U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cellular schwannoma

MedGen UID:
98124
•Concept ID:
C0431124
•
Neoplastic Process
Synonyms: Cellular neurilemmoma; Cellular Neurilemmoma; cellular neurilemmoma; Cellular Neurinoma; cellular neurinoma; Cellular Schwannoma; cellular schwannoma; CSCHW
SNOMED CT: Cellular neurilemmoma (404026003); Cellular schwannoma (404026003); Cellular neurilemmoma (253086004); Cellular schwannoma (253086004)
 
Monarch Initiative: MONDO:0002548

Definition

A morphologic variant of schwannoma characterized by hypercellularity, Antoni A pattern, and the absence of well-formed Verocay bodies. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCellular schwannoma

Professional guidelines

PubMed

Consensus recommendations on counselling in Phelan-McDermid syndrome, with special attention to recurrence risk and to ring chromosome 22.
Koza SA, Tabet AC, Bonaglia MC, Andres S, Anderlid BM, Aten E, Stiefsohn D; European Phelan-McDermid syndrome consortium, Evans DG, van Ravenswaaij-Arts CMA, Kant SG
Eur J Med Genet 2023 Jul;66(7):104773. Epub 2023 Apr 28 doi: 10.1016/j.ejmg.2023.104773. PMID: 37120077
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661
An update on the diagnosis and treatment of vestibular schwannoma.
Halliday J, Rutherford SA, McCabe MG, Evans DG
Expert Rev Neurother 2018 Jan;18(1):29-39. Epub 2017 Nov 7 doi: 10.1080/14737175.2018.1399795. PMID: 29088993

Recent clinical studies

Etiology

Long-term postoperative outcomes of spinal cellular schwannoma: study of 93 consecutive cases.
Jia Q, Lou Y, Chen D, Li X, Liu Y, Chu R, Wang T, Zhou Z, Li D, Wan W, Huang Q, Yang X, Wang T, Wu Z, Xiao J
Spine J 2024 May;24(5):858-866. Epub 2024 Jan 23 doi: 10.1016/j.spinee.2024.01.006. PMID: 38272127
Orbito-cranial schwannoma-a multicentre experience.
Shapira Y, Juniat V, Dave T, Hussain A, McNeely D, Watanabe A, Yoneda A, Saeed P, Woo KI, Hardy TG, Price B, Drummond K, Selva D
Eye (Lond) 2023 Jan;37(1):48-53. Epub 2022 Jan 9 doi: 10.1038/s41433-021-01850-1. PMID: 34999720Free PMC Article
Vestibular Schwannomas in Young Patients: A 12-Year Experience in a Single Center.
Zhang Z, Zheng X, Zhang D, Zhang J, Li F, Li C, Wang X, Li J, Han D, Zhang J
World Neurosurg 2022 Feb;158:e166-e178. Epub 2021 Oct 26 doi: 10.1016/j.wneu.2021.10.145. PMID: 34710579
Comparison of pathological, radiological, and prognostic features between cellular schwannoma and non-cellular schwannoma.
Zhu J, Yang Z, Tang R, Tang G
Eur J Radiol 2021 Aug;141:109783. Epub 2021 May 21 doi: 10.1016/j.ejrad.2021.109783. PMID: 34049057
Spinal cellular schwannoma: An analysis of imaging manifestation and clinicopathological findings.
Zhang E, Zhang J, Lang N, Yuan H
Eur J Radiol 2018 Aug;105:81-86. Epub 2018 May 30 doi: 10.1016/j.ejrad.2018.05.025. PMID: 30017303

Diagnosis

Orbito-cranial schwannoma-a multicentre experience.
Shapira Y, Juniat V, Dave T, Hussain A, McNeely D, Watanabe A, Yoneda A, Saeed P, Woo KI, Hardy TG, Price B, Drummond K, Selva D
Eye (Lond) 2023 Jan;37(1):48-53. Epub 2022 Jan 9 doi: 10.1038/s41433-021-01850-1. PMID: 34999720Free PMC Article
An update on the CNS manifestations of neurofibromatosis type 2.
Coy S, Rashid R, Stemmer-Rachamimov A, Santagata S
Acta Neuropathol 2020 Apr;139(4):643-665. Epub 2019 Jun 4 doi: 10.1007/s00401-019-02029-5. PMID: 31161239Free PMC Article
Spinal cellular schwannoma: An analysis of imaging manifestation and clinicopathological findings.
Zhang E, Zhang J, Lang N, Yuan H
Eur J Radiol 2018 Aug;105:81-86. Epub 2018 May 30 doi: 10.1016/j.ejrad.2018.05.025. PMID: 30017303
Intrapulmonary cellular schwannoma.
Domen H, Iwashiro N, Kimura N, Jinushi E, Komuro K, Ohara M, Ishizaka M
Ann Thorac Surg 2010 Oct;90(4):1352-5. doi: 10.1016/j.athoracsur.2010.04.023. PMID: 20868846
The pathobiologic spectrum of Schwannomas.
Kurtkaya-Yapicier O, Scheithauer B, Woodruff JM
Histol Histopathol 2003 Jul;18(3):925-34. doi: 10.14670/HH-18.925. PMID: 12792904

