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Abnormal 3rd finger morphology

MedGen UID:
867319
•Concept ID:
C4021682
•
Anatomical Abnormality
Synonyms: Abnormality of the 3rd finger; Abnormality of the middle finger
 
HPO: HP:0004150

Definition

An anomaly of the third finger. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal 3rd finger morphology

Conditions with this feature

Mesoaxial hexadactyly and cardiac malformation
MedGen UID:
167099
•Concept ID:
C0796057
•
Disease or Syndrome
A syndrome of mental retardation, short stature, delayed puberty, polydactyly, synmetracarpalia, ocular torticollis, orofacial dysmorphism, and multiple cardiac malformations.
See: Condition Record
Mesoaxial hexadactyly and cardiac malformation

Recent clinical studies

Etiology

Microduplication of Xq24 and Hartsfield syndrome with holoprosencephaly, ectrodactyly, and clefting.
Takenouchi T, Okuno H, Kosaki R, Ariyasu D, Torii C, Momoshima S, Harada N, Yoshihashi H, Takahashi T, Awazu M, Kosaki K
Am J Med Genet A 2012 Oct;158A(10):2537-41. Epub 2012 Aug 10 doi: 10.1002/ajmg.a.35465. PMID: 22887648
Simpson-Golabi-Behmel syndrome type 1 in a 27-week macrosomic preterm newborn: the diagnostic value of rib malformations and index nail and finger hypoplasia.
Garavelli L, Gargano G, Simonte G, Rosato S, Wischmeijer A, Melli N, Braibanti S, Gelmini C, Forzano F, Pietrobono R, Pomponi MG, Andreucci E, Toutain A, Superti-Furga A, Neri G
Am J Med Genet A 2012 Sep;158A(9):2245-9. Epub 2012 Jul 17 doi: 10.1002/ajmg.a.35474. PMID: 22807161
Autosomal dominant syndrome of camptodactyly, clinodactyly, syndactyly, and bifid toes.
Malik S, Afzal M, Gul S, Wahab A, Ahmad M
Am J Med Genet A 2010 Sep;152A(9):2313-7. doi: 10.1002/ajmg.a.33552. PMID: 20683984
Functional and morphological evaluation of hand microcirculation with nailfold capillaroscopy and laser Doppler imaging in Raynaud's and Sjögren's syndrome and poly/dermatomyositis.
Szabo N, Csiki Z, Szanto A, Danko K, Szodoray P, Zeher M
Scand J Rheumatol 2008 Jan-Feb;37(1):23-9. doi: 10.1080/03009740701640209. PMID: 18189191
Transcranial sonography in spinocerebellar ataxia type 3.
Postert T, Eyding J, Berg D, Przuntek H, Becker G, Finger M, Schöls L
J Neural Transm Suppl 2004;(68):123-33. doi: 10.1007/978-3-7091-0579-5_15. PMID: 15354398

Diagnosis

Concomitance of types D and E brachydactyly: a case report.
Tülay Koca T, Çiledağ Özdemir F
Eur Rev Med Pharmacol Sci 2015 Dec;19(23):4549-52. PMID: 26698251
Poland's syndrome with unusual hand and chest anomalies: a rare case report.
Yadav GK, Lal S, Dange N, Marwah KG, Singh JP
Indian J Chest Dis Allied Sci 2014 Jul-Sep;56(3):191-4. PMID: 25823118
Non-invasive quick diagnosis of cardiovascular problems from visible and invisible abnormal changes with increased cardiac troponin I appearing on cardiovascular representation areas of the eyebrows, left upper lip, etc. of the face & hands: beneficial manual stimulation of hands for acute anginal chest pain, and important factors in safe, effective treatment.
Omura Y, Jones MK, Duvvi H, Shimotsuura Y, Ohki M, Rodriques A
Acupunct Electrother Res 2014;39(2):135-67. doi: 10.3727/036012914x14054537750463. PMID: 25219029
Simpson-Golabi-Behmel syndrome type 1 in a 27-week macrosomic preterm newborn: the diagnostic value of rib malformations and index nail and finger hypoplasia.
Garavelli L, Gargano G, Simonte G, Rosato S, Wischmeijer A, Melli N, Braibanti S, Gelmini C, Forzano F, Pietrobono R, Pomponi MG, Andreucci E, Toutain A, Superti-Furga A, Neri G
Am J Med Genet A 2012 Sep;158A(9):2245-9. Epub 2012 Jul 17 doi: 10.1002/ajmg.a.35474. PMID: 22807161
Transcranial sonography in spinocerebellar ataxia type 3.
Postert T, Eyding J, Berg D, Przuntek H, Becker G, Finger M, Schöls L
J Neural Transm Suppl 2004;(68):123-33. doi: 10.1007/978-3-7091-0579-5_15. PMID: 15354398

