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Membranous Nephropathy - PLA2R Induced

MedGen UID:
882712
Concept ID:
C4054537
Disease or Syndrome

Definition

Membranous nephropathy due to phospholipase 2 receptor (PLA2R) antibodies. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMembranous Nephropathy - PLA2R Induced

Professional guidelines

PubMed

Chen X, Jiao S, Li S, Li J, Li P, Song F, Yan Z
Balkan Med J 2023 Jul 12;40(4):287-293. Epub 2023 Jun 1 doi: 10.4274/balkanmedj.galenos.2023.2022-9-7. PMID: 37260416Free PMC Article

Recent clinical studies

Etiology

Ronco P, Beck L, Debiec H, Fervenza FC, Hou FF, Jha V, Sethi S, Tong A, Vivarelli M, Wetzels J
Nat Rev Dis Primers 2021 Sep 30;7(1):69. doi: 10.1038/s41572-021-00303-z. PMID: 34593809
Fernández-Juárez G, Rojas-Rivera J, Logt AV, Justino J, Sevillano A, Caravaca-Fontán F, Ávila A, Rabasco C, Cabello V, Varela A, Díez M, Martín-Reyes G, Diezhandino MG, Quintana LF, Agraz I, Gómez-Martino JR, Cao M, Rodríguez-Moreno A, Rivas B, Galeano C, Bonet J, Romera A, Shabaka A, Plaisier E, Espinosa M, Egido J, Segarra A, Lambeau G, Ronco P, Wetzels J, Praga M; STARMEN Investigators
Kidney Int 2021 Apr;99(4):986-998. Epub 2020 Nov 7 doi: 10.1016/j.kint.2020.10.014. PMID: 33166580
Ronco P, Debiec H
Annu Rev Pathol 2020 Jan 24;15:287-313. Epub 2019 Oct 17 doi: 10.1146/annurev-pathol-020117-043811. PMID: 31622560
Fervenza FC, Appel GB, Barbour SJ, Rovin BH, Lafayette RA, Aslam N, Jefferson JA, Gipson PE, Rizk DV, Sedor JR, Simon JF, McCarthy ET, Brenchley P, Sethi S, Avila-Casado C, Beanlands H, Lieske JC, Philibert D, Li T, Thomas LF, Green DF, Juncos LA, Beara-Lasic L, Blumenthal SS, Sussman AN, Erickson SB, Hladunewich M, Canetta PA, Hebert LA, Leung N, Radhakrishnan J, Reich HN, Parikh SV, Gipson DS, Lee DK, da Costa BR, Jüni P, Cattran DC; MENTOR Investigators
N Engl J Med 2019 Jul 4;381(1):36-46. doi: 10.1056/NEJMoa1814427. PMID: 31269364
Beck LH Jr
J Am Soc Nephrol 2017 Sep;28(9):2579-2589. Epub 2017 Jul 3 doi: 10.1681/ASN.2017020178. PMID: 28674044Free PMC Article

Diagnosis

Wang YN, Miao H, Yu XY, Guo Y, Su W, Liu F, Cao G, Zhao YY
Free Radic Biol Med 2023 Oct;207:89-106. Epub 2023 Jul 13 doi: 10.1016/j.freeradbiomed.2023.07.014. PMID: 37451370
Ronco P, Beck L, Debiec H, Fervenza FC, Hou FF, Jha V, Sethi S, Tong A, Vivarelli M, Wetzels J
Nat Rev Dis Primers 2021 Sep 30;7(1):69. doi: 10.1038/s41572-021-00303-z. PMID: 34593809
Zhang P, Huang W, Zheng Q, Tang J, Dong Z, Jiang Y, Liu Y, Liu W
J Immunol Res 2021;2021:8163298. Epub 2021 Jul 14 doi: 10.1155/2021/8163298. PMID: 34337081Free PMC Article
Ronco P, Debiec H
Annu Rev Pathol 2020 Jan 24;15:287-313. Epub 2019 Oct 17 doi: 10.1146/annurev-pathol-020117-043811. PMID: 31622560
Beck LH Jr
J Am Soc Nephrol 2017 Sep;28(9):2579-2589. Epub 2017 Jul 3 doi: 10.1681/ASN.2017020178. PMID: 28674044Free PMC Article

