Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Sclerosis of finger phalanx

MedGen UID:: 866595
•Concept ID:: C4020941
•: Anatomical Abnormality

Synonyms:	Increased bone density in the finger bone; Sclerosis of the phalanges of the hand

HPO:	HP:0100899

Definition

An elevation in bone density in one or more phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSclerosis of finger phalanx

Abnormality of limbs
- Abnormality of limb bone
  - Abnormal limb bone morphology
    - Abnormal digit morphology
      - Abnormal finger morphology
        Abnormal finger phalanx morphology
        Sclerosis of finger phalanx
        Ivory epiphyses of the phalanges of the hand
        Patchy sclerosis of finger phalanx
        Sclerosis of 2nd finger phalanx
        Ivory epiphyses of the 2nd finger
        Patchy sclerosis of 2nd finger phalanx
        Sclerosis of the distal phalanx of the 2nd finger
        Patchy sclerosis of the distal phalanx of the 2nd finger
        Sclerosis of the middle phalanx of the 2nd finger
        Patchy sclerosis of the middle phalanx of the 2nd finger
        Sclerosis of the proximal phalanx of the 2nd finger
        Patchy sclerosis of the proximal phalanx of the 2nd finger
        Sclerosis of 3rd finger phalanx
        Ivory epiphyses of the 3rd finger
        Patchy sclerosis of 3rd finger phalanx
        Sclerosis of the distal phalanx of the 3rd finger
        Patchy sclerosis of the distal phalanx of the 3rd finger
        Sclerosis of the middle phalanx of the 3rd finger
        Patchy sclerosis of the middle phalanx of the 3rd finger
        Sclerosis of the proximal phalanx of the 3rd finger
        Patchy sclerosis of the proximal phalanx of the 3rd finger
        Sclerosis of 4th finger phalanx
        Ivory epiphyses of the 4th finger
        Patchy sclerosis of 4th finger phalanx
        Sclerosis of the distal phalanx of the 4th finger
        Patchy sclerosis of the distal phalanx of the 4th finger
        Sclerosis of the middle phalanx of the 4th finger
        Patchy sclerosis of the middle phalanx of the 4th finger
        Sclerosis of the proximal phalanx of the 4th finger
        Patchy sclerosis of the proximal phalanx of the 4th finger
        Sclerosis of 5th finger phalanx
        Ivory epiphyses of the 5th finger
        Patchy sclerosis of 5th finger phalanx
        Sclerosis of the distal phalanx of the 5th finger
        Patchy sclerosis of the distal phalanx of the 5th finger
        Sclerosis of the middle phalanx of the 5th finger
        Patchy sclerosis of the middle phalanx of the 5th finger
        Sclerosis of the proximal phalanx of the 5th finger
        Patchy sclerosis of the proximal phalanx of the 5th finger
        Sclerosis of distal finger phalanx
        Ivory epiphyses of the distal phalanges of the hand
        Ivory epiphysis of the distal phalanx of the 2nd finger
        Ivory epiphysis of the distal phalanx of the 3rd finger
        Ivory epiphysis of the distal phalanx of the 4th finger
        Ivory epiphysis of the distal phalanx of the 5th finger
        Ivory epiphysis of the distal phalanx of the thumb
        Patchy sclerosis of distal phalanx of finger
        Sclerosis of middle finger phalanx
        Ivory epiphyses of the middle phalanges of the hand
        Ivory epiphysis of the middle phalanx of the 2nd finger
        Ivory epiphysis of the middle phalanx of the 3rd finger
        Ivory epiphysis of the middle phalanx of the 4th finger
        Ivory epiphysis of the middle phalanx of the 5th finger
        Ivory epiphysis of the proximal phalanx of the thumb
        Patchy sclerosis of middle phalanx of finger
        Sclerosis of proximal finger phalanx
        Ivory epiphyses of the proximal phalanges of the hand
        Ivory epiphysis of the 1st metacarpal
        Ivory epiphysis of the proximal phalanx of the 2nd finger
        Ivory epiphysis of the proximal phalanx of the 3rd finger
        Ivory epiphysis of the proximal phalanx of the 4th finger
        Ivory epiphysis of the proximal phalanx of the 5th finger
        Patchy sclerosis of proximal phalanx of finger
        Sclerosis of the 1st metacarpal
        Patchy sclerosis of the 1st metacarpal
        Sclerosis of thumb phalanx
        Ivory epiphysis of the thumb
        Patchy sclerosis of thumb phalanx
        Sclerosis of the distal phalanx of the thumb
        Patchy sclerosis of the distal phalanx of the thumb
        Sclerosis of the proximal phalanx of the thumb
        Patchy sclerosis of the proximal phalanx of the thumb