Therapy

Olmsted syndrome.
Ali ME, Sikdar AU, Akhtar N, Islam ZM
Mymensingh Med J 2007 Jan;16(1):100-3. doi: 10.3329/mmj.v16i1.262. PMID: 17344790
Multiple malformations in a male and maternal osteopathia strata with cranial sclerosis (OSCS).
Rott HD, Krieg P, Rütschle H, Kraus C
Genet Couns 2003;14(3):281-8. PMID: 14577672
Hydrocephalus and abnormal digits after failed first-trimester prostaglandin abortion attempt.
Collins FS, Mahoney MJ
J Pediatr 1983 Apr;102(4):620-1. doi: 10.1016/s0022-3476(83)80204-2. PMID: 6572713
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

Prognosis

Autosomal dominant syndrome of camptodactyly, clinodactyly, syndactyly, and bifid toes.
Malik S, Afzal M, Gul S, Wahab A, Ahmad M
Am J Med Genet A 2010 Sep;152A(9):2313-7. doi: 10.1002/ajmg.a.33552. PMID: 20683984
A dermatoglyphic study of a group of Sicilian children with fragile-X syndrome.
Milone G, Conti L, Rizzo R, Sanfilippo S, Sammito V, Romano C
Am J Med Genet 1988 May-Jun;30(1-2):177-83. doi: 10.1002/ajmg.1320300116. PMID: 3177443

Clinical prediction guides

Validation and incorporation of digital entheses into a preliminary GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis.
Naredo E, D'Agostino MA, Terslev L, Pineda C, Miguel MI, Blasi J, Bruyn GA, Kortekaas MC, Mandl P, Nestorova R, Szkudlarek M, Todorov P, Vlad V, Wong P, Bakewell C, Filippucci E, Zabotti A, Micu M, Vreju F, Mortada M, Mendonça JA, Guillen-Astete CA, Olivas-Vergara O, Iagnocco A, Hanova P, Tinazzi I, Balint PV, Aydin SZ, Kane D, Keen H, Kaeley GS, Möller I
Ann Rheum Dis 2024 Jul 15;83(8):1060-1071. doi: 10.1136/ard-2023-225278. PMID: 38531611
Cartilage evaluation in finger joints in healthy controls and early hand osteoarthritis patients using high-resolution MRI.
Saltzherr MS, Muradin GSR, Haugen IK, Selles RW, van Neck JW, Coert JH, Hazes JMW, Luime JJ
Osteoarthritis Cartilage 2019 Aug;27(8):1148-1151. Epub 2019 May 18 doi: 10.1016/j.joca.2019.05.003. PMID: 31108225
Concomitance of types D and E brachydactyly: a case report.
Tülay Koca T, Çiledağ Özdemir F
Eur Rev Med Pharmacol Sci 2015 Dec;19(23):4549-52. PMID: 26698251
A case of symbrachydactyly with oligodactyly.
Seven M, Yuksel A, Ozkilic A
Genet Couns 2001;12(1):77-83. PMID: 11332981
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

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