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Untreated Childhood Myeloid Neoplasm

MedGen UID:
856820
•Concept ID:
C3897226
•
Finding

Definition

A finding of myeloid neoplasm in childhood that has not been treated. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUntreated Childhood Myeloid Neoplasm

Professional guidelines

PubMed

Management of acute lymphoblastic and acute myeloblastic leukemia in childhood.
Sallan SE, Weinstein HJ
Paediatrician 1980;9(2):56-67. PMID: 6930624
The definitive treatment of children with acute leukemia.
Walters TR
Med Clin North Am 1976 Sep;60(5):987-1000. doi: 10.1016/s0025-7125(16)31844-2. PMID: 781418
Treatment of acute leukemia in adults.
Clarkson BD, Dowling MD, Gee TS, Cunningham IB, Burchenal JH
Cancer 1975 Aug;36(2):775-95. doi: 10.1002/1097-0142(197508)36:2+<775::aid-cncr2820360824>3.0.co;2-v. PMID: 1057450

Recent clinical studies

Etiology

Effect of Chemotherapy Cytarabine and Acute Myeloid Leukemia on the Development of Spermatogenesis at the Adult Age of Immature Treated Mice.
Khaleel B, Lunenfeld E, Kapelushnik J, Huleihel M
Int J Mol Sci 2022 Apr 4;23(7) doi: 10.3390/ijms23074013. PMID: 35409373Free PMC Article
Idarubicin plus behenoyl cytarabine and 6-thioguanine compares favorably with idarubicin plus cytarabine-based regimen for children with previously untreated acute myeloid leukemia: 10-year retrospective, multicenter study in Korea.
Lee DH, Chung NG, Cho B, Kim HK, Kang HJ, Shin HY, Ahn HS, Yoo KH, Sung KW, Koo HH, Kook H, Hwang TJ, Im HJ, Seo JJ, Park HJ
J Korean Med Sci 2010 Jan;25(1):9-15. Epub 2009 Dec 26 doi: 10.3346/jkms.2010.25.1.9. PMID: 20052341Free PMC Article
Maintenance therapy in childhood acute myeloid leukemia.
Perel Y, Auvrignon A, Leblanc T, Michel G, Vannier JP, Dalle JH, Gandemer V, Schmitt C, Mèchinaud F, Lamagnere JP, Piguet Ch, Couillaud G, Pautard B, Baruchel A, Leverger G; Group LAME; French Society of Pediatric Hematology and Immunology
Ann Hematol 2004;83 Suppl 1:S116-9. doi: 10.1007/s00277-004-0850-2. PMID: 15124700
Cellular drug resistance in childhood acute myeloid leukemia is related to chromosomal abnormalities.
Zwaan CM, Kaspers GJ, Pieters R, Hählen K, Huismans DR, Zimmermann M, Harbott J, Slater RM, Creutzig U, Veerman AJ
Blood 2002 Nov 1;100(9):3352-60. doi: 10.1182/blood.V100.9.3352. PMID: 12384437
Childhood acute myeloid leukemia: outcome in a single center using chemotherapy and consolidation with busulfan/cyclophosphamide for bone marrow transplantation.
Shaw PJ, Bergin ME, Burgess MA, Dalla Pozza L, Kellie SJ, Rowell G, Stevens MM, Webster BH, Bradstock KF
J Clin Oncol 1994 Oct;12(10):2138-45. doi: 10.1200/JCO.1994.12.10.2138. PMID: 7931485

Diagnosis

Effect of Chemotherapy Cytarabine and Acute Myeloid Leukemia on the Development of Spermatogenesis at the Adult Age of Immature Treated Mice.
Khaleel B, Lunenfeld E, Kapelushnik J, Huleihel M
Int J Mol Sci 2022 Apr 4;23(7) doi: 10.3390/ijms23074013. PMID: 35409373Free PMC Article
Cellular drug resistance in childhood acute myeloid leukemia is related to chromosomal abnormalities.
Zwaan CM, Kaspers GJ, Pieters R, Hählen K, Huismans DR, Zimmermann M, Harbott J, Slater RM, Creutzig U, Veerman AJ
Blood 2002 Nov 1;100(9):3352-60. doi: 10.1182/blood.V100.9.3352. PMID: 12384437
Glucocorticoid resistance in childhood leukemia.
Kaspers GJ, Pieters R, Klumper E, De Waal FC, Veerman AJ
Leuk Lymphoma 1994 Apr;13(3-4):187-201. doi: 10.3109/10428199409056282. PMID: 8049644
Childhood acute myeloid leukemia: outcome in a single center using chemotherapy and consolidation with busulfan/cyclophosphamide for bone marrow transplantation.
Shaw PJ, Bergin ME, Burgess MA, Dalla Pozza L, Kellie SJ, Rowell G, Stevens MM, Webster BH, Bradstock KF
J Clin Oncol 1994 Oct;12(10):2138-45. doi: 10.1200/JCO.1994.12.10.2138. PMID: 7931485
The clinical and biological correlates of coagulopathy in children with acute leukemia.
Ribeiro RC, Pui CH
J Clin Oncol 1986 Aug;4(8):1212-8. doi: 10.1200/JCO.1986.4.8.1212. PMID: 3525766

