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Abnormality of the distal phalanges of the toes

MedGen UID:: 869554
•Concept ID:: C4023982
•: Anatomical Abnormality

Synonym:	Abnormality of the outermost bone of the toes

HPO:	HP:0010182

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormality of the distal phalanges of the toes

Abnormality of limbs
- Abnormality of limb bone
  - Abnormal limb bone morphology
    - Abnormal digit morphology
      - Abnormal toe morphology
        Abnormal toe phalanx morphology
        Abnormality of the distal phalanges of the toes
        Abnormality of the distal phalanx of the 5th toe
        Aplasia/Hypoplasia of the distal phalanx of the 5th toe
        Aplasia of the distal phalanx of the 5th toe
        Short distal phalanx of the 5th toe
        Broad distal phalanx of the 5th toe
        Curved distal phalanx of the 5th toe
        Duplication of the distal phalanx of the 5th toe
        Complete duplication of the distal phalanx of the 5th toe
        Partial duplication of the distal phalanx of the 5th toe
        Abnormality of the distal phalanx of the hallux
        Broad distal phalanx of the toes
        Broad distal phalanx of the hallux
        Bullet-shaped distal toe phalanx
        Bullet-shaped distal phalanx of the hallux
        Curved distal toe phalanx
        Curved distal phalanx of the hallux
        Duplication of distal phalanx of toe
        Duplication of the distal phalanx of the hallux
        Osteolytic defects of the distal phalanges of the toes
        Acroosteolysis of distal phalanges (feet)
        Osteolytic defects of the distal phalanx of the hallux
        Symphalangism affecting the distal phalanges of the toes
        Symphalangism affecting the distal phalanx of the hallux
        Triangular shaped distal phalanges of the toes
        Triangular shaped distal phalanx of the hallux

Professional guidelines

PubMed

The Use of Biologic Therapy in the Treatment of Acrodermatitis Continua of Hallopeau: A Review.

Maliyar K, Crowley EL, Rodriguez-Bolanos F, O'Toole A, Gooderham MJ
J Cutan Med Surg 2019 Jul/Aug;23(4):428-435. Epub 2019 Apr 2 doi: 10.1177/1203475419836435. PMID: 30938189

Clinical study of treatment for recalcitrant ingrown toenail by partial distal phalanx removal.

Li J, Chen J, Hong G, Chen Z, Weng Y, Wang F
J Plast Reconstr Aesthet Surg 2009 Oct;62(10):1327-30. Epub 2008 Aug 3 doi: 10.1016/j.bjps.2008.05.010. PMID: 18678536

Prenatal sonographic diagnosis of Aarskog syndrome.

Sepulveda W, Dezerega V, Horvath E, Aracena M
J Ultrasound Med 1999 Oct;18(10):707-10. doi: 10.7863/jum.1999.18.10.707. PMID: 10511304

See all (3)

Recent clinical studies

Etiology

Midterm and Long-term Follow-up After Surgical Reconstruction for Lateral Polydactyly of the Foot With Mosaic-like Alignment of the Phalanx Bones.

Iba K, Ozasa Y, Hanaka M, Hayakawa H, Kanaya K, Yamashita T
J Pediatr Orthop 2020 Jan;40(1):e30-e36. doi: 10.1097/BPO.0000000000001381. PMID: 30950938

The spectrum of preaxial polydactyly of the foot.

Belthur MV, Linton JL, Barnes DA
J Pediatr Orthop 2011 Jun;31(4):435-47. doi: 10.1097/BPO.0b013e3182199a68. PMID: 21572282

Polydactyly of the foot. Literature review and case presentations.

Galois L, Mainard D, Delagoutte JP
Acta Orthop Belg 2002 Oct;68(4):376-80. PMID: 12415940

Prenatal sonographic diagnosis of Aarskog syndrome.

Sepulveda W, Dezerega V, Horvath E, Aracena M
J Ultrasound Med 1999 Oct;18(10):707-10. doi: 10.7863/jum.1999.18.10.707. PMID: 10511304

Idiopathic phalangeal osteolysis.

Todd G, Saxe N
Arch Dermatol 1994 Jun;130(6):759-62. PMID: 8002647

See all (20)

Diagnosis

Hypothesis: Symbrachydactyly.

Holmes LB, Nasri HZ
Am J Med Genet A 2022 Nov;188(11):3236-3241. Epub 2022 Sep 8 doi: 10.1002/ajmg.a.62941. PMID: 36073773

Hypothesis: Central digit hypoplasia.

Holmes LB, Nasri HZ
Am J Med Genet A 2022 Jun;188(6):1746-1751. Epub 2022 Mar 2 doi: 10.1002/ajmg.a.62697. PMID: 35234329

The Use of Biologic Therapy in the Treatment of Acrodermatitis Continua of Hallopeau: A Review.

Maliyar K, Crowley EL, Rodriguez-Bolanos F, O'Toole A, Gooderham MJ
J Cutan Med Surg 2019 Jul/Aug;23(4):428-435. Epub 2019 Apr 2 doi: 10.1177/1203475419836435. PMID: 30938189

Variant of Coffin-Siris syndrome or previously undescribed syndrome?

