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Hantavirus pulmonary syndrome(HARDS)

MedGen UID:
66205
•Concept ID:
C0243025
•
Disease or Syndrome
Synonyms: Four corners hantavirus; Hantavirus-associated respiratory distress syndrome; HARDS
SNOMED CT: Hantavirus pulmonary syndrome (120639003)
 
Monarch Initiative: MONDO:0017879
Orphanet: ORPHA319247

Definition

A rare viral hemorrhagic fever characterized by virus-induced microvascular leakage rapidly leading to a severe illness with diffuse pulmonary edema and respiratory failure. These symptoms set in after a short first disease stage with fever, myalgia, and headache, followed by severe gastrointestinal symptoms such as abdominal pain, vomiting, and diarrhea. The high lethality of the disease is due to the possible development of hypotension and cardiogenic shock. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHantavirus pulmonary syndrome
Follow this link to review classifications for Hantavirus pulmonary syndrome in Orphanet.

Professional guidelines

PubMed

Progress on the Prevention and Treatment of Hantavirus Disease.
Brocato RL, Hooper JW
Viruses 2019 Jul 4;11(7) doi: 10.3390/v11070610. PMID: 31277410Free PMC Article
Hantavirus infections for the clinician: from case presentation to diagnosis and treatment.
Sargianou M, Watson DC, Chra P, Papa A, Starakis I, Gogos C, Panos G
Crit Rev Microbiol 2012 Nov;38(4):317-29. Epub 2012 May 3 doi: 10.3109/1040841X.2012.673553. PMID: 22553984
Treatment of hantavirus pulmonary syndrome.
Jonsson CB, Hooper J, Mertz G
Antiviral Res 2008 Apr;78(1):162-9. Epub 2007 Nov 21 doi: 10.1016/j.antiviral.2007.10.012. PMID: 18093668Free PMC Article

Recent clinical studies

Etiology

Hantavirus in humans: a review of clinical aspects and management.
Vial PA, Ferrés M, Vial C, Klingström J, Ahlm C, López R, Le Corre N, Mertz GJ
Lancet Infect Dis 2023 Sep;23(9):e371-e382. Epub 2023 Apr 24 doi: 10.1016/S1473-3099(23)00128-7. PMID: 37105214
Hantavirus Pulmonary Syndrome: 1993-2018.
Thorp L, Fullerton L, Whitesell A, Dehority W
Pediatrics 2023 Apr 1;151(4) doi: 10.1542/peds.2022-059352. PMID: 36855865
Hantavirus infections.
Avšič-Županc T, Saksida A, Korva M
Clin Microbiol Infect 2019 Apr;21S:e6-e16. Epub 2015 Jun 22 doi: 10.1111/1469-0691.12291. PMID: 24750436
Community-Acquired Pneumonia in Latin America.
Iannella HA, Luna CM
Semin Respir Crit Care Med 2016 Dec;37(6):868-875. Epub 2016 Dec 13 doi: 10.1055/s-0036-1592076. PMID: 27960210
A global perspective on hantavirus ecology, epidemiology, and disease.
Jonsson CB, Figueiredo LT, Vapalahti O
Clin Microbiol Rev 2010 Apr;23(2):412-41. doi: 10.1128/CMR.00062-09. PMID: 20375360Free PMC Article

Diagnosis

Hantavirus in humans: a review of clinical aspects and management.
Vial PA, Ferrés M, Vial C, Klingström J, Ahlm C, López R, Le Corre N, Mertz GJ
Lancet Infect Dis 2023 Sep;23(9):e371-e382. Epub 2023 Apr 24 doi: 10.1016/S1473-3099(23)00128-7. PMID: 37105214
Hantavirus Pulmonary Syndrome: 1993-2018.
Thorp L, Fullerton L, Whitesell A, Dehority W
Pediatrics 2023 Apr 1;151(4) doi: 10.1542/peds.2022-059352. PMID: 36855865
Hantavirus.
Riquelme R
Semin Respir Crit Care Med 2021 Dec;42(6):822-827. Epub 2021 Dec 16 doi: 10.1055/s-0041-1733803. PMID: 34918323
Hantavirus infections.
Avšič-Županc T, Saksida A, Korva M
Clin Microbiol Infect 2019 Apr;21S:e6-e16. Epub 2015 Jun 22 doi: 10.1111/1469-0691.12291. PMID: 24750436
Human hantavirus infections: epidemiology, clinical features, pathogenesis and immunology.
Manigold T, Vial P
Swiss Med Wkly 2014 Mar 20;144:w13937. doi: 10.4414/smw.2014.13937. PMID: 24652684

