U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal peripheral action potential amplitude

MedGen UID:
868204
•Concept ID:
C4022596
•
Finding
HPO: HP:0030179

Definition

An anomaly in the magnitude of the action potential along a peripheral nerve, that is, of the rapid rise and fall of the electrical membrane potential of the nerve. [from HPO]

Professional guidelines

PubMed

Assessment of diagnostic criteria for multifocal motor neuropathy in patients included in the Italian database.
Doneddu PE, Gentile L, Cocito D, Fazio R, Luigetti M, Briani C, Filosto M, Siciliano G, Benedetti L, Antonini G, Matà S, Marfia GA, Inghilleri M, Manganelli F, Cosentino G, Brighina F, Carpo M, Carta F, Mazzeo A, Peci E, Strano C, Romano A, Campagnolo M, Cotti-Piccinelli S, Viola DV, Germano F, Leonardi L, Sperti M, Mataluni G, Ceccanti M, Spina E, Vegezzi E, Di Stefano V, Nobile-Orazio E
Eur J Neurol 2024 May;31(5):e16248. Epub 2024 Feb 20 doi: 10.1111/ene.16248. PMID: 38376074Free PMC Article
Clinical utility of sensory nerve conduction of medial femoral cutaneous nerve.
Oh SJ, Hatanaka Y, Ohira M, Kurokawa K, Claussen GC
Muscle Nerve 2012 Feb;45(2):195-9. doi: 10.1002/mus.22287. PMID: 22246874
MFN2 mutation distribution and genotype/phenotype correlation in Charcot-Marie-Tooth type 2.
Verhoeven K, Claeys KG, Züchner S, Schröder JM, Weis J, Ceuterick C, Jordanova A, Nelis E, De Vriendt E, Van Hul M, Seeman P, Mazanec R, Saifi GM, Szigeti K, Mancias P, Butler IJ, Kochanski A, Ryniewicz B, De Bleecker J, Van den Bergh P, Verellen C, Van Coster R, Goemans N, Auer-Grumbach M, Robberecht W, Milic Rasic V, Nevo Y, Tournev I, Guergueltcheva V, Roelens F, Vieregge P, Vinci P, Moreno MT, Christen HJ, Shy ME, Lupski JR, Vance JM, De Jonghe P, Timmerman V
Brain 2006 Aug;129(Pt 8):2093-102. Epub 2006 May 19 doi: 10.1093/brain/awl126. PMID: 16714318

Recent clinical studies

Etiology

Electroneurological changes in peripheral nerves in patients post-COVID.
Stępień J, Pastuszak Ż
J Neurophysiol 2023 Feb 1;129(2):392-398. Epub 2022 Dec 14 doi: 10.1152/jn.00396.2022. PMID: 36515426Free PMC Article
Electrophysiological characteristics of patients with nitrous oxide abuse.
Li Y, Zhang X, Zhao C
Neurol Res 2021 Oct;43(10):793-801. Epub 2021 Jun 8 doi: 10.1080/01616412.2021.1935101. PMID: 34101535
Progressive length-dependent polyneuropathy in xeroderma pigmentosum group A.
Tsuji Y, Ueda T, Sekiguchi K, Nishiyama M, Kanda F, Nishigori C, Toda T, Matsumoto R
Muscle Nerve 2020 Oct;62(4):534-540. Epub 2020 Aug 10 doi: 10.1002/mus.27028. PMID: 32696477
Clinical Characteristics and Electrodiagnostic Features of Guillain-Barré Syndrome Among the Pediatric Population.
Ashrafi MR, Mohammadalipoor A, Naeini AR, Amanat M, Tavasoli AR, Heidari M, Badv RS, Mohammadi M, Zamani GR, Rahimi-Dehgolan S, Rahimi R, Akbari MG
J Child Neurol 2020 Jun;35(7):448-455. Epub 2020 Mar 10 doi: 10.1177/0883073820905157. PMID: 32156188
Ultrasound differentiation of axonal and demyelinating neuropathies.
Grimm A, Heiling B, Schumacher U, Witte OW, Axer H
Muscle Nerve 2014 Dec;50(6):976-83. Epub 2014 Oct 30 doi: 10.1002/mus.24238. PMID: 24634226

