U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Malignant Neoplasm in the Bone Marrow

MedGen UID:
91111
•Concept ID:
C0346979
•
Neoplastic Process
Synonyms: Cancer metastatic to bone marrow; Metastases to the Bone Marrow; Metastasis to bone marrow; Metastasis to the Bone Marrow; Metastatic malignant neoplasm of bone marrow; Metastatic malignant neoplasm to bone marrow; Metastatic Malignant Neoplasm to the Bone Marrow; Metastatic Neoplasm to the Bone Marrow; Metastatic Tumor to the Bone Marrow; Secondary malignant neoplasm of bone marrow
SNOMED CT: Secondary malignant neoplasm of bone marrow (94217008); Metastatic malignant neoplasm to bone marrow (94217008); Cancer metastatic to bone marrow (94217008); Metastatic malignant neoplasm of bone marrow (94217008); Metastasis to bone marrow (94217008)

Definition

The spread of a malignant neoplasm from its original site of growth to the bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Bone Marrow

Professional guidelines

PubMed

2022 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer, including patients with COVID-19.
Farge D, Frere C, Connors JM, Khorana AA, Kakkar A, Ay C, Muñoz A, Brenner B, Prata PH, Brilhante D, Antic D, Casais P, Guillermo Esposito MC, Ikezoe T, Abutalib SA, Meillon-García LA, Bounameaux H, Pabinger I, Douketis J; International Initiative on Thrombosis and Cancer (ITAC) advisory panel
Lancet Oncol 2022 Jul;23(7):e334-e347. doi: 10.1016/S1470-2045(22)00160-7. PMID: 35772465Free PMC Article
Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767

Recent clinical studies

Etiology

Tumor dormancy in bone.
Mayhew V, Omokehinde T, Johnson RW
Cancer Rep (Hoboken) 2020 Feb;3(1):e1156. Epub 2019 Jan 29 doi: 10.1002/cnr2.1156. PMID: 32632400Free PMC Article
MDS overlap disorders and diagnostic boundaries.
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443
The impact of NF-κB signaling on pathogenesis and current treatment strategies in multiple myeloma.
Vrábel D, Pour L, Ševčíková S
Blood Rev 2019 Mar;34:56-66. Epub 2018 Nov 23 doi: 10.1016/j.blre.2018.11.003. PMID: 30501907
Hypoxia and Bone Metastatic Disease.
Johnson RW, Sowder ME, Giaccia AJ
Curr Osteoporos Rep 2017 Aug;15(4):231-238. doi: 10.1007/s11914-017-0378-8. PMID: 28597139Free PMC Article
The bone marrow metastasis niche in retinoblastoma.
Khosravi A, Shahrabi S, Shahjahani M, Saki N
Cell Oncol (Dordr) 2015 Aug;38(4):253-63. Epub 2015 Jun 11 doi: 10.1007/s13402-015-0232-x. PMID: 26063518

Diagnosis

Myeloid-like tumor hybrid cells in bone marrow promote progression of prostate cancer bone metastasis.
Ye X, Huang X, Fu X, Zhang X, Lin R, Zhang W, Zhang J, Lu Y
J Hematol Oncol 2023 May 3;16(1):46. doi: 10.1186/s13045-023-01442-4. PMID: 37138326Free PMC Article
Hypoxia-mediated changes in bone marrow microenvironment in breast cancer dormancy.
Ferrer A, Roser CT, El-Far MH, Savanur VH, Eljarrah A, Gergues M, Kra JA, Etchegaray JP, Rameshwar P
Cancer Lett 2020 Sep 28;488:9-17. Epub 2020 May 30 doi: 10.1016/j.canlet.2020.05.026. PMID: 32479768
The impact of NF-κB signaling on pathogenesis and current treatment strategies in multiple myeloma.
Vrábel D, Pour L, Ševčíková S
Blood Rev 2019 Mar;34:56-66. Epub 2018 Nov 23 doi: 10.1016/j.blre.2018.11.003. PMID: 30501907
The bone marrow metastasis niche in retinoblastoma.
Khosravi A, Shahrabi S, Shahjahani M, Saki N
Cell Oncol (Dordr) 2015 Aug;38(4):253-63. Epub 2015 Jun 11 doi: 10.1007/s13402-015-0232-x. PMID: 26063518
Occult metastasis.
Hawes D, Neville AM, Cote RJ
Biomed Pharmacother 2001 May;55(4):229-42. doi: 10.1016/s0753-3322(01)00052-x. PMID: 11393810

Therapy

MDS overlap disorders and diagnostic boundaries.
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443
The impact of NF-κB signaling on pathogenesis and current treatment strategies in multiple myeloma.
Vrábel D, Pour L, Ševčíková S
Blood Rev 2019 Mar;34:56-66. Epub 2018 Nov 23 doi: 10.1016/j.blre.2018.11.003. PMID: 30501907
Bone metastasis: histological changes and pathophysiological mechanisms in osteolytic or osteosclerotic localizations. A review.
Chappard D, Bouvard B, Baslé MF, Legrand E, Audran M
Morphologie 2011 Jun;95(309):65-75. Epub 2011 May 28 doi: 10.1016/j.morpho.2011.02.004. PMID: 21620753
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F, Pelicci PG, Martelli MF; GIMEMA Acute Leukemia Working Party
N Engl J Med 2005 Jan 20;352(3):254-66. doi: 10.1056/NEJMoa041974. PMID: 15659725
Metastatic breast cancer.
Rubens RD
Curr Opin Oncol 1993 Nov;5(6):991-5. doi: 10.1097/00001622-199311000-00007. PMID: 8305549

