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Abnormal oligodendroglia morphology

MedGen UID:
867606
•Concept ID:
C4021992
•
Finding
Synonym: Abnormality of the oligodendroglia
 
HPO: HP:0100706

Definition

One of the three types of glia cells that, with the nerve cells, compose the central nervous system and are characterized by sheetlike processes that wrap around individual axons to form the myelin sheath of nerve fibers. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal oligodendroglia morphology

Professional guidelines

PubMed

Intranasal epidermal growth factor treatment rescues neonatal brain injury.
Scafidi J, Hammond TR, Scafidi S, Ritter J, Jablonska B, Roncal M, Szigeti-Buck K, Coman D, Huang Y, McCarter RJ Jr, Hyder F, Horvath TL, Gallo V
Nature 2014 Feb 13;506(7487):230-4. Epub 2013 Dec 25 doi: 10.1038/nature12880. PMID: 24390343Free PMC Article
Quetiapine fumarate for the treatment of multiple sclerosis: focus on myelin repair.
Zhornitsky S, Wee Yong V, Koch MW, Mackie A, Potvin S, Patten SB, Metz LM
CNS Neurosci Ther 2013 Oct;19(10):737-44. Epub 2013 Jul 22 doi: 10.1111/cns.12154. PMID: 23870612Free PMC Article
Inflammatory demyelinating neuropathies and neuropathies associated with monoclonal gammopathies: treatment update.
Steck AJ, Czaplinski A, Renaud S
Neurotherapeutics 2008 Oct;5(4):528-34. doi: 10.1016/j.nurt.2008.08.012. PMID: 19019303Free PMC Article

Recent clinical studies

Etiology

Stress-Induced Metabolic Disorder in Peripheral CD4(+) T Cells Leads to Anxiety-like Behavior.
Fan KQ, Li YY, Wang HL, Mao XT, Guo JX, Wang F, Huang LJ, Li YN, Ma XY, Gao ZJ, Chen W, Qian DD, Xue WJ, Cao Q, Zhang L, Shen L, Zhang L, Tong C, Zhong JY, Lu W, Lu L, Ren KM, Zhong G, Wang Y, Tang M, Feng XH, Chai RJ, Jin J
Cell 2019 Oct 31;179(4):864-879.e19. doi: 10.1016/j.cell.2019.10.001. PMID: 31675497
White matter changes in Alzheimer's disease: a focus on myelin and oligodendrocytes.
Nasrabady SE, Rizvi B, Goldman JE, Brickman AM
Acta Neuropathol Commun 2018 Mar 2;6(1):22. doi: 10.1186/s40478-018-0515-3. PMID: 29499767Free PMC Article
Myelin, myelin-related disorders, and psychosis.
Mighdoll MI, Tao R, Kleinman JE, Hyde TM
Schizophr Res 2015 Jan;161(1):85-93. Epub 2014 Oct 23 doi: 10.1016/j.schres.2014.09.040. PMID: 25449713
Models of multiple system atrophy.
Fellner L, Wenning GK, Stefanova N
Curr Top Behav Neurosci 2015;22:369-93. doi: 10.1007/7854_2013_269. PMID: 24338664Free PMC Article
Neuropathological spectrum of synucleinopathies.
Jellinger KA
Mov Disord 2003 Sep;18 Suppl 6:S2-12. doi: 10.1002/mds.10557. PMID: 14502650

Diagnosis

Leukodystrophy: Basic and Clinical.
Raymond GV
Adv Neurobiol 2017;15:365-382. doi: 10.1007/978-3-319-57193-5_14. PMID: 28674989
Non-vision adverse events with vigabatrin therapy.
Walker SD, Kälviäinen R
Acta Neurol Scand Suppl 2011;(192):72-82. doi: 10.1111/j.1600-0404.2011.01602.x. PMID: 22061182
Neuropathological spectrum of synucleinopathies.
Jellinger KA
Mov Disord 2003 Sep;18 Suppl 6:S2-12. doi: 10.1002/mds.10557. PMID: 14502650
Pelizaeus-Merzbacher disease.
Koeppen AH, Robitaille Y
J Neuropathol Exp Neurol 2002 Sep;61(9):747-59. doi: 10.1093/jnen/61.9.747. PMID: 12230321
Imaging of remyelination.
Barkhof F
Mult Scler 1997 Apr;3(2):129-32. doi: 10.1177/135245859700300212. PMID: 9291166

