U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Viral hemorrhagic fever

MedGen UID:
9213
•Concept ID:
C0019104
•
Disease or Syndrome
Synonyms: Fever, Viral Hemorrhagic; Fevers, Viral Hemorrhagic; Hemorrhagic Fever, Viral; Hemorrhagic Fevers, Viral; Viral Hemorrhagic Fever; Viral Hemorrhagic Fevers
SNOMED CT: VHF - Viral hemorrhagic fever (240523007); Viral hemorrhagic fever (240523007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018087
Orphanet: ORPHA341

Definition

Viral hemorrhagic fever is a group of recently discovered contagious viral infections characterized by severe, multiple, and often fatal hemorrhages. African fevers include Lassa fever discovered in 1969, Marburg's disease that first occurred in 1967, and Ebola fever that appeared in 1976. Other viruses may also cause hemorrhagic fevers (for example, arbovirus fever). [from ORDO]

Professional guidelines

PubMed

Management of Hemorrhagic Fever Viruses: Intervention of Natural and Synthetic Products.
Lashgari NA, Roudsari NM, Khayatan D, Samani N, Eskandari Rad N, Mortazavi M, Abdolghaffari AH, Momtaz S
Mini Rev Med Chem 2023;23(15):1575-1589. doi: 10.2174/1389557523666230202111337. PMID: 36733245
Editorial: Antibody Therapeutics for the Treatment of Filoviral Infection.
Murin CD, Gunn BM, Parren PWHI, Kobinger GP
Front Immunol 2022;13:859919. Epub 2022 Feb 18 doi: 10.3389/fimmu.2022.859919. PMID: 35251051Free PMC Article
Crimean-Congo Hemorrhagic Fever in Differential Diagnosis During the Coronavirus Disease-2019 Pandemic.
Sağmak Tartar A, Akbulut A, Demirdağ K, Balin ŞÖ
Turkiye Parazitol Derg 2022 Mar 1;46(1):50-53. doi: 10.4274/tpd.galenos.2021.32042. PMID: 35232706

Recent clinical studies

Etiology

Lassa Virus Genetics.
Klitting R, Mehta SB, Oguzie JU, Oluniyi PE, Pauthner MG, Siddle KJ, Andersen KG, Happi CT, Sabeti PC
Curr Top Microbiol Immunol 2023;440:23-65. doi: 10.1007/82_2020_212. PMID: 32418034
Yellow Fever: A Perennial Threat.
Tuells J, Henao-Martínez AF, Franco-Paredes C
Arch Med Res 2022 Nov;53(7):649-657. Epub 2022 Oct 28 doi: 10.1016/j.arcmed.2022.10.005. PMID: 36404585
Fever in the Returning Traveler.
Paquet D, Jung L, Trawinski H, Wendt S, Lübbert C
Dtsch Arztebl Int 2022 Jun 7;119(22):400-407. doi: 10.3238/arztebl.m2022.0182. PMID: 35469592Free PMC Article
Crimean-Congo hemorrhagic fever: An update.
Fillâtre P, Revest M, Tattevin P
Med Mal Infect 2019 Nov;49(8):574-585. Epub 2019 Oct 10 doi: 10.1016/j.medmal.2019.09.005. PMID: 31607406
Hemorrhagic fever viruses.
Pigott DC
Crit Care Clin 2005 Oct;21(4):765-83, vii. doi: 10.1016/j.ccc.2005.06.007. PMID: 16168314Free PMC Article

Diagnosis

Fever in the Returning Traveler.
Paquet D, Jung L, Trawinski H, Wendt S, Lübbert C
Dtsch Arztebl Int 2022 Jun 7;119(22):400-407. doi: 10.3238/arztebl.m2022.0182. PMID: 35469592Free PMC Article
Crimean-Congo hemorrhagic fever: An update.
Fillâtre P, Revest M, Tattevin P
Med Mal Infect 2019 Nov;49(8):574-585. Epub 2019 Oct 10 doi: 10.1016/j.medmal.2019.09.005. PMID: 31607406
Viral Hemorrhagic Fever Diagnostics.
Racsa LD, Kraft CS, Olinger GG, Hensley LE
Clin Infect Dis 2016 Jan 15;62(2):214-9. Epub 2015 Sep 9 doi: 10.1093/cid/civ792. PMID: 26354968Free PMC Article
Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity.
Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M
Antiviral Res 2013 Oct;100(1):159-89. Epub 2013 Jul 29 doi: 10.1016/j.antiviral.2013.07.006. PMID: 23906741
Hemorrhagic fever viruses.
Pigott DC
Crit Care Clin 2005 Oct;21(4):765-83, vii. doi: 10.1016/j.ccc.2005.06.007. PMID: 16168314Free PMC Article