Prognosis

Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature.
Mei S, Alchahin AM, Embaie BT, Gavriliuc IM, Verhoeven BM, Zhao T, Li X, Jeffries NE, Pepich A, Sarkar H, Olsen TK, Wickström M, Stenman J, Reina-Bedoya O, Kharchenko PV, Saylor PJ, Johnsen JI, Sykes DB, Kogner P, Baryawno N
JCI Insight 2024 Feb 15;9(6) doi: 10.1172/jci.insight.173337. PMID: 38358826Free PMC Article
Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis.
Yip RKH, Rimes JS, Capaldo BD, Vaillant F, Mouchemore KA, Pal B, Chen Y, Surgenor E, Murphy AJ, Anderson RL, Smyth GK, Lindeman GJ, Hawkins ED, Visvader JE
Nat Commun 2021 Nov 26;12(1):6920. doi: 10.1038/s41467-021-26556-6. PMID: 34836954Free PMC Article
Breast Cancer Dormancy in Bone.
Clements ME, Johnson RW
Curr Osteoporos Rep 2019 Oct;17(5):353-361. doi: 10.1007/s11914-019-00532-y. PMID: 31468498Free PMC Article
The hypoxia signalling pathway in haematological malignancies.
Irigoyen M, García-Ruiz JC, Berra E
Oncotarget 2017 May 30;8(22):36832-36844. doi: 10.18632/oncotarget.15981. PMID: 28415662Free PMC Article
The bone marrow metastasis niche in retinoblastoma.
Khosravi A, Shahrabi S, Shahjahani M, Saki N
Cell Oncol (Dordr) 2015 Aug;38(4):253-63. Epub 2015 Jun 11 doi: 10.1007/s13402-015-0232-x. PMID: 26063518

Clinical prediction guides

Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature.
Mei S, Alchahin AM, Embaie BT, Gavriliuc IM, Verhoeven BM, Zhao T, Li X, Jeffries NE, Pepich A, Sarkar H, Olsen TK, Wickström M, Stenman J, Reina-Bedoya O, Kharchenko PV, Saylor PJ, Johnsen JI, Sykes DB, Kogner P, Baryawno N
JCI Insight 2024 Feb 15;9(6) doi: 10.1172/jci.insight.173337. PMID: 38358826Free PMC Article
The Bone Microenvironment: a Fertile Soil for Tumor Growth.
Buenrostro D, Mulcrone PL, Owens P, Sterling JA
Curr Osteoporos Rep 2016 Aug;14(4):151-8. doi: 10.1007/s11914-016-0315-2. PMID: 27255469Free PMC Article
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article
Bone marrow and the control of immunity.
Zhao E, Xu H, Wang L, Kryczek I, Wu K, Hu Y, Wang G, Zou W
Cell Mol Immunol 2012 Jan;9(1):11-9. Epub 2011 Oct 24 doi: 10.1038/cmi.2011.47. PMID: 22020068Free PMC Article
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F, Pelicci PG, Martelli MF; GIMEMA Acute Leukemia Working Party
N Engl J Med 2005 Jan 20;352(3):254-66. doi: 10.1056/NEJMoa041974. PMID: 15659725

Recent systematic reviews

Efficacy and safety of immunosuppressive agents for adults with lupus nephritis: a systematic review and network meta-analysis.
Jiang N, Jin S, Yu C, Zhao J, Wang Q, Tian X, Li M, Zeng X
Front Immunol 2023;14:1232244. Epub 2023 Oct 13 doi: 10.3389/fimmu.2023.1232244. PMID: 37901212Free PMC Article
The Role of Cytokines in the Metastasis of Solid Tumors to the Spine: Systematic Review.
Łabędź W, Przybyla A, Zimna A, Dąbrowski M, Kubaszewski Ł
Int J Mol Sci 2023 Feb 14;24(4) doi: 10.3390/ijms24043785. PMID: 36835198Free PMC Article
Pelvic bone marrow sparing radiotherapy for cervical cancer: A systematic review and meta-analysis.
Zhou P, Zhang Y, Luo S, Zhang S
Radiother Oncol 2021 Dec;165:103-118. Epub 2021 Oct 27 doi: 10.1016/j.radonc.2021.10.015. PMID: 34718055
Systematic review of site distribution of bone metastases in differentiated thyroid cancer.
Osorio M, Moubayed SP, Su H, Urken ML
Head Neck 2017 Apr;39(4):812-818. Epub 2017 Jan 11 doi: 10.1002/hed.24655. PMID: 28079945
The key role of bisphosphonates in the supportive care of cancer patients.
Tolia M, Zygogianni A, Kouvaris JR, Meristoudis C, Margari N, Karakitsos P, Kokakis I, Kardamakis D, Papadimitriou C, Mystakidou K, Tsoukalas N, Kyrgias G, Armonis B, Filippiadis DK, Kelekis AD, Kelekis N, Kouloulias V
Anticancer Res 2014 Jan;34(1):23-37. PMID: 24403442

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...