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Erythrophagocytosis

MedGen UID:
86219
•Concept ID:
C0302486
•
Disease or Syndrome
Synonyms: Erythrocytophagy; Erythrophagia
SNOMED CT: Erythrophagocytosis (61070002); Erythrophagia (61070002)

Definition

Erythrophagocytosis; phagocytosis of erythrocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVErythrophagocytosis

Professional guidelines

PubMed

Signet-ring cell sinus histiocytosis: report of the clinicopathologic characteristics of 4 cases with emphasis on the differential diagnosis of signet-ring cell lesions.
Argyris PP, Koutlas IG, Wakely PE Jr
Hum Pathol 2023 Sep;139:47-54. Epub 2023 Jul 15 doi: 10.1016/j.humpath.2023.07.006. PMID: 37459900
Pathogenesis and treatment of anaemia of chronic disease.
Weiss G
Blood Rev 2002 Jun;16(2):87-96. doi: 10.1054/blre.2002.0193. PMID: 12127952
The mode of action of treatment by IgG of haemolytic anaemia induced by an anti-erythrocyte monoclonal antibody.
Pottier Y, Pierard I, Barclay A, Masson PL, Coutelier JP
Clin Exp Immunol 1996 Oct;106(1):103-7. doi: 10.1046/j.1365-2249.1996.d01-818.x. PMID: 8870706Free PMC Article

Recent clinical studies

Etiology

Reticulocytes in donor blood units enhance red blood cell alloimmunization.
Thomas TA, Qiu A, Kim CY, Gordy DE, Miller A, Tredicine M, Dzieciatkowska M, Dei Zotti F, Hod EA, D'Alessandro A, Zimring JC, Spitalnik SL, Hudson KE
Haematologica 2023 Oct 1;108(10):2639-2651. doi: 10.3324/haematol.2023.282815. PMID: 37078267Free PMC Article
Proteomic and Functional Analysis of the Effects of Quinoxaline Derivatives on Entamoeba histolytica.
Avila-Bonilla RG, López-Sandoval Á, Soto-Sánchez J, Marchat LA, Rivera G, Medina-Contreras O, Ramírez-Moreno E
Front Cell Infect Microbiol 2022;12:887647. Epub 2022 Jun 27 doi: 10.3389/fcimb.2022.887647. PMID: 35832378Free PMC Article
Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 (V617F) Mice.
Wang W, Liu W, Fidler T, Wang Y, Tang Y, Woods B, Welch C, Cai B, Silvestre-Roig C, Ai D, Yang YG, Hidalgo A, Soehnlein O, Tabas I, Levine RL, Tall AR, Wang N
Circ Res 2018 Nov 9;123(11):e35-e47. doi: 10.1161/CIRCRESAHA.118.313283. PMID: 30571460Free PMC Article
Red blood cell storage duration and trauma.
Sparrow RL
Transfus Med Rev 2015 Apr;29(2):120-6. Epub 2014 Dec 18 doi: 10.1016/j.tmrv.2014.09.007. PMID: 25573415
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Diagnosis

Erythrophagocytosis is not a reproducible finding in liver biopsies, and is not associated with clinical diagnosis of hemophagocytic lymphohistiocytosis.
Desai N, Kudose S, Remotti HE, Del Portillo A, Fazlollahi L, Lee MJ, Xiong Y, Moreira RK, Salomao M, Fiel MI, Gonzalez RS, Misdraji J, Gill RM, Hart J, Kleiner DE, Drebber U, Bellizzi AM, Lagana SM
Virchows Arch 2024 Jan;484(1):61-69. Epub 2023 Nov 4 doi: 10.1007/s00428-023-03683-7. PMID: 37924345
Bone marrow haematopoiesis in patients with COVID-19.
Marques-Maggio E, Maccio U, Marx A, Galli S, Schwab N, Frank A, Hamelin B, Varga Z, Nombela-Arrieta C, Mertz KD, Theocharides AP, Koelzer VH
Histopathology 2023 Oct;83(4):582-590. Epub 2023 Jun 14 doi: 10.1111/his.14969. PMID: 37317636
Lupus Erythematosus Tumidus Associated With Hemophagocytosis.
Georgiadou N, Singh S, Singh M
Am J Dermatopathol 2022 Jul 1;44(7):519-522. Epub 2022 Apr 6 doi: 10.1097/DAD.0000000000002188. PMID: 35385850
Pigmented atypical fibroxanthoma.
Diaz-Cascajo C, Borghi S, Bonczkowitz M
Histopathology 1998 Dec;33(6):537-41. doi: 10.1046/j.1365-2559.1998.00567.x. PMID: 9870148
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Therapy

