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Vulva cancer

MedGen UID:
91196
•Concept ID:
C0375071
•
Neoplastic Process
Synonyms: Cancer of the Vulva; Cancer of Vulva; Cancer, Vulva; Cancer, Vulvar; Cancers, Vulva; Cancers, Vulvar; Vulva Cancer; Vulva Cancers; Vulvar Cancer; Vulvar Cancers
SNOMED CT: Cancer of vulva (363367000); Malignant tumor of vulva (363367000)
 
Monarch Initiative: MONDO:0001528

Definition

A primary or metastatic malignant neoplasm involving the vulva. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulva cancer

Professional guidelines

PubMed

Sexual and Psychosexual Consequences of Treatment for Gynaecological Cancers.
Rizzuto I, Oehler MK, Lalondrelle S
Clin Oncol (R Coll Radiol) 2021 Sep;33(9):602-607. Epub 2021 Jul 17 doi: 10.1016/j.clon.2021.07.003. PMID: 34281725
Negative pressure wound treatment (NPWT) in vulva and groin wounds in gynaecologic oncology.
Wahab NAA, Saadeh FA, Wong A, Gleeson N
Eur J Gynaecol Oncol 2016;37(5):632-637. PMID: 29787000
Chemotherapy and radiation therapy in the treatment of squamous cell carcinoma of the vulva: Are two therapies better than one?
Moore DH
Gynecol Oncol 2009 Jun;113(3):379-83. Epub 2009 Feb 20 doi: 10.1016/j.ygyno.2009.01.004. PMID: 19232700

Recent clinical studies

Etiology

Comorbidity in patients with Lichen sclerosus: a retrospective cohort study.
Gulin SJ, Lundin F, Seifert O
Eur J Med Res 2023 Sep 11;28(1):338. doi: 10.1186/s40001-023-01335-9. PMID: 37697418Free PMC Article
The accuracy of intraoperative frozen section examination of sentinel lymph nodes in squamous cell cancer of the vulva.
Swift BE, Tigert M, Nica A, Covens A, Vicus D, Parra-Herran C, Kupets R, Osborne R, Gien LT
Gynecol Oncol 2022 Feb;164(2):393-397. Epub 2021 Dec 8 doi: 10.1016/j.ygyno.2021.11.020. PMID: 34893347
Locally advanced vulva cancer: A single centre review of anovulvectomy and a systematic review of surgical, chemotherapy and radiotherapy alternatives. Is an international collaborative RCT destined for the "too difficult to do" box?
O'Donnell RL, Verleye L, Ratnavelu N, Galaal K, Fisher A, Naik R
Gynecol Oncol 2017 Feb;144(2):438-447. Epub 2016 Dec 27 doi: 10.1016/j.ygyno.2016.12.007. PMID: 28034465
Sexual, psychological, and relational functioning in women after surgical treatment for vulvar malignancy: a literature review.
Aerts L, Enzlin P, Vergote I, Verhaeghe J, Poppe W, Amant F
J Sex Med 2012 Feb;9(2):361-71. Epub 2011 Nov 14 doi: 10.1111/j.1743-6109.2011.02520.x. PMID: 22082135
Sexuality and intimacy after gynecological cancer.
Ratner ES, Foran KA, Schwartz PE, Minkin MJ
Maturitas 2010 May;66(1):23-6. Epub 2010 Mar 19 doi: 10.1016/j.maturitas.2010.01.015. PMID: 20303222

