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Pancreatic anastomotic leak

MedGen UID:
83325
•Concept ID:
C0341498
•
Pathologic Function
Synonym: Pancreatic Anastomotic Leakage
SNOMED CT: Pancreatic anastomotic leak (235980000)

Definition

Leakage due to breakdown of a pancreatic anastomosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic anastomotic leak

Professional guidelines

PubMed

Pancreatic fistula after pancreatic head resection; incidence, significance and management.
Hashimoto N, Yasuda C, Ohyanagi H
Hepatogastroenterology 2003 Sep-Oct;50(53):1658-60. PMID: 14571810
Role of surgery in the treatment of bilio-pancreatic cancer: the European experience.
Pedrazzoli S, Pasquali C, Sperti C
Semin Oncol 2002 Dec;29(6 Suppl 20):23-30. doi: 10.1053/sonc.2002.37379. PMID: 12577230
Advances in the surgical management of pancreatic cancer.
Spanknebel K, Conlon KC
Cancer J 2001 Jul-Aug;7(4):312-23. PMID: 11561607

Recent clinical studies

Etiology

Complications of pancreato-duodenectomy.
Kapoor VK
Rozhl Chir 2016 Feb;95(2):53-9. PMID: 27008166
Pancreatic fistula after pancreaticoduodenectomy: the impact of a standardized technique of pancreaticojejunostomy.
Shrikhande SV, Barreto G, Shukla PJ
Langenbecks Arch Surg 2008 Jan;393(1):87-91. Epub 2007 Aug 17 doi: 10.1007/s00423-007-0221-2. PMID: 17703319
Pancreatic anastomotic leak after the Whipple procedure is reduced using the surgical microscope.
Wada K, Traverso LW
Surgery 2006 Jun;139(6):735-42. doi: 10.1016/j.surg.2005.11.001. PMID: 16782427
Pancreatic fistula after pancreatic head resection; incidence, significance and management.
Hashimoto N, Yasuda C, Ohyanagi H
Hepatogastroenterology 2003 Sep-Oct;50(53):1658-60. PMID: 14571810
Prospective, randomized trial of octreotide to prevent pancreatic fistula after pancreaticoduodenectomy for malignant disease.
Lowy AM, Lee JE, Pisters PW, Davidson BS, Fenoglio CJ, Stanford P, Jinnah R, Evans DB
Ann Surg 1997 Nov;226(5):632-41. doi: 10.1097/00000658-199711000-00008. PMID: 9389397Free PMC Article

Diagnosis

Central pancreatectomy: single-center experience of 50 cases.
Adham M, Giunippero A, Hervieu V, Courbière M, Partensky C
Arch Surg 2008 Feb;143(2):175-80; discussion 180-1. doi: 10.1001/archsurg.2007.52. PMID: 18283143
Advances in the surgical management of pancreatic cancer.
Spanknebel K, Conlon KC
Cancer J 2001 Jul-Aug;7(4):312-23. PMID: 11561607
Are the results of pancreatectomy for pancreatic cancer improving?
Tsiotos GG, Farnell MB, Sarr MG
World J Surg 1999 Sep;23(9):913-9. doi: 10.1007/s002689900599. PMID: 10449820
Prospective, randomized trial of octreotide to prevent pancreatic fistula after pancreaticoduodenectomy for malignant disease.
Lowy AM, Lee JE, Pisters PW, Davidson BS, Fenoglio CJ, Stanford P, Jinnah R, Evans DB
Ann Surg 1997 Nov;226(5):632-41. doi: 10.1097/00000658-199711000-00008. PMID: 9389397Free PMC Article
Pancreatic anastomotic leak after pancreaticoduodenectomy: incidence, significance, and management.
Cullen JJ, Sarr MG, Ilstrup DM
Am J Surg 1994 Oct;168(4):295-8. doi: 10.1016/s0002-9610(05)80151-5. PMID: 7524375

