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Functional abnormality of the gastrointestinal tract

MedGen UID:
868361
•Concept ID:
C4022755
•
Pathologic Function
Synonyms: Functional abnormality of the GI tract; GI dysfunction
 
HPO: HP:0012719

Definition

Abnormal functionality of the gastrointestinal tract. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFunctional abnormality of the gastrointestinal tract

Professional guidelines

PubMed

The Role of Probiotics and Their Metabolites in the Treatment of Depression.
Jach ME, Serefko A, Szopa A, Sajnaga E, Golczyk H, Santos LS, Borowicz-Reutt K, Sieniawska E
Molecules 2023 Apr 4;28(7) doi: 10.3390/molecules28073213. PMID: 37049975Free PMC Article
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066
Management Options for Irritable Bowel Syndrome.
Camilleri M
Mayo Clin Proc 2018 Dec;93(12):1858-1872. doi: 10.1016/j.mayocp.2018.04.032. PMID: 30522596Free PMC Article

Recent clinical studies

Etiology

The science of Hirschsprung disease: What we know and where we are headed.
Mueller JL, Goldstein AM
Semin Pediatr Surg 2022 Apr;31(2):151157. Epub 2022 Apr 18 doi: 10.1016/j.sempedsurg.2022.151157. PMID: 35690468
Abdominal Wall Defects.
Slater BJ, Pimpalwar A
Neoreviews 2020 Jun;21(6):e383-e391. doi: 10.1542/neo.21-6-e383. PMID: 32482700
Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression.
Israelyan N, Del Colle A, Li Z, Park Y, Xing A, Jacobsen JPR, Luna RA, Jensen DD, Madra M, Saurman V, Rahim R, Latorre R, Law K, Carson W, Bunnett NW, Caron MG, Margolis KG
Gastroenterology 2019 Aug;157(2):507-521.e4. Epub 2019 May 7 doi: 10.1053/j.gastro.2019.04.022. PMID: 31071306Free PMC Article
Rethinking "posterior" tongue-tie.
Douglas PS
Breastfeed Med 2013 Dec;8(6):503-6. Epub 2013 Oct 21 doi: 10.1089/bfm.2013.0103. PMID: 24143939
Side effects of long-term glutamine supplementation.
Holecek M
JPEN J Parenter Enteral Nutr 2013 Sep;37(5):607-16. Epub 2012 Sep 18 doi: 10.1177/0148607112460682. PMID: 22990615

Diagnosis

Intestinal Atresias.
Rich BS, Bornstein E, Dolgin SE
Pediatr Rev 2022 May 1;43(5):266-274. doi: 10.1542/pir.2021-005177. PMID: 35490204
Diagnosis of Hirschsprung Disease.
Ambartsumyan L, Smith C, Kapur RP
Pediatr Dev Pathol 2020 Jan-Feb;23(1):8-22. Epub 2019 Dec 2 doi: 10.1177/1093526619892351. PMID: 31791203
The developmental etiology and pathogenesis of Hirschsprung disease.
Butler Tjaden NE, Trainor PA
Transl Res 2013 Jul;162(1):1-15. Epub 2013 Mar 22 doi: 10.1016/j.trsl.2013.03.001. PMID: 23528997Free PMC Article
VACTERL/VATER Association.
Solomon BD
Orphanet J Rare Dis 2011 Aug 16;6:56. doi: 10.1186/1750-1172-6-56. PMID: 21846383Free PMC Article
Gastrointestinal system.
Cheng LK, O'Grady G, Du P, Egbuji JU, Windsor JA, Pullan AJ
Wiley Interdiscip Rev Syst Biol Med 2010 Jan-Feb;2(1):65-79. doi: 10.1002/wsbm.19. PMID: 20836011Free PMC Article

Therapy

Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota.
Kang DW, Adams JB, Coleman DM, Pollard EL, Maldonado J, McDonough-Means S, Caporaso JG, Krajmalnik-Brown R
Sci Rep 2019 Apr 9;9(1):5821. doi: 10.1038/s41598-019-42183-0. PMID: 30967657Free PMC Article
Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study.
Kang DW, Adams JB, Gregory AC, Borody T, Chittick L, Fasano A, Khoruts A, Geis E, Maldonado J, McDonough-Means S, Pollard EL, Roux S, Sadowsky MJ, Lipson KS, Sullivan MB, Caporaso JG, Krajmalnik-Brown R
Microbiome 2017 Jan 23;5(1):10. doi: 10.1186/s40168-016-0225-7. PMID: 28122648Free PMC Article
Artificial sweeteners induce glucose intolerance by altering the gut microbiota.
Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y, Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E
Nature 2014 Oct 9;514(7521):181-6. Epub 2014 Sep 17 doi: 10.1038/nature13793. PMID: 25231862
Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.
Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH, Mazmanian SK
Cell 2013 Dec 19;155(7):1451-63. Epub 2013 Dec 5 doi: 10.1016/j.cell.2013.11.024. PMID: 24315484Free PMC Article
Side effects of long-term glutamine supplementation.
Holecek M
JPEN J Parenter Enteral Nutr 2013 Sep;37(5):607-16. Epub 2012 Sep 18 doi: 10.1177/0148607112460682. PMID: 22990615

