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Human T-lymphotropic virus 1 infectious disease

MedGen UID:
6919
•Concept ID:
C0020097
•
Disease or Syndrome
Synonyms: HTLV I Infections; HTLV-I Infection; HTLV-I Infections; Human T lymphotropic Virus 1 Infection; Human T lymphotropic Virus 1 Infections; Human T-lymphotropic Virus 1 Infection; Human T-lymphotropic Virus 1 Infections; Infection, HTLV-I; Infections, HTLV I; Infections, HTLV-I
SNOMED CT: Human T-cell lymphotropic virus (HTLV) 1 infection (429659006); Human T-cell lymphotropic virus 1 infection (429659006); HTLV 1 infection (429659006); HTLV I infection (429659006); Human T-lymphotropic virus 1 infection (429659006)
 
Monarch Initiative: MONDO:0005801

Definition

An infection that is caused by HTLV-1. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHuman T-lymphotropic virus 1 infectious disease

Professional guidelines

PubMed

Treatment of Adult T-Cell Leukemia/Lymphoma: Established Paradigms and Emerging Directions.
Stuver R, Horwitz SM, Epstein-Peterson ZD
Curr Treat Options Oncol 2023 Aug;24(8):948-964. Epub 2023 Jun 10 doi: 10.1007/s11864-023-01111-1. PMID: 37300656Free PMC Article
HTLV-1-related adult T-cell leukemia/lymphoma: insights in early detection and management.
Wolf S, Vercruyssen M, Cook L
Curr Opin Oncol 2022 Sep 1;34(5):446-453. Epub 2022 Jul 25 doi: 10.1097/CCO.0000000000000883. PMID: 35880453
Reliability of a screening assay for the simultaneous detection of antibodies to HIV-1/2 and HTLV-I/II.
Gómez-Hernando C, Gutiérrez M, Toro C, Soriano V
Vox Sang 1996;70(2):119-20. doi: 10.1111/j.1423-0410.1996.tb01306.x. PMID: 8801762

Recent clinical studies

Etiology

HTLV in Sweden.
Vesterbacka J, Svensson AK, Nowak P
AIDS Rev 2024;26(1):41-47. doi: 10.24875/AIDSRev.24000002. PMID: 38530748
Treatment of Adult T-Cell Leukemia/Lymphoma: Established Paradigms and Emerging Directions.
Stuver R, Horwitz SM, Epstein-Peterson ZD
Curr Treat Options Oncol 2023 Aug;24(8):948-964. Epub 2023 Jun 10 doi: 10.1007/s11864-023-01111-1. PMID: 37300656Free PMC Article
RAISING is a high-performance method for identifying random transgene integration sites.
Wada Y, Sato T, Hasegawa H, Matsudaira T, Nao N, Coler-Reilly ALG, Tasaka T, Yamauchi S, Okagawa T, Momose H, Tanio M, Kuramitsu M, Sasaki D, Matsumoto N, Yagishita N, Yamauchi J, Araya N, Tanabe K, Yamagishi M, Nakashima M, Nakahata S, Iha H, Ogata M, Muramatsu M, Imaizumi Y, Uchimaru K, Miyazaki Y, Konnai S, Yanagihara K, Morishita K, Watanabe T, Yamano Y, Saito M
Commun Biol 2022 Jun 2;5(1):535. doi: 10.1038/s42003-022-03467-w. PMID: 35654946Free PMC Article
Stop, think SCORTCH: rethinking the traditional 'TORCH' screen in an era of re-emerging syphilis.
Penner J, Hernstadt H, Burns JE, Randell P, Lyall H
Arch Dis Child 2021 Feb;106(2):117-124. Epub 2020 Jun 25 doi: 10.1136/archdischild-2020-318841. PMID: 32586930
Emerging sexually transmitted viral infections: Review of human T-lymphotropic virus-1 disease.
Caswell RJ, Manavi K
Int J STD AIDS 2020 Feb;31(2):92-99. Epub 2020 Jan 21 doi: 10.1177/0956462419886940. PMID: 31964238

