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Acute necrotizing pancreatitis

MedGen UID:
75645
•Concept ID:
C0267941
•
Disease or Syndrome
Synonyms: Acute Necrotizing Pancreatitis; Necrosis, Pancreatic; Necrotizing Pancreatitis, Acute; Pancreatic Necroses; Pancreatic Necrosis; Pancreatitis Necrotising; Pancreatitis Necrotisings; Pancreatitis Necrotizing; Pancreatitis Necrotizings; Pancreatitis, Acute Necrotizing
SNOMED CT: Acute necrotizing pancreatitis (7881005); Necrotizing pancreatitis (7881005)
 
Monarch Initiative: MONDO:0850420

Definition

An acute pancreatitis that is characterized by one or more areas of necrosis in the pancreas with varying degree of involvement of the surrounding tissues or organ systems. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute necrotizing pancreatitis

Professional guidelines

PubMed

ESPEN practical guideline on clinical nutrition in acute and chronic pancreatitis.
Arvanitakis M, Ockenga J, Bezmarevic M, Gianotti L, Krznarić Ž, Lobo DN, Löser C, Madl C, Meier R, Phillips M, Rasmussen HH, Van Hooft JE, Bischoff SC
Clin Nutr 2024 Feb;43(2):395-412. Epub 2023 Dec 27 doi: 10.1016/j.clnu.2023.12.019. PMID: 38169174
ESPEN guideline on clinical nutrition in acute and chronic pancreatitis.
Arvanitakis M, Ockenga J, Bezmarevic M, Gianotti L, Krznarić Ž, Lobo DN, Löser C, Madl C, Meier R, Phillips M, Rasmussen HH, Van Hooft JE, Bischoff SC
Clin Nutr 2020 Mar;39(3):612-631. Epub 2020 Jan 22 doi: 10.1016/j.clnu.2020.01.004. PMID: 32008871
American Gastroenterological Association Clinical Practice Update: Management of Pancreatic Necrosis.
Baron TH, DiMaio CJ, Wang AY, Morgan KA
Gastroenterology 2020 Jan;158(1):67-75.e1. Epub 2019 Aug 31 doi: 10.1053/j.gastro.2019.07.064. PMID: 31479658

Recent clinical studies

Etiology

Management of Necrotizing Pancreatitis.
Maatman TK, Zyromski NJ
Adv Surg 2022 Sep;56(1):13-35. doi: 10.1016/j.yasu.2022.02.010. PMID: 36096565
Acute pancreatitis.
Valverde-López F, Martínez-Cara JG, Redondo-Cerezo E
Med Clin (Barc) 2022 Jun 10;158(11):556-563. Epub 2022 Mar 8 doi: 10.1016/j.medcli.2021.12.012. PMID: 35277268
Consensus guidelines on severe acute pancreatitis.
Italian Association for the Study of the Pancreas (AISP), Pezzilli R, Zerbi A, Campra D, Capurso G, Golfieri R, Arcidiacono PG, Billi P, Butturini G, Calculli L, Cannizzaro R, Carrara S, Crippa S, De Gaudio R, De Rai P, Frulloni L, Mazza E, Mutignani M, Pagano N, Rabitti P, Balzano G
Dig Liver Dis 2015 Jul;47(7):532-43. Epub 2015 Apr 2 doi: 10.1016/j.dld.2015.03.022. PMID: 25921277
Treatment of severe acute pancreatitis and its complications.
Zerem E
World J Gastroenterol 2014 Oct 14;20(38):13879-92. doi: 10.3748/wjg.v20.i38.13879. PMID: 25320523Free PMC Article
Necrotizing pancreatitis.
Bradley EL 3rd
Br J Surg 1999 Feb;86(2):147-8. doi: 10.1046/j.1365-2168.1999.01036.x. PMID: 10100779

