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Metastatic Malignant Neoplasm in the Bone Marrow

MedGen UID:
91111
•Concept ID:
C0346979
•
Neoplastic Process
Synonyms: Cancer metastatic to bone marrow; Metastases to the Bone Marrow; Metastasis to bone marrow; Metastasis to the Bone Marrow; Metastatic malignant neoplasm of bone marrow; Metastatic malignant neoplasm to bone marrow; Metastatic Malignant Neoplasm to the Bone Marrow; Metastatic Neoplasm to the Bone Marrow; Metastatic Tumor to the Bone Marrow; Secondary malignant neoplasm of bone marrow
SNOMED CT: Secondary malignant neoplasm of bone marrow (94217008); Metastatic malignant neoplasm to bone marrow (94217008); Cancer metastatic to bone marrow (94217008); Metastatic malignant neoplasm of bone marrow (94217008); Metastasis to bone marrow (94217008)

Definition

The spread of a malignant neoplasm from its original site of growth to the bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Bone Marrow

Professional guidelines

PubMed

2022 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer, including patients with COVID-19.
Farge D, Frere C, Connors JM, Khorana AA, Kakkar A, Ay C, Muñoz A, Brenner B, Prata PH, Brilhante D, Antic D, Casais P, Guillermo Esposito MC, Ikezoe T, Abutalib SA, Meillon-García LA, Bounameaux H, Pabinger I, Douketis J; International Initiative on Thrombosis and Cancer (ITAC) advisory panel
Lancet Oncol 2022 Jul;23(7):e334-e347. doi: 10.1016/S1470-2045(22)00160-7. PMID: 35772465Free PMC Article
Clinical Profile and Treatment in Hypereosinophilic Syndrome Variants: A Pragmatic Review.
Requena G, van den Bosch J, Akuthota P, Kovalszki A, Steinfeld J, Kwon N, Van Dyke MK
J Allergy Clin Immunol Pract 2022 Aug;10(8):2125-2134. Epub 2022 Apr 22 doi: 10.1016/j.jaip.2022.03.034. PMID: 35470096
Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767

Recent clinical studies

Etiology

MDS overlap disorders and diagnostic boundaries.
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443
ICUS, IDUS, CHIP and CCUS: Diagnostic Criteria, Separation from MDS and Clinical Implications.
Valent P
Pathobiology 2019;86(1):30-38. Epub 2018 Jun 1 doi: 10.1159/000489042. PMID: 29860246Free PMC Article
Bone Marrow Function After (131)I Therapy in Patients With Differentiated Thyroid Carcinoma.
Prinsen HT, Klein Hesselink EN, Brouwers AH, Plukker JT, Sluiter WJ, van der Horst-Schrivers AN, van Imhoff GW, Links TP
J Clin Endocrinol Metab 2015 Oct;100(10):3911-7. Epub 2015 Aug 11 doi: 10.1210/jc.2015-2124. PMID: 26262436
Whole-body-MR-diffusion weighted imaging in oncology.
Wilhelm T, Stieltjes B, Schlemmer HP
Rofo 2013 Sep;184(10):950-8. Epub 2013 Sep 2 doi: 10.1055/s-0033-1335428. PMID: 23999789
Gingival involvement in a patient with CD56+ chronic myelomonocytic leukemia.
Vural F, Ozcan MA, Ozsan GH, Demirkan F, Piskin O, Ates H, Kargi A, Undar B
Leuk Lymphoma 2004 Feb;45(2):415-8. doi: 10.1080/1042819031000139639. PMID: 15101735