Therapy

Zhang S, Huang J, Dong J, Li Z, Sun M, Sun Y, Chen B
Front Immunol 2023;14:1156470. Epub 2023 Apr 28 doi: 10.3389/fimmu.2023.1156470. PMID: 37187749Free PMC Article
Ma Q, Li X, Xu G
Viruses 2022 Sep 28;14(10) doi: 10.3390/v14102143. PMID: 36298697Free PMC Article
Ronco P, Beck L, Debiec H, Fervenza FC, Hou FF, Jha V, Sethi S, Tong A, Vivarelli M, Wetzels J
Nat Rev Dis Primers 2021 Sep 30;7(1):69. doi: 10.1038/s41572-021-00303-z. PMID: 34593809
Fernández-Juárez G, Rojas-Rivera J, Logt AV, Justino J, Sevillano A, Caravaca-Fontán F, Ávila A, Rabasco C, Cabello V, Varela A, Díez M, Martín-Reyes G, Diezhandino MG, Quintana LF, Agraz I, Gómez-Martino JR, Cao M, Rodríguez-Moreno A, Rivas B, Galeano C, Bonet J, Romera A, Shabaka A, Plaisier E, Espinosa M, Egido J, Segarra A, Lambeau G, Ronco P, Wetzels J, Praga M; STARMEN Investigators
Kidney Int 2021 Apr;99(4):986-998. Epub 2020 Nov 7 doi: 10.1016/j.kint.2020.10.014. PMID: 33166580
Fervenza FC, Appel GB, Barbour SJ, Rovin BH, Lafayette RA, Aslam N, Jefferson JA, Gipson PE, Rizk DV, Sedor JR, Simon JF, McCarthy ET, Brenchley P, Sethi S, Avila-Casado C, Beanlands H, Lieske JC, Philibert D, Li T, Thomas LF, Green DF, Juncos LA, Beara-Lasic L, Blumenthal SS, Sussman AN, Erickson SB, Hladunewich M, Canetta PA, Hebert LA, Leung N, Radhakrishnan J, Reich HN, Parikh SV, Gipson DS, Lee DK, da Costa BR, Jüni P, Cattran DC; MENTOR Investigators
N Engl J Med 2019 Jul 4;381(1):36-46. doi: 10.1056/NEJMoa1814427. PMID: 31269364

Prognosis

Ma Q, Li X, Xu G
Viruses 2022 Sep 28;14(10) doi: 10.3390/v14102143. PMID: 36298697Free PMC Article
Ronco P, Beck L, Debiec H, Fervenza FC, Hou FF, Jha V, Sethi S, Tong A, Vivarelli M, Wetzels J
Nat Rev Dis Primers 2021 Sep 30;7(1):69. doi: 10.1038/s41572-021-00303-z. PMID: 34593809
Jo HA, Hyeon JS, Yang SH, Jung Y, Ha H, Jeong CW, Kwak C, Kim Y, Lee H, Lee JP, Joo KW, Lim CS, Kim YS, Hwang GS, Kim DK
Kidney Int 2021 Feb;99(2):443-455. Epub 2020 Jul 23 doi: 10.1016/j.kint.2020.06.031. PMID: 32712166
Kronbichler A, Gauckler P, Lee KH, Shin JI, Malvezzi P, Mayer G
Atheroscler Suppl 2019 Dec;40:55-60. Epub 2019 Aug 17 doi: 10.1016/j.atherosclerosissup.2019.08.027. PMID: 31447217
Glassock RJ
Curr Opin Nephrol Hypertens 2012 May;21(3):235-42. doi: 10.1097/MNH.0b013e3283522ea8. PMID: 22388552

Clinical prediction guides

Li X, Song D, Hao Y, Ren M, Guo Y, Zhao H, Wang Y, Tang L
Sci Rep 2024 Sep 9;14(1):20981. doi: 10.1038/s41598-024-72082-y. PMID: 39251782Free PMC Article
Zhang S, Huang J, Dong J, Li Z, Sun M, Sun Y, Chen B
Front Immunol 2023;14:1156470. Epub 2023 Apr 28 doi: 10.3389/fimmu.2023.1156470. PMID: 37187749Free PMC Article
Ronco P, Beck L, Debiec H, Fervenza FC, Hou FF, Jha V, Sethi S, Tong A, Vivarelli M, Wetzels J
Nat Rev Dis Primers 2021 Sep 30;7(1):69. doi: 10.1038/s41572-021-00303-z. PMID: 34593809
Fernández-Juárez G, Rojas-Rivera J, Logt AV, Justino J, Sevillano A, Caravaca-Fontán F, Ávila A, Rabasco C, Cabello V, Varela A, Díez M, Martín-Reyes G, Diezhandino MG, Quintana LF, Agraz I, Gómez-Martino JR, Cao M, Rodríguez-Moreno A, Rivas B, Galeano C, Bonet J, Romera A, Shabaka A, Plaisier E, Espinosa M, Egido J, Segarra A, Lambeau G, Ronco P, Wetzels J, Praga M; STARMEN Investigators
Kidney Int 2021 Apr;99(4):986-998. Epub 2020 Nov 7 doi: 10.1016/j.kint.2020.10.014. PMID: 33166580
Glassock RJ
Curr Opin Nephrol Hypertens 2012 May;21(3):235-42. doi: 10.1097/MNH.0b013e3283522ea8. PMID: 22388552

Recent systematic reviews

Xue C, Wang J, Pan J, Liang C, Zhou C, Wu J, Song S, Cui L, Zhang L, Liu Y, Dai B
BMC Nephrol 2023 Sep 22;24(1):280. doi: 10.1186/s12882-023-03307-x. PMID: 37740193Free PMC Article

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