From HPO
Chest pain- MedGen UID:
- 2992
- •Concept ID:
- C0008031
- •
- Sign or Symptom
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest.
Fatigue- MedGen UID:
- 41971
- •Concept ID:
- C0015672
- •
- Sign or Symptom
A subjective feeling of tiredness characterized by a lack of energy and motivation.
Chills- MedGen UID:
- 43211
- •Concept ID:
- C0085593
- •
- Sign or Symptom
A sudden sensation of feeling cold.
Proteinuria- MedGen UID:
- 10976
- •Concept ID:
- C0033687
- •
- Finding
Increased levels of protein in the urine.
Cylindruria- MedGen UID:
- 101807
- •Concept ID:
- C0151990
- •
- Body Substance
The presence of renal casts (cylindrical, cigar-shaped structures produced by the kidney in certain disease states) in the urine.
Macroscopic hematuria- MedGen UID:
- 633103
- •Concept ID:
- C0473237
- •
- Finding
Hematuria that is visible upon inspection of the urine.
Erythrocyte cylindruria- MedGen UID:
- 637069
- •Concept ID:
- C0522129
- •
- Finding
Presence of erythrocyte casts (cylindrical structures produced by the kidney in certain disease states) in the urