Enteric neuronal degeneration

MedGen UID:: 927577
•Concept ID:: C4293668
•: Pathologic Function

Synonym:	Degenerative enteric neuropathy

HPO:	HP:0025030

Definition

Deterioration of enteric neurons with impairment of enteric neuronal structure. Typical neuropathological findings include qualitative (e.g., neuronal swelling, intranuclear inclusions, axonal degeneration) and quantitative (e.g., reduction in the number of neurons) abnormalities of the enteric neurons. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVEnteric neuronal degeneration

Abnormality of the nervous system
- Abnormality of the peripheral nervous system
  - Abnormality of the autonomic nervous system
    - Abnormal autonomic nervous system morphology
      - Abnormal enteric nervous system morphology
        Abnormal enteric neuron morphology
        Enteric neuronal degeneration

Professional guidelines

PubMed

Clinical aspects of neurointestinal disease: Pathophysiology, diagnosis, and treatment.

Goldstein AM, Thapar N, Karunaratne TB, De Giorgio R
Dev Biol 2016 Sep 15;417(2):217-28. Epub 2016 Apr 6 doi: 10.1016/j.ydbio.2016.03.032. PMID: 27059882

New and emerging treatment options for chronic constipation.

Schiller LR
Rev Gastroenterol Disord 2004;4 Suppl 2:S43-51. PMID: 15184816

Histologic criteria for the diagnosis of allied diseases of Hirschsprung's disease in adults.

Munakata K, Fukuzawa M, Nemoto N
Eur J Pediatr Surg 2002 Jun;12(3):186-91. doi: 10.1055/s-2002-32731. PMID: 12101501

See all (3)

Recent clinical studies

Diagnosis

Enteric nervous system manifestations of neurodegenerative disease.

Chalazonitis A, Rao M
Brain Res 2018 Aug 15;1693(Pt B):207-213. Epub 2018 Jan 31 doi: 10.1016/j.brainres.2018.01.011. PMID: 29360466 Free PMC Article

See all (1)

Therapy

Caspase-11-mediated enteric neuronal pyroptosis underlies Western diet-induced colonic dysmotility.

Ye L, Li G, Goebel A, Raju AV, Kong F, Lv Y, Li K, Zhu Y, Raja S, He P, Li F, Mwangi SM, Hu W, Srinivasan S
J Clin Invest 2020 Jul 1;130(7):3621-3636. doi: 10.1172/JCI130176. PMID: 32484462 Free PMC Article

Enteric Neuronal Degeneration: Is it Due to Your Mother's Diet?

Ye L, Srinivasan S
Neuroscience 2018 Nov 21;393:366-368. doi: 10.1016/j.neuroscience.2018.10.017. PMID: 30454863

Octreotide treatment for paraneoplastic intestinal pseudo-obstruction complicating SCLC.

Sørhaug S, Steinshamn SL, Waldum HL
Lung Cancer 2005 Apr;48(1):137-40. doi: 10.1016/j.lungcan.2004.09.008. PMID: 15777981

See all (3)