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Conventional Schwannoma

MedGen UID:
886415
•Concept ID:
C4055182
•
Neoplastic Process

Definition

A common, usually encapsulated benign nerve sheath tumor composed of well-differentiated Schwann cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConventional Schwannoma

Professional guidelines

PubMed

Is conventional brain MRI useful for the diagnosis of cluster headache in patients who meet ICHD-3 criteria? Experience in three hospitals in Spain.
Pérez-Pereda S, Madera J, González-Quintanilla V, Drake-Pérez M, Marzal Espí CN, Serrano Munuera C, García SC, Aguilella Linares C, Fernández Recio M, Velamazán Delgado G, Pascual J
J Neurol Sci 2022 Mar 15;434:120122. Epub 2021 Dec 29 doi: 10.1016/j.jns.2021.120122. PMID: 34979370
Hear me out: rethinking internal auditory meatus magnetic resonance imaging in primary care. A cohort evaluation.
Sajid IM, Frost K
J Laryngol Otol 2022 Jan;136(1):37-44. Epub 2021 Aug 20 doi: 10.1017/S0022215121002243. PMID: 34412715
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article

Recent clinical studies

Etiology

Hybrid schwannoma-perineurioma frequently harbors VGLL3 rearrangement.
Dickson BC, Antonescu CR, Demicco EG, Leong DI, Anderson ND, Swanson D, Zhang L, Fletcher CDM, Hornick JL
Mod Pathol 2021 Jun;34(6):1116-1124. Epub 2021 Mar 1 doi: 10.1038/s41379-021-00783-0. PMID: 33649458Free PMC Article
High-Grade Sarcoma Arising within a Previously Irradiated Vestibular Schwannoma: A Case Report and Literature Review.
Boucher AB, Mendoza P, Neill SG, Eaton B, Olson JJ
World Neurosurg 2020 Dec;144:99-105. Epub 2020 Sep 2 doi: 10.1016/j.wneu.2020.08.170. PMID: 32889192
Calcification and ossification in conventional schwannoma: A clinicopathologic study of 32 cases.
Din NU, Fritchie K, Tariq MU, Ahmed A, Ahmad Z
Neuropathology 2020 Apr;40(2):144-151. Epub 2019 Dec 3 doi: 10.1111/neup.12622. PMID: 31793063
Intraosseous schwannoma of the mobile spine: a report of twenty cases.
Wang YQ, Hu JX, Yang SM, Jiang L, Liu XG, Yuan HS, Wei F, Liu ZJ
Eur Spine J 2018 Dec;27(12):3092-3104. Epub 2018 Sep 18 doi: 10.1007/s00586-018-5766-y. PMID: 30229535
Improved discrimination of melanotic schwannoma from melanocytic lesions by combined morphological and GNAQ mutational analysis.
Küsters-Vandevelde HV, van Engen-van Grunsven IA, Küsters B, van Dijk MR, Groenen PJ, Wesseling P, Blokx WA
Acta Neuropathol 2010 Dec;120(6):755-64. Epub 2010 Sep 24 doi: 10.1007/s00401-010-0749-z. PMID: 20865267Free PMC Article

Diagnosis

Calcification and ossification in conventional schwannoma: A clinicopathologic study of 32 cases.
Din NU, Fritchie K, Tariq MU, Ahmed A, Ahmad Z
Neuropathology 2020 Apr;40(2):144-151. Epub 2019 Dec 3 doi: 10.1111/neup.12622. PMID: 31793063
Intraosseous schwannoma of the mobile spine: a report of twenty cases.
Wang YQ, Hu JX, Yang SM, Jiang L, Liu XG, Yuan HS, Wei F, Liu ZJ
Eur Spine J 2018 Dec;27(12):3092-3104. Epub 2018 Sep 18 doi: 10.1007/s00586-018-5766-y. PMID: 30229535
SMARCB1/INI1 Loss in Epithelioid Schwannoma: A Clinicopathologic and Immunohistochemical Study of 65 Cases.
Jo VY, Fletcher CDM
Am J Surg Pathol 2017 Aug;41(8):1013-1022. doi: 10.1097/PAS.0000000000000849. PMID: 28368924
The pathobiologic spectrum of Schwannomas.
Kurtkaya-Yapicier O, Scheithauer B, Woodruff JM
Histol Histopathol 2003 Jul;18(3):925-34. doi: 10.14670/HH-18.925. PMID: 12792904
Neuroblastoma-like neurilemoma.
Goldblum JR, Beals TF, Weiss SW
Am J Surg Pathol 1994 Mar;18(3):266-73. doi: 10.1097/00000478-199403000-00006. PMID: 8116794

Prognosis

High-Grade Sarcoma Arising within a Previously Irradiated Vestibular Schwannoma: A Case Report and Literature Review.
Boucher AB, Mendoza P, Neill SG, Eaton B, Olson JJ
World Neurosurg 2020 Dec;144:99-105. Epub 2020 Sep 2 doi: 10.1016/j.wneu.2020.08.170. PMID: 32889192
Intraosseous schwannoma of the mobile spine: a report of twenty cases.
Wang YQ, Hu JX, Yang SM, Jiang L, Liu XG, Yuan HS, Wei F, Liu ZJ
Eur Spine J 2018 Dec;27(12):3092-3104. Epub 2018 Sep 18 doi: 10.1007/s00586-018-5766-y. PMID: 30229535
SMARCB1/INI1 Loss in Epithelioid Schwannoma: A Clinicopathologic and Immunohistochemical Study of 65 Cases.
Jo VY, Fletcher CDM
Am J Surg Pathol 2017 Aug;41(8):1013-1022. doi: 10.1097/PAS.0000000000000849. PMID: 28368924
Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases.
Laskin WB, Fetsch JF, Lasota J, Miettinen M
Am J Surg Pathol 2005 Jan;29(1):39-51. doi: 10.1097/01.pas.0000146044.90901.4c. PMID: 15613855
The pathobiologic spectrum of Schwannomas.
Kurtkaya-Yapicier O, Scheithauer B, Woodruff JM
Histol Histopathol 2003 Jul;18(3):925-34. doi: 10.14670/HH-18.925. PMID: 12792904

Clinical prediction guides

Intraosseous schwannoma of the mobile spine: a report of twenty cases.
Wang YQ, Hu JX, Yang SM, Jiang L, Liu XG, Yuan HS, Wei F, Liu ZJ
Eur Spine J 2018 Dec;27(12):3092-3104. Epub 2018 Sep 18 doi: 10.1007/s00586-018-5766-y. PMID: 30229535
SMARCB1/INI1 Loss in Epithelioid Schwannoma: A Clinicopathologic and Immunohistochemical Study of 65 Cases.
Jo VY, Fletcher CDM
Am J Surg Pathol 2017 Aug;41(8):1013-1022. doi: 10.1097/PAS.0000000000000849. PMID: 28368924
Malignant melanotic schwannian tumor: a clinicopathologic, immunohistochemical, and gene expression profiling study of 40 cases, with a proposal for the reclassification of "melanotic schwannoma".
Torres-Mora J, Dry S, Li X, Binder S, Amin M, Folpe AL
Am J Surg Pathol 2014 Jan;38(1):94-105. doi: 10.1097/PAS.0b013e3182a0a150. PMID: 24145644

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