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Abnormal microglia morphology

MedGen UID:
867604
Concept ID:
C4021990
Finding
Synonym: Abnormality of the microglia
 
HPO: HP:0100708

Definition

An abnormality of the microglial cells. They are also known as brain-resident macrophages or Hortega cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal microglia morphology

Professional guidelines

PubMed

Hu X, Ma YN, Xia Y
Biosci Trends 2024 Jun 6;18(2):195-197. Epub 2024 Apr 17 doi: 10.5582/bst.2024.01092. PMID: 38631884
Tipton PW, Kenney-Jung D, Rush BK, Middlebrooks EH, Nascene D, Singh B, Holtan S, Ayala E, Broderick DF, Lund T, Wszolek ZK
Mov Disord 2021 Dec;36(12):2901-2909. Epub 2021 Jul 30 doi: 10.1002/mds.28734. PMID: 34329526
Zhornitsky S, Wee Yong V, Koch MW, Mackie A, Potvin S, Patten SB, Metz LM
CNS Neurosci Ther 2013 Oct;19(10):737-44. Epub 2013 Jul 22 doi: 10.1111/cns.12154. PMID: 23870612Free PMC Article

Recent clinical studies

Etiology

Traetta ME, Chaves Filho AM, Akinluyi ET, Tremblay MÈ
Adv Neurobiol 2024;37:457-495. doi: 10.1007/978-3-031-55529-9_26. PMID: 39207708
Zeng J, Liao Z, Yang H, Wang Q, Wu Z, Hua F, Zhou Z
Neurobiol Dis 2024 Apr;193:106461. Epub 2024 Mar 2 doi: 10.1016/j.nbd.2024.106461. PMID: 38437992
Taddei RN, Perbet R, Mate de Gerando A, Wiedmer AE, Sanchez-Mico M, Connors Stewart T, Gaona A, Melloni A, Amaral AC, Duff K, Frosch MP, Gómez-Isla T
JAMA Neurol 2023 Nov 1;80(11):1209-1221. doi: 10.1001/jamaneurol.2023.3530. PMID: 37812432Free PMC Article
Jin M, Xu R, Wang L, Alam MM, Ma Z, Zhu S, Martini AC, Jadali A, Bernabucci M, Xie P, Kwan KY, Pang ZP, Head E, Liu Y, Hart RP, Jiang P
Cell Stem Cell 2022 Jul 7;29(7):1135-1153.e8. doi: 10.1016/j.stem.2022.06.007. PMID: 35803230Free PMC Article
Lue LF, Beach TG, Walker DG
Cells 2019 Aug 5;8(8) doi: 10.3390/cells8080838. PMID: 31387311Free PMC Article

Diagnosis

Xie M, Pallegar PN, Parusel S, Nguyen AT, Wu LJ
Mol Neurodegener 2023 Oct 19;18(1):75. doi: 10.1186/s13024-023-00665-w. PMID: 37858176Free PMC Article
Christian KM, Song H, Ming GL
Annu Rev Neurosci 2019 Jul 8;42:249-269. doi: 10.1146/annurev-neuro-080317-062231. PMID: 31283901Free PMC Article
Brocca ME, Pietranera L, de Kloet ER, De Nicola AF
Cell Mol Neurobiol 2019 May;39(4):483-492. Epub 2018 Aug 16 doi: 10.1007/s10571-018-0610-9. PMID: 30117098
Mckee AC, Abdolmohammadi B, Stein TD
Handb Clin Neurol 2018;158:297-307. doi: 10.1016/B978-0-444-63954-7.00028-8. PMID: 30482357
Valotassiou V, Malamitsi J, Papatriantafyllou J, Dardiotis E, Tsougos I, Psimadas D, Alexiou S, Hadjigeorgiou G, Georgoulias P
Ann Nucl Med 2018 Nov;32(9):583-593. Epub 2018 Aug 20 doi: 10.1007/s12149-018-1292-6. PMID: 30128693

Therapy

Plowey ED, Bussiere T, Rajagovindan R, Sebalusky J, Hamann S, von Hehn C, Castrillo-Viguera C, Sandrock A, Budd Haeberlein S, van Dyck CH, Huttner A
Acta Neuropathol 2022 Jul;144(1):143-153. Epub 2022 May 17 doi: 10.1007/s00401-022-02433-4. PMID: 35581440Free PMC Article
Sun XY, Li LJ, Dong QX, Zhu J, Huang YR, Hou SJ, Yu XL, Liu RT
J Neuroinflammation 2021 Jun 11;18(1):131. doi: 10.1186/s12974-021-02182-3. PMID: 34116706Free PMC Article
Jia X, Gao Z, Hu H
Sci China Life Sci 2021 Jun;64(6):911-925. Epub 2020 Oct 14 doi: 10.1007/s11427-020-1815-6. PMID: 33068286
Pinto B, Morelli G, Rastogi M, Savardi A, Fumagalli A, Petretto A, Bartolucci M, Varea E, Catelani T, Contestabile A, Perlini LE, Cancedda L
Neuron 2020 Dec 9;108(5):887-904.e12. Epub 2020 Oct 6 doi: 10.1016/j.neuron.2020.09.010. PMID: 33027640Free PMC Article
Perry VH, Holmes C
Nat Rev Neurol 2014 Apr;10(4):217-24. Epub 2014 Mar 18 doi: 10.1038/nrneurol.2014.38. PMID: 24638131

