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Abnormal renal glomerulus morphology

MedGen UID:
871392
•Concept ID:
C4025889
•
Anatomical Abnormality
Synonyms: Abnormality of renal glomerulus morphology; Morphologic abnormality of the renal glomerulus
 
HPO: HP:0000095

Definition

A structural anomaly of the glomerulus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal renal glomerulus morphology

Conditions with this feature

Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome
MedGen UID:
1373459
•Concept ID:
C4317151
•
Disease or Syndrome
Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome is an autosomal dominant disorder characterized by these 4 features, which begin in early childhood and are progressive (summary by Moalem et al., 2015).
See: Condition Record
Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome

Professional guidelines

PubMed

Broadening horizons in mechanisms, management, and treatment of diabetic kidney disease.
Petrazzuolo A, Sabiu G, Assi E, Maestroni A, Pastore I, Lunati ME, Montefusco L, Loretelli C, Rossi G, Ben Nasr M, Usuelli V, Xie Y, Balasubramanian HB, Zocchi M, El Essawy B, Yang J, D'Addio F, Fiorina P
Pharmacol Res 2023 Apr;190:106710. Epub 2023 Mar 4 doi: 10.1016/j.phrs.2023.106710. PMID: 36871895
Membranoproliferative glomerulonephritis: no longer the same disease and may need very different treatment.
Noris M, Daina E, Remuzzi G
Nephrol Dial Transplant 2023 Feb 13;38(2):283-290. doi: 10.1093/ndt/gfab281. PMID: 34596686
Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.
Braun DA, Rao J, Mollet G, Schapiro D, Daugeron MC, Tan W, Gribouval O, Boyer O, Revy P, Jobst-Schwan T, Schmidt JM, Lawson JA, Schanze D, Ashraf S, Ullmann JFP, Hoogstraten CA, Boddaert N, Collinet B, Martin G, Liger D, Lovric S, Furlano M, Guerrera IC, Sanchez-Ferras O, Hu JF, Boschat AC, Sanquer S, Menten B, Vergult S, De Rocker N, Airik M, Hermle T, Shril S, Widmeier E, Gee HY, Choi WI, Sadowski CE, Pabst WL, Warejko JK, Daga A, Basta T, Matejas V, Scharmann K, Kienast SD, Behnam B, Beeson B, Begtrup A, Bruce M, Ch'ng GS, Lin SP, Chang JH, Chen CH, Cho MT, Gaffney PM, Gipson PE, Hsu CH, Kari JA, Ke YY, Kiraly-Borri C, Lai WM, Lemyre E, Littlejohn RO, Masri A, Moghtaderi M, Nakamura K, Ozaltin F, Praet M, Prasad C, Prytula A, Roeder ER, Rump P, Schnur RE, Shiihara T, Sinha MD, Soliman NA, Soulami K, Sweetser DA, Tsai WH, Tsai JD, Topaloglu R, Vester U, Viskochil DH, Vatanavicharn N, Waxler JL, Wierenga KJ, Wolf MTF, Wong SN, Leidel SA, Truglio G, Dedon PC, Poduri A, Mane S, Lifton RP, Bouchard M, Kannu P, Chitayat D, Magen D, Callewaert B, van Tilbeurgh H, Zenker M, Antignac C, Hildebrandt F
Nat Genet 2017 Oct;49(10):1529-1538. Epub 2017 Aug 14 doi: 10.1038/ng.3933. PMID: 28805828Free PMC Article

Recent clinical studies

Etiology

IgA Nephropathy: Core Curriculum 2021.
Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883
Better understanding of transplant glomerulopathy secondary to chronic antibody-mediated rejection.
Remport A, Ivanyi B, Mathe Z, Tinckam K, Mucsi I, Molnar MZ
Nephrol Dial Transplant 2015 Nov;30(11):1825-33. Epub 2014 Dec 3 doi: 10.1093/ndt/gfu371. PMID: 25473123
Obesity-related glomerulopathy and the nephron complement.
Tsuboi N, Utsunomiya Y, Hosoya T
Nephrol Dial Transplant 2013 Nov;28 Suppl 4:iv108-13. Epub 2013 Jul 17 doi: 10.1093/ndt/gft258. PMID: 23868145
C3 glomerulopathy: a new classification.
Fakhouri F, Frémeaux-Bacchi V, Noël LH, Cook HT, Pickering MC
Nat Rev Nephrol 2010 Aug;6(8):494-9. Epub 2010 Jul 6 doi: 10.1038/nrneph.2010.85. PMID: 20606628
Kidney disease in nail-patella syndrome.
Lemley KV
Pediatr Nephrol 2009 Dec;24(12):2345-54. Epub 2008 Jun 6 doi: 10.1007/s00467-008-0836-8. PMID: 18535845Free PMC Article