Diagnosis

Assessment of diagnostic criteria for multifocal motor neuropathy in patients included in the Italian database.
Doneddu PE, Gentile L, Cocito D, Fazio R, Luigetti M, Briani C, Filosto M, Siciliano G, Benedetti L, Antonini G, Matà S, Marfia GA, Inghilleri M, Manganelli F, Cosentino G, Brighina F, Carpo M, Carta F, Mazzeo A, Peci E, Strano C, Romano A, Campagnolo M, Cotti-Piccinelli S, Viola DV, Germano F, Leonardi L, Sperti M, Mataluni G, Ceccanti M, Spina E, Vegezzi E, Di Stefano V, Nobile-Orazio E
Eur J Neurol 2024 May;31(5):e16248. Epub 2024 Feb 20 doi: 10.1111/ene.16248. PMID: 38376074Free PMC Article
Diagnostic accuracy of nerve ultrasonography for the detection of peripheral neuropathy in type 2 diabetes.
Dhanapalaratnam R, Issar T, Poynten AM, Milner KL, Kwai NCG, Krishnan AV
Eur J Neurol 2022 Dec;29(12):3571-3579. Epub 2022 Sep 14 doi: 10.1111/ene.15534. PMID: 36039540Free PMC Article
Electrophysiological characteristics of patients with nitrous oxide abuse.
Li Y, Zhang X, Zhao C
Neurol Res 2021 Oct;43(10):793-801. Epub 2021 Jun 8 doi: 10.1080/01616412.2021.1935101. PMID: 34101535
F-waves--physiology and clinical uses.
Fisher MA
ScientificWorldJournal 2007 Feb 2;7:144-60. doi: 10.1100/tsw.2007.49. PMID: 17334607Free PMC Article
Electrodiagnosis of radiculopathies.
Eisen A
Neurol Clin 1985 Aug;3(3):495-510. PMID: 2995782

Therapy

Lenalidomide long-term neurotoxicity: Clinical and neurophysiologic prospective study.
Dalla Torre C, Zambello R, Cacciavillani M, Campagnolo M, Berno T, Salvalaggio A, De March E, Barilà G, Lico A, Lucchetta M, Ermani M, Briani C
Neurology 2016 Sep 13;87(11):1161-6. Epub 2016 Aug 17 doi: 10.1212/WNL.0000000000003093. PMID: 27534712
Long- and short-term health effects of pesticide exposure: a cohort study from China.
Hu R, Huang X, Huang J, Li Y, Zhang C, Yin Y, Chen Z, Jin Y, Cai J, Cui F
PLoS One 2015;10(6):e0128766. Epub 2015 Jun 4 doi: 10.1371/journal.pone.0128766. PMID: 26042669Free PMC Article
AAV1.NT-3 gene therapy for charcot-marie-tooth neuropathy.
Sahenk Z, Galloway G, Clark KR, Malik V, Rodino-Klapac LR, Kaspar BK, Chen L, Braganza C, Montgomery C, Mendell JR
Mol Ther 2014 Mar;22(3):511-521. Epub 2013 Oct 28 doi: 10.1038/mt.2013.250. PMID: 24162799Free PMC Article
Nerve excitability assessment in chemotherapy-induced neurotoxicity.
Park SB, Lin CS, Kiernan MC
J Vis Exp 2012 Apr 26;(62) doi: 10.3791/3439. PMID: 22565594Free PMC Article
Sural sensory action potential identifies diabetic peripheral neuropathy responders to therapy.
Vinik AI, Bril V, Litchy WJ, Price KL, Bastyr EJ 3rd; MBBQ Study Group
Muscle Nerve 2005 Nov;32(5):619-25. doi: 10.1002/mus.20423. PMID: 16116628