Therapy

Systematic review of pancreaticoduodenectomy for locally advanced gastric cancer.
Roberts P, Seevaratnam R, Cardoso R, Law C, Helyer L, Coburn N
Gastric Cancer 2012 Sep;15 Suppl 1:S108-15. Epub 2011 Aug 26 doi: 10.1007/s10120-011-0086-5. PMID: 21870150
Pancreatic anastomotic leak after the Whipple procedure is reduced using the surgical microscope.
Wada K, Traverso LW
Surgery 2006 Jun;139(6):735-42. doi: 10.1016/j.surg.2005.11.001. PMID: 16782427
Pancreatic anastomoses after pancreaticoduodenectomy: do we need further studies?
Shrikhande SV, Qureshi SS, Rajneesh N, Shukla PJ
World J Surg 2005 Dec;29(12):1642-9. doi: 10.1007/s00268-005-0137-3. PMID: 16311866
Prospective, randomized trial of octreotide to prevent pancreatic fistula after pancreaticoduodenectomy for malignant disease.
Lowy AM, Lee JE, Pisters PW, Davidson BS, Fenoglio CJ, Stanford P, Jinnah R, Evans DB
Ann Surg 1997 Nov;226(5):632-41. doi: 10.1097/00000658-199711000-00008. PMID: 9389397Free PMC Article
Pancreatic anastomotic leak after pancreaticoduodenectomy: incidence, significance, and management.
Cullen JJ, Sarr MG, Ilstrup DM
Am J Surg 1994 Oct;168(4):295-8. doi: 10.1016/s0002-9610(05)80151-5. PMID: 7524375

Prognosis

Complications of pancreato-duodenectomy.
Kapoor VK
Rozhl Chir 2016 Feb;95(2):53-9. PMID: 27008166
Systematic review of pancreaticoduodenectomy for locally advanced gastric cancer.
Roberts P, Seevaratnam R, Cardoso R, Law C, Helyer L, Coburn N
Gastric Cancer 2012 Sep;15 Suppl 1:S108-15. Epub 2011 Aug 26 doi: 10.1007/s10120-011-0086-5. PMID: 21870150
Pancreatic fistula after pancreaticoduodenectomy: the impact of a standardized technique of pancreaticojejunostomy.
Shrikhande SV, Barreto G, Shukla PJ
Langenbecks Arch Surg 2008 Jan;393(1):87-91. Epub 2007 Aug 17 doi: 10.1007/s00423-007-0221-2. PMID: 17703319
Prospective, randomized trial of octreotide to prevent pancreatic fistula after pancreaticoduodenectomy for malignant disease.
Lowy AM, Lee JE, Pisters PW, Davidson BS, Fenoglio CJ, Stanford P, Jinnah R, Evans DB
Ann Surg 1997 Nov;226(5):632-41. doi: 10.1097/00000658-199711000-00008. PMID: 9389397Free PMC Article
Pancreatic anastomotic leak after pancreaticoduodenectomy: incidence, significance, and management.
Cullen JJ, Sarr MG, Ilstrup DM
Am J Surg 1994 Oct;168(4):295-8. doi: 10.1016/s0002-9610(05)80151-5. PMID: 7524375

Clinical prediction guides

Pancreatic anastomotic leakage after pancreaticoduodenectomy in 1,507 patients: a report from the Pancreatic Anastomotic Leak Study Group.
Reid-Lombardo KM, Farnell MB, Crippa S, Barnett M, Maupin G, Bassi C, Traverso LW; Pancreatic Anastomotic Leak Study Group
J Gastrointest Surg 2007 Nov;11(11):1451-8; discussion 1459. Epub 2007 Aug 21 doi: 10.1007/s11605-007-0270-4. PMID: 17710506
Pancreatic anastomotic leak after the Whipple procedure is reduced using the surgical microscope.
Wada K, Traverso LW
Surgery 2006 Jun;139(6):735-42. doi: 10.1016/j.surg.2005.11.001. PMID: 16782427
The usefulness of drain data to identify a clinically relevant pancreatic anastomotic leak after pancreaticoduodenectomy?
Shinchi H, Wada K, Traverso LW
J Gastrointest Surg 2006 Apr;10(4):490-8. doi: 10.1016/j.gassur.2005.08.029. PMID: 16627213
Pancreatic anastomoses after pancreaticoduodenectomy: do we need further studies?
Shrikhande SV, Qureshi SS, Rajneesh N, Shukla PJ
World J Surg 2005 Dec;29(12):1642-9. doi: 10.1007/s00268-005-0137-3. PMID: 16311866
The Whipple partial duodenopancreatectomy for the treatment of chronic pancreatitis.
Rumstadt B, Forssmann K, Singer MV, Trede M
Hepatogastroenterology 1997 Nov-Dec;44(18):1554-9. PMID: 9427021

Recent systematic reviews

Systematic review of pancreaticoduodenectomy for locally advanced gastric cancer.
Roberts P, Seevaratnam R, Cardoso R, Law C, Helyer L, Coburn N
Gastric Cancer 2012 Sep;15 Suppl 1:S108-15. Epub 2011 Aug 26 doi: 10.1007/s10120-011-0086-5. PMID: 21870150

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