Diagnosis

Comorbidity in patients with Lichen sclerosus: a retrospective cohort study.
Gulin SJ, Lundin F, Seifert O
Eur J Med Res 2023 Sep 11;28(1):338. doi: 10.1186/s40001-023-01335-9. PMID: 37697418Free PMC Article
The accuracy of intraoperative frozen section examination of sentinel lymph nodes in squamous cell cancer of the vulva.
Swift BE, Tigert M, Nica A, Covens A, Vicus D, Parra-Herran C, Kupets R, Osborne R, Gien LT
Gynecol Oncol 2022 Feb;164(2):393-397. Epub 2021 Dec 8 doi: 10.1016/j.ygyno.2021.11.020. PMID: 34893347
Sexual and Psychosexual Consequences of Treatment for Gynaecological Cancers.
Rizzuto I, Oehler MK, Lalondrelle S
Clin Oncol (R Coll Radiol) 2021 Sep;33(9):602-607. Epub 2021 Jul 17 doi: 10.1016/j.clon.2021.07.003. PMID: 34281725
Mapping evidence on ovarian, endometrial, vaginal, and vulva cancer research in Africa: a scoping review protocol.
Ninimiya SY, Ansu-Mensah M, Bawontuo V, Kuupiel D
Syst Rev 2021 Apr 14;10(1):108. doi: 10.1186/s13643-021-01654-0. PMID: 33849664Free PMC Article
Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology.
Zubor P, Wang Y, Liskova A, Samec M, Koklesova L, Dankova Z, Dørum A, Kajo K, Dvorska D, Lucansky V, Malicherova B, Kasubova I, Bujnak J, Mlyncek M, Dussan CA, Kubatka P, Büsselberg D, Golubnitschaja O
Int J Mol Sci 2020 Oct 27;21(21) doi: 10.3390/ijms21217988. PMID: 33121141Free PMC Article

Therapy

Immunotherapy and radiation therapy sequencing: State of the data on timing, efficacy, and safety.
Williamson CW, Sherer MV, Zamarin D, Sharabi AB, Dyer BA, Mell LK, Mayadev JS
Cancer 2021 May 15;127(10):1553-1567. Epub 2021 Feb 23 doi: 10.1002/cncr.33424. PMID: 33620731Free PMC Article
Locally advanced vulva cancer: A single centre review of anovulvectomy and a systematic review of surgical, chemotherapy and radiotherapy alternatives. Is an international collaborative RCT destined for the "too difficult to do" box?
O'Donnell RL, Verleye L, Ratnavelu N, Galaal K, Fisher A, Naik R
Gynecol Oncol 2017 Feb;144(2):438-447. Epub 2016 Dec 27 doi: 10.1016/j.ygyno.2016.12.007. PMID: 28034465
A review of complications associated with the surgical treatment of vulvar cancer.
Wills A, Obermair A
Gynecol Oncol 2013 Nov;131(2):467-79. Epub 2013 Jul 14 doi: 10.1016/j.ygyno.2013.07.082. PMID: 23863358
Feasibility and acute toxicity of Concurrent Chemoradiotherapy (CCRT) with high-dose rate intracavitary brachytherapy (HDR-ICBT) and 40-mg/m2 weekly cisplatin for Japanese patients with cervical cancer: results of a Multi-Institutional Phase 2 Study (JGOG1066).
Toita T, Kitagawa R, Hamano T, Umayahara K, Hirashima Y, Aoki Y, Oguchi M, Mikami M, Takizawa K; Cervical Cancer Vulva Cancer Committee of the Japanese Gynecologic Oncology Group
Int J Gynecol Cancer 2012 Oct;22(8):1420-6. doi: 10.1097/IGC.0b013e3182647265. PMID: 22932262
Bleomycin, methotrexate, and CCNU in locally advanced or recurrent, inoperable, squamous-cell carcinoma of the vulva: an EORTC Gynaecological Cancer Cooperative Group Study. European Organization for Research and Treatment of Cancer.
Wagenaar HC, Colombo N, Vergote I, Hoctin-Boes G, Zanetta G, Pecorelli S, Lacave AJ, van Hoesel Q, Cervantes A, Bolis G, Namer M, Lhommé C, Guastalla JP, Nooij MA, Poveda A, Scotto di Palumbo V, Vermorken JB
Gynecol Oncol 2001 Jun;81(3):348-54. doi: 10.1006/gyno.2001.6180. PMID: 11371121

