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Tropical pancreatitis

MedGen UID:
334069
•Concept ID:
C1842402
•
Disease or Syndrome
Synonym: Tropical calcific pancreatitis
SNOMED CT: Tropical calcific chronic pancreatitis (724540009)
 
Gene (location): SPINK1 (5q32)
 
Monarch Initiative: MONDO:0011986
OMIM®: 608189
Orphanet: ORPHA103918

Definition

Tropical calcific pancreatitis (TCP) is a type of chronic pancreatitis unique to tropical regions. Large intraductal calculi are present, and evidence of pancreatic calcification is seen on imaging studies (summary by Mahurkar et al., 2006). [from OMIM]

Clinical features

From HPO
Abdominal pain
MedGen UID:
7803
•Concept ID:
C0000737
•
Sign or Symptom
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.
See: Feature record | Search on this feature
Neoplasm of the pancreas
MedGen UID:
18279
•Concept ID:
C0030297
•
Neoplastic Process
A tumor (abnormal growth of tissue) of the pancreas.
See: Feature record | Search on this feature
Pancreatic calcification
MedGen UID:
330843
•Concept ID:
C1842406
•
Finding
The presence of abnormal calcium deposition lesions in the pancreas.
See: Feature record | Search on this feature
Chronic pancreatitis
MedGen UID:
101753
•Concept ID:
C0149521
•
Disease or Syndrome
A chronic form of pancreatitis.
See: Feature record | Search on this feature
Insulin-dependent but ketosis-resistant diabetes
MedGen UID:
334070
•Concept ID:
C1842404
•
Finding
Ketosis-resistant diabetes is a synonym for type II diabetes. This term thus refers to a form of type II diabetes in which patients are dependent on insulin.
See: Feature record | Search on this feature
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Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
Follow this link to review classifications for Tropical pancreatitis in Orphanet.

Professional guidelines

PubMed

Genetic factors in chronic pancreatitis; implications for diagnosis, management and prognosis.
Derikx MH, Drenth JP
Best Pract Res Clin Gastroenterol 2010 Jun;24(3):251-70. doi: 10.1016/j.bpg.2010.02.001. PMID: 20510827
Genotype-phenotype correlation in 9 patients with tropical pancreatitis and identified gene mutations.
Rajesh G, Elango EM, Vidya V, Balakrishnan V
Indian J Gastroenterol 2009 Mar-Apr;28(2):68-71. Epub 2009 Aug 21 doi: 10.1007/s12664-009-0022-3. PMID: 19696993
Endoscopic therapy for the treatment of pain in chronic pancreatitis: a success story in tropical pancreatitis.
Siddiqui UD, Jamidar PA
Gastrointest Endosc 2007 Jul;66(1):76-8. doi: 10.1016/j.gie.2007.05.005. PMID: 17591477

Recent clinical studies

Etiology

Diet, nutrient deficiency and chronic pancreatitis.
Rajesh G, Girish BN, Vaidyanathan K, Balakrishnan V
Trop Gastroenterol 2013 Apr-Jun;34(2):68-73. doi: 10.7869/tg.2012.100. PMID: 24377152
Nonalcoholic, nonbiliary pancreatitis: cross-sectional imaging spectrum.
Sunnapwar A, Prasad SR, Menias CO, Shanbhogue AK, Katre R, Raut A
AJR Am J Roentgenol 2010 Jul;195(1):67-75. doi: 10.2214/AJR.09.4048. PMID: 20566798
Tropical pancreatitis.
Petersen JM
J Clin Gastroenterol 2002 Jul;35(1):61-6. doi: 10.1097/00004836-200207000-00013. PMID: 12080228
Chronic pancreatitis: Asia-Pacific consensus report.
Tandon RK, Sato N, Garg PK; Consensus Study Group
J Gastroenterol Hepatol 2002 Apr;17(4):508-18. doi: 10.1046/j.1440-1746.2002.02762.x. PMID: 11982735
Tropical pancreatitis.
Ramesh H
Indian J Gastroenterol 1997 Jan;16(1):20-5. PMID: 9167376