Therapy

Progress on the Prevention and Treatment of Hantavirus Disease.
Brocato RL, Hooper JW
Viruses 2019 Jul 4;11(7) doi: 10.3390/v11070610. PMID: 31277410Free PMC Article
Extracorporeal life support during pregnancy.
Moore SA, Dietl CA, Coleman DM
J Thorac Cardiovasc Surg 2016 Apr;151(4):1154-60. Epub 2015 Dec 22 doi: 10.1016/j.jtcvs.2015.12.027. PMID: 26825433
Hantavirus pulmonary syndrome.
Macneil A, Nichol ST, Spiropoulou CF
Virus Res 2011 Dec;162(1-2):138-47. Epub 2011 Sep 17 doi: 10.1016/j.virusres.2011.09.017. PMID: 21945215
Vaccines for hantaviruses.
Schmaljohn C
Vaccine 2009 Nov 5;27 Suppl 4:D61-4. doi: 10.1016/j.vaccine.2009.07.096. PMID: 19837289
Emerging infectious diseases: a cause for concern.
Berns DS, Rager B
Isr Med Assoc J 2000 Dec;2(12):919-23. PMID: 11344776

Prognosis

Hantavirus Expansion Trends in Natural Host Populations in Brazil.
Mello JHF, Muylaert RL, Grelle CEV
Viruses 2024 Jul 17;16(7) doi: 10.3390/v16071154. PMID: 39066316Free PMC Article
Design and validation of a novel multi-epitopes vaccine against hantavirus.
Almanaa TN, Mubarak A, Sajjad M, Ullah A, Hassan M, Waheed Y, Irfan M, Khan S, Ahmad S
J Biomol Struct Dyn 2024 May;42(8):4185-4195. Epub 2023 Jun 1 doi: 10.1080/07391102.2023.2219324. PMID: 37261466
Hantavirus Pulmonary Syndrome: 1993-2018.
Thorp L, Fullerton L, Whitesell A, Dehority W
Pediatrics 2023 Apr 1;151(4) doi: 10.1542/peds.2022-059352. PMID: 36855865
Hantavirus Disease and COVID-19.
Joyce AK, Oliver TT, Kofman AD, Talker DL, Safaeian S, Peker Barclift D, Perricone AJ, D'Andrea SM, Whitesell AN, Yazzie D, Guarner J, Saleki M, Ingall GB, Choi MJ, Antone-Nez R
Am J Clin Pathol 2022 Mar 3;157(3):470-475. doi: 10.1093/ajcp/aqab155. PMID: 34643226
Epidemiology of Hantavirus infections in humans: a comprehensive, global overview.
Watson DC, Sargianou M, Papa A, Chra P, Starakis I, Panos G
Crit Rev Microbiol 2014 Aug;40(3):261-72. Epub 2013 Apr 22 doi: 10.3109/1040841X.2013.783555. PMID: 23607444

Clinical prediction guides

Hantavirus Expansion Trends in Natural Host Populations in Brazil.
Mello JHF, Muylaert RL, Grelle CEV
Viruses 2024 Jul 17;16(7) doi: 10.3390/v16071154. PMID: 39066316Free PMC Article
Design and validation of a novel multi-epitopes vaccine against hantavirus.
Almanaa TN, Mubarak A, Sajjad M, Ullah A, Hassan M, Waheed Y, Irfan M, Khan S, Ahmad S
J Biomol Struct Dyn 2024 May;42(8):4185-4195. Epub 2023 Jun 1 doi: 10.1080/07391102.2023.2219324. PMID: 37261466
Hantavirus Disease and COVID-19.
Joyce AK, Oliver TT, Kofman AD, Talker DL, Safaeian S, Peker Barclift D, Perricone AJ, D'Andrea SM, Whitesell AN, Yazzie D, Guarner J, Saleki M, Ingall GB, Choi MJ, Antone-Nez R
Am J Clin Pathol 2022 Mar 3;157(3):470-475. doi: 10.1093/ajcp/aqab155. PMID: 34643226
Climate change and sugarcane expansion increase Hantavirus infection risk.
Prist PR, Uriarte M, Fernandes K, Metzger JP
PLoS Negl Trop Dis 2017 Jul;11(7):e0005705. Epub 2017 Jul 20 doi: 10.1371/journal.pntd.0005705. PMID: 28727744Free PMC Article
Hantavirus infections.
Escutenaire S, Pastoret PP
Rev Sci Tech 2000 Apr;19(1):64-78. doi: 10.20506/rst.19.1.1209. PMID: 11189727

Recent systematic reviews

Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review.
Toledo J, Haby MM, Reveiz L, Sosa Leon L, Angerami R, Aldighieri S
J Infect Dis 2022 Oct 17;226(8):1362-1371. doi: 10.1093/infdis/jiab461. PMID: 34515290Free PMC Article
Current Situation and Perspectives on Hantaviruses in Mexico.
Vigueras-Galván AL, López-Pérez AM, García-Peña GE, Rico-Chávez O, Sarmiento-Silva RE, Suzán G
Viruses 2019 Jul 12;11(7) doi: 10.3390/v11070642. PMID: 31336858Free PMC Article

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