U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 5q

MedGen UID:
888150
•Concept ID:
C4055250
•
Neoplastic Process

Definition

A rare acute myeloid leukemia that occurs in childhood and is characterized primarily by deletions of 5q. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Acute Myeloid Leukemia with Abnormalities of Chromosome 5q

Professional guidelines

PubMed

Outcome of pediatric patients with acute myeloid leukemia (AML) and -5/5q- abnormalities from five pediatric AML treatment protocols: a report from the Children's Oncology Group.
Johnston DL, Alonzo TA, Gerbing RB, Hirsch B, Heerema NA, Ravindranath Y, Woods WG, Lange BJ, Gamis AS, Raimondi SC
Pediatr Blood Cancer 2013 Dec;60(12):2073-8. Epub 2013 Aug 30 doi: 10.1002/pbc.24573. PMID: 24039149
Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12.
Harrison CJ, Hills RK, Moorman AV, Grimwade DJ, Hann I, Webb DK, Wheatley K, de Graaf SS, van den Berg E, Burnett AK, Gibson BE
J Clin Oncol 2010 Jun 1;28(16):2674-81. Epub 2010 May 3 doi: 10.1200/JCO.2009.24.8997. PMID: 20439644

Recent clinical studies

Etiology

Changes in cytogenetics and molecular genetics in acute myeloid leukemia from childhood to adult age groups.
Creutzig U, Zimmermann M, Reinhardt D, Rasche M, von Neuhoff C, Alpermann T, Dworzak M, Perglerová K, Zemanova Z, Tchinda J, Bradtke J, Thiede C, Haferlach C
Cancer 2016 Dec 15;122(24):3821-3830. Epub 2016 Aug 16 doi: 10.1002/cncr.30220. PMID: 27529519
Outcome of pediatric patients with acute myeloid leukemia (AML) and -5/5q- abnormalities from five pediatric AML treatment protocols: a report from the Children's Oncology Group.
Johnston DL, Alonzo TA, Gerbing RB, Hirsch B, Heerema NA, Ravindranath Y, Woods WG, Lange BJ, Gamis AS, Raimondi SC
Pediatr Blood Cancer 2013 Dec;60(12):2073-8. Epub 2013 Aug 30 doi: 10.1002/pbc.24573. PMID: 24039149
Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12.
Harrison CJ, Hills RK, Moorman AV, Grimwade DJ, Hann I, Webb DK, Wheatley K, de Graaf SS, van den Berg E, Burnett AK, Gibson BE
J Clin Oncol 2010 Jun 1;28(16):2674-81. Epub 2010 May 3 doi: 10.1200/JCO.2009.24.8997. PMID: 20439644
Acute megakaryoblastic leukaemia (AMKL) in children: a comparison of AMKL with and without Down syndrome.
Hama A, Yagasaki H, Takahashi Y, Nishio N, Muramatsu H, Yoshida N, Tanaka M, Hidaka H, Watanabe N, Yoshimi A, Matsumoto K, Kudo K, Kato K, Horibe K, Kojima S
Br J Haematol 2008 Mar;140(5):552-61. doi: 10.1111/j.1365-2141.2007.06971.x. PMID: 18275433
Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Français de Cytogénétique Hématologique (GFCH).
Dastugue N, Lafage-Pochitaloff M, Pagès MP, Radford I, Bastard C, Talmant P, Mozziconacci MJ, Léonard C, Bilhou-Nabéra C, Cabrol C, Capodano AM, Cornillet-Lefebvre P, Lessard M, Mugneret F, Pérot C, Taviaux S, Fenneteaux O, Duchayne E, Berger R; Groupe Français d'Hematologie Cellulaire
Blood 2002 Jul 15;100(2):618-26. doi: 10.1182/blood-2001-12-0241. PMID: 12091356

Diagnosis

Changes in cytogenetics and molecular genetics in acute myeloid leukemia from childhood to adult age groups.
Creutzig U, Zimmermann M, Reinhardt D, Rasche M, von Neuhoff C, Alpermann T, Dworzak M, Perglerová K, Zemanova Z, Tchinda J, Bradtke J, Thiede C, Haferlach C
Cancer 2016 Dec 15;122(24):3821-3830. Epub 2016 Aug 16 doi: 10.1002/cncr.30220. PMID: 27529519
Outcome of pediatric patients with acute myeloid leukemia (AML) and -5/5q- abnormalities from five pediatric AML treatment protocols: a report from the Children's Oncology Group.
Johnston DL, Alonzo TA, Gerbing RB, Hirsch B, Heerema NA, Ravindranath Y, Woods WG, Lange BJ, Gamis AS, Raimondi SC
Pediatr Blood Cancer 2013 Dec;60(12):2073-8. Epub 2013 Aug 30 doi: 10.1002/pbc.24573. PMID: 24039149
Acute megakaryoblastic leukaemia (AMKL) in children: a comparison of AMKL with and without Down syndrome.
Hama A, Yagasaki H, Takahashi Y, Nishio N, Muramatsu H, Yoshida N, Tanaka M, Hidaka H, Watanabe N, Yoshimi A, Matsumoto K, Kudo K, Kato K, Horibe K, Kojima S
Br J Haematol 2008 Mar;140(5):552-61. doi: 10.1111/j.1365-2141.2007.06971.x. PMID: 18275433
A cryptic t(5;11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assay.
Brown J, Jawad M, Twigg SR, Saracoglu K, Sauerbrey A, Thomas AE, Eils R, Harbott J, Kearney L
Blood 2002 Apr 1;99(7):2526-31. doi: 10.1182/blood.v99.7.2526. PMID: 11895789
Chromosome examinations on a six-hour culture of unstimulated peripheral blood from a patient with childhood erythroleukaemia.
Selypes A, László A, Virág I
Haematologia (Budap) 1989;22(1):19-24. PMID: 2707646

