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Benign Skin Fibroblastic Neoplasm

MedGen UID:
87602
•Concept ID:
C0349526
•
Neoplastic Process
Synonyms: Benign Cutaneous Fibroblastic Neoplasm; Benign Cutaneous Fibroblastic Tumor; Benign Cutaneous Fibrocytic Neoplasm; Benign Cutaneous Fibrous Neoplasm; Benign Cutaneous Fibrous Tissue Neoplasm; Benign Fibrous Tissue Neoplasm of Skin; Benign Fibrous Tissue Skin Neoplasm; Benign Fibrous Tissue Skin Tumor; Benign Fibrous Tissue Tumor of Skin

Definition

A benign neoplasm arising from the dermis. It is characterized by the presence of neoplastic fibroblasts without malignant characteristics. [from NCI]

Professional guidelines

PubMed

Dermatofibrosarcoma Protuberans: The Current State of Multidisciplinary Management.
Ramirez-Fort MK, Meier-Schiesser B, Niaz MJ, Niaz MO, Feily A, Fort M, Lange CS, Caba D
Skinmed 2020;18(5):288-293. Epub 2020 Oct 1 PMID: 33160438
Acquired digital fibrokeratoma: review of its clinical and dermoscopic features and differential diagnosis.
Shih S, Khachemoune A
Int J Dermatol 2019 Feb;58(2):151-158. Epub 2018 May 19 doi: 10.1111/ijd.14046. PMID: 29777543
Advances in the management of Dupuytren disease: collagenase.
Hentz VR, Watt AJ, Desai SS, Curtin C
Hand Clin 2012 Nov;28(4):551-63. Epub 2012 Sep 18 doi: 10.1016/j.hcl.2012.08.003. PMID: 23101605

Recent clinical studies

Etiology

Fibroblastic and Myofibroblastic Soft-Tissue Tumors: Imaging Spectrum and Radiologic-Pathologic Correlation.
Haseli S, Mansoori B, Christensen D, Abadi A, Pooyan A, Shomal Zadeh F, Mau B, Khalili N, Murphey M, Chalian M
Radiographics 2023 Aug;43(8):e230005. doi: 10.1148/rg.230005. PMID: 37440448
Intramuscular Eyelid Myxoma.
Liu CK, Williamson JE 3rd, Milman T, Lally SE, Shields CL
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):e180-e183. Epub 2022 Jul 4 doi: 10.1097/IOP.0000000000002236. PMID: 35793663
Fibrohistiocytic Tumors.
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503
Cutaneous paraneoplasia.
Ramos-E-Silva M, Carvalho JC, Carneiro SC
Clin Dermatol 2011 Sep-Oct;29(5):541-7. doi: 10.1016/j.clindermatol.2010.09.022. PMID: 21855730
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Diagnosis

Atypical Fibroxanthoma.
Chapman LW, Yu SS, Arron ST
Semin Cutan Med Surg 2019 Mar 1;38(1):E65-E66. doi: 10.12788/j.sder.2019.008. PMID: 31051027
Histologic Mimics of Basal Cell Carcinoma.
Stanoszek LM, Wang GY, Harms PW
Arch Pathol Lab Med 2017 Nov;141(11):1490-1502. doi: 10.5858/arpa.2017-0222-RA. PMID: 29072946
Fibrohistiocytic Tumors.
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503
Dermatomyofibroma.
Campagnolo OA, Morais CF, Ughini MO, Aoki CM, Menegazzo M
An Bras Dermatol 2017 Jan-Feb;92(1):101-103. doi: 10.1590/abd1806-4841.20175189. PMID: 28225965Free PMC Article
Atypical fibroxanthoma.
Ziemer M
J Dtsch Dermatol Ges 2012 Aug;10(8):537-50. Epub 2012 Jun 19 doi: 10.1111/j.1610-0387.2012.07980.x. PMID: 22709412

