.0169. PMID: 11358403

Clinical prediction guides

The role of corticosteroids in the palliation of dyspnea in cancer patients: an evidence-based review.
Hui D, Yennurajalingam S
Curr Opin Support Palliat Care 2023 Dec 1;17(4):270-276. Epub 2023 Sep 29 doi: 10.1097/SPC.0000000000000677. PMID: 37773042
Prognostic value of pretherapeutic FDG PET/CT in non-small cell lung cancer with pulmonary lymphangitic carcinomatosis.
Park YJ, Im Y, Kwon OJ, Han J, Ahn MJ, Kim J, Um SW, Choi JY
Sci Rep 2023 Jan 7;13(1):345. doi: 10.1038/s41598-022-24875-2. PMID: 36611038Free PMC Article
Fluorodeoxyglucose Uptake in Advanced Non-small Cell Lung Cancer With and Without Pulmonary Lymphangitic Carcinomatosis.
Ooi H, Chen CY, Hsiao YC, Huang WS, Hsieh BT
Anticancer Res 2016 Aug;36(8):4313-20. PMID: 27466550
CT of pulmonary metastases with pathological correlation.
Hirakata K, Nakata H, Nakagawa T
Semin Ultrasound CT MR 1995 Oct;16(5):379-94. doi: 10.1016/0887-2171(95)90027-6. PMID: 8527171
CT findings in lymphangitic carcinomatosis of the lung: correlation with histologic findings and pulmonary function tests.
Johkoh T, Ikezoe J, Tomiyama N, Nagareda T, Kohno N, Takeuchi N, Yamagami H, Kido S, Takashima S, Arisawa J
AJR Am J Roentgenol 1992 Jun;158(6):1217-22. doi: 10.2214/ajr.158.6.1590110. PMID: 1590110

Recent systematic reviews

CT Characteristics of Non-Small Cell Lung Cancer With Anaplastic Lymphoma Kinase Rearrangement: A Systematic Review and Meta-Analysis.
Kim TH, Woo S, Yoon SH, Halpenny DF, Han S, Suh CH
AJR Am J Roentgenol 2019 Nov;213(5):1059-1072. Epub 2019 Aug 15 doi: 10.2214/AJR.19.21485. PMID: 31414902Free PMC Article
Computed Tomography Imaging Characteristics of Non-Small-Cell Lung Cancer With Anaplastic Lymphoma Kinase Rearrangements: A Systematic Review and Meta-Analysis.
Mendoza DP, Stowell J, Muzikansky A, Shepard JO, Shaw AT, Digumarthy SR
Clin Lung Cancer 2019 Sep;20(5):339-349. Epub 2019 May 11 doi: 10.1016/j.cllc.2019.05.006. PMID: 31164317

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