Diagnosis

Chronic pancreatitis.
DiMagno MJ, DiMagno EP
Curr Opin Gastroenterol 2011 Sep;27(5):452-9. doi: 10.1097/MOG.0b013e328349e333. PMID: 21844753Free PMC Article
Nonalcoholic, nonbiliary pancreatitis: cross-sectional imaging spectrum.
Sunnapwar A, Prasad SR, Menias CO, Shanbhogue AK, Katre R, Raut A
AJR Am J Roentgenol 2010 Jul;195(1):67-75. doi: 10.2214/AJR.09.4048. PMID: 20566798
Tropical pancreatitis.
Tandon RK
J Gastroenterol 2007 Jan;42 Suppl 17:141-7. doi: 10.1007/s00535-006-1930-y. PMID: 17238044
Tropical pancreatitis.
Tandon RK, Garg PK
Dig Dis 2004;22(3):258-66. doi: 10.1159/000082797. PMID: 15753608
Tropical pancreatitis.
Ramesh H
Indian J Gastroenterol 1997 Jan;16(1):20-5. PMID: 9167376

Therapy

Diet, nutrient deficiency and chronic pancreatitis.
Rajesh G, Girish BN, Vaidyanathan K, Balakrishnan V
Trop Gastroenterol 2013 Apr-Jun;34(2):68-73. doi: 10.7869/tg.2012.100. PMID: 24377152
Therapeutic roles of curcumin: lessons learned from clinical trials.
Gupta SC, Patchva S, Aggarwal BB
AAPS J 2013 Jan;15(1):195-218. Epub 2012 Nov 10 doi: 10.1208/s12248-012-9432-8. PMID: 23143785Free PMC Article
A fire inside: current concepts in chronic pancreatitis.
Tattersall SJ, Apte MV, Wilson JS
Intern Med J 2008 Jul;38(7):592-8. doi: 10.1111/j.1445-5994.2008.01715.x. PMID: 18715303
Disorders of the pancreas in children.
Werlin SL
Curr Opin Pediatr 1998 Oct;10(5):507-11. doi: 10.1097/00008480-199810000-00010. PMID: 9818249
Observations and surgical management of tropical pancreatitis in Kerala and southern India.
Thomas PG, Augustine P, Ramesh H, Rangabashyam N
World J Surg 1990 Jan-Feb;14(1):32-42. doi: 10.1007/BF01670542. PMID: 2407037

Prognosis

Nonalcoholic, nonbiliary pancreatitis: cross-sectional imaging spectrum.
Sunnapwar A, Prasad SR, Menias CO, Shanbhogue AK, Katre R, Raut A
AJR Am J Roentgenol 2010 Jul;195(1):67-75. doi: 10.2214/AJR.09.4048. PMID: 20566798
Genetic factors in chronic pancreatitis; implications for diagnosis, management and prognosis.
Derikx MH, Drenth JP
Best Pract Res Clin Gastroenterol 2010 Jun;24(3):251-70. doi: 10.1016/j.bpg.2010.02.001. PMID: 20510827
Tropical pancreatitis.
Tandon RK, Garg PK
Dig Dis 2004;22(3):258-66. doi: 10.1159/000082797. PMID: 15753608
Chronic pancreatitis: Asia-Pacific consensus report.
Tandon RK, Sato N, Garg PK; Consensus Study Group
J Gastroenterol Hepatol 2002 Apr;17(4):508-18. doi: 10.1046/j.1440-1746.2002.02762.x. PMID: 11982735
Tropical pancreatitis.
Ramesh H
Indian J Gastroenterol 1997 Jan;16(1):20-5. PMID: 9167376

Clinical prediction guides

Therapeutic roles of curcumin: lessons learned from clinical trials.
Gupta SC, Patchva S, Aggarwal BB
AAPS J 2013 Jan;15(1):195-218. Epub 2012 Nov 10 doi: 10.1208/s12248-012-9432-8. PMID: 23143785Free PMC Article
Chronic pancreatitis.
DiMagno MJ, DiMagno EP
Curr Opin Gastroenterol 2011 Sep;27(5):452-9. doi: 10.1097/MOG.0b013e328349e333. PMID: 21844753Free PMC Article
Genetic factors in chronic pancreatitis; implications for diagnosis, management and prognosis.
Derikx MH, Drenth JP
Best Pract Res Clin Gastroenterol 2010 Jun;24(3):251-70. doi: 10.1016/j.bpg.2010.02.001. PMID: 20510827
Pancreatic lesions and modifications of pancreatic juice in tropical chronic pancreatitis (tropical calcific diabetes).
Sarles H, Augustine P, Laugier R, Mathew S, Dupuy P
Dig Dis Sci 1994 Jun;39(6):1337-44. doi: 10.1007/BF02093802. PMID: 8200268
Observations and surgical management of tropical pancreatitis in Kerala and southern India.
Thomas PG, Augustine P, Ramesh H, Rangabashyam N
World J Surg 1990 Jan-Feb;14(1):32-42. doi: 10.1007/BF01670542. PMID: 2407037

Supplemental Content

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    Clinical resources

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    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
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