Prognosis

TP53 mutation and human papilloma virus status as independent prognostic factors in a Norwegian cohort of vulva squamous cell carcinoma.
Dongre HN, Elnour R, Tornaas S, Fromreide S, Thomsen LCV, Kolseth IBM, Nginamau ES, Johannessen AC, Vintermyr OK, Costea DE, Bjørge L
Acta Obstet Gynecol Scand 2024 Jan;103(1):165-175. Epub 2023 Oct 15 doi: 10.1111/aogs.14689. PMID: 37840151Free PMC Article
Sexual and Psychosexual Consequences of Treatment for Gynaecological Cancers.
Rizzuto I, Oehler MK, Lalondrelle S
Clin Oncol (R Coll Radiol) 2021 Sep;33(9):602-607. Epub 2021 Jul 17 doi: 10.1016/j.clon.2021.07.003. PMID: 34281725
The forgotten woman's cancer: vulvar squamous cell carcinoma (VSCC) and a targeted approach to therapy.
Clancy AA, Spaans JN, Weberpals JI
Ann Oncol 2016 Sep;27(9):1696-705. Epub 2016 Jun 20 doi: 10.1093/annonc/mdw242. PMID: 27329249
Sexual, psychological, and relational functioning in women after surgical treatment for vulvar malignancy: a literature review.
Aerts L, Enzlin P, Vergote I, Verhaeghe J, Poppe W, Amant F
J Sex Med 2012 Feb;9(2):361-71. Epub 2011 Nov 14 doi: 10.1111/j.1743-6109.2011.02520.x. PMID: 22082135
Clinico-pathological profile of vulva cancer in southern Thailand: analysis of 66 cases.
Hanprasertpong J, Chichareon S, Wootipoom V, Buhachat R, Tocharoenvanich S, Geater A
J Med Assoc Thai 2005 May;88(5):575-81. PMID: 16149671

Clinical prediction guides

TP53 mutation and human papilloma virus status as independent prognostic factors in a Norwegian cohort of vulva squamous cell carcinoma.
Dongre HN, Elnour R, Tornaas S, Fromreide S, Thomsen LCV, Kolseth IBM, Nginamau ES, Johannessen AC, Vintermyr OK, Costea DE, Bjørge L
Acta Obstet Gynecol Scand 2024 Jan;103(1):165-175. Epub 2023 Oct 15 doi: 10.1111/aogs.14689. PMID: 37840151Free PMC Article
Locally advanced vulva cancer: A single centre review of anovulvectomy and a systematic review of surgical, chemotherapy and radiotherapy alternatives. Is an international collaborative RCT destined for the "too difficult to do" box?
O'Donnell RL, Verleye L, Ratnavelu N, Galaal K, Fisher A, Naik R
Gynecol Oncol 2017 Feb;144(2):438-447. Epub 2016 Dec 27 doi: 10.1016/j.ygyno.2016.12.007. PMID: 28034465
The comparative study of former and latest FIGO staging of vulva cancer.
Sun X, Zhang Y, Sun J, Feng S, Yan M, Cheng H
Minerva Chir 2012 Apr;67(2):187-95. PMID: 22487921
Sexual, psychological, and relational functioning in women after surgical treatment for vulvar malignancy: a literature review.
Aerts L, Enzlin P, Vergote I, Verhaeghe J, Poppe W, Amant F
J Sex Med 2012 Feb;9(2):361-71. Epub 2011 Nov 14 doi: 10.1111/j.1743-6109.2011.02520.x. PMID: 22082135
Clinico-pathological profile of vulva cancer in southern Thailand: analysis of 66 cases.
Hanprasertpong J, Chichareon S, Wootipoom V, Buhachat R, Tocharoenvanich S, Geater A
J Med Assoc Thai 2005 May;88(5):575-81. PMID: 16149671

Recent systematic reviews

Assessing Patient-reported Quality of Life Outcomes in Vulva Cancer Patients: A Systematic Literature Review.
Froeding LP, Greimel E, Lanceley A, Oberguggenberger A, Schmalz C, Radisic VB, Nordin A, Galalaei R, Kuljanic K, Vistad I, Schnack TH, Jensen PT; European Organization of Research Treatment of Cancer Quality of Life Group the Gynecological Cancer group
Int J Gynecol Cancer 2018 May;28(4):808-817. doi: 10.1097/IGC.0000000000001211. PMID: 29420364
Locally advanced vulva cancer: A single centre review of anovulvectomy and a systematic review of surgical, chemotherapy and radiotherapy alternatives. Is an international collaborative RCT destined for the "too difficult to do" box?
O'Donnell RL, Verleye L, Ratnavelu N, Galaal K, Fisher A, Naik R
Gynecol Oncol 2017 Feb;144(2):438-447. Epub 2016 Dec 27 doi: 10.1016/j.ygyno.2016.12.007. PMID: 28034465

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