Professional guidelines

PubMed

Imaging Helps Guide Physical Therapy Treatment in a Patient With Diffuse Systemic Sclerosis (Scleroderma).

Curley RA, Markowski A
J Orthop Sports Phys Ther 2018 Mar;48(3):226. doi: 10.2519/jospt.2018.7662. PMID: 29490598

See all (1)

Recent clinical studies

Etiology

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.

Nagaraja V, Spino C, Bush E, Tsou PS, Domsic RT, Lafyatis R, Frech T, Gordon JK, Steen VD, Khanna D
Arthritis Res Ther 2019 Sep 3;21(1):202. doi: 10.1186/s13075-019-1979-7. PMID: 31481106 Free PMC Article

Acro-osteolysis.

Botou A, Bangeas A, Alexiou I, Sakkas LI
Clin Rheumatol 2017 Jan;36(1):9-14. Epub 2016 Oct 29 doi: 10.1007/s10067-016-3459-7. PMID: 27796661

Imaging features of osteoid osteoma of the phalanges.

Kotnis N, James SL
Skeletal Radiol 2015 Oct;44(10):1461-6. Epub 2015 Jun 21 doi: 10.1007/s00256-015-2191-8. PMID: 26093538

Acro-osteolysis in systemic sclerosis is associated with digital ischaemia and severe calcinosis.

Johnstone EM, Hutchinson CE, Vail A, Chevance A, Herrick AL
Rheumatology (Oxford) 2012 Dec;51(12):2234-8. Epub 2012 Aug 25 doi: 10.1093/rheumatology/kes214. PMID: 22923763

Radiological hand involvement in systemic sclerosis.

Avouac J, Guerini H, Wipff J, Assous N, Chevrot A, Kahan A, Allanore Y
Ann Rheum Dis 2006 Aug;65(8):1088-92. Epub 2006 Jan 13 doi: 10.1136/ard.2005.044602. PMID: 16414976 Free PMC Article

See all (13)

Diagnosis

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.

Fingolimod-Associated Peripheral Vascular Adverse Effects.

Russo M, Guarneri C, Mazzon E, Sessa E, Bramanti P, Calabrò RS
Mayo Clin Proc 2015 Oct;90(10):1424-7. Epub 2015 Sep 5 doi: 10.1016/j.mayocp.2015.07.019. PMID: 26349949

Imaging features of osteoid osteoma of the phalanges.

Kotnis N, James SL
Skeletal Radiol 2015 Oct;44(10):1461-6. Epub 2015 Jun 21 doi: 10.1007/s00256-015-2191-8. PMID: 26093538

Reliability of ultrasound measurements of dermal thickness at digits in systemic sclerosis: role of elastosonography.

Di Geso L, Filippucci E, Girolimetti R, Tardella M, Gutierrez M, De Angelis R, Salaffi F, Grassi W
Clin Exp Rheumatol 2011 Nov-Dec;29(6):926-32. Epub 2011 Dec 22 PMID: 22032470

Radiological hand involvement in systemic sclerosis.