Therapy

Lassa Virus Infection: a Summary for Clinicians.
Raabe V, Mehta AK, Evans JD; Science Working Group of the National Emerging Special Pathogens Training and Education Center (NETEC) Special Pathogens Research Network (SPRN)
Int J Infect Dis 2022 Jun;119:187-200. Epub 2022 Apr 6 doi: 10.1016/j.ijid.2022.04.004. PMID: 35395384
BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity.
Arts RJW, Moorlag SJCFM, Novakovic B, Li Y, Wang SY, Oosting M, Kumar V, Xavier RJ, Wijmenga C, Joosten LAB, Reusken CBEM, Benn CS, Aaby P, Koopmans MP, Stunnenberg HG, van Crevel R, Netea MG
Cell Host Microbe 2018 Jan 10;23(1):89-100.e5. doi: 10.1016/j.chom.2017.12.010. PMID: 29324233
Ebola and Marburg virus vaccines.
Reynolds P, Marzi A
Virus Genes 2017 Aug;53(4):501-515. Epub 2017 Apr 26 doi: 10.1007/s11262-017-1455-x. PMID: 28447193Free PMC Article
Animal models of viral hemorrhagic fever.
Smith DR, Holbrook MR, Gowen BB
Antiviral Res 2014 Dec;112:59-79. Epub 2014 Oct 18 doi: 10.1016/j.antiviral.2014.10.001. PMID: 25448088
Yellow fever vaccine.
Monath TP
Expert Rev Vaccines 2005 Aug;4(4):553-74. doi: 10.1586/14760584.4.4.553. PMID: 16117712

Prognosis

Fever in the Returning Traveler.
Paquet D, Jung L, Trawinski H, Wendt S, Lübbert C
Dtsch Arztebl Int 2022 Jun 7;119(22):400-407. doi: 10.3238/arztebl.m2022.0182. PMID: 35469592Free PMC Article
Dengue Hemorrhagic Fever Virus in Saudi Arabia: A Review.
Al-Tawfiq JA, Memish ZA
Vector Borne Zoonotic Dis 2018 Feb;18(2):75-81. Epub 2018 Jan 10 doi: 10.1089/vbz.2017.2209. PMID: 29319426
A Primate Model for Viral Hemorrhagic Fever.
Salvato MS, Lukashevich IS, Yang Y, Medina-Moreno S, Djavani M, Bryant J, Rodas JD, Zapata JC
Methods Mol Biol 2018;1604:279-290. doi: 10.1007/978-1-4939-6981-4_22. PMID: 28986843
The Pathogenesis of Ebola Virus Disease.
Baseler L, Chertow DS, Johnson KM, Feldmann H, Morens DM
Annu Rev Pathol 2017 Jan 24;12:387-418. doi: 10.1146/annurev-pathol-052016-100506. PMID: 27959626
Other viral bioweapons: Ebola and Marburg hemorrhagic fever.
Salvaggio MR, Baddley JW
Dermatol Clin 2004 Jul;22(3):291-302, vi. doi: 10.1016/j.det.2004.03.003. PMID: 15207310

Clinical prediction guides

ICD2Vec: Mathematical representation of diseases.
Lee YC, Jung SH, Kumar A, Shim I, Song M, Kim MS, Kim K, Myung W, Park WY, Won HH
J Biomed Inform 2023 May;141:104361. Epub 2023 Apr 11 doi: 10.1016/j.jbi.2023.104361. PMID: 37054960
Fever in the Returning Traveler.
Paquet D, Jung L, Trawinski H, Wendt S, Lübbert C
Dtsch Arztebl Int 2022 Jun 7;119(22):400-407. doi: 10.3238/arztebl.m2022.0182. PMID: 35469592Free PMC Article
A Primate Model for Viral Hemorrhagic Fever.
Salvato MS, Lukashevich IS, Yang Y, Medina-Moreno S, Djavani M, Bryant J, Rodas JD, Zapata JC
Methods Mol Biol 2018;1604:279-290. doi: 10.1007/978-1-4939-6981-4_22. PMID: 28986843
Ebola and Marburg virus vaccines.
Reynolds P, Marzi A
Virus Genes 2017 Aug;53(4):501-515. Epub 2017 Apr 26 doi: 10.1007/s11262-017-1455-x. PMID: 28447193Free PMC Article
The Pathogenesis of Ebola Virus Disease.
Baseler L, Chertow DS, Johnson KM, Feldmann H, Morens DM
Annu Rev Pathol 2017 Jan 24;12:387-418. doi: 10.1146/annurev-pathol-052016-100506. PMID: 27959626

Recent systematic reviews

Risk factors associated with sustained circulation of six zoonotic arboviruses: a systematic review for selection of surveillance sites in non-endemic areas.
Esser HJ, Mögling R, Cleton NB, van der Jeugd H, Sprong H, Stroo A, Koopmans MPG, de Boer WF, Reusken CBEM
Parasit Vectors 2019 May 27;12(1):265. doi: 10.1186/s13071-019-3515-7. PMID: 31133059Free PMC Article
Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers.
Ergönül Ö, Keske Ş, Çeldir MG, Kara İA, Pshenichnaya N, Abuova G, Blumberg L, Gönen M
Emerg Infect Dis 2018 Sep;24(9):1642-1648. doi: 10.3201/eid2409.171709. PMID: 30124196Free PMC Article
Crimean-Congo hemorrhagic fever in pregnancy: A systematic review and case series from Russia, Kazakhstan and Turkey.
Pshenichnaya NY, Leblebicioglu H, Bozkurt I, Sannikova IV, Abuova GN, Zhuravlev AS, Barut S, Shermetova MB, Fletcher TE
Int J Infect Dis 2017 May;58:58-64. Epub 2017 Feb 27 doi: 10.1016/j.ijid.2017.02.019. PMID: 28249811Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...