Diagnosis

Treatment of Adult T-Cell Leukemia/Lymphoma: Established Paradigms and Emerging Directions.
Stuver R, Horwitz SM, Epstein-Peterson ZD
Curr Treat Options Oncol 2023 Aug;24(8):948-964. Epub 2023 Jun 10 doi: 10.1007/s11864-023-01111-1. PMID: 37300656Free PMC Article
HTLV-1 encephalitis.
King-Robson J, Hampton T, Rosadas C, Taylor GP, Stanton B
Pract Neurol 2022 Feb;22(1):60-63. Epub 2021 Aug 30 doi: 10.1136/practneurol-2021-003053. PMID: 34462338
Stop, think SCORTCH: rethinking the traditional 'TORCH' screen in an era of re-emerging syphilis.
Penner J, Hernstadt H, Burns JE, Randell P, Lyall H
Arch Dis Child 2021 Feb;106(2):117-124. Epub 2020 Jun 25 doi: 10.1136/archdischild-2020-318841. PMID: 32586930
Emerging sexually transmitted viral infections: Review of human T-lymphotropic virus-1 disease.
Caswell RJ, Manavi K
Int J STD AIDS 2020 Feb;31(2):92-99. Epub 2020 Jan 21 doi: 10.1177/0956462419886940. PMID: 31964238
The epidemiology of the human T-cell lymphotrophic virus type I and type II: etiologic role in human disease.
Manns A, Blattner WA
Transfusion 1991 Jan;31(1):67-75. doi: 10.1046/j.1537-2995.1991.31191096189.x. PMID: 1986467

Therapy

B-cell depletion limits HTLV-1-infected T-cell expansion and ameliorate HTLV-1-associated myelopathy.
Lv A, Fang Y, Lin X, Chen J, Song H, Wang N, Chen WJ, Fu Y, Li R, Lin Y
Ann Clin Transl Neurol 2024 Oct;11(10):2756-2768. Epub 2024 Aug 26 doi: 10.1002/acn3.52190. PMID: 39186315Free PMC Article
HTLV-1-related adult T-cell leukemia/lymphoma: insights in early detection and management.
Wolf S, Vercruyssen M, Cook L
Curr Opin Oncol 2022 Sep 1;34(5):446-453. Epub 2022 Jul 25 doi: 10.1097/CCO.0000000000000883. PMID: 35880453
Adult T-cell leukemia-lymphoma as a viral disease: Subtypes based on viral aspects.
Nosaka K, Matsuoka M
Cancer Sci 2021 May;112(5):1688-1694. Epub 2021 Mar 30 doi: 10.1111/cas.14869. PMID: 33630351Free PMC Article
A Potential of an Anti-HTLV-I gp46 Neutralizing Monoclonal Antibody (LAT-27) for Passive Immunization against Both Horizontal and Mother-to-Child Vertical Infection with Human T Cell Leukemia Virus Type-I.
Fujii H, Shimizu M, Miyagi T, Kunihiro M, Tanaka R, Takahashi Y, Tanaka Y
Viruses 2016 Feb 3;8(2) doi: 10.3390/v8020041. PMID: 26848684Free PMC Article
Human T-lymphotropic virus/HIV co-infection: a clinical review.
Dhasmana D, Taylor GP
Curr Opin Infect Dis 2014 Feb;27(1):16-28. doi: 10.1097/QCO.0000000000000027. PMID: 24305042

Prognosis

Systemic cytokines and GlycA discriminate disease status and predict corticosteroid response in HTLV-1-associated neuroinflammation.
Assone T, Menezes SM, de Toledo Gonçalves F, Folgosi VA, da Silva Prates G, Dierckx T, Braz M, Smid J, Haziot ME, Marcusso RMN, Dahy FE, Vanderlinden E, Claes S, Schols D, Bruhn R, Murphy EL, Penalva de Oliveira AC, Daelemans D, Vercauteren J, Casseb J, Van Weyenbergh J
J Neuroinflammation 2022 Dec 8;19(1):293. doi: 10.1186/s12974-022-02658-w. PMID: 36482436Free PMC Article
HTLV-1-related adult T-cell leukemia/lymphoma: insights in early detection and management.
Wolf S, Vercruyssen M, Cook L
Curr Opin Oncol 2022 Sep 1;34(5):446-453. Epub 2022 Jul 25 doi: 10.1097/CCO.0000000000000883. PMID: 35880453
Septic Meningitis and Liver Abscess due to Hypermucoviscous Klebsiella pneumoniae Complicated with Chronic Strongyloidiasis in a Human T-lymphotropic Virus 1 Carrier.
Hosoda T, Sakamoto M, Orikasa H, Kubomura A, Misaki T, Okabe N
Intern Med 2020 Jan 1;59(1):129-133. Epub 2019 Aug 21 doi: 10.2169/internalmedicine.3403-19. PMID: 31434825Free PMC Article
Immunopathogenesis of HIV and HTLV-1 infection: mechanisms for lymphomagenesis.
Khorana AA, Rosenblatt JD, Young FM
Cancer Treat Res 2001;104:19-74. doi: 10.1007/978-1-4615-1601-9_2. PMID: 11191127
Mother-to-child transmission of human T-cell lymphotropic virus types I and II (HTLV-I/II) in Gabon: a prospective follow-up of 4 years.
Nyambi PN, Ville Y, Louwagie J, Bedjabaga I, Glowaczower E, Peeters M, Kerouedan D, Dazza M, Larouze B, van der Groen G, Delaporte E
J Acquir Immune Defic Syndr Hum Retrovirol 1996 Jun 1;12(2):187-92. doi: 10.1097/00042560-199606010-00013. PMID: 8680891