Avouac J, Guerini H, Wipff J, Assous N, Chevrot A, Kahan A, Allanore Y
Ann Rheum Dis 2006 Aug;65(8):1088-92. Epub 2006 Jan 13 doi: 10.1136/ard.2005.044602. PMID: 16414976 Free PMC Article

See all (16)

Therapy

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.

Fingolimod-Associated Peripheral Vascular Adverse Effects.

Russo M, Guarneri C, Mazzon E, Sessa E, Bramanti P, Calabrò RS
Mayo Clin Proc 2015 Oct;90(10):1424-7. Epub 2015 Sep 5 doi: 10.1016/j.mayocp.2015.07.019. PMID: 26349949

Multiple malformations in a male and maternal osteopathia strata with cranial sclerosis (OSCS).

Rott HD, Krieg P, Rütschle H, Kraus C
Genet Couns 2003;14(3):281-8. PMID: 14577672

Sonographic imaging of the distal phalanx.

Grassi W, Filippucci E, Farina A, Cervini C
Semin Arthritis Rheum 2000 Jun;29(6):379-84. doi: 10.1053/sarh.2000.7002. PMID: 10924024

See all (4)

Prognosis

Optimizing finger systolic blood pressure measurements with laser Doppler: Validation of the second phalanx site.

Blaise S, Constans J, Pellegrini L, Senet P, Lazareth I, Cracowski JL, Carpentier P
Microvasc Res 2020 Sep;131:104029. Epub 2020 Jun 9 doi: 10.1016/j.mvr.2020.104029. PMID: 32531354

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.

Longitudinal development of skin involvement and reliability of high frequency ultrasound in systemic sclerosis.

Akesson A, Hesselstrand R, Scheja A, Wildt M
Ann Rheum Dis 2004 Jul;63(7):791-6. doi: 10.1136/ard.2003.012146. PMID: 15194573 Free PMC Article

See all (3)

Clinical prediction guides

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.

Acro-osteolysis in systemic sclerosis is associated with digital ischaemia and severe calcinosis.

Johnstone EM, Hutchinson CE, Vail A, Chevance A, Herrick AL
Rheumatology (Oxford) 2012 Dec;51(12):2234-8. Epub 2012 Aug 25 doi: 10.1093/rheumatology/kes214. PMID: 22923763

Reliability of ultrasound measurements of dermal thickness at digits in systemic sclerosis: role of elastosonography.

Di Geso L, Filippucci E, Girolimetti R, Tardella M, Gutierrez M, De Angelis R, Salaffi F, Grassi W
Clin Exp Rheumatol 2011 Nov-Dec;29(6):926-32. Epub 2011 Dec 22 PMID: 22032470

Hand vascular involvement assessed by magnetic resonance angiography in systemic sclerosis.

Allanore Y, Seror R, Chevrot A, Kahan A, Drapé JL
Arthritis Rheum 2007 Aug;56(8):2747-54. doi: 10.1002/art.22734. PMID: 17665441

Radiological hand involvement in systemic sclerosis.

Avouac J, Guerini H, Wipff J, Assous N, Chevrot A, Kahan A, Allanore Y
Ann Rheum Dis 2006 Aug;65(8):1088-92. Epub 2006 Jan 13 doi: 10.1136/ard.2005.044602. PMID: 16414976 Free PMC Article

See all (14)

Recent systematic reviews

Radiographic changes of the distal phalangeal tuft of the hands in subjects with systemic sclerosis. Systematic review.

Izquierdo YE, Calvo Páramo E, Castañeda LM, Gómez SV, Zambrano FS
Reumatol Clin (Engl Ed) 2018 Jan-Feb;14(1):20-26. Epub 2016 Oct 13 doi: 10.1016/j.reuma.2016.08.009. PMID: 27746086

See all (1)

MedGen

National Center for Biotechnology Information

Send to:

Sclerosis of finger phalanx

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

Recent activity