Immunity and reproduction protective effects of Chitosan Oligosaccharides in Cyclophosphamide/Busulfan-induced premature ovarian failure model mice.
Li X, Ye H, Su T, Hu C, Huang Y, Fu X, Zhong Z, Du X, Zheng Y
Front Immunol 2023;14:1185921. Epub 2023 May 9 doi: 10.3389/fimmu.2023.1185921. PMID: 37228612Free PMC Article
Ligufalimab, a novel anti-CD47 antibody with no hemagglutination demonstrates both monotherapy and combo antitumor activity.
Qu T, Zhong T, Pang X, Huang Z, Jin C, Wang ZM, Li B, Xia Y
J Immunother Cancer 2022 Nov;10(11) doi: 10.1136/jitc-2022-005517. PMID: 36450383Free PMC Article
Haemoglobin scavenging in intracranial bleeding: biology and clinical implications.
Bulters D, Gaastra B, Zolnourian A, Alexander S, Ren D, Blackburn SL, Borsody M, Doré S, Galea J, Iihara K, Nyquist P, Galea I
Nat Rev Neurol 2018 Jul;14(7):416-432. doi: 10.1038/s41582-018-0020-0. PMID: 29925923
Red blood cell storage duration and trauma.
Sparrow RL
Transfus Med Rev 2015 Apr;29(2):120-6. Epub 2014 Dec 18 doi: 10.1016/j.tmrv.2014.09.007. PMID: 25573415
Iron overload in nonalcoholic steatohepatitis.
Fujita N, Takei Y
Adv Clin Chem 2011;55:105-32. doi: 10.1016/b978-0-12-387042-1.00006-x. PMID: 22126026

Prognosis

Pharmacological Prevention of Ectopic Erythrophagocytosis by Cilostazol Mitigates Ferroptosis in NASH.
Park JB, Ko K, Baek YH, Kwon WY, Suh S, Han SH, Kim YH, Kim HY, Yoo YH
Int J Mol Sci 2023 Aug 16;24(16) doi: 10.3390/ijms241612862. PMID: 37629045Free PMC Article
The Critical Role of Erythrolysis and Microglia/Macrophages in Clot Resolution After Intracerebral Hemorrhage: A Review of the Mechanisms and Potential Therapeutic Targets.
Zheng Y, Tan X, Cao S
Cell Mol Neurobiol 2023 Jan;43(1):59-67. Epub 2022 Jan 4 doi: 10.1007/s10571-021-01175-3. PMID: 34981286
Ligufalimab, a novel anti-CD47 antibody with no hemagglutination demonstrates both monotherapy and combo antitumor activity.
Qu T, Zhong T, Pang X, Huang Z, Jin C, Wang ZM, Li B, Xia Y
J Immunother Cancer 2022 Nov;10(11) doi: 10.1136/jitc-2022-005517. PMID: 36450383Free PMC Article
Neuron derived fractalkine promotes microglia to absorb hematoma via CD163/HO-1 after intracerebral hemorrhage.
You M, Long C, Wan Y, Guo H, Shen J, Li M, He Q, Hu B
Cell Mol Life Sci 2022 Apr 7;79(5):224. doi: 10.1007/s00018-022-04212-6. PMID: 35389112Free PMC Article
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Clinical prediction guides

High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen.
Yang WP, Li MQ, Ding J, Li JY, Wu G, Liu B, Gao YQ, Wang GH, Luo QQ
Elife 2024 Apr 17;12 doi: 10.7554/eLife.87496. PMID: 38629942Free PMC Article
Pharmacological Prevention of Ectopic Erythrophagocytosis by Cilostazol Mitigates Ferroptosis in NASH.
Park JB, Ko K, Baek YH, Kwon WY, Suh S, Han SH, Kim YH, Kim HY, Yoo YH
Int J Mol Sci 2023 Aug 16;24(16) doi: 10.3390/ijms241612862. PMID: 37629045Free PMC Article
Bone marrow haematopoiesis in patients with COVID-19.
Marques-Maggio E, Maccio U, Marx A, Galli S, Schwab N, Frank A, Hamelin B, Varga Z, Nombela-Arrieta C, Mertz KD, Theocharides AP, Koelzer VH
Histopathology 2023 Oct;83(4):582-590. Epub 2023 Jun 14 doi: 10.1111/his.14969. PMID: 37317636
Immunity and reproduction protective effects of Chitosan Oligosaccharides in Cyclophosphamide/Busulfan-induced premature ovarian failure model mice.
Li X, Ye H, Su T, Hu C, Huang Y, Fu X, Zhong Z, Du X, Zheng Y
Front Immunol 2023;14:1185921. Epub 2023 May 9 doi: 10.3389/fimmu.2023.1185921. PMID: 37228612Free PMC Article
Cutaneous amebiasis in pediatrics.
Magaña ML, Fernández-Díez J, Magaña M
Arch Dermatol 2008 Oct;144(10):1369-72. doi: 10.1001/archderm.144.10.1369. PMID: 18936402

Recent systematic reviews

Haemophagocytic syndrome in rheumatic patients. A systematic review.
Atteritano M, David A, Bagnato G, Beninati C, Frisina A, Iaria C, Bagnato G, Cascio A
Eur Rev Med Pharmacol Sci 2012 Oct;16(10):1414-24. PMID: 23104659
Secondary hemophagocytic lymphohistiocytosis in zoonoses. A systematic review.
Cascio A, Pernice LM, Barberi G, Delfino D, Biondo C, Beninati C, Mancuso G, Rodriguez-Morales AJ, Iaria C
Eur Rev Med Pharmacol Sci 2012 Oct;16(10):1324-37. PMID: 23104648

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