Therapy

Clinical outcomes following resection of giant spinal schwannomas: a case series of 32 patients.
J Neurosurg Spine 2017 Apr;26(4):494-500. Epub 2017 Jan 13 doi: 10.3171/2016.9.SPINE16778. PMID: 28084933
Review of a series with abducens nerve palsy.
Ayberk G, Ozveren MF, Yildirim T, Ercan K, Cay EK, Koçak A
Turk Neurosurg 2008 Oct;18(4):366-73. PMID: 19107682
A rare case of cellular schwannoma involving the trigeminal ganglion.
Koyye RT, Mahadevan A, Santosh V, Chickabasaviah YT, Govindappa SS, Hegde T, Shankar SK
Brain Tumor Pathol 2003;20(2):79-83. doi: 10.1007/BF02483451. PMID: 14756445

Prognosis

Long-term postoperative outcomes of spinal cellular schwannoma: study of 93 consecutive cases.
Jia Q, Lou Y, Chen D, Li X, Liu Y, Chu R, Wang T, Zhou Z, Li D, Wan W, Huang Q, Yang X, Wang T, Wu Z, Xiao J
Spine J 2024 May;24(5):858-866. Epub 2024 Jan 23 doi: 10.1016/j.spinee.2024.01.006. PMID: 38272127
Comparison of pathological, radiological, and prognostic features between cellular schwannoma and non-cellular schwannoma.
Zhu J, Yang Z, Tang R, Tang G
Eur J Radiol 2021 Aug;141:109783. Epub 2021 May 21 doi: 10.1016/j.ejrad.2021.109783. PMID: 34049057
An update on the CNS manifestations of neurofibromatosis type 2.
Coy S, Rashid R, Stemmer-Rachamimov A, Santagata S
Acta Neuropathol 2020 Apr;139(4):643-665. Epub 2019 Jun 4 doi: 10.1007/s00401-019-02029-5. PMID: 31161239Free PMC Article
Spinal cellular schwannoma: An analysis of imaging manifestation and clinicopathological findings.
Zhang E, Zhang J, Lang N, Yuan H
Eur J Radiol 2018 Aug;105:81-86. Epub 2018 May 30 doi: 10.1016/j.ejrad.2018.05.025. PMID: 30017303
The pathobiologic spectrum of Schwannomas.
Kurtkaya-Yapicier O, Scheithauer B, Woodruff JM
Histol Histopathol 2003 Jul;18(3):925-34. doi: 10.14670/HH-18.925. PMID: 12792904

Clinical prediction guides

Orbito-cranial schwannoma-a multicentre experience.
Shapira Y, Juniat V, Dave T, Hussain A, McNeely D, Watanabe A, Yoneda A, Saeed P, Woo KI, Hardy TG, Price B, Drummond K, Selva D
Eye (Lond) 2023 Jan;37(1):48-53. Epub 2022 Jan 9 doi: 10.1038/s41433-021-01850-1. PMID: 34999720Free PMC Article
Tongue Schwannoma: A Clinicopathologic Study of 19 Cases.
Thompson LDR, Koh SS, Lau SK
Head Neck Pathol 2020 Sep;14(3):571-576. Epub 2019 Sep 4 doi: 10.1007/s12105-019-01071-9. PMID: 31485983Free PMC Article
Expression of PAX3 Distinguishes Biphenotypic Sinonasal Sarcoma From Histologic Mimics.
Jo VY, Mariño-Enríquez A, Fletcher CDM, Hornick JL
Am J Surg Pathol 2018 Oct;42(10):1275-1285. doi: 10.1097/PAS.0000000000001092. PMID: 29863547
Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas.
Pekmezci M, Reuss DE, Hirbe AC, Dahiya S, Gutmann DH, von Deimling A, Horvai AE, Perry A
Mod Pathol 2015 Feb;28(2):187-200. Epub 2014 Sep 5 doi: 10.1038/modpathol.2014.109. PMID: 25189642Free PMC Article
Cellular schwannoma. A clinicopathologic, DNA flow cytometric, and proliferation marker study of 70 patients.
Casadei GP, Scheithauer BW, Hirose T, Manfrini M, Van Houton C, Wood MB
Cancer 1995 Mar 1;75(5):1109-19. doi: 10.1002/1097-0142(19950301)75:5<1109::aid-cncr2820750510>3.0.co;2-m. PMID: 7850709

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...