Therapy

When to suspect a non-melanoma skin cancer.
Smith H, Wernham A, Patel A
BMJ 2020 Mar 11;368:m692. doi: 10.1136/bmj.m692. PMID: 32161002
Molecular pathology of skin neoplasms of the head and neck.
Kraft S, Granter SR
Arch Pathol Lab Med 2014 Jun;138(6):759-87. doi: 10.5858/arpa.2013-0157-RA. PMID: 24878016
Cutaneous cryosurgery.
Zimmerman EE, Crawford P
Am Fam Physician 2012 Dec 15;86(12):1118-24. PMID: 23316984
Infantile digital fibromatosis.
Taylor HO, Gellis SE, Schmidt BA, Upton J, Rogers GF
Ann Plast Surg 2008 Oct;61(4):472-6. doi: 10.1097/SAP.0b013e31816d8236. PMID: 18812724
Cutaneous lesions: benign and malignant.
Padgett JK
Facial Plast Surg Clin North Am 2005 May;13(2):195-202, v. doi: 10.1016/j.fsc.2004.11.006. PMID: 15817400

Prognosis

Intramuscular Eyelid Myxoma.
Liu CK, Williamson JE 3rd, Milman T, Lally SE, Shields CL
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):e180-e183. Epub 2022 Jul 4 doi: 10.1097/IOP.0000000000002236. PMID: 35793663
Nail tumors.
Richert B, Lecerf P, Caucanas M, André J
Clin Dermatol 2013 Sep-Oct;31(5):602-17. doi: 10.1016/j.clindermatol.2013.06.014. PMID: 24079590
Cutaneous paraneoplasia.
Ramos-E-Silva M, Carvalho JC, Carneiro SC
Clin Dermatol 2011 Sep-Oct;29(5):541-7. doi: 10.1016/j.clindermatol.2010.09.022. PMID: 21855730
Cutaneous histiocytosis syndromes.
Roper SS, Spraker MK
Pediatr Dermatol 1985 Nov;3(1):19-30. doi: 10.1111/j.1525-1470.1985.tb00480.x. PMID: 2999740
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Clinical prediction guides

Fibroblastic and Myofibroblastic Soft-Tissue Tumors: Imaging Spectrum and Radiologic-Pathologic Correlation.
Haseli S, Mansoori B, Christensen D, Abadi A, Pooyan A, Shomal Zadeh F, Mau B, Khalili N, Murphey M, Chalian M
Radiographics 2023 Aug;43(8):e230005. doi: 10.1148/rg.230005. PMID: 37440448
Miliary fibromas in tuberous sclerosis complex.
Cartron AM, Buccine D, Treichel AM, Lee CR, Moss J, Darling TN
J Eur Acad Dermatol Venereol 2021 May;35(5):1226-1229. Epub 2021 Feb 23 doi: 10.1111/jdv.17161. PMID: 33565654Free PMC Article
Soft Tissue Special Issue: Cutaneous Pleomorphic Spindle Cell Tumors.
Brenn T
Head Neck Pathol 2020 Mar;14(1):109-120. Epub 2020 Jan 16 doi: 10.1007/s12105-019-01084-4. PMID: 31950467Free PMC Article
Cutaneous cryosurgery.
Zimmerman EE, Crawford P
Am Fam Physician 2012 Dec 15;86(12):1118-24. PMID: 23316984
Granular cell dermatofibroma.
Soyer HP, Metze D, Kerl H
Am J Dermatopathol 1997 Apr;19(2):168-73. doi: 10.1097/00000372-199704000-00011. PMID: 9129702

Recent systematic reviews

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review.
Seifi G, Kalantari Y, Etesami I
J Dtsch Dermatol Ges 2022 Dec;20(12):1569-1579. Epub 2022 Dec 4 doi: 10.1111/ddg.14888. PMID: 36464809
Clinicopathologic Features of Facial Dermatofibromas, a Cohort Study, and a Systematic Review of Literature.
Alsawas M, Dundar B, Prokop L, Murad MH, Swick B
Am J Dermatopathol 2022 Nov 1;44(11):822-827. Epub 2022 Apr 27 doi: 10.1097/DAD.0000000000002211. PMID: 35503883
Generalized multinucleate cell angiohistiocytoma: case report and literature review.
Wang M, Abdul-Fattah B, Wang C, Zhao Y, Qu X, Al-Muriesh M, Wang X, Zhu L, Qian Y, Huang C, Chen S
J Cutan Pathol 2017 Feb;44(2):125-134. Epub 2016 Nov 28 doi: 10.1111/cup.12853. PMID: 27813137
Surgery for Dupuytren's contracture of the fingers.
Rodrigues JN, Becker GW, Ball C, Zhang W, Giele H, Hobby J, Pratt AL, Davis T
Cochrane Database Syst Rev 2015 Dec 9;2015(12):CD010143. doi: 10.1002/14651858.CD010143.pub2. PMID: 26648251Free PMC Article

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