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Absence of memory B cells

MedGen UID:
868167
•Concept ID:
C4022559
•
Finding
HPO: HP:0030251

Definition

Complete lack of memory B cells, that is, of mature B cell type that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbsence of memory B cells

Professional guidelines

PubMed

Aberrant B-cell activation and B-cell subpopulations in rheumatoid arthritis: analysis by clinical activity, autoantibody seropositivity, and treatment.
Morales-Núñez JJ, Muñoz-Valle JF, García-Chagollán M, Cerpa-Cruz S, Martínez-Bonilla GE, Medina-Rosales VM, Díaz-Pérez SA, Nicoletti F, Hernández-Bello J
Clin Exp Immunol 2023 Dec 13;214(3):314-327. doi: 10.1093/cei/uxad076. PMID: 37464892Free PMC Article
Clinical impact and a prognostic marker of early rituximab treatment after rituximab reimbursement in Korean pemphigus patients.
Song A, Jang J, Lee A, Min SY, Lee SG, Kim SC, Shin J, Kim JH
Front Immunol 2022;13:932909. Epub 2022 Aug 2 doi: 10.3389/fimmu.2022.932909. PMID: 35983042Free PMC Article
Diagnosis and prognosis models for hepatocellular carcinoma patient's management based on tumor mutation burden.
Tang B, Zhu J, Zhao Z, Lu C, Liu S, Fang S, Zheng L, Zhang N, Chen M, Xu M, Yu R, Ji J
J Adv Res 2021 Nov;33:153-165. Epub 2021 Feb 9 doi: 10.1016/j.jare.2021.01.018. PMID: 34603786Free PMC Article

Recent clinical studies

Etiology

ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis.
Barisic D, Chin CR, Meydan C, Teater M, Tsialta I, Mlynarczyk C, Chadburn A, Wang X, Sarkozy M, Xia M, Carson SE, Raggiri S, Debek S, Pelzer B, Durmaz C, Deng Q, Lakra P, Rivas M, Steidl C, Scott DW, Weng AP, Mason CE, Green MR, Melnick A
Cancer Cell 2024 Apr 8;42(4):583-604.e11. Epub 2024 Mar 7 doi: 10.1016/j.ccell.2024.02.010. PMID: 38458187Free PMC Article
Integrative single-cell transcriptomic analyses reveal the cellular ontological and functional heterogeneities of primary and metastatic liver tumors.
Gui M, Huang S, Li S, Chen Y, Cheng F, Liu Y, Wang JA, Wang Y, Guo R, Lu Y, Cao P, Zhou G
J Transl Med 2024 Feb 27;22(1):206. doi: 10.1186/s12967-024-04947-9. PMID: 38414027Free PMC Article
The immune factors have complex causal regulation effects on bone mineral density.
Cao RR, Yu XH, Xiong MF, Li XT, Deng FY, Lei SF
Front Immunol 2022;13:959417. Epub 2022 Oct 20 doi: 10.3389/fimmu.2022.959417. PMID: 36341399Free PMC Article
Asplenia and spleen hypofunction.
Lenti MV, Luu S, Carsetti R, Osier F, Ogwang R, Nnodu OE, Wiedermann U, Spencer J, Locatelli F, Corazza GR, Di Sabatino A
Nat Rev Dis Primers 2022 Nov 3;8(1):71. doi: 10.1038/s41572-022-00399-x. PMID: 36329079
The Multifaceted Roles of B Cells in the Thymus: From Immune Tolerance to Autoimmunity.
Castañeda J, Hidalgo Y, Sauma D, Rosemblatt M, Bono MR, Núñez S
Front Immunol 2021;12:766698. Epub 2021 Nov 1 doi: 10.3389/fimmu.2021.766698. PMID: 34790201Free PMC Article

