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Abnormality of body weight

MedGen UID:
892367
•Concept ID:
C4025357
•
Finding
Synonym: Abnormality of habitus
 
HPO: HP:0004323

Definition

An abnormal increase or decrease of weight or an abnormal distribution of mass in the body. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of body weight

Professional guidelines

PubMed

Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment.
Escobar-Morreale HF
Nat Rev Endocrinol 2018 May;14(5):270-284. Epub 2018 Mar 23 doi: 10.1038/nrendo.2018.24. PMID: 29569621
Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents.
Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, Carroll AE, Daniels SR, de Ferranti SD, Dionne JM, Falkner B, Flinn SK, Gidding SS, Goodwin C, Leu MG, Powers ME, Rea C, Samuels J, Simasek M, Thaker VV, Urbina EM; SUBCOMMITTEE ON SCREENING AND MANAGEMENT OF HIGH BLOOD PRESSURE IN CHILDREN
Pediatrics 2017 Sep;140(3) Epub 2017 Aug 21 doi: 10.1542/peds.2017-1904. PMID: 28827377

Recent clinical studies

Etiology

Effects of Overweight and Obesity in Pregnancy on Health of the Offspring.
Dow ML, Szymanski LM
Endocrinol Metab Clin North Am 2020 Jun;49(2):251-263. Epub 2020 Apr 16 doi: 10.1016/j.ecl.2020.02.005. PMID: 32418588
Addressing Obesity in Clinical Gynecology Practice.
Kahan S, Winston G
Clin Obstet Gynecol 2018 Mar;61(1):10-26. doi: 10.1097/GRF.0000000000000334. PMID: 29309285
Preconception care: nutritional risks and interventions.
Dean SV, Lassi ZS, Imam AM, Bhutta ZA
Reprod Health 2014 Sep 26;11 Suppl 3(Suppl 3):S3. doi: 10.1186/1742-4755-11-S3-S3. PMID: 25415364Free PMC Article
Fetal and perinatal consequences of maternal obesity.
Vasudevan C, Renfrew M, McGuire W
Arch Dis Child Fetal Neonatal Ed 2011 Sep;96(5):F378-82. Epub 2010 Jun 7 doi: 10.1136/adc.2009.170928. PMID: 20530101
Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis.
Stothard KJ, Tennant PW, Bell R, Rankin J
JAMA 2009 Feb 11;301(6):636-50. doi: 10.1001/jama.2009.113. PMID: 19211471

Diagnosis

Chromosomal abnormalities associated with fetal megacystis.
Chen CP
Taiwan J Obstet Gynecol 2024 Jan;63(1):17-18. doi: 10.1016/j.tjog.2023.11.006. PMID: 38216262
Obstetrical and neonatal outcomes of cardio-facio-cutaneous syndrome: Prenatal consequences of Ras/MAPK dysregulation.
Jelin AC, Mahle A, Tran SH, Sparks TN, Rauen KA
Am J Med Genet A 2023 Feb;191(2):323-331. Epub 2022 Oct 29 doi: 10.1002/ajmg.a.63020. PMID: 36308388Free PMC Article
Obesity Prevention for Individuals with Spina Bifida.
Polfuss M, Bandini LG, Sawin KJ
Curr Obes Rep 2017 Jun;6(2):116-126. doi: 10.1007/s13679-017-0254-y. PMID: 28455677
Baraitser-Winter cerebrofrontofacial syndrome.
Yates TM, Turner CL, Firth HV, Berg J, Pilz DT
Clin Genet 2017 Jul;92(1):3-9. Epub 2016 Nov 30 doi: 10.1111/cge.12864. PMID: 27625340
Preconception care: nutritional risks and interventions.
Dean SV, Lassi ZS, Imam AM, Bhutta ZA
Reprod Health 2014 Sep 26;11 Suppl 3(Suppl 3):S3. doi: 10.1186/1742-4755-11-S3-S3. PMID: 25415364Free PMC Article

Therapy

Efficacy and safety of setmelanotide, a melanocortin-4 receptor agonist, in patients with Bardet-Biedl syndrome and Alström syndrome: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial with an open-label period.
Haqq AM, Chung WK, Dollfus H, Haws RM, Martos-Moreno GÁ, Poitou C, Yanovski JA, Mittleman RS, Yuan G, Forsythe E, Clément K, Argente J
Lancet Diabetes Endocrinol 2022 Dec;10(12):859-868. Epub 2022 Nov 7 doi: 10.1016/S2213-8587(22)00277-7. PMID: 36356613Free PMC Article
Clinical Opinion: The diagnosis and management of suspected fetal growth restriction: an evidence-based approach.
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
Discussion.
Chen JM
J Thorac Cardiovasc Surg 2022 Jan;163(1):204-207. Epub 2021 Mar 14 doi: 10.1016/j.jtcvs.2021.01.106. PMID: 33726911
Treadmill interventions in children under six years of age at risk of neuromotor delay.
Valentín-Gudiol M, Mattern-Baxter K, Girabent-Farrés M, Bagur-Calafat C, Hadders-Algra M, Angulo-Barroso RM
Cochrane Database Syst Rev 2017 Jul 29;7(7):CD009242. doi: 10.1002/14651858.CD009242.pub3. PMID: 28755534Free PMC Article
Preconception care: nutritional risks and interventions.
Dean SV, Lassi ZS, Imam AM, Bhutta ZA
Reprod Health 2014 Sep 26;11 Suppl 3(Suppl 3):S3. doi: 10.1186/1742-4755-11-S3-S3. PMID: 25415364Free PMC Article

