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Abnormal microglia morphology

MedGen UID:
867604
•Concept ID:
C4021990
•
Finding
Synonym: Abnormality of the microglia
 
HPO: HP:0100708

Definition

An abnormality of the microglial cells. They are also known as brain-resident macrophages or Hortega cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal microglia morphology

Professional guidelines

PubMed

Treatment of CSF1R-Related Leukoencephalopathy: Breaking New Ground.
Tipton PW, Kenney-Jung D, Rush BK, Middlebrooks EH, Nascene D, Singh B, Holtan S, Ayala E, Broderick DF, Lund T, Wszolek ZK
Mov Disord 2021 Dec;36(12):2901-2909. Epub 2021 Jul 30 doi: 10.1002/mds.28734. PMID: 34329526
Amylin Treatment Reduces Neuroinflammation and Ameliorates Abnormal Patterns of Gene Expression in the Cerebral Cortex of an Alzheimer's Disease Mouse Model.
Wang E, Zhu H, Wang X, Gower AC, Wallack M, Blusztajn JK, Kowall N, Qiu WQ
J Alzheimers Dis 2017;56(1):47-61. doi: 10.3233/JAD-160677. PMID: 27911303Free PMC Article
Quetiapine fumarate for the treatment of multiple sclerosis: focus on myelin repair.
Zhornitsky S, Wee Yong V, Koch MW, Mackie A, Potvin S, Patten SB, Metz LM
CNS Neurosci Ther 2013 Oct;19(10):737-44. Epub 2013 Jul 22 doi: 10.1111/cns.12154. PMID: 23870612Free PMC Article

Recent clinical studies

Etiology

Thrombin, a Key Driver of Pathological Inflammation in the Brain.
Iannucci J, Grammas P
Cells 2023 Apr 23;12(9) doi: 10.3390/cells12091222. PMID: 37174621Free PMC Article
Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease.
Jin M, Xu R, Wang L, Alam MM, Ma Z, Zhu S, Martini AC, Jadali A, Bernabucci M, Xie P, Kwan KY, Pang ZP, Head E, Liu Y, Hart RP, Jiang P
Cell Stem Cell 2022 Jul 7;29(7):1135-1153.e8. doi: 10.1016/j.stem.2022.06.007. PMID: 35803230Free PMC Article
Primary Microglia Dysfunction or Microgliopathy: A Cause of Dementias and Other Neurological or Psychiatric Disorders.
Bianchin MM, Snow Z
Neuroscience 2022 Aug 10;497:324-339. Epub 2022 Jun 24 doi: 10.1016/j.neuroscience.2022.06.032. PMID: 35760218
The Neurovascular Unit Dysfunction in Alzheimer's Disease.
Soto-Rojas LO, Pacheco-Herrero M, Martínez-Gómez PA, Campa-Córdoba BB, Apátiga-Pérez R, Villegas-Rojas MM, Harrington CR, de la Cruz F, Garcés-Ramírez L, Luna-Muñoz J
Int J Mol Sci 2021 Feb 18;22(4) doi: 10.3390/ijms22042022. PMID: 33670754Free PMC Article
Etiology and pathogenesis of Parkinson's disease.
Schapira AH, Jenner P
Mov Disord 2011 May;26(6):1049-55. doi: 10.1002/mds.23732. PMID: 21626550

Diagnosis

Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System.
Christian KM, Song H, Ming GL
Annu Rev Neurosci 2019 Jul 8;42:249-269. doi: 10.1146/annurev-neuro-080317-062231. PMID: 31283901Free PMC Article
Mineralocorticoid Receptors, Neuroinflammation and Hypertensive Encephalopathy.
Brocca ME, Pietranera L, de Kloet ER, De Nicola AF
Cell Mol Neurobiol 2019 May;39(4):483-492. Epub 2018 Aug 16 doi: 10.1007/s10571-018-0610-9. PMID: 30117098
The neuropathology of chronic traumatic encephalopathy.
Mckee AC, Abdolmohammadi B, Stein TD
Handb Clin Neurol 2018;158:297-307. doi: 10.1016/B978-0-444-63954-7.00028-8. PMID: 30482357
SPECT and PET imaging in Alzheimer's disease.
Valotassiou V, Malamitsi J, Papatriantafyllou J, Dardiotis E, Tsougos I, Psimadas D, Alexiou S, Hadjigeorgiou G, Georgoulias P
Ann Nucl Med 2018 Nov;32(9):583-593. Epub 2018 Aug 20 doi: 10.1007/s12149-018-1292-6. PMID: 30128693
Neuropathogenesis of human immunodeficiency virus infection.
Sillman B, Woldstad C, Mcmillan J, Gendelman HE
Handb Clin Neurol 2018;152:21-40. doi: 10.1016/B978-0-444-63849-6.00003-7. PMID: 29604978

Therapy

Alzheimer disease neuropathology in a patient previously treated with aducanumab.
Plowey ED, Bussiere T, Rajagovindan R, Sebalusky J, Hamann S, von Hehn C, Castrillo-Viguera C, Sandrock A, Budd Haeberlein S, van Dyck CH, Huttner A
Acta Neuropathol 2022 Jul;144(1):143-153. Epub 2022 May 17 doi: 10.1007/s00401-022-02433-4. PMID: 35581440Free PMC Article
Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease.
Sun XY, Li LJ, Dong QX, Zhu J, Huang YR, Hou SJ, Yu XL, Liu RT
J Neuroinflammation 2021 Jun 11;18(1):131. doi: 10.1186/s12974-021-02182-3. PMID: 34116706Free PMC Article
Microglia in depression: current perspectives.
Jia X, Gao Z, Hu H
Sci China Life Sci 2021 Jun;64(6):911-925. Epub 2020 Oct 14 doi: 10.1007/s11427-020-1815-6. PMID: 33068286
Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome.
Pinto B, Morelli G, Rastogi M, Savardi A, Fumagalli A, Petretto A, Bartolucci M, Varea E, Catelani T, Contestabile A, Perlini LE, Cancedda L
Neuron 2020 Dec 9;108(5):887-904.e12. Epub 2020 Oct 6 doi: 10.1016/j.neuron.2020.09.010. PMID: 33027640Free PMC Article
Kinins and microglial responses in bipolar disorder: a neuroinflammation hypothesis.
Naaldijk YM, Bittencourt MC, Sack U, Ulrich H
Biol Chem 2016 Apr;397(4):283-96. doi: 10.1515/hsz-2015-0257. PMID: 26859499