Therapy

Effect of Chemotherapy Cytarabine and Acute Myeloid Leukemia on the Development of Spermatogenesis at the Adult Age of Immature Treated Mice.
Khaleel B, Lunenfeld E, Kapelushnik J, Huleihel M
Int J Mol Sci 2022 Apr 4;23(7) doi: 10.3390/ijms23074013. PMID: 35409373Free PMC Article
Maintenance therapy in childhood acute myeloid leukemia.
Perel Y, Auvrignon A, Leblanc T, Michel G, Vannier JP, Dalle JH, Gandemer V, Schmitt C, Mèchinaud F, Lamagnere JP, Piguet Ch, Couillaud G, Pautard B, Baruchel A, Leverger G; Group LAME; French Society of Pediatric Hematology and Immunology
Ann Hematol 2004;83 Suppl 1:S116-9. doi: 10.1007/s00277-004-0850-2. PMID: 15124700
Glucocorticoid resistance in childhood leukemia.
Kaspers GJ, Pieters R, Klumper E, De Waal FC, Veerman AJ
Leuk Lymphoma 1994 Apr;13(3-4):187-201. doi: 10.3109/10428199409056282. PMID: 8049644
The definitive treatment of children with acute leukemia.
Walters TR
Med Clin North Am 1976 Sep;60(5):987-1000. doi: 10.1016/s0025-7125(16)31844-2. PMID: 781418
Daunorubicin. Results in childhood leukaemia.
Matthews RN, Colebatch JH
Arch Dis Child 1972 Apr;47(252):272-7. doi: 10.1136/adc.47.252.272. PMID: 4502569Free PMC Article

Prognosis

Maintenance therapy in childhood acute myeloid leukemia.
Perel Y, Auvrignon A, Leblanc T, Michel G, Vannier JP, Dalle JH, Gandemer V, Schmitt C, Mèchinaud F, Lamagnere JP, Piguet Ch, Couillaud G, Pautard B, Baruchel A, Leverger G; Group LAME; French Society of Pediatric Hematology and Immunology
Ann Hematol 2004;83 Suppl 1:S116-9. doi: 10.1007/s00277-004-0850-2. PMID: 15124700
Cellular drug resistance in childhood acute myeloid leukemia is related to chromosomal abnormalities.
Zwaan CM, Kaspers GJ, Pieters R, Hählen K, Huismans DR, Zimmermann M, Harbott J, Slater RM, Creutzig U, Veerman AJ
Blood 2002 Nov 1;100(9):3352-60. doi: 10.1182/blood.V100.9.3352. PMID: 12384437
Glucocorticoid resistance in childhood leukemia.
Kaspers GJ, Pieters R, Klumper E, De Waal FC, Veerman AJ
Leuk Lymphoma 1994 Apr;13(3-4):187-201. doi: 10.3109/10428199409056282. PMID: 8049644
The definitive treatment of children with acute leukemia.
Walters TR
Med Clin North Am 1976 Sep;60(5):987-1000. doi: 10.1016/s0025-7125(16)31844-2. PMID: 781418
Daunorubicin. Results in childhood leukaemia.
Matthews RN, Colebatch JH
Arch Dis Child 1972 Apr;47(252):272-7. doi: 10.1136/adc.47.252.272. PMID: 4502569Free PMC Article

Clinical prediction guides

Evolution of histomorphologic, cytogenetic, and genetic abnormalities in an untreated patient with MIRAGE syndrome.
Rentas S, Pillai V, Wertheim GB, Akgumus GT, Nichols KE, Deardorff MA, Conlin LK, Li MM, Olson TS, Luo M
Cancer Genet 2020 Jul;245:42-48. Epub 2020 Jun 14 doi: 10.1016/j.cancergen.2020.06.002. PMID: 32619790
Low-dose cytarabine to prevent myeloid leukemia in children with Down syndrome: TMD Prevention 2007 study.
Flasinski M, Scheibke K, Zimmermann M, Creutzig U, Reinhardt K, Verwer F, de Haas V, van der Velden VHJ, von Neuhoff C, Zwaan CM, Reinhardt D, Klusmann JH
Blood Adv 2018 Jul 10;2(13):1532-1540. doi: 10.1182/bloodadvances.2018018945. PMID: 29959152Free PMC Article
In vitro sensitivity and cross-resistance to deoxynucleoside analogs in childhood acute leukemia.
Hubeek I, Peters GJ, Broekhuizen R, Zwaan CM, Kaaijk P, van Wering ES, Gibson BE, Creutzig U, Janka-Schaub GE, den Boer ML, Pieters R, Kaspers GJ
Haematologica 2006 Jan;91(1):17-23. PMID: 16434366
Cellular drug resistance in childhood acute myeloid leukemia is related to chromosomal abnormalities.
Zwaan CM, Kaspers GJ, Pieters R, Hählen K, Huismans DR, Zimmermann M, Harbott J, Slater RM, Creutzig U, Veerman AJ
Blood 2002 Nov 1;100(9):3352-60. doi: 10.1182/blood.V100.9.3352. PMID: 12384437
Bcl-2 expression and prognosis in childhood acute leukemia. Children's Cancer and Leukemia Study Group.
Tsurusawa M, Saeki K, Katano N, Fujimoto T
Pediatr Hematol Oncol 1998 Mar-Apr;15(2):143-55. doi: 10.3109/08880019809167229. PMID: 9592841

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