Prognosis

Outcomes From Polyhydramnios With Normal Ultrasound.
Yefet E, Daniel-Spiegel E
Pediatrics 2016 Feb;137(2):e20151948. Epub 2016 Jan 11 doi: 10.1542/peds.2015-1948. PMID: 26755694
The Effects of Maternal Obesity on Neonates, Infants, Children, Adolescents, and Adults.
Hemond J, Robbins RB, Young PC
Clin Obstet Gynecol 2016 Mar;59(1):216-27. doi: 10.1097/GRF.0000000000000179. PMID: 26694497
Fetal and perinatal consequences of maternal obesity.
Vasudevan C, Renfrew M, McGuire W
Arch Dis Child Fetal Neonatal Ed 2011 Sep;96(5):F378-82. Epub 2010 Jun 7 doi: 10.1136/adc.2009.170928. PMID: 20530101
Follow-up studies of children born after frozen sperm donation.
Lansac J, Royere D
Hum Reprod Update 2001 Jan-Feb;7(1):33-7. doi: 10.1093/humupd/7.1.33. PMID: 11212072
Late sequelae of induced abortion: complications and outcome of pregnancy and labor.
Harlap S, Davies AM
Am J Epidemiol 1975 Sep;102(3):217-24. doi: 10.1093/oxfordjournals.aje.a112150. PMID: 1163527

Clinical prediction guides

Clinical and molecular spectrum of CHOPS syndrome.
Raible SE, Mehta D, Bettale C, Fiordaliso S, Kaur M, Medne L, Rio M, Haan E, White SM, Cusmano-Ozog K, Nishi E, Guo Y, Wu H, Shi X, Zhao Q, Zhang X, Lei Q, Lu A, He X, Okamoto N, Miyake N, Piccione J, Allen J, Matsumoto N, Pipan M, Krantz ID, Izumi K
Am J Med Genet A 2019 Jul;179(7):1126-1138. Epub 2019 May 6 doi: 10.1002/ajmg.a.61174. PMID: 31058441Free PMC Article
Role of ultrasound in the management of diabetes in pregnancy.
Ahmed B, Abushama M, Khraisheh M, Dudenhausen J
J Matern Fetal Neonatal Med 2015;28(15):1856-63. Epub 2014 Nov 4 doi: 10.3109/14767058.2014.971745. PMID: 25367382
Preconception care: nutritional risks and interventions.
Dean SV, Lassi ZS, Imam AM, Bhutta ZA
Reprod Health 2014 Sep 26;11 Suppl 3(Suppl 3):S3. doi: 10.1186/1742-4755-11-S3-S3. PMID: 25415364Free PMC Article
Safety of topical corticosteroids in pregnancy.
Chi CC, Lee CW, Wojnarowska F, Kirtschig G
Cochrane Database Syst Rev 2009 Jul 8;(3):CD007346. doi: 10.1002/14651858.CD007346.pub2. PMID: 19588425
Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis.
Stothard KJ, Tennant PW, Bell R, Rankin J
JAMA 2009 Feb 11;301(6):636-50. doi: 10.1001/jama.2009.113. PMID: 19211471

Recent systematic reviews

Adipose Tissue Dysfunction in Polycystic Ovary Syndrome.
Bril F, Ezeh U, Amiri M, Hatoum S, Pace L, Chen YH, Bertrand F, Gower B, Azziz R
J Clin Endocrinol Metab 2023 Dec 21;109(1):10-24. doi: 10.1210/clinem/dgad356. PMID: 37329216Free PMC Article
Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies.
Sanchez-Garrido MA, Tena-Sempere M
Mol Metab 2020 May;35:100937. Epub 2020 Feb 5 doi: 10.1016/j.molmet.2020.01.001. PMID: 32244180Free PMC Article
Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article
Short and long term health effects of parental tobacco smoking during pregnancy and lactation: a descriptive review.
Banderali G, Martelli A, Landi M, Moretti F, Betti F, Radaelli G, Lassandro C, Verduci E
J Transl Med 2015 Oct 15;13:327. doi: 10.1186/s12967-015-0690-y. PMID: 26472248Free PMC Article
Swaddling: a systematic review.
van Sleuwen BE, Engelberts AC, Boere-Boonekamp MM, Kuis W, Schulpen TW, L'Hoir MP
Pediatrics 2007 Oct;120(4):e1097-106. doi: 10.1542/peds.2006-2083. PMID: 17908730

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