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Chronic periodontitis

MedGen UID:
987655
•Concept ID:
CN305296
•
Disease or Syndrome
Synonyms: chronic periodontitis; periodontitis, chronic
 
Related gene: CTSC
 
Monarch Initiative: MONDO:0005593

Definition

A chronic inflammatory process that affects the tissues that surround and support the teeth. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Orthodontic treatment in periodontally compromised patients: a systematic review.
Erbe C, Heger S, Kasaj A, Berres M, Wehrbein H
Clin Oral Investig 2023 Jan;27(1):79-89. Epub 2022 Dec 11 doi: 10.1007/s00784-022-04822-1. PMID: 36502508Free PMC Article
Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.
Dominy SS, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A, Nguyen M, Haditsch U, Raha D, Griffin C, Holsinger LJ, Arastu-Kapur S, Kaba S, Lee A, Ryder MI, Potempa B, Mydel P, Hellvard A, Adamowicz K, Hasturk H, Walker GD, Reynolds EC, Faull RLM, Curtis MA, Dragunow M, Potempa J
Sci Adv 2019 Jan;5(1):eaau3333. Epub 2019 Jan 23 doi: 10.1126/sciadv.aau3333. PMID: 30746447Free PMC Article
Evidence-Based Update on Diagnosis and Management of Gingivitis and Periodontitis.
Kumar S
Dent Clin North Am 2019 Jan;63(1):69-81. Epub 2018 Oct 29 doi: 10.1016/j.cden.2018.08.005. PMID: 30447793

Recent clinical studies

Therapy

Vitamin D and Periodontitis: A Systematic Review and Meta-Analysis.
Machado V, Lobo S, Proença L, Mendes JJ, Botelho J
Nutrients 2020 Jul 22;12(8) doi: 10.3390/nu12082177. PMID: 32708032Free PMC Article
Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial.
Invernici MM, Salvador SL, Silva PHF, Soares MSM, Casarin R, Palioto DB, Souza SLS, Taba M Jr, Novaes AB Jr, Furlaneto FAC, Messora MR
J Clin Periodontol 2018 Oct;45(10):1198-1210. Epub 2018 Sep 24 doi: 10.1111/jcpe.12995. PMID: 30076613Free PMC Article
Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis.
Manresa C, Sanz-Miralles EC, Twigg J, Bravo M
Cochrane Database Syst Rev 2018 Jan 1;1(1):CD009376. doi: 10.1002/14651858.CD009376.pub2. PMID: 29291254Free PMC Article
Benefits of non-surgical periodontal treatment in patients with type 2 diabetes mellitus and chronic periodontitis: A randomized controlled trial.
Mauri-Obradors E, Merlos A, Estrugo-Devesa A, Jané-Salas E, López-López J, Viñas M
J Clin Periodontol 2018 Mar;45(3):345-353. Epub 2018 Jan 19 doi: 10.1111/jcpe.12858. PMID: 29265454
Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study.
Teughels W, Durukan A, Ozcelik O, Pauwels M, Quirynen M, Haytac MC
J Clin Periodontol 2013 Nov;40(11):1025-35. Epub 2013 Sep 15 doi: 10.1111/jcpe.12155. PMID: 24164569Free PMC Article

Prognosis

Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial.
Gómez-Sandoval JR, Robles-Cervantes JA, Hernández-González SO, Espinel-Bermudez MC, Mariaud-Schmidt R, Martínez-Rodríguez V, Morgado-Castillo KC, Mercado-Sesma AR
BMJ Open Diabetes Res Care 2020 Jan;8(1) doi: 10.1136/bmjdrc-2019-000665. PMID: 31958293Free PMC Article
Success of non-surgical periodontal therapy in adult periodontitis patients: A retrospective analysis.
Van der Weijden GAF, Dekkers GJ, Slot DE
Int J Dent Hyg 2019 Nov;17(4):309-317. Epub 2019 May 16 doi: 10.1111/idh.12399. PMID: 30942938Free PMC Article
Impact of diabetes on clinical periodontal outcomes following non-surgical periodontal therapy.
Hsu YT, Nair M, Angelov N, Lalla E, Lee CT
J Clin Periodontol 2019 Feb;46(2):206-217. Epub 2019 Jan 20 doi: 10.1111/jcpe.13044. PMID: 30536853
Human intrabony defect regeneration with micrografts containing dental pulp stem cells: A randomized controlled clinical trial.
Ferrarotti F, Romano F, Gamba MN, Quirico A, Giraudi M, Audagna M, Aimetti M
J Clin Periodontol 2018 Jul;45(7):841-850. Epub 2018 Jun 15 doi: 10.1111/jcpe.12931. PMID: 29779220
Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study.
Teughels W, Durukan A, Ozcelik O, Pauwels M, Quirynen M, Haytac MC
J Clin Periodontol 2013 Nov;40(11):1025-35. Epub 2013 Sep 15 doi: 10.1111/jcpe.12155. PMID: 24164569Free PMC Article

