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Early Disseminated Lyme Disease

MedGen UID:
858876
•Concept ID:
C3899282
•
Disease or Syndrome

Definition

An early stage of Lyme disease that may present days to weeks after a tick bite with relapsing signs of a red, concentrically-expanding rash (erythema migrans), facial palsy, meningismus, neuralgia, heart palpitations, and dizziness. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEarly Disseminated Lyme Disease

Professional guidelines

PubMed

Management and clinical outcomes of Lyme disease in acute care facilities in 2 endemic regions of Quebec, Canada: a multicentre retrospective cohort study.
Musonera JB, Valiquette L, Baron G, Milord F, Marcoux D, Thivierge K, Bedard-Dallaire S, Pelletier AA, Lachance R, Bourget J, Simard C, Cantin E, Abbasi F, Haraoui LP, Carignan A
CMAJ Open 2022 Apr-Jun;10(2):E570-E576. Epub 2022 Jun 28 doi: 10.9778/cmajo.20210063. PMID: 35764331Free PMC Article
Antibiotic treatment duration and long-term outcomes of patients with early lyme disease from a lyme disease-hyperendemic area.
Kowalski TJ, Tata S, Berth W, Mathiason MA, Agger WA
Clin Infect Dis 2010 Feb 15;50(4):512-20. doi: 10.1086/649920. PMID: 20070237
Borrelia burgdorferi genotype predicts the capacity for hematogenous dissemination during early Lyme disease.
Wormser GP, Brisson D, Liveris D, Hanincová K, Sandigursky S, Nowakowski J, Nadelman RB, Ludin S, Schwartz I
J Infect Dis 2008 Nov 1;198(9):1358-64. doi: 10.1086/592279. PMID: 18781866Free PMC Article

Recent clinical studies

Etiology

Management and clinical outcomes of Lyme disease in acute care facilities in 2 endemic regions of Quebec, Canada: a multicentre retrospective cohort study.
Musonera JB, Valiquette L, Baron G, Milord F, Marcoux D, Thivierge K, Bedard-Dallaire S, Pelletier AA, Lachance R, Bourget J, Simard C, Cantin E, Abbasi F, Haraoui LP, Carignan A
CMAJ Open 2022 Apr-Jun;10(2):E570-E576. Epub 2022 Jun 28 doi: 10.9778/cmajo.20210063. PMID: 35764331Free PMC Article
Two-Tier Lyme Disease Serology Test Results Can Vary According to the Specific First-Tier Test Used.
Maulden AB, Garro AC, Balamuth F, Levas MN, Bennett JE, Neville DN, Branda JA, Nigrovic LE
J Pediatric Infect Dis Soc 2020 Apr 30;9(2):128-133. doi: 10.1093/jpids/piy133. PMID: 30793167
Expression of C-Reactive Protein and Serum Amyloid A in Early to Late Manifestations of Lyme Disease.
Uhde M, Ajamian M, Li X, Wormser GP, Marques A, Alaedini A
Clin Infect Dis 2016 Dec 1;63(11):1399-1404. Epub 2016 Sep 1 doi: 10.1093/cid/ciw599. PMID: 27585799Free PMC Article
Disseminated Lyme disease presenting with nonsexual acute genital ulcers.
Finch JJ, Wald J, Ferenczi K, Khalid S, Murphy M
JAMA Dermatol 2014 Nov;150(11):1202-4. doi: 10.1001/jamadermatol.2014.1072. PMID: 25162635
Liver function in early Lyme disease.
Horowitz HW, Dworkin B, Forseter G, Nadelman RB, Connolly C, Luciano BB, Nowakowski J, O'Brien TA, Calmann M, Wormser GP
Hepatology 1996 Jun;23(6):1412-7. doi: 10.1002/hep.510230617. PMID: 8675158

Diagnosis

Early Disseminated Lyme Disease: Cranial Neuropathy, Meningitis, and Polyradiculopathy.
Crissinger T, Baldwin K
Infect Dis Clin North Am 2022 Sep;36(3):541-551. doi: 10.1016/j.idc.2022.02.006. PMID: 36116833
Host Metabolic Response in Early Lyme Disease.
Fitzgerald BL, Molins CR, Islam MN, Graham B, Hove PR, Wormser GP, Hu L, Ashton LV, Belisle JT
J Proteome Res 2020 Feb 7;19(2):610-623. Epub 2020 Jan 9 doi: 10.1021/acs.jproteome.9b00470. PMID: 31821002Free PMC Article
Early disseminated Lyme disease.
Bender PD, Ilgen JS
BMJ Case Rep 2018 May 2;2018 doi: 10.1136/bcr-2017-223889. PMID: 29724873Free PMC Article
Early Disseminated Lyme Disease.
Blackwell WA
Mayo Clin Proc 2017 Apr;92(4):687-688. doi: 10.1016/j.mayocp.2017.01.007. PMID: 28385207
Early disseminated Lyme disease: Lyme meningitis.
Pachner AR
Am J Med 1995 Apr 24;98(4A):30S-37S; discussion 37S-43S. doi: 10.1016/s0002-9343(99)80042-4. PMID: 7726190