Clinical prediction guides

B-cell depletion limits HTLV-1-infected T-cell expansion and ameliorate HTLV-1-associated myelopathy.
Lv A, Fang Y, Lin X, Chen J, Song H, Wang N, Chen WJ, Fu Y, Li R, Lin Y
Ann Clin Transl Neurol 2024 Oct;11(10):2756-2768. Epub 2024 Aug 26 doi: 10.1002/acn3.52190. PMID: 39186315Free PMC Article
Viral, genetic, and immune factors in the oncogenesis of adult T-cell leukemia/lymphoma.
Yasunaga JI
Int J Hematol 2023 Apr;117(4):504-511. Epub 2023 Jan 27 doi: 10.1007/s12185-023-03547-5. PMID: 36705848
HTLV-1-related adult T-cell leukemia/lymphoma: insights in early detection and management.
Wolf S, Vercruyssen M, Cook L
Curr Opin Oncol 2022 Sep 1;34(5):446-453. Epub 2022 Jul 25 doi: 10.1097/CCO.0000000000000883. PMID: 35880453
HTLV, a multi organ oncovirus.
Ramezani S, Rezaee SA, Farjami Z, Ebrahimi N, Abdullabass HK, Ibrahim Jebur MI, Rafatpanah H, Akbarin MM
Microb Pathog 2022 Aug;169:105622. Epub 2022 Jun 7 doi: 10.1016/j.micpath.2022.105622. PMID: 35688412
Mother-to-child transmission of human T-cell lymphotropic virus types I and II (HTLV-I/II) in Gabon: a prospective follow-up of 4 years.
Nyambi PN, Ville Y, Louwagie J, Bedjabaga I, Glowaczower E, Peeters M, Kerouedan D, Dazza M, Larouze B, van der Groen G, Delaporte E
J Acquir Immune Defic Syndr Hum Retrovirol 1996 Jun 1;12(2):187-92. doi: 10.1097/00042560-199606010-00013. PMID: 8680891

Recent systematic reviews

Human T Cell Lymphotropic Virus Type 1 Global Prevalence Associated with the Human Development Index: Systematic Review with Meta-Analysis.
Sampaio GCL, Ribeiro JR, de Almeida CN, Boa-Sorte N, Galvão-Castro B, Grassi MFR, Nunes Sá K, Dias CMCC
AIDS Res Hum Retroviruses 2023 Apr;39(4):145-165. Epub 2023 Feb 15 doi: 10.1089/AID.2021.0230. PMID: 36571250
Human T-Cell Leukemia Virus Type 1-Related Diseases May Constitute a Threat to the Elimination of Human Immunodeficiency Virus, by 2030, in Gabon, Central Africa.
Oloumbou EF, Engone-Ondo JD, Mamimandjiami Idam I, Moussavou-Boudzanga P, Mfouo-Tynga I, Mouinga-Ondeme A
Viruses 2022 Dec 16;14(12) doi: 10.3390/v14122808. PMID: 36560812Free PMC Article
Clinical and Laboratory Outcomes in HIV-1 and HTLV-1/2 Coinfection: A Systematic Review.
Montaño-Castellón I, Marconi CSC, Saffe C, Brites C
Front Public Health 2022;10:820727. Epub 2022 Mar 7 doi: 10.3389/fpubh.2022.820727. PMID: 35359787Free PMC Article
Prevalence and Molecular Epidemiology of Human T-Lymphotropic Virus Type 1 among Women Attending Antenatal Clinics in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.
Ngoma AM, Mutombo PB, Omokoko MD, Mvika ES, Nollet KE, Ohto H
Am J Trop Med Hyg 2019 Oct;101(4):908-915. doi: 10.4269/ajtmh.19-0182. PMID: 31407658Free PMC Article
Hepatitis C virus infection and development of type 2 diabetes mellitus: Systematic review and meta-analysis of the literature.
Fabiani S, Fallahi P, Ferrari SM, Miccoli M, Antonelli A
Rev Endocr Metab Disord 2018 Dec;19(4):405-420. doi: 10.1007/s11154-017-9440-1. PMID: 29322398

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