Diagnosis

Myeloid-like tumor hybrid cells in bone marrow promote progression of prostate cancer bone metastasis.
Ye X, Huang X, Fu X, Zhang X, Lin R, Zhang W, Zhang J, Lu Y
J Hematol Oncol 2023 May 3;16(1):46. doi: 10.1186/s13045-023-01442-4. PMID: 37138326Free PMC Article
Secondary Plasma Cell Leukaemia.
Idris M, Farid J, Javed N
J Ayub Med Coll Abbottabad 2020 Apr-Jun;32(2):277-279. PMID: 32584011
Whole-body-MR-diffusion weighted imaging in oncology.
Wilhelm T, Stieltjes B, Schlemmer HP
Rofo 2013 Sep;184(10):950-8. Epub 2013 Sep 2 doi: 10.1055/s-0033-1335428. PMID: 23999789
Bony metastases: assessing response to therapy with whole-body diffusion MRI.
Padhani AR, Gogbashian A
Cancer Imaging 2011 Oct 3;11 Spec No A(1A):S129-45. doi: 10.1102/1470-7330.2011.9034. PMID: 22185786Free PMC Article
Whole-body magnetic resonance imaging: techniques, clinical indications, and future applications.
Walker RE, Eustace SJ
Semin Musculoskelet Radiol 2001;5(1):5-20. doi: 10.1055/s-2001-12923. PMID: 11371332

Therapy

Immunotherapy and Radiotherapy for Older Cancer Patients during the COVID-19 Era: Proposed Paradigm by the International Geriatric Radiotherapy Group.
Nguyen NP, Baumert BG, Oboite E, Motta M, Appalanaido GK, Arenas M, Lara PC, Bonet M, Zamagni A, Vuong T, Popescu T, Karlsson U, Trigo L, Sun Myint A, Thariat J, Vinh-Hung V
Gerontology 2021;67(4):379-385. Epub 2021 Mar 30 doi: 10.1159/000514451. PMID: 33784693Free PMC Article
MDS overlap disorders and diagnostic boundaries.
Tanaka TN, Bejar R
Blood 2019 Mar 7;133(10):1086-1095. Epub 2019 Jan 22 doi: 10.1182/blood-2018-10-844670. PMID: 30670443
Bone Marrow Function After (131)I Therapy in Patients With Differentiated Thyroid Carcinoma.
Prinsen HT, Klein Hesselink EN, Brouwers AH, Plukker JT, Sluiter WJ, van der Horst-Schrivers AN, van Imhoff GW, Links TP
J Clin Endocrinol Metab 2015 Oct;100(10):3911-7. Epub 2015 Aug 11 doi: 10.1210/jc.2015-2124. PMID: 26262436
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F, Pelicci PG, Martelli MF; GIMEMA Acute Leukemia Working Party
N Engl J Med 2005 Jan 20;352(3):254-66. doi: 10.1056/NEJMoa041974. PMID: 15659725
The role of radioimmunotherapy in bone marrow transplantation.
Corcoran MC, Press OW, Matthews DC, Appelbaum FR, Bernstein ID
Curr Opin Hematol 1996 Nov;3(6):438-45. doi: 10.1097/00062752-199603060-00007. PMID: 9372115

Prognosis

Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis.
Yip RKH, Rimes JS, Capaldo BD, Vaillant F, Mouchemore KA, Pal B, Chen Y, Surgenor E, Murphy AJ, Anderson RL, Smyth GK, Lindeman GJ, Hawkins ED, Visvader JE
Nat Commun 2021 Nov 26;12(1):6920. doi: 10.1038/s41467-021-26556-6. PMID: 34836954Free PMC Article
Breast Cancer Dormancy in Bone.
Clements ME, Johnson RW
Curr Osteoporos Rep 2019 Oct;17(5):353-361. doi: 10.1007/s11914-019-00532-y. PMID: 31468498Free PMC Article
Blast Transformation in Myeloproliferative Neoplasms: Risk Factors, Biological Findings, and Targeted Therapeutic Options.
Iurlo A, Cattaneo D, Gianelli U
Int J Mol Sci 2019 Apr 13;20(8) doi: 10.3390/ijms20081839. PMID: 31013941Free PMC Article
Whole-body-MR-diffusion weighted imaging in oncology.
Wilhelm T, Stieltjes B, Schlemmer HP
Rofo 2013 Sep;184(10):950-8. Epub 2013 Sep 2 doi: 10.1055/s-0033-1335428. PMID: 23999789
Detection and clinical implications of minimal residual disease in gastro-intestinal cancer.
Wolfrum F, Vogel I, Fändrich F, Kalthoff H
Langenbecks Arch Surg 2005 Sep;390(5):430-41. Epub 2005 Jul 1 doi: 10.1007/s00423-005-0558-3. PMID: 15991048

