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Anaplasmosis

MedGen UID:
8053
•Concept ID:
C0002797
•
Disease or Syndrome
Synonyms: Anaplasma Infection; Anaplasma Infections; Anaplasma phagocytophilum Infection; Anaplasma phagocytophilum Infections; Anaplasmoses; Infection, Anaplasma; Infections, Anaplasma
SNOMED CT: Anaplasmosis (13906002); Gallsickness (13906002)
 
Monarch Initiative: MONDO:0025303

Definition

An infection that is caused by Anaplasma phagocytophilum, which is transmitted to humans by infected ticks; it is characterized by fever, headache, chills, and myalgia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplasmosis

Professional guidelines

PubMed

Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378Free PMC Article
The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America.
Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Krause PJ, Bakken JS, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler JS, Nadelman RB
Clin Infect Dis 2006 Nov 1;43(9):1089-134. Epub 2006 Oct 2 doi: 10.1086/508667. PMID: 17029130

Recent clinical studies

Etiology

Human Granulocytic Anaplasmosis.
MacQueen D, Centellas F
Infect Dis Clin North Am 2022 Sep;36(3):639-654. doi: 10.1016/j.idc.2022.02.008. PMID: 36116840
Ehrlichiosis and Anaplasmosis among Transfusion and Transplant Recipients in the United States.
Mowla SJ, Drexler NA, Cherry CC, Annambholta PD, Kracalik IT, Basavaraju SV
Emerg Infect Dis 2021 Nov;27(11):2768-2775. doi: 10.3201/eid2711.211127. PMID: 34670661Free PMC Article
Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Human granulocytic anaplasmosis.
Bakken JS, Dumler JS
Infect Dis Clin North Am 2015 Jun;29(2):341-55. doi: 10.1016/j.idc.2015.02.007. PMID: 25999228Free PMC Article
Prevention of tick-borne diseases.
Piesman J, Eisen L
Annu Rev Entomol 2008;53:323-43. doi: 10.1146/annurev.ento.53.103106.093429. PMID: 17877457

Diagnosis

Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Tick-Borne Emerging Infections: Ehrlichiosis and Anaplasmosis.
Ismail N, McBride JW
Clin Lab Med 2017 Jun;37(2):317-340. Epub 2017 Mar 25 doi: 10.1016/j.cll.2017.01.006. PMID: 28457353
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378Free PMC Article
Tick-Borne Illnesses.
Choi E, Pyzocha NJ, Maurer DM
Curr Sports Med Rep 2016 Mar-Apr;15(2):98-104. doi: 10.1249/JSR.0000000000000238. PMID: 26963018
Human granulocytic anaplasmosis.
Bakken JS, Dumler JS
Infect Dis Clin North Am 2015 Jun;29(2):341-55. doi: 10.1016/j.idc.2015.02.007. PMID: 25999228Free PMC Article

Therapy

Human Granulocytic Anaplasmosis.
MacQueen D, Centellas F
Infect Dis Clin North Am 2022 Sep;36(3):639-654. doi: 10.1016/j.idc.2022.02.008. PMID: 36116840
Ehrlichiosis and Anaplasmosis among Transfusion and Transplant Recipients in the United States.
Mowla SJ, Drexler NA, Cherry CC, Annambholta PD, Kracalik IT, Basavaraju SV
Emerg Infect Dis 2021 Nov;27(11):2768-2775. doi: 10.3201/eid2711.211127. PMID: 34670661Free PMC Article
Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378Free PMC Article
Human granulocytic anaplasmosis.
Bakken JS, Dumler S
Infect Dis Clin North Am 2008 Sep;22(3):433-48, viii. doi: 10.1016/j.idc.2008.03.011. PMID: 18755383