Prognosis

Frias-Anaya E, Gallego-Gutierrez H, Gongol B, Weinsheimer S, Lai CC, Orecchioni M, Sriram A, Bui CM, Nelsen B, Hale P, Pham A, Shenkar R, DeBiasse D, Lightle R, Girard R, Li Y, Srinath A, Daneman R, Nudleman E, Sun H, Guma M, Dubrac A, Mesarwi OA, Ley K, Kim H, Awad IA, Ginsberg MH, Lopez-Ramirez MA
Arterioscler Thromb Vasc Biol 2024 Jun;44(6):1246-1264. Epub 2024 Apr 25 doi: 10.1161/ATVBAHA.123.320367. PMID: 38660801Free PMC Article
Huang W, Xia Q, Zheng F, Zhao X, Ge F, Xiao J, Liu Z, Shen Y, Ye K, Wang D, Li Y
J Alzheimers Dis 2023;94(s1):S335-S354. doi: 10.3233/JAD-221064. PMID: 36683511Free PMC Article
Gao S, Jiang Y, Chen Z, Zhao X, Gu J, Wu H, Liao Y, Sun H, Wang J, Chen W
Curr Neuropharmacol 2023;21(9):1992-2005. doi: 10.2174/1570159X21666221216162606. PMID: 36529923Free PMC Article
Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P
Nat Med 2021 Sep;27(9):1592-1599. Epub 2021 Aug 26 doi: 10.1038/s41591-021-01456-w. PMID: 34446931
Valotassiou V, Malamitsi J, Papatriantafyllou J, Dardiotis E, Tsougos I, Psimadas D, Alexiou S, Hadjigeorgiou G, Georgoulias P
Ann Nucl Med 2018 Nov;32(9):583-593. Epub 2018 Aug 20 doi: 10.1007/s12149-018-1292-6. PMID: 30128693

Clinical prediction guides

Frias-Anaya E, Gallego-Gutierrez H, Gongol B, Weinsheimer S, Lai CC, Orecchioni M, Sriram A, Bui CM, Nelsen B, Hale P, Pham A, Shenkar R, DeBiasse D, Lightle R, Girard R, Li Y, Srinath A, Daneman R, Nudleman E, Sun H, Guma M, Dubrac A, Mesarwi OA, Ley K, Kim H, Awad IA, Ginsberg MH, Lopez-Ramirez MA
Arterioscler Thromb Vasc Biol 2024 Jun;44(6):1246-1264. Epub 2024 Apr 25 doi: 10.1161/ATVBAHA.123.320367. PMID: 38660801Free PMC Article
Beckers J, Tharkeshwar AK, Fumagalli L, Contardo M, Van Schoor E, Fazal R, Thal DR, Chandran S, Mancuso R, Van Den Bosch L, Van Damme P
Acta Neuropathol Commun 2023 Sep 18;11(1):151. doi: 10.1186/s40478-023-01648-0. PMID: 37723585Free PMC Article
Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P
Nat Med 2021 Sep;27(9):1592-1599. Epub 2021 Aug 26 doi: 10.1038/s41591-021-01456-w. PMID: 34446931
Guo M, Wang J, Zhao Y, Feng Y, Han S, Dong Q, Cui M, Tieu K
Brain 2020 May 1;143(5):1476-1497. doi: 10.1093/brain/awaa090. PMID: 32355963Free PMC Article
Valotassiou V, Malamitsi J, Papatriantafyllou J, Dardiotis E, Tsougos I, Psimadas D, Alexiou S, Hadjigeorgiou G, Georgoulias P
Ann Nucl Med 2018 Nov;32(9):583-593. Epub 2018 Aug 20 doi: 10.1007/s12149-018-1292-6. PMID: 30128693

Recent systematic reviews

Yamamoto M, Sakai M, Yu Z, Nakanishi M, Yoshii H
Int J Mol Sci 2024 May 25;25(11) doi: 10.3390/ijms25115750. PMID: 38891940Free PMC Article
Dulski J, Souza J, Santos ML, Wszolek ZK
Orphanet J Rare Dis 2023 Jun 22;18(1):160. doi: 10.1186/s13023-023-02772-9. PMID: 37349768Free PMC Article
Di Stadio A, Dipietro L, Ralli M, Meneghello F, Minni A, Greco A, Stabile MR, Bernitsas E
Eur Rev Med Pharmacol Sci 2018 Jul;22(14):4611-4624. doi: 10.26355/eurrev_201807_15520. PMID: 30058696
Najjar S, Pearlman DM
Schizophr Res 2015 Jan;161(1):102-12. Epub 2014 Jun 16 doi: 10.1016/j.schres.2014.04.041. PMID: 24948485

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