U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormality of peripheral nerve conduction

MedGen UID:
866458
Concept ID:
C4020690
Finding
Synonyms: Abnormal peripheral nerve transmission; Sensory and motor nerve conduction abnormalities
 
HPO: HP:0003134

Definition

An abnormality of the conduction of electrical impulses by peripheral (motor or sensory) nerves. This finding is elicited by a nerve conduction study (NCS). [from HPO]

Conditions with this feature

Friedreich ataxia 2
MedGen UID:
356134
Concept ID:
C1865981
Disease or Syndrome
Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder characterized by progressive gait and limb ataxia with associated limb muscle weakness, absent lower limb reflexes, extensor plantar responses, dysarthria, and decreased vibratory sense and proprioception. Onset is usually in the first or second decade, before the end of puberty (summary by Delatycki et al., 2000). For a general phenotypic description of Friedreich ataxia (FRDA), see FRDA1 (229300), which is caused by mutation in the FXN gene (606829) on chromosome 9q13.

Professional guidelines

PubMed

Ecoffey C, Bosenberg A, Lonnqvist PA, Suresh S, Delbos A, Ivani G
J Clin Anesth 2022 Aug;79:110725. Epub 2022 Mar 18 doi: 10.1016/j.jclinane.2022.110725. PMID: 35313269
Stino AM, Naddaf E, Dyck PJ, Dyck PJB
Muscle Nerve 2021 Feb;63(2):157-169. Epub 2020 Sep 11 doi: 10.1002/mus.27046. PMID: 32914902
Pareyson D, Marchesi C
Lancet Neurol 2009 Jul;8(7):654-67. doi: 10.1016/S1474-4422(09)70110-3. PMID: 19539237

Recent clinical studies

Etiology

Fearon JA, Barrientos S, Ditthakasem K, Herbert M
Plast Reconstr Surg 2022 Aug 1;150(2):381e-386e. Epub 2022 Jun 8 doi: 10.1097/PRS.0000000000009367. PMID: 35671456
Casseb RF, Martinez AR, de Paiva JL, França MC Jr
J Neuroimaging 2015 Sep-Oct;25(5):704-9. Epub 2015 Feb 10 doi: 10.1111/jon.12210. PMID: 25678358
Keller MP, Chance PF
Semin Neurol 1999;19(4):353-62. doi: 10.1055/s-2008-1040850. PMID: 10716658
Lewis RA, Shy ME
Ann N Y Acad Sci 1999 Sep 14;883:504-7. PMID: 10586285
Feldman RG
Yale J Biol Med 1987 Mar-Apr;60(2):179-86. PMID: 3577214Free PMC Article

Diagnosis

Koike H, Katsuno M
Neurol Sci 2021 Nov;42(11):4489-4501. Epub 2021 Sep 16 doi: 10.1007/s10072-021-05583-7. PMID: 34529193
Vecchione T, Waisel D, Boretsky K
Reg Anesth Pain Med 2021 Feb;46(2):184-185. Epub 2020 Sep 24 doi: 10.1136/rapm-2020-101900. PMID: 32972920
Stino AM, Naddaf E, Dyck PJ, Dyck PJB
Muscle Nerve 2021 Feb;63(2):157-169. Epub 2020 Sep 11 doi: 10.1002/mus.27046. PMID: 32914902
Attarian S, Fatehi F, Rajabally YA, Pareyson D
J Neurol 2020 Aug;267(8):2198-2206. Epub 2019 Apr 15 doi: 10.1007/s00415-019-09319-8. PMID: 30989370
Eisen A
Neurol Clin 1985 Aug;3(3):495-510. PMID: 2995782

Therapy

Stino AM, Naddaf E, Dyck PJ, Dyck PJB
Muscle Nerve 2021 Feb;63(2):157-169. Epub 2020 Sep 11 doi: 10.1002/mus.27046. PMID: 32914902
Pareyson D, Marchesi C
Lancet Neurol 2009 Jul;8(7):654-67. doi: 10.1016/S1474-4422(09)70110-3. PMID: 19539237
Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Gordon MO
Arch Ophthalmol 2002 Jun;120(6):701-13; discussion 829-30. doi: 10.1001/archopht.120.6.701. PMID: 12049574
Markland C
Obstet Gynecol Annu 1975;4:309-30. PMID: 1095990
Kurland LT
Res Publ Assoc Res Nerv Ment Dis 1973;51:283-97. PMID: 4590404