Diagnosis

Management of Necrotizing Pancreatitis.
Maatman TK, Zyromski NJ
Adv Surg 2022 Sep;56(1):13-35. doi: 10.1016/j.yasu.2022.02.010. PMID: 36096565
Acute Pancreatitis: Rapid Evidence Review.
Oppenlander KE, Chadwick C, Carman K
Am Fam Physician 2022 Jul;106(1):44-50. PMID: 35839366
Acute pancreatitis.
Valverde-López F, Martínez-Cara JG, Redondo-Cerezo E
Med Clin (Barc) 2022 Jun 10;158(11):556-563. Epub 2022 Mar 8 doi: 10.1016/j.medcli.2021.12.012. PMID: 35277268
Acute pancreatitis.
Johnson CD, Besselink MG, Carter R
BMJ 2014 Aug 12;349:g4859. doi: 10.1136/bmj.g4859. PMID: 25116169
Acute necrotizing pancreatitis.
Baron TH, Morgan DE
N Engl J Med 1999 May 6;340(18):1412-7. doi: 10.1056/NEJM199905063401807. PMID: 10228193

Therapy

Acute pancreatitis.
Boxhoorn L, Voermans RP, Bouwense SA, Bruno MJ, Verdonk RC, Boermeester MA, van Santvoort HC, Besselink MG
Lancet 2020 Sep 5;396(10252):726-734. doi: 10.1016/S0140-6736(20)31310-6. PMID: 32891214
American Gastroenterological Association Clinical Practice Update: Management of Pancreatic Necrosis.
Baron TH, DiMaio CJ, Wang AY, Morgan KA
Gastroenterology 2020 Jan;158(1):67-75.e1. Epub 2019 Aug 31 doi: 10.1053/j.gastro.2019.07.064. PMID: 31479658
Acute pancreatitis.
Johnson CD, Besselink MG, Carter R
BMJ 2014 Aug 12;349:g4859. doi: 10.1136/bmj.g4859. PMID: 25116169
Acute pancreatitis: etiology and common pathogenesis.
Wang GJ, Gao CF, Wei D, Wang C, Ding SQ
World J Gastroenterol 2009 Mar 28;15(12):1427-30. doi: 10.3748/wjg.15.1427. PMID: 19322914Free PMC Article
Acute necrotizing pancreatitis.
Baron TH, Morgan DE
N Engl J Med 1999 May 6;340(18):1412-7. doi: 10.1056/NEJM199905063401807. PMID: 10228193

Prognosis

Management of Disconnected Pancreatic Duct.
Basha J, Lakhtakia S
Gastrointest Endosc Clin N Am 2023 Oct;33(4):753-770. Epub 2023 May 20 doi: 10.1016/j.giec.2023.04.004. PMID: 37709409
Current Concepts in Severe Acute and Necrotizing Pancreatitis: An Evidence-Based Approach.
Trikudanathan G, Wolbrink DRJ, van Santvoort HC, Mallery S, Freeman M, Besselink MG
Gastroenterology 2019 May;156(7):1994-2007.e3. Epub 2019 Feb 15 doi: 10.1053/j.gastro.2019.01.269. PMID: 30776347
Treatment of severe acute pancreatitis and its complications.
Zerem E
World J Gastroenterol 2014 Oct 14;20(38):13879-92. doi: 10.3748/wjg.v20.i38.13879. PMID: 25320523Free PMC Article
Emphysematous pancreatitis.
Okamoto H, Kuriyama A
Emerg Med J 2013 May;30(5):396. Epub 2013 Jan 10 doi: 10.1136/emermed-2012-202214. PMID: 23307755
Ezetimibe-induced acute pancreatitis.
Ahmad I, Ruby E, Usman H, Hotiana M, Hussain M, Rahman F
South Med J 2007 Apr;100(4):409-10. doi: 10.1097/SMJ.0b013e3180374e4b. PMID: 17458405