Prognosis

Microglial activation and tau propagate jointly across Braak stages.
Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P
Nat Med 2021 Sep;27(9):1592-1599. Epub 2021 Aug 26 doi: 10.1038/s41591-021-01456-w. PMID: 34446931
Involvement of Microglia in the Pathophysiology of Intracranial Aneurysms and Vascular Malformations-A Short Overview.
Timis TL, Florian IA, Susman S, Florian IS
Int J Mol Sci 2021 Jun 7;22(11) doi: 10.3390/ijms22116141. PMID: 34200256Free PMC Article
SPECT and PET imaging in Alzheimer's disease.
Valotassiou V, Malamitsi J, Papatriantafyllou J, Dardiotis E, Tsougos I, Psimadas D, Alexiou S, Hadjigeorgiou G, Georgoulias P
Ann Nucl Med 2018 Nov;32(9):583-593. Epub 2018 Aug 20 doi: 10.1007/s12149-018-1292-6. PMID: 30128693
Investigating microglia-brain tumor cell interactions in vivo in the larval zebrafish brain.
Astell KR, Sieger D
Methods Cell Biol 2017;138:593-626. Epub 2016 Oct 31 doi: 10.1016/bs.mcb.2016.10.001. PMID: 28129859
Microglial activation and progressive brain changes in schizophrenia.
Laskaris LE, Di Biase MA, Everall I, Chana G, Christopoulos A, Skafidas E, Cropley VL, Pantelis C
Br J Pharmacol 2016 Feb;173(4):666-80. Epub 2016 Jan 8 doi: 10.1111/bph.13364. PMID: 26455353Free PMC Article

Clinical prediction guides

Dysfunctional microglia and tau pathology in Alzheimer's disease.
Ayyubova G
Rev Neurosci 2023 Jun 27;34(4):443-458. Epub 2022 Oct 28 doi: 10.1515/revneuro-2022-0087. PMID: 36302379
Neuropathological Variability within a Spectrum of NMDAR-Encephalitis.
Zrzavy T, Endmayr V, Bauer J, Macher S, Mossaheb N, Schwaiger C, Ricken G, Winklehner M, Glatter S, Breu M, Wimmer I, Kovacs GG, Risser DU, Klupp N, Simonitsch-Klupp I, Roetzer T, Rommer P, Berger T, Gelpi E, Lassmann H, Graus F, Dalmau J, Höftberger R
Ann Neurol 2021 Nov;90(5):725-737. Epub 2021 Oct 9 doi: 10.1002/ana.26223. PMID: 34562035
Microglial activation and tau propagate jointly across Braak stages.
Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P
Nat Med 2021 Sep;27(9):1592-1599. Epub 2021 Aug 26 doi: 10.1038/s41591-021-01456-w. PMID: 34446931
Microglial exosomes facilitate α-synuclein transmission in Parkinson's disease.
Guo M, Wang J, Zhao Y, Feng Y, Han S, Dong Q, Cui M, Tieu K
Brain 2020 May 1;143(5):1476-1497. doi: 10.1093/brain/awaa090. PMID: 32355963Free PMC Article
SPECT and PET imaging in Alzheimer's disease.
Valotassiou V, Malamitsi J, Papatriantafyllou J, Dardiotis E, Tsougos I, Psimadas D, Alexiou S, Hadjigeorgiou G, Georgoulias P
Ann Nucl Med 2018 Nov;32(9):583-593. Epub 2018 Aug 20 doi: 10.1007/s12149-018-1292-6. PMID: 30128693

Recent systematic reviews

Glial Markers of Suicidal Behavior in the Human Brain-A Systematic Review of Postmortem Studies.
Yamamoto M, Sakai M, Yu Z, Nakanishi M, Yoshii H
Int J Mol Sci 2024 May 25;25(11) doi: 10.3390/ijms25115750. PMID: 38891940Free PMC Article
Brain abnormalities, neurodegeneration, and dysosteosclerosis (BANDDOS): new cases, systematic literature review, and associations with CSF1R-ALSP.
Dulski J, Souza J, Santos ML, Wszolek ZK
Orphanet J Rare Dis 2023 Jun 22;18(1):160. doi: 10.1186/s13023-023-02772-9. PMID: 37349768Free PMC Article
Sudden hearing loss as an early detector of multiple sclerosis: a systematic review.
Di Stadio A, Dipietro L, Ralli M, Meneghello F, Minni A, Greco A, Stabile MR, Bernitsas E
Eur Rev Med Pharmacol Sci 2018 Jul;22(14):4611-4624. doi: 10.26355/eurrev_201807_15520. PMID: 30058696
Neuroinflammation and white matter pathology in schizophrenia: systematic review.
Najjar S, Pearlman DM
Schizophr Res 2015 Jan;161(1):102-12. Epub 2014 Jun 16 doi: 10.1016/j.schres.2014.04.041. PMID: 24948485

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