Therapy

Outcome of pediatric patients with acute myeloid leukemia (AML) and -5/5q- abnormalities from five pediatric AML treatment protocols: a report from the Children's Oncology Group.
Johnston DL, Alonzo TA, Gerbing RB, Hirsch B, Heerema NA, Ravindranath Y, Woods WG, Lange BJ, Gamis AS, Raimondi SC
Pediatr Blood Cancer 2013 Dec;60(12):2073-8. Epub 2013 Aug 30 doi: 10.1002/pbc.24573. PMID: 24039149
Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12.
Harrison CJ, Hills RK, Moorman AV, Grimwade DJ, Hann I, Webb DK, Wheatley K, de Graaf SS, van den Berg E, Burnett AK, Gibson BE
J Clin Oncol 2010 Jun 1;28(16):2674-81. Epub 2010 May 3 doi: 10.1200/JCO.2009.24.8997. PMID: 20439644
Acute megakaryoblastic leukaemia (AMKL) in children: a comparison of AMKL with and without Down syndrome.
Hama A, Yagasaki H, Takahashi Y, Nishio N, Muramatsu H, Yoshida N, Tanaka M, Hidaka H, Watanabe N, Yoshimi A, Matsumoto K, Kudo K, Kato K, Horibe K, Kojima S
Br J Haematol 2008 Mar;140(5):552-61. doi: 10.1111/j.1365-2141.2007.06971.x. PMID: 18275433

Prognosis

Changes in cytogenetics and molecular genetics in acute myeloid leukemia from childhood to adult age groups.
Creutzig U, Zimmermann M, Reinhardt D, Rasche M, von Neuhoff C, Alpermann T, Dworzak M, Perglerová K, Zemanova Z, Tchinda J, Bradtke J, Thiede C, Haferlach C
Cancer 2016 Dec 15;122(24):3821-3830. Epub 2016 Aug 16 doi: 10.1002/cncr.30220. PMID: 27529519
Outcome of pediatric patients with acute myeloid leukemia (AML) and -5/5q- abnormalities from five pediatric AML treatment protocols: a report from the Children's Oncology Group.
Johnston DL, Alonzo TA, Gerbing RB, Hirsch B, Heerema NA, Ravindranath Y, Woods WG, Lange BJ, Gamis AS, Raimondi SC
Pediatr Blood Cancer 2013 Dec;60(12):2073-8. Epub 2013 Aug 30 doi: 10.1002/pbc.24573. PMID: 24039149
Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12.
Harrison CJ, Hills RK, Moorman AV, Grimwade DJ, Hann I, Webb DK, Wheatley K, de Graaf SS, van den Berg E, Burnett AK, Gibson BE
J Clin Oncol 2010 Jun 1;28(16):2674-81. Epub 2010 May 3 doi: 10.1200/JCO.2009.24.8997. PMID: 20439644
Acute megakaryoblastic leukaemia (AMKL) in children: a comparison of AMKL with and without Down syndrome.
Hama A, Yagasaki H, Takahashi Y, Nishio N, Muramatsu H, Yoshida N, Tanaka M, Hidaka H, Watanabe N, Yoshimi A, Matsumoto K, Kudo K, Kato K, Horibe K, Kojima S
Br J Haematol 2008 Mar;140(5):552-61. doi: 10.1111/j.1365-2141.2007.06971.x. PMID: 18275433
A new recurrent translocation, t(5;11)(q35;p15.5), associated with del(5q) in childhood acute myeloid leukemia. The UK Cancer Cytogenetics Group (UKCCG).
Jaju RJ, Haas OA, Neat M, Harbott J, Saha V, Boultwood J, Brown JM, Pirc-Danoewinata H, Krings BW, Müller U, Morris SW, Wainscoat JS, Kearney L
Blood 1999 Jul 15;94(2):773-80. PMID: 10397745

Clinical prediction guides

Changes in cytogenetics and molecular genetics in acute myeloid leukemia from childhood to adult age groups.
Creutzig U, Zimmermann M, Reinhardt D, Rasche M, von Neuhoff C, Alpermann T, Dworzak M, Perglerová K, Zemanova Z, Tchinda J, Bradtke J, Thiede C, Haferlach C
Cancer 2016 Dec 15;122(24):3821-3830. Epub 2016 Aug 16 doi: 10.1002/cncr.30220. PMID: 27529519
Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12.
Harrison CJ, Hills RK, Moorman AV, Grimwade DJ, Hann I, Webb DK, Wheatley K, de Graaf SS, van den Berg E, Burnett AK, Gibson BE
J Clin Oncol 2010 Jun 1;28(16):2674-81. Epub 2010 May 3 doi: 10.1200/JCO.2009.24.8997. PMID: 20439644

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...