Clinical prediction guides

A Mendelian randomization study between chronic periodontitis and non-alcoholic fatty liver disease.
Tan L, He Y, Wang T, Gao X, Fan W, Fan B
J Periodontal Res 2024 Apr;59(2):346-354. Epub 2023 Dec 15 doi: 10.1111/jre.13218. PMID: 38102730
Association of chronic periodontitis with multiple sclerosis: A systematic review and meta-analysis.
Tsimpiris A, Tsolianos I, Grigoriadis A, Tsimtsiou Z, Goulis DG, Grigoriadis N
Mult Scler Relat Disord 2023 Sep;77:104874. Epub 2023 Jul 7 doi: 10.1016/j.msard.2023.104874. PMID: 37478676
Reverse causal relationship between periodontitis and shortened telomere length: Bidirectional two-sample Mendelian random analysis.
Hu J, Song J, Chen Z, Yang J, Shi Q, Jin F, Pang Q, Chang X, Tian Y, Luo Y, Chen L
Front Immunol 2022;13:1057602. Epub 2022 Dec 19 doi: 10.3389/fimmu.2022.1057602. PMID: 36601105Free PMC Article
Oxidative stress-related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis: A systematic review and meta-analysis.
Chen M, Cai W, Zhao S, Shi L, Chen Y, Li X, Sun X, Mao Y, He B, Hou Y, Zhou Y, Zhou Q, Ma J, Huang S
J Clin Periodontol 2019 Jun;46(6):608-622. doi: 10.1111/jcpe.13112. PMID: 30989678
Relationship between alexithymia and chronic periodontitis.
Sezer U, Üstün K, Şenyurt SZ, Altınbaş K, Erciyas K
Niger J Clin Pract 2017 May;20(5):530-536. doi: 10.4103/1119-3077.183244. PMID: 28513509

Recent systematic reviews

Association between Periodontal Disease and Cognitive Impairment in Adults.
Said-Sadier N, Sayegh B, Farah R, Abbas LA, Dweik R, Tang N, Ojcius DM
Int J Environ Res Public Health 2023 Mar 7;20(6) doi: 10.3390/ijerph20064707. PMID: 36981618Free PMC Article
Orthodontic treatment in periodontally compromised patients: a systematic review.
Erbe C, Heger S, Kasaj A, Berres M, Wehrbein H
Clin Oral Investig 2023 Jan;27(1):79-89. Epub 2022 Dec 11 doi: 10.1007/s00784-022-04822-1. PMID: 36502508Free PMC Article
Vitamin D and Periodontitis: A Systematic Review and Meta-Analysis.
Machado V, Lobo S, Proença L, Mendes JJ, Botelho J
Nutrients 2020 Jul 22;12(8) doi: 10.3390/nu12082177. PMID: 32708032Free PMC Article
Oxidative stress-related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis: A systematic review and meta-analysis.
Chen M, Cai W, Zhao S, Shi L, Chen Y, Li X, Sun X, Mao Y, He B, Hou Y, Zhou Y, Zhou Q, Ma J, Huang S
J Clin Periodontol 2019 Jun;46(6):608-622. doi: 10.1111/jcpe.13112. PMID: 30989678
Hyaluronic acid: Perspectives in dentistry. A systematic review.
Casale M, Moffa A, Vella P, Sabatino L, Capuano F, Salvinelli B, Lopez MA, Carinci F, Salvinelli F
Int J Immunopathol Pharmacol 2016 Dec;29(4):572-582. Epub 2016 Jun 8 doi: 10.1177/0394632016652906. PMID: 27280412Free PMC Article

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