Braun-Quentin C, Kapferer L, Kotzot D
Am J Med Genet 1996 Sep 6;64(4):568-72. doi: 10.1002/(SICI)1096-8628(19960906)64:4<568::AID-AJMG8>3.0.CO;2-L. PMID: 8870924

Brachymorphism-onychodysplasia-dysphalangism syndrome.

Verloes A, Bonneau D, Guidi O, Berthier M, Oriot D, Van Maldergem L, Koulischer L
J Med Genet 1993 Feb;30(2):158-61. doi: 10.1136/jmg.30.2.158. PMID: 8445623 Free PMC Article

See all (43)

Therapy

Midterm and Long-term Follow-up After Surgical Reconstruction for Lateral Polydactyly of the Foot With Mosaic-like Alignment of the Phalanx Bones.

Iba K, Ozasa Y, Hanaka M, Hayakawa H, Kanaya K, Yamashita T
J Pediatr Orthop 2020 Jan;40(1):e30-e36. doi: 10.1097/BPO.0000000000001381. PMID: 30950938

The Use of Biologic Therapy in the Treatment of Acrodermatitis Continua of Hallopeau: A Review.

Maliyar K, Crowley EL, Rodriguez-Bolanos F, O'Toole A, Gooderham MJ
J Cutan Med Surg 2019 Jul/Aug;23(4):428-435. Epub 2019 Apr 2 doi: 10.1177/1203475419836435. PMID: 30938189

Acrodermatitis continua of Hallopeau (ACH): two cases successfully treated with adalimumab.

Di Costanzo L, Napolitano M, Patruno C, Cantelli M, Balato N
J Dermatolog Treat 2014 Dec;25(6):489-94. Epub 2013 Nov 12 doi: 10.3109/09546634.2013.848259. PMID: 24215490

Treatment of acrodermatitis continua of Hallopeau with TNF-blocking agents: case report and review.

Puig L, Barco D, Vilarrasa E, Alomar A
Dermatology 2010;220(2):154-8. Epub 2010 Jan 26 doi: 10.1159/000277415. PMID: 20110631

Deformities of the smaller toes and surgical treatment.

Turan I
J Foot Surg 1990 Mar-Apr;29(2):176-8. PMID: 2338477

See all (10)

Prognosis

The spectrum of preaxial polydactyly of the foot.

Belthur MV, Linton JL, Barnes DA
J Pediatr Orthop 2011 Jun;31(4):435-47. doi: 10.1097/BPO.0b013e3182199a68. PMID: 21572282

Treatment of acrodermatitis continua of Hallopeau with TNF-blocking agents: case report and review.

Puig L, Barco D, Vilarrasa E, Alomar A
Dermatology 2010;220(2):154-8. Epub 2010 Jan 26 doi: 10.1159/000277415. PMID: 20110631

Mandibuloacral dysplasia type A in childhood.

Garavelli L, D'Apice MR, Rivieri F, Bertoli M, Wischmeijer A, Gelmini C, De Nigris V, Albertini E, Rosato S, Virdis R, Bacchini E, Dal Zotto R, Banchini G, Iughetti L, Bernasconi S, Superti-Furga A, Novelli G
Am J Med Genet A 2009 Oct;149A(10):2258-64. doi: 10.1002/ajmg.a.33005. PMID: 19764019

Polydactyly of the foot. Literature review and case presentations.

Galois L, Mainard D, Delagoutte JP
Acta Orthop Belg 2002 Oct;68(4):376-80. PMID: 12415940

Symphalangism (two phalanges) in the digits of the Japanese foot.

Nakashima T, Hojo T, Suzuki K, Ijichi M
Ann Anat 1995 May;177(3):275-8. doi: 10.1016/S0940-9602(11)80199-8. PMID: 7598223

See all (22)

Clinical prediction guides

Unilateral clubbing-like digital thickening as a clinical manifestation of low-flow vascular malformations: a series of 13 cases.

García-Souto F, López-Gutiérrez JC, Narváez-Moreno B, Fernández-Pineda I, Bernabéu-Wittel J
Int J Dermatol 2021 Oct;60(10):1248-1252. Epub 2021 Apr 13 doi: 10.1111/ijd.15585. PMID: 33846978

Duplicated distal phalanx of thumb or hallux in trisomy 13: A recurrent feature in a series of 42 fetuses.

Létard P, Guimiot F, Dupont C, Rosenblatt J, Delezoide AL, Khung-Savatovsky S
Am J Med Genet A 2018 Nov;176(11):2325-2330. Epub 2018 Oct 17 doi: 10.1002/ajmg.a.40505. PMID: 30328679

The spectrum of preaxial polydactyly of the foot.

Belthur MV, Linton JL, Barnes DA
J Pediatr Orthop 2011 Jun;31(4):435-47. doi: 10.1097/BPO.0b013e3182199a68. PMID: 21572282

Symphalangism (two phalanges) in the digits of the Japanese foot.

Nakashima T, Hojo T, Suzuki K, Ijichi M
Ann Anat 1995 May;177(3):275-8. doi: 10.1016/S0940-9602(11)80199-8. PMID: 7598223

Idiopathic phalangeal osteolysis.

Todd G, Saxe N
Arch Dermatol 1994 Jun;130(6):759-62. PMID: 8002647

See all (24)

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Abnormality of the distal phalanges of the toes

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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