Therapy

Global Transcriptome Analysis Identifies a Diagnostic Signature for Early Disseminated Lyme Disease and Its Resolution.
Petzke MM, Volyanskyy K, Mao Y, Arevalo B, Zohn R, Quituisaca J, Wormser GP, Dimitrova N, Schwartz I
mBio 2020 Mar 17;11(2) doi: 10.1128/mBio.00047-20. PMID: 32184234Free PMC Article
Disseminated Lyme disease presenting as multiple non-target cellulitic-appearing skin lesions and oral pseudomembrane.
Sharma U
BMJ Case Rep 2018 Jul 30;2018 doi: 10.1136/bcr-2018-225921. PMID: 30061140Free PMC Article
Early disseminated Lyme disease.
Bender PD, Ilgen JS
BMJ Case Rep 2018 May 2;2018 doi: 10.1136/bcr-2017-223889. PMID: 29724873Free PMC Article
Early Disseminated Lyme Disease.
Blackwell WA
Mayo Clin Proc 2017 Apr;92(4):687-688. doi: 10.1016/j.mayocp.2017.01.007. PMID: 28385207
Liver function in early Lyme disease.
Horowitz HW, Dworkin B, Forseter G, Nadelman RB, Connolly C, Luciano BB, Nowakowski J, O'Brien TA, Calmann M, Wormser GP
Hepatology 1996 Jun;23(6):1412-7. doi: 10.1002/hep.510230617. PMID: 8675158

Prognosis

Early Disseminated Lyme Disease: Cranial Neuropathy, Meningitis, and Polyradiculopathy.
Crissinger T, Baldwin K
Infect Dis Clin North Am 2022 Sep;36(3):541-551. doi: 10.1016/j.idc.2022.02.006. PMID: 36116833
Management and clinical outcomes of Lyme disease in acute care facilities in 2 endemic regions of Quebec, Canada: a multicentre retrospective cohort study.
Musonera JB, Valiquette L, Baron G, Milord F, Marcoux D, Thivierge K, Bedard-Dallaire S, Pelletier AA, Lachance R, Bourget J, Simard C, Cantin E, Abbasi F, Haraoui LP, Carignan A
CMAJ Open 2022 Apr-Jun;10(2):E570-E576. Epub 2022 Jun 28 doi: 10.9778/cmajo.20210063. PMID: 35764331Free PMC Article
Lyme carditis: Early occurrence and prolonged recovery.
Fu Md J, Bhatta L
J Electrocardiol 2018 May-Jun;51(3):516-518. Epub 2017 Dec 14 doi: 10.1016/j.jelectrocard.2017.12.035. PMID: 29275956
Early disseminated Lyme disease: Lyme meningitis.
Pachner AR
Am J Med 1995 Apr 24;98(4A):30S-37S; discussion 37S-43S. doi: 10.1016/s0002-9343(99)80042-4. PMID: 7726190
Early disseminated Lyme disease: cardiac manifestations.
Sigal LH
Am J Med 1995 Apr 24;98(4A):25S-28S; discussion 28S-29S. doi: 10.1016/s0002-9343(99)80041-2. PMID: 7726189

Clinical prediction guides

Management and clinical outcomes of Lyme disease in acute care facilities in 2 endemic regions of Quebec, Canada: a multicentre retrospective cohort study.
Musonera JB, Valiquette L, Baron G, Milord F, Marcoux D, Thivierge K, Bedard-Dallaire S, Pelletier AA, Lachance R, Bourget J, Simard C, Cantin E, Abbasi F, Haraoui LP, Carignan A
CMAJ Open 2022 Apr-Jun;10(2):E570-E576. Epub 2022 Jun 28 doi: 10.9778/cmajo.20210063. PMID: 35764331Free PMC Article
Global Transcriptome Analysis Identifies a Diagnostic Signature for Early Disseminated Lyme Disease and Its Resolution.
Petzke MM, Volyanskyy K, Mao Y, Arevalo B, Zohn R, Quituisaca J, Wormser GP, Dimitrova N, Schwartz I
mBio 2020 Mar 17;11(2) doi: 10.1128/mBio.00047-20. PMID: 32184234Free PMC Article
Lyme carditis in children: presentation, predictive factors, and clinical course.
Costello JM, Alexander ME, Greco KM, Perez-Atayde AR, Laussen PC
Pediatrics 2009 May;123(5):e835-41. doi: 10.1542/peds.2008-3058. PMID: 19403477
Subpopulations of the peripheral lymphocytes in the early clinical forms of Lyme disease.
Zajkowska JM, Hermanowska-Szpakowicz T
Med Sci Monit 2000 Mar-Apr;6(2):278-84. PMID: 11208323
Early disseminated Lyme disease: Lyme meningitis.
Pachner AR
Am J Med 1995 Apr 24;98(4A):30S-37S; discussion 37S-43S. doi: 10.1016/s0002-9343(99)80042-4. PMID: 7726190

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