Clinical prediction guides

FDG PETCT for assessing marrow involvement at staging pediatric nonhematological round cell malignancies.
Shah S, Purandare N, Kembhavi S, Puranik A, Agrawal A, Bedmutha A, Qureshi S, Chinnaswamy G, Vora T, Prasad M, Parambil B, Rangarajan V
Nucl Med Commun 2022 Jan 1;43(1):56-63. doi: 10.1097/MNM.0000000000001491. PMID: 34618718
Malignant Infantile Osteopetrosis.
Gillani S, Abbas Z
J Ayub Med Coll Abbottabad 2017 Apr-Jun;29(2):350-352. PMID: 28718264
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, La Starza R, Diverio D, Colombo E, Santucci A, Bigerna B, Pacini R, Pucciarini A, Liso A, Vignetti M, Fazi P, Meani N, Pettirossi V, Saglio G, Mandelli F, Lo-Coco F, Pelicci PG, Martelli MF; GIMEMA Acute Leukemia Working Party
N Engl J Med 2005 Jan 20;352(3):254-66. doi: 10.1056/NEJMoa041974. PMID: 15659725
Gingival involvement in a patient with CD56+ chronic myelomonocytic leukemia.
Vural F, Ozcan MA, Ozsan GH, Demirkan F, Piskin O, Ates H, Kargi A, Undar B
Leuk Lymphoma 2004 Feb;45(2):415-8. doi: 10.1080/1042819031000139639. PMID: 15101735

Recent systematic reviews

Efficacy and safety of immunosuppressive agents for adults with lupus nephritis: a systematic review and network meta-analysis.
Jiang N, Jin S, Yu C, Zhao J, Wang Q, Tian X, Li M, Zeng X
Front Immunol 2023;14:1232244. Epub 2023 Oct 13 doi: 10.3389/fimmu.2023.1232244. PMID: 37901212Free PMC Article
Systematic review of isolated disseminated carcinomatosis of bone marrow from colorectal cancer.
Chan WK, Lin NS, Tay KV, Teo LT
ANZ J Surg 2023 May;93(5):1169-1175. Epub 2023 Feb 11 doi: 10.1111/ans.18324. PMID: 36772885
Efficacy and safety of allogeneic hematopoietic stem cell transplant in adults with hemophagocytic lymphohistiocytosis: a systematic review of literature.
Masood A, Wahab A, Iqbal Q, Davis J, Ehsan H, Hashmi H
Bone Marrow Transplant 2022 Jun;57(6):866-873. Epub 2022 Apr 11 doi: 10.1038/s41409-022-01668-9. PMID: 35411107
Role of one, two and three doses of high-dose chemotherapy with autologous transplantation in the treatment of high-risk or relapsed testicular cancer: a systematic review.
Bin Riaz I, Umar M, Zahid U, Husnain M, Iftikhar A, McBride A, Bilal J, Javed A, Akbar S, Singh P, Ali Z, Sipra QUAR, Gondal FR, Ahman F, Anwer F
Bone Marrow Transplant 2018 Oct;53(10):1242-1254. Epub 2018 Apr 27 doi: 10.1038/s41409-018-0188-3. PMID: 29703969
Chlorambucil for the treatment of patients with chronic lymphocytic leukemia (CLL) - a systematic review and meta-analysis of randomized trials.
Vidal L, Gurion R, Ram R, Raanani P, Bairey O, Robak T, Gafter-Gvili A, Shpilberg O
Leuk Lymphoma 2016 Sep;57(9):2047-57. Epub 2016 Mar 16 doi: 10.3109/10428194.2016.1154956. PMID: 26980554

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