Clinical prediction guides

Acute Pancreatitis: Rapid Evidence Review.
Oppenlander KE, Chadwick C, Carman K
Am Fam Physician 2022 Jul;106(1):44-50. PMID: 35839366
Predicting Severity of Acute Pancreatitis.
Lee DW, Cho CM
Medicina (Kaunas) 2022 Jun 11;58(6) doi: 10.3390/medicina58060787. PMID: 35744050Free PMC Article
Immediate versus Postponed Intervention for Infected Necrotizing Pancreatitis.
Boxhoorn L, van Dijk SM, van Grinsven J, Verdonk RC, Boermeester MA, Bollen TL, Bouwense SAW, Bruno MJ, Cappendijk VC, Dejong CHC, van Duijvendijk P, van Eijck CHJ, Fockens P, Francken MFG, van Goor H, Hadithi M, Hallensleben NDL, Haveman JW, Jacobs MAJM, Jansen JM, Kop MPM, van Lienden KP, Manusama ER, Mieog JSD, Molenaar IQ, Nieuwenhuijs VB, Poen AC, Poley JW, van de Poll M, Quispel R, Römkens TEH, Schwartz MP, Seerden TC, Stommel MWJ, Straathof JWA, Timmerhuis HC, Venneman NG, Voermans RP, van de Vrie W, Witteman BJ, Dijkgraaf MGW, van Santvoort HC, Besselink MG; Dutch Pancreatitis Study Group
N Engl J Med 2021 Oct 7;385(15):1372-1381. doi: 10.1056/NEJMoa2100826. PMID: 34614330
Current Concepts in Severe Acute and Necrotizing Pancreatitis: An Evidence-Based Approach.
Trikudanathan G, Wolbrink DRJ, van Santvoort HC, Mallery S, Freeman M, Besselink MG
Gastroenterology 2019 May;156(7):1994-2007.e3. Epub 2019 Feb 15 doi: 10.1053/j.gastro.2019.01.269. PMID: 30776347
IAP/APA evidence-based guidelines for the management of acute pancreatitis.
Working Group IAP/APA Acute Pancreatitis Guidelines
Pancreatology 2013 Jul-Aug;13(4 Suppl 2):e1-15. doi: 10.1016/j.pan.2013.07.063. PMID: 24054878

Recent systematic reviews

Persistently High Procalcitonin and C-Reactive Protein Are Good Predictors of Infection in Acute Necrotizing Pancreatitis: A Systematic Review and Meta-Analysis.
Tarján D, Szalai E, Lipp M, Verbói M, Kói T, Erőss B, Teutsch B, Faluhelyi N, Hegyi P, Mikó A
Int J Mol Sci 2024 Jan 20;25(2) doi: 10.3390/ijms25021273. PMID: 38279274Free PMC Article
Treatment of walled-off necrosis using lumen-apposing metal stents versus plastic stents: a systematic review and meta-analysis of data from randomized trials.
Bang JY, Wilcox CM, Navaneethan U, Hawes RH, Varadarajulu S
Endoscopy 2024 Mar;56(3):184-195. Epub 2023 Sep 6 doi: 10.1055/a-2169-0362. PMID: 37673106
Clinical Practice Guideline—Acute and Chronic Pancreatitis.
Beyer G, Hoffmeister A, Lorenz P, Lynen P, Lerch MM, Mayerle J
Dtsch Arztebl Int 2022 Jul 25;119(29-30):495-501. doi: 10.3238/arztebl.m2022.0223. PMID: 35945698Free PMC Article
The clinical outcome from early versus delayed minimally invasive intervention for infected pancreatic necrosis: a systematic review and meta-analysis.
Gao L, Zhang H, Li G, Ye B, Zhou J, Tong Z, Ke L, Windsor JA, Li W; Chinese Acute Pancreatitis Clinical Trials Group (CAPCTG)
J Gastroenterol 2022 Jun;57(6):397-406. Epub 2022 Apr 29 doi: 10.1007/s00535-022-01876-6. PMID: 35488104
Pharmacological interventions for acute pancreatitis.
Moggia E, Koti R, Belgaumkar AP, Fazio F, Pereira SP, Davidson BR, Gurusamy KS
Cochrane Database Syst Rev 2017 Apr 21;4(4):CD011384. doi: 10.1002/14651858.CD011384.pub2. PMID: 28431202Free PMC Article

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