Diagnosis

Crosstalk between septic shock and venous thromboembolism: a bioinformatics and immunoassay analysis.
Li Z, Wang C, Zhang X, Xu X, Wang M, Dong L
Front Cell Infect Microbiol 2023;13:1235269. Epub 2023 Nov 9 doi: 10.3389/fcimb.2023.1235269. PMID: 38029239Free PMC Article
Monoclonal antibodies constructed from COVID-19 convalescent memory B cells exhibit potent binding activity to MERS-CoV spike S2 subunit and other human coronaviruses.
Peng Y, Liu Y, Hu Y, Chang F, Wu Q, Yang J, Chen J, Teng S, Zhang J, He R, Wei Y, Bostina M, Luo T, Liu W, Qu X, Li YP
Front Immunol 2022;13:1056272. Epub 2022 Dec 22 doi: 10.3389/fimmu.2022.1056272. PMID: 36618428Free PMC Article
The immune factors have complex causal regulation effects on bone mineral density.
Cao RR, Yu XH, Xiong MF, Li XT, Deng FY, Lei SF
Front Immunol 2022;13:959417. Epub 2022 Oct 20 doi: 10.3389/fimmu.2022.959417. PMID: 36341399Free PMC Article
Asplenia and spleen hypofunction.
Lenti MV, Luu S, Carsetti R, Osier F, Ogwang R, Nnodu OE, Wiedermann U, Spencer J, Locatelli F, Corazza GR, Di Sabatino A
Nat Rev Dis Primers 2022 Nov 3;8(1):71. doi: 10.1038/s41572-022-00399-x. PMID: 36329079
Machine-Learning Algorithm-Based Prediction of Diagnostic Gene Biomarkers Related to Immune Infiltration in Patients With Chronic Obstructive Pulmonary Disease.
Zhang Y, Xia R, Lv M, Li Z, Jin L, Chen X, Han Y, Shi C, Jiang Y, Jin S
Front Immunol 2022;13:740513. Epub 2022 Mar 8 doi: 10.3389/fimmu.2022.740513. PMID: 35350787Free PMC Article

Therapy

The immune factors have complex causal regulation effects on bone mineral density.
Cao RR, Yu XH, Xiong MF, Li XT, Deng FY, Lei SF
Front Immunol 2022;13:959417. Epub 2022 Oct 20 doi: 10.3389/fimmu.2022.959417. PMID: 36341399Free PMC Article
Asplenia and spleen hypofunction.
Lenti MV, Luu S, Carsetti R, Osier F, Ogwang R, Nnodu OE, Wiedermann U, Spencer J, Locatelli F, Corazza GR, Di Sabatino A
Nat Rev Dis Primers 2022 Nov 3;8(1):71. doi: 10.1038/s41572-022-00399-x. PMID: 36329079
Pulmonary-Resident Memory Lymphocytes: Pivotal Orchestrators of Local Immunity Against Respiratory Infections.
Humphries DC, O'Connor RA, Larocque D, Chabaud-Riou M, Dhaliwal K, Pavot V
Front Immunol 2021;12:738955. Epub 2021 Sep 17 doi: 10.3389/fimmu.2021.738955. PMID: 34603321Free PMC Article
Evolution of Human Memory B Cells From Childhood to Old Age.
Ciocca M, Zaffina S, Fernandez Salinas A, Bocci C, Palomba P, Conti MG, Terreri S, Frisullo G, Giorda E, Scarsella M, Brugaletta R, Vinci MR, Magnavita N, Carsetti R, Piano Mortari E
Front Immunol 2021;12:690534. Epub 2021 Jul 23 doi: 10.3389/fimmu.2021.690534. PMID: 34367150Free PMC Article
Memory B Cells in Multiple Sclerosis: Emerging Players in Disease Pathogenesis.
DiSano KD, Gilli F, Pachner AR
Front Immunol 2021;12:676686. Epub 2021 Jun 8 doi: 10.3389/fimmu.2021.676686. PMID: 34168647Free PMC Article