Prognosis

Sanchez-Sotelo J
Tech Hand Up Extrem Surg 2024 Sep 1;28(3):182-191. doi: 10.1097/BTH.0000000000000484. PMID: 39155676
Dhanapalaratnam R, Issar T, Lee ATK, Poynten AM, Milner KL, Kwai NCG, Krishnan AV
Diabetologia 2024 Mar;67(3):561-566. Epub 2024 Jan 8 doi: 10.1007/s00125-023-06072-6. PMID: 38189936
Uncini A, Kuwabara S
J Neurol Neurosurg Psychiatry 2015 Nov;86(11):1186-95. Epub 2015 Feb 19 doi: 10.1136/jnnp-2014-310097. PMID: 25699569
Pareyson D, Marchesi C
Lancet Neurol 2009 Jul;8(7):654-67. doi: 10.1016/S1474-4422(09)70110-3. PMID: 19539237
Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Gordon MO
Arch Ophthalmol 2002 Jun;120(6):701-13; discussion 829-30. doi: 10.1001/archopht.120.6.701. PMID: 12049574

Clinical prediction guides

Draaisma F, Leenders EKSM, Erasmus CE, Braakman HMH, Burgers MCJ, Coppens CH, Rinne T, Zenker M, Tartaglia M, Reintjes W, Voermans NC, van Engelen BGM, van Alfen N, Draaisma JMT
Am J Med Genet A 2024 Nov;194(11):e63810. Epub 2024 Jul 3 doi: 10.1002/ajmg.a.63810. PMID: 38958480
Chaudhary SK, Kalita J, Misra UK
Neurol India 2023 May-Jun;71(3):458-462. doi: 10.4103/0028-3886.378653. PMID: 37322740
Dhanapalaratnam R, Issar T, Poynten AM, Milner KL, Kwai NCG, Krishnan AV
Eur J Neurol 2022 Dec;29(12):3571-3579. Epub 2022 Sep 14 doi: 10.1111/ene.15534. PMID: 36039540Free PMC Article
Fearon JA, Barrientos S, Ditthakasem K, Herbert M
Plast Reconstr Surg 2022 Aug 1;150(2):381e-386e. Epub 2022 Jun 8 doi: 10.1097/PRS.0000000000009367. PMID: 35671456
Pitt M
Curr Opin Pediatr 2013 Dec;25(6):676-81. doi: 10.1097/MOP.0000000000000023. PMID: 24136299

Recent systematic reviews

Abdelnaby R, Elgenidy A, Sonbol YT, Dardeer KT, Ebrahim MA, Maallem I, Youssef MW, Moawad MHED, Hassan YG, Rabie SA, Mohammed MK, Abdelrhem HAH, Mohamed KA, Walter U
Ultrasound Med Biol 2022 Aug;48(8):1397-1409. Epub 2022 Jun 3 doi: 10.1016/j.ultrasmedbio.2022.04.220. PMID: 35667977
Zhang K, Fried J, Nguyen SA, Meyer TA, White DR
Ear Hear 2022 Jan/Feb;43(1):23-31. doi: 10.1097/AUD.0000000000001082. PMID: 34282088
Zaidman M, Novak CB, Borschel GH, Joachim K, Zuker RM
J Plast Reconstr Aesthet Surg 2021 Jul;74(7):1436-1445. Epub 2021 Mar 30 doi: 10.1016/j.bjps.2021.03.059. PMID: 33952434
Shabeeb D, Najafi M, Hasanzadeh G, Hadian MR, Musa AE, Shirazi A
Diabetes Metab Syndr 2018 Jul;12(4):591-600. Epub 2018 Mar 28 doi: 10.1016/j.dsx.2018.03.026. PMID: 29610062
Ginanneschi F, Mondelli M, Cioncoloni D, Rossi A
J Electromyogr Kinesiol 2018 Jun;40:32-38. Epub 2018 Mar 20 doi: 10.1016/j.jelekin.2018.03.004. PMID: 29587171

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...