Diagnosis

IgA Nephropathy: Core Curriculum 2021.
Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883
C3 glomerulopathy and current dilemmas.
Ito N, Ohashi R, Nagata M
Clin Exp Nephrol 2017 Aug;21(4):541-551. Epub 2016 Nov 23 doi: 10.1007/s10157-016-1358-5. PMID: 27878657Free PMC Article
Postinfectious glomerulonephritis.
Kambham N
Adv Anat Pathol 2012 Sep;19(5):338-47. doi: 10.1097/PAP.0b013e31826663d9. PMID: 22885383
Genetics and CKD.
Vehaskari VM
Adv Chronic Kidney Dis 2011 Sep;18(5):317-23. doi: 10.1053/j.ackd.2011.07.001. PMID: 21896372
Alport's syndrome, Goodpasture's syndrome, and type IV collagen.
Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG
N Engl J Med 2003 Jun 19;348(25):2543-56. doi: 10.1056/NEJMra022296. PMID: 12815141

Therapy

IgA Nephropathy: Core Curriculum 2021.
Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883
Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors.
DeFronzo RA, Reeves WB, Awad AS
Nat Rev Nephrol 2021 May;17(5):319-334. Epub 2021 Feb 5 doi: 10.1038/s41581-021-00393-8. PMID: 33547417
Post-transplant immunoglobulin A deposition and nephropathy in allografts.
Sofue T, Suzuki H, Ueda N, Kushida Y, Minamino T
Nephrology (Carlton) 2018 Jul;23 Suppl 2:4-9. doi: 10.1111/nep.13281. PMID: 29968406
C3 glomerulopathy and current dilemmas.
Ito N, Ohashi R, Nagata M
Clin Exp Nephrol 2017 Aug;21(4):541-551. Epub 2016 Nov 23 doi: 10.1007/s10157-016-1358-5. PMID: 27878657Free PMC Article
An update on the pathomechanisms and future therapies of Alport syndrome.
Noone D, Licht C
Pediatr Nephrol 2013 Jul;28(7):1025-36. Epub 2012 Aug 18 doi: 10.1007/s00467-012-2272-z. PMID: 22903660

Prognosis

IgA Nephropathy: Core Curriculum 2021.
Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883
Podocytopathies.
Kopp JB, Anders HJ, Susztak K, Podestà MA, Remuzzi G, Hildebrandt F, Romagnani P
Nat Rev Dis Primers 2020 Aug 13;6(1):68. doi: 10.1038/s41572-020-0196-7. PMID: 32792490Free PMC Article
Nail-patella syndrome.
Witzgall R
Pflugers Arch 2017 Aug;469(7-8):927-936. Epub 2017 Jul 5 doi: 10.1007/s00424-017-2013-z. PMID: 28681095
C3 glomerulopathy and current dilemmas.
Ito N, Ohashi R, Nagata M
Clin Exp Nephrol 2017 Aug;21(4):541-551. Epub 2016 Nov 23 doi: 10.1007/s10157-016-1358-5. PMID: 27878657Free PMC Article
Genetics and CKD.
Vehaskari VM
Adv Chronic Kidney Dis 2011 Sep;18(5):317-23. doi: 10.1053/j.ackd.2011.07.001. PMID: 21896372

Clinical prediction guides

The spatially resolved transcriptome signatures of glomeruli in chronic kidney disease.
Clair G, Soloyan H, Cravedi P, Angeletti A, Salem F, Al-Rabadi L, De Filippo RE, Da Sacco S, Lemley KV, Sedrakyan S, Perin L
JCI Insight 2024 Mar 22;9(6) doi: 10.1172/jci.insight.165515. PMID: 38516889Free PMC Article
IgA Nephropathy: Core Curriculum 2021.
Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883
C3 glomerulopathy and current dilemmas.
Ito N, Ohashi R, Nagata M
Clin Exp Nephrol 2017 Aug;21(4):541-551. Epub 2016 Nov 23 doi: 10.1007/s10157-016-1358-5. PMID: 27878657Free PMC Article
Immunopathogenesis of idiopathic nephrotic syndrome with relapse.
Sahali D, Sendeyo K, Mangier M, Audard V, Zhang SY, Lang P, Ollero M, Pawlak A
Semin Immunopathol 2014 Jul;36(4):421-9. Epub 2014 Jan 9 doi: 10.1007/s00281-013-0415-3. PMID: 24402710Free PMC Article
Pathophysiology of proteinuria.
D'Amico G, Bazzi C
Kidney Int 2003 Mar;63(3):809-25. doi: 10.1046/j.1523-1755.2003.00840.x. PMID: 12631062

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