Prognosis

Human Tick-Borne Diseases in Australia.
Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ
Front Cell Infect Microbiol 2019;9:3. Epub 2019 Jan 28 doi: 10.3389/fcimb.2019.00003. PMID: 30746341Free PMC Article
The Blacklegged Tick, Ixodes scapularis: An Increasing Public Health Concern.
Eisen RJ, Eisen L
Trends Parasitol 2018 Apr;34(4):295-309. Epub 2018 Jan 11 doi: 10.1016/j.pt.2017.12.006. PMID: 29336985Free PMC Article
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.
Sanchez E, Vannier E, Wormser GP, Hu LT
JAMA 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884. PMID: 27115378Free PMC Article
Lyme Disease Coinfections in the United States.
Caulfield AJ, Pritt BS
Clin Lab Med 2015 Dec;35(4):827-46. Epub 2015 Sep 1 doi: 10.1016/j.cll.2015.07.006. PMID: 26593260
Vector-borne diseases in humans and animals: activities of the Swiss Tropical Institute and risks for Switzerland.
Zinsstag J, Schelling E
Schweiz Arch Tierheilkd 2003 Dec;145(12):559-66, 568-9. doi: 10.1024/0036-7281.145.12.559. PMID: 14725182

Clinical prediction guides

Zoonotic Babesia: A scoping review of the global evidence.
Young KM, Corrin T, Wilhelm B, Uhland C, Greig J, Mascarenhas M, Waddell LA
PLoS One 2019;14(12):e0226781. Epub 2019 Dec 30 doi: 10.1371/journal.pone.0226781. PMID: 31887120Free PMC Article
Human Tick-Borne Diseases in Australia.
Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ
Front Cell Infect Microbiol 2019;9:3. Epub 2019 Jan 28 doi: 10.3389/fcimb.2019.00003. PMID: 30746341Free PMC Article
Distribution of tick-borne diseases in China.
Wu XB, Na RH, Wei SS, Zhu JS, Peng HJ
Parasit Vectors 2013 Apr 23;6:119. doi: 10.1186/1756-3305-6-119. PMID: 23617899Free PMC Article
Coinfections acquired from ixodes ticks.
Swanson SJ, Neitzel D, Reed KD, Belongia EA
Clin Microbiol Rev 2006 Oct;19(4):708-27. doi: 10.1128/CMR.00011-06. PMID: 17041141Free PMC Article
Vector-borne diseases in humans and animals: activities of the Swiss Tropical Institute and risks for Switzerland.
Zinsstag J, Schelling E
Schweiz Arch Tierheilkd 2003 Dec;145(12):559-66, 568-9. doi: 10.1024/0036-7281.145.12.559. PMID: 14725182

Recent systematic reviews

Human granulocytotropic anaplasmosis-A systematic review and analysis of the literature.
Schudel S, Gygax L, Kositz C, Kuenzli E, Neumayr A
PLoS Negl Trop Dis 2024 Aug;18(8):e0012313. Epub 2024 Aug 5 doi: 10.1371/journal.pntd.0012313. PMID: 39102427Free PMC Article
Global status of Anaplasma phagocytophilum infections in human population: A 50-year (1970-2020) meta-analysis.
Karshima SN, Ahmed MI, Mohammed KM, Pam VA
J Vector Borne Dis 2023 Jul-Sep;60(3):265-278. doi: 10.4103/0972-9062.364756. PMID: 37843237
Epidemiological and phylogenetic characteristics of emerging Anaplasma capra: A systematic review with modeling analysis.
Lin ZT, Ye RZ, Liu JY, Wang XY, Zhu WJ, Li YY, Cui XM, Cao WC
Infect Genet Evol 2023 Nov;115:105510. Epub 2023 Sep 30 doi: 10.1016/j.meegid.2023.105510. PMID: 37778674
Systematic review and meta-analysis of tick-borne disease risk factors in residential yards, neighborhoods, and beyond.
Fischhoff IR, Bowden SE, Keesing F, Ostfeld RS
BMC Infect Dis 2019 Oct 17;19(1):861. doi: 10.1186/s12879-019-4484-3. PMID: 31623574Free PMC Article
Epidemiology and control of human granulocytic anaplasmosis: a systematic review.
Jin H, Wei F, Liu Q, Qian J
Vector Borne Zoonotic Dis 2012 Apr;12(4):269-74. Epub 2012 Jan 4 doi: 10.1089/vbz.2011.0753. PMID: 22217177

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