Prognosis

Integrative single-cell transcriptomic analyses reveal the cellular ontological and functional heterogeneities of primary and metastatic liver tumors.
Gui M, Huang S, Li S, Chen Y, Cheng F, Liu Y, Wang JA, Wang Y, Guo R, Lu Y, Cao P, Zhou G
J Transl Med 2024 Feb 27;22(1):206. doi: 10.1186/s12967-024-04947-9. PMID: 38414027Free PMC Article
Immunosuppressive landscape in hepatocellular carcinoma revealed by single-cell sequencing.
Bai Y, Chen D, Cheng C, Li Z, Chi H, Zhang Y, Zhang X, Tang S, Zhao Q, Ang B, Zhang Y
Front Immunol 2022;13:950536. Epub 2022 Jul 28 doi: 10.3389/fimmu.2022.950536. PMID: 35967424Free PMC Article
Role of IgM Memory B Cells and Spleen Function in COVID-19.
Rossi CM, Lenti MV, Merli S, Di Sabatino A
Front Immunol 2022;13:889876. Epub 2022 Jun 30 doi: 10.3389/fimmu.2022.889876. PMID: 35844543Free PMC Article
Machine-Learning Algorithm-Based Prediction of Diagnostic Gene Biomarkers Related to Immune Infiltration in Patients With Chronic Obstructive Pulmonary Disease.
Zhang Y, Xia R, Lv M, Li Z, Jin L, Chen X, Han Y, Shi C, Jiang Y, Jin S
Front Immunol 2022;13:740513. Epub 2022 Mar 8 doi: 10.3389/fimmu.2022.740513. PMID: 35350787Free PMC Article
Memory B Cells in Pregnancy Sensitization.
Nellore A, Killian JT Jr, Porrett PM
Front Immunol 2021;12:688987. Epub 2021 Jun 30 doi: 10.3389/fimmu.2021.688987. PMID: 34276679Free PMC Article

Clinical prediction guides

ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis.
Barisic D, Chin CR, Meydan C, Teater M, Tsialta I, Mlynarczyk C, Chadburn A, Wang X, Sarkozy M, Xia M, Carson SE, Raggiri S, Debek S, Pelzer B, Durmaz C, Deng Q, Lakra P, Rivas M, Steidl C, Scott DW, Weng AP, Mason CE, Green MR, Melnick A
Cancer Cell 2024 Apr 8;42(4):583-604.e11. Epub 2024 Mar 7 doi: 10.1016/j.ccell.2024.02.010. PMID: 38458187Free PMC Article
Single-cell transcriptomics reveals peripheral immune responses in non-segmental vitiligo.
Yang P, Luan M, Li W, Niu M, He Q, Zhao Y, Chen J, Mao B, Mou K, Li P
Front Immunol 2023;14:1221260. Epub 2023 Nov 22 doi: 10.3389/fimmu.2023.1221260. PMID: 38077333Free PMC Article
The immune factors have complex causal regulation effects on bone mineral density.
Cao RR, Yu XH, Xiong MF, Li XT, Deng FY, Lei SF
Front Immunol 2022;13:959417. Epub 2022 Oct 20 doi: 10.3389/fimmu.2022.959417. PMID: 36341399Free PMC Article
Role of IgM Memory B Cells and Spleen Function in COVID-19.
Rossi CM, Lenti MV, Merli S, Di Sabatino A
Front Immunol 2022;13:889876. Epub 2022 Jun 30 doi: 10.3389/fimmu.2022.889876. PMID: 35844543Free PMC Article
Machine-Learning Algorithm-Based Prediction of Diagnostic Gene Biomarkers Related to Immune Infiltration in Patients With Chronic Obstructive Pulmonary Disease.
Zhang Y, Xia R, Lv M, Li Z, Jin L, Chen X, Han Y, Shi C, Jiang Y, Jin S
Front Immunol 2022;13:740513. Epub 2022 Mar 8 doi: 10.3389/fimmu.2022.740513. PMID: 35350787Free PMC Article

Recent systematic reviews

B-Cell Immunophenotyping to Predict Vaccination Outcome in the Immunocompromised - A Systematic Review.
Diks AM, Overduin LA, van Leenen LD, Slobbe L, Jolink H, Visser LG, van Dongen JJM, Berkowska MA
Front Immunol 2021;12:690328. Epub 2021 Sep 7 doi: 10.3389/fimmu.2021.690328. PMID: 34557188Free PMC Article

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