Prognosis

Diagnostic accuracy of nerve ultrasonography for the detection of peripheral neuropathy in type 2 diabetes.
Dhanapalaratnam R, Issar T, Poynten AM, Milner KL, Kwai NCG, Krishnan AV
Eur J Neurol 2022 Dec;29(12):3571-3579. Epub 2022 Sep 14 doi: 10.1111/ene.15534. PMID: 36039540Free PMC Article
Vibratory testing with the 64 Hz Rydel-Seiffer tuning fork and its relation to the sural nerve action potential.
Xirou S, Kokotis P, Zambelis T, Anagnostou E
J Peripher Nerv Syst 2020 Dec;25(4):395-400. Epub 2020 Oct 31 doi: 10.1111/jns.12418. PMID: 33107143
Lenalidomide long-term neurotoxicity: Clinical and neurophysiologic prospective study.
Dalla Torre C, Zambello R, Cacciavillani M, Campagnolo M, Berno T, Salvalaggio A, De March E, Barilà G, Lico A, Lucchetta M, Ermani M, Briani C
Neurology 2016 Sep 13;87(11):1161-6. Epub 2016 Aug 17 doi: 10.1212/WNL.0000000000003093. PMID: 27534712
Polyneuropathy improvement following autologous stem cell transplantation for POEMS syndrome.
Karam C, Klein CJ, Dispenzieri A, Dyck PJ, Mandrekar J, D'Souza A, Mauermann ML
Neurology 2015 May 12;84(19):1981-7. Epub 2015 Apr 15 doi: 10.1212/WNL.0000000000001565. PMID: 25878176Free PMC Article
"Benign" early repolarization versus malignant early abnormalities: clinical-electrocardiographic distinction and genetic basis.
Pérez-Riera AR, Abreu LC, Yanowitz F, Barros RB, Femenía F, McIntyre WF, Baranchuk A
Cardiol J 2012;19(4):337-46. doi: 10.5603/cj.2012.0063. PMID: 22825893

Clinical prediction guides

Electroneurological changes in peripheral nerves in patients post-COVID.
Stępień J, Pastuszak Ż
J Neurophysiol 2023 Feb 1;129(2):392-398. Epub 2022 Dec 14 doi: 10.1152/jn.00396.2022. PMID: 36515426Free PMC Article
Progressive length-dependent polyneuropathy in xeroderma pigmentosum group A.
Tsuji Y, Ueda T, Sekiguchi K, Nishiyama M, Kanda F, Nishigori C, Toda T, Matsumoto R
Muscle Nerve 2020 Oct;62(4):534-540. Epub 2020 Aug 10 doi: 10.1002/mus.27028. PMID: 32696477
Clinical Characteristics and Electrodiagnostic Features of Guillain-Barré Syndrome Among the Pediatric Population.
Ashrafi MR, Mohammadalipoor A, Naeini AR, Amanat M, Tavasoli AR, Heidari M, Badv RS, Mohammadi M, Zamani GR, Rahimi-Dehgolan S, Rahimi R, Akbari MG
J Child Neurol 2020 Jun;35(7):448-455. Epub 2020 Mar 10 doi: 10.1177/0883073820905157. PMID: 32156188
Lenalidomide long-term neurotoxicity: Clinical and neurophysiologic prospective study.
Dalla Torre C, Zambello R, Cacciavillani M, Campagnolo M, Berno T, Salvalaggio A, De March E, Barilà G, Lico A, Lucchetta M, Ermani M, Briani C
Neurology 2016 Sep 13;87(11):1161-6. Epub 2016 Aug 17 doi: 10.1212/WNL.0000000000003093. PMID: 27534712
"Benign" early repolarization versus malignant early abnormalities: clinical-electrocardiographic distinction and genetic basis.
Pérez-Riera AR, Abreu LC, Yanowitz F, Barros RB, Femenía F, McIntyre WF, Baranchuk A
Cardiol J 2012;19(4):337-46. doi: 10.5603/cj.2012.0063. PMID: 22825893

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...