Bone marrow neoplasm

MedGen UID:: 129203
•Concept ID:: C0282609
•: Neoplastic Process

Synonyms:	Bone Marrow Neoplasm; Bone Marrow Neoplasms; Neoplasm, Bone Marrow; Neoplasms, Bone Marrow
SNOMED CT:	Neoplasm of bone marrow (414824005)

Monarch Initiative:	MONDO:0005374

Definition

A neoplasm that affects the bone marrow. It may arise in the bone marrow (e.g., myeloid leukemia) or may involve the bone marrow as a secondary, metastatic tumor (e.g., metastatic carcinoma to the bone marrow). [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBone marrow neoplasm

Pathological process
- Disease
  - Disorder by Site
    - Hematopoietic and Lymphatic System Disorder
      - Hematologic disorder
        Bone marrow disorder
        Bone marrow neoplasm
        Acquired polycythemia vera
        Polycythemia Vera, Polycythemic Phase
        Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase
        Bone marrow cancer
        Erythroid neoplasm
        Acute myeloid leukemia, M6 type
        Megakaryocytic Neoplasm
        Acute megakaryoblastic leukemia
        Essential thrombocythemia
        Metastatic Malignant Neoplasm in the Bone Marrow
        Myelodysplastic syndrome
        Adult Myelodysplastic Syndrome
        Childhood myelodysplastic syndrome
        de novo Myelodysplastic Syndrome
        Familial monosomy 7 syndrome
        Hereditary Myelodysplastic Syndrome
        Monocytopenia with susceptibility to infections
        Myelodysplastic syndrome associated with isolated del(5q)
        Myelodysplastic Syndrome with del(5q)
        Myelodysplastic syndrome with excess blasts
        Myelodysplastic syndrome with multilineage dysplasia
        Myelodysplastic syndrome with ring sideroblasts
        Myelodysplastic Syndrome with Somatic Mutation
        Myelodysplastic Syndrome, Unclassifiable
        Paroxysmal Hemoglobinuria
        Recurrent Myelodysplastic Syndrome
        Refractory anemia
        Refractory anemia with excess blasts in transformation
        Refractory anemia with ringed sideroblasts
        Refractory cytopenia with unilineage dysplasia
        Refractory Myelodysplastic Syndrome
        Secondary Myelodysplastic Syndrome
        Sideroblastic anemia
        Myelodysplastic/myeloproliferative neoplasm
        Atypical chronic myeloid leukemia, BCR-ABL1 negative
        Chronic myelomonocytic leukemia
        Juvenile myelomonocytic leukemia
        Myelodysplastic/Myeloproliferative Neoplasm Post Cytotoxic Therapy
        Myelodysplastic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis, Not Otherwise Specified
        Recurrent Myelodysplastic/Myeloproliferative Neoplasm
        Refractory Myelodysplastic/Myeloproliferative Neoplasm
        Unclassified myelodysplastic/myeloproliferative disease
        Myeloid leukemia
        Acute myeloid leukemia
        Acute myelomonocytic leukemia M4
        Chronic myelogenous leukemia, BCR-ABL1 positive
        Chronic Myeloid Leukemia, BCR-ABL1 Positive
        Myeloid sarcoma
        Philadelphia-positive myelogenous leukemia
        Myeloproliferative neoplasm
        14q32 duplication syndrome
        Chronic eosinophilic leukemia
        Chronic neutrophilic leukemia
        Myeloproliferative neoplasm, unclassifiable
        Primary myelofibrosis
        Recurrent Myeloproliferative Neoplasm
        Refractory Myeloproliferative Neoplasm
        Thrombocytopenia 6
        Transient myeloproliferative syndrome
        Therapy related acute myeloid leukemia and myelodysplastic syndrome
        Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent
        Acute myeloid leukemia and myelodysplastic syndromes related to radiation
        Acute myeloid leukemia and myelodysplastic syndromes related to topoisomerase type 2 inhibitor
        Acute Myeloid Leukemia Post Cytotoxic Therapy
        Myelodysplastic Syndrome Post Cytotoxic Therapy

Professional guidelines

PubMed

Essential thrombocythemia: 2024 update on diagnosis, risk stratification, and management.

Tefferi A, Vannucchi AM, Barbui T
Am J Hematol 2024 Apr;99(4):697-718. Epub 2024 Jan 25 doi: 10.1002/ajh.27216. PMID: 38269572

Polycythemia vera: 2024 update on diagnosis, risk-stratification, and management.

Tefferi A, Barbui T
Am J Hematol 2023 Sep;98(9):1465-1487. Epub 2023 Jun 26 doi: 10.1002/ajh.27002. PMID: 37357958

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.

Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511

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Recent clinical studies

Etiology

Feasibility of whole body vibration during intensive chemotherapy in patients with hematological malignancies - a randomized controlled pilot study.

Pahl A, Wehrle A, Kneis S, Gollhofer A, Bertz H
BMC Cancer 2018 Sep 25;18(1):920. doi: 10.1186/s12885-018-4813-8. PMID: 30253746 Free PMC Article

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Diagnosis

Feasibility of whole body vibration during intensive chemotherapy in patients with hematological malignancies - a randomized controlled pilot study.

Pahl A, Wehrle A, Kneis S, Gollhofer A, Bertz H
BMC Cancer 2018 Sep 25;18(1):920. doi: 10.1186/s12885-018-4813-8. PMID: 30253746 Free PMC Article

Diagnostic Performance of In-Phase and Opposed-Phase Chemical-Shift Imaging for Differentiating Benign and Malignant Vertebral Marrow Lesions: A Meta-Analysis.

Suh CH, Yun SJ, Jin W, Park SY, Ryu CW, Lee SH
AJR Am J Roentgenol 2018 Oct;211(4):W188-W197. Epub 2018 Aug 30 doi: 10.2214/AJR.17.19306. PMID: 30160981

ADC as a useful diagnostic tool for differentiating benign and malignant vertebral bone marrow lesions and compression fractures: a systematic review and meta-analysis.

Suh CH, Yun SJ, Jin W, Lee SH, Park SY, Ryu CW
Eur Radiol 2018 Jul;28(7):2890-2902. Epub 2018 Feb 15 doi: 10.1007/s00330-018-5330-5. PMID: 29450718

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