Prognosis

Abdominal Wall Defects.
Slater BJ, Pimpalwar A
Neoreviews 2020 Jun;21(6):e383-e391. doi: 10.1542/neo.21-6-e383. PMID: 32482700
Diagnosis of Hirschsprung Disease.
Ambartsumyan L, Smith C, Kapur RP
Pediatr Dev Pathol 2020 Jan-Feb;23(1):8-22. Epub 2019 Dec 2 doi: 10.1177/1093526619892351. PMID: 31791203
Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota.
Kang DW, Adams JB, Coleman DM, Pollard EL, Maldonado J, McDonough-Means S, Caporaso JG, Krajmalnik-Brown R
Sci Rep 2019 Apr 9;9(1):5821. doi: 10.1038/s41598-019-42183-0. PMID: 30967657Free PMC Article
VACTERL/VATER Association.
Solomon BD
Orphanet J Rare Dis 2011 Aug 16;6:56. doi: 10.1186/1750-1172-6-56. PMID: 21846383Free PMC Article
Anorectal malformations.
Levitt MA, Peña A
Orphanet J Rare Dis 2007 Jul 26;2:33. doi: 10.1186/1750-1172-2-33. PMID: 17651510Free PMC Article

Clinical prediction guides

Gastroparesis.
Camilleri M, Sanders KM
Gastroenterology 2022 Jan;162(1):68-87.e1. Epub 2021 Oct 27 doi: 10.1053/j.gastro.2021.10.028. PMID: 34717924Free PMC Article
Currarino syndrome: a comprehensive genetic review of a rare congenital disorder.
Dworschak GC, Reutter HM, Ludwig M
Orphanet J Rare Dis 2021 Apr 9;16(1):167. doi: 10.1186/s13023-021-01799-0. PMID: 33836786Free PMC Article
Gut-liver crosstalk in sepsis-induced liver injury.
Sun J, Zhang J, Wang X, Ji F, Ronco C, Tian J, Yin Y
Crit Care 2020 Oct 19;24(1):614. doi: 10.1186/s13054-020-03327-1. PMID: 33076940Free PMC Article
Diagnosis of Hirschsprung Disease.
Ambartsumyan L, Smith C, Kapur RP
Pediatr Dev Pathol 2020 Jan-Feb;23(1):8-22. Epub 2019 Dec 2 doi: 10.1177/1093526619892351. PMID: 31791203
Hirschsprung's associated enterocolitis.
Gosain A, Brinkman AS
Curr Opin Pediatr 2015 Jun;27(3):364-9. doi: 10.1097/MOP.0000000000000210. PMID: 25944307Free PMC Article

Recent systematic reviews

Breathing Exercises in Gastroesophageal Reflux Disease: A Systematic Review.
Zdrhova L, Bitnar P, Balihar K, Kolar P, Madle K, Martinek M, Pandolfino JE, Martinek J
Dysphagia 2023 Apr;38(2):609-621. Epub 2022 Jul 16 doi: 10.1007/s00455-022-10494-6. PMID: 35842548Free PMC Article
Hypermobile Ehlers-Danlos syndrome and disorders of the gastrointestinal tract: What the gastroenterologist needs to know.
Thwaites PA, Gibson PR, Burgell RE
J Gastroenterol Hepatol 2022 Sep;37(9):1693-1709. Epub 2022 Jul 20 doi: 10.1111/jgh.15927. PMID: 35750466Free PMC Article
The global prevalence of oropharyngeal dysphagia in different populations: a systematic review and meta-analysis.
Rajati F, Ahmadi N, Naghibzadeh ZA, Kazeminia M
J Transl Med 2022 Apr 11;20(1):175. doi: 10.1186/s12967-022-03380-0. PMID: 35410274Free PMC Article
Impact of fetal alcohol exposure on body systems: A systematic review.
Caputo C, Wood E, Jabbour L
Birth Defects Res C Embryo Today 2016 Jun;108(2):174-80. Epub 2016 Jun 13 doi: 10.1002/bdrc.21129. PMID: 27297122
Achalasia: a systematic review.
Pandolfino JE, Gawron AJ
JAMA 2015 May 12;313(18):1841-52. doi: 10.1001/jama.2015.2996. PMID: 25965233

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