Therapy

Drug-Induced Demyelinating Neuropathies.
Niimi N, Takaku S, Yako H, Sango K
Adv Exp Med Biol 2019;1190:357-369. doi: 10.1007/978-981-32-9636-7_23. PMID: 31760656
The Emerging Role of Zinc in the Pathogenesis of Multiple Sclerosis.
Choi BY, Jung JW, Suh SW
Int J Mol Sci 2017 Sep 28;18(10) doi: 10.3390/ijms18102070. PMID: 28956834Free PMC Article
Novel therapeutic approaches in multiple system atrophy.
Palma JA, Kaufmann H
Clin Auton Res 2015 Feb;25(1):37-45. Epub 2014 Jun 14 doi: 10.1007/s10286-014-0249-7. PMID: 24928797Free PMC Article
Non-vision adverse events with vigabatrin therapy.
Walker SD, Kälviäinen R
Acta Neurol Scand Suppl 2011;(192):72-82. doi: 10.1111/j.1600-0404.2011.01602.x. PMID: 22061182
Molecular mechanisms of inherited demyelinating neuropathies.
Scherer SS, Wrabetz L
Glia 2008 Nov 1;56(14):1578-1589. doi: 10.1002/glia.20751. PMID: 18803325Free PMC Article

Prognosis

Ethanol-mediated alterations in oligodendrocyte differentiation in the developing brain.
Darbinian N, Darbinyan A, Merabova N, Bajwa A, Tatevosian G, Martirosyan D, Zhao H, Selzer ME, Goetzl L
Neurobiol Dis 2021 Jan;148:105181. Epub 2020 Nov 13 doi: 10.1016/j.nbd.2020.105181. PMID: 33189883Free PMC Article
Are PrP(C)s involved in some human myelin diseases? Relating experimental studies to human pathology.
Veber D, Scalabrino G
J Neurol Sci 2015 Dec 15;359(1-2):396-403. Epub 2015 Oct 23 doi: 10.1016/j.jns.2015.09.365. PMID: 26478128
One hundred and one dysembryoplastic neuroepithelial tumors: an adult epilepsy series with immunohistochemical, molecular genetic, and clinical correlations and a review of the literature.
Thom M, Toma A, An S, Martinian L, Hadjivassiliou G, Ratilal B, Dean A, McEvoy A, Sisodiya SM, Brandner S
J Neuropathol Exp Neurol 2011 Oct;70(10):859-78. doi: 10.1097/NEN.0b013e3182302475. PMID: 21937911
Cytokines and myelination in the central nervous system.
Schmitz T, Chew LJ
ScientificWorldJournal 2008 Nov 2;8:1119-47. doi: 10.1100/tsw.2008.140. PMID: 18979053Free PMC Article
Multiple sclerosis: neuroimmunologic puzzle.
Barna BP
Clin Lab Med 1986 Mar;6(1):103-16. doi: 10.1016/S0272-2712(18)30828-X. PMID: 3514094Free PMC Article

Clinical prediction guides

Infantile status epilepticus disrupts myelin development.
Bencurova P, Laakso H, Salo RA, Paasonen E, Manninen E, Paasonen J, Michaeli S, Mangia S, Bares M, Brazdil M, Kubova H, Gröhn O
Neurobiol Dis 2022 Jan;162:105566. Epub 2021 Nov 24 doi: 10.1016/j.nbd.2021.105566. PMID: 34838665Free PMC Article
Defective Oligodendroglial Lineage and Demyelination in Amyotrophic Lateral Sclerosis.
Traiffort E, Morisset-Lopez S, Moussaed M, Zahaf A
Int J Mol Sci 2021 Mar 26;22(7) doi: 10.3390/ijms22073426. PMID: 33810425Free PMC Article
Central nervous system diseases related to pathological microglial phagocytosis.
Wang K, Li J, Zhang Y, Huang Y, Chen D, Shi Z, Smith AD, Li W, Gao Y
CNS Neurosci Ther 2021 May;27(5):528-539. Epub 2021 Mar 2 doi: 10.1111/cns.13619. PMID: 33650762Free PMC Article
The Relevance of Iron in the Pathogenesis of Multiple System Atrophy: A Viewpoint.
Kaindlstorfer C, Jellinger KA, Eschlböck S, Stefanova N, Weiss G, Wenning GK
J Alzheimers Dis 2018;61(4):1253-1273. doi: 10.3233/JAD-170601. PMID: 29376857Free PMC Article
The Emerging Role of Zinc in the Pathogenesis of Multiple Sclerosis.
Choi BY, Jung JW, Suh SW
Int J Mol Sci 2017 Sep 28;18(10) doi: 10.3390/ijms18102070. PMID: 28956834Free PMC Article

Recent systematic reviews

Neuroinflammation and white matter pathology in schizophrenia: systematic review.
Najjar S, Pearlman DM
Schizophr Res 2015 Jan;161(1):102-12. Epub 2014 Jun 16 doi: 10.1016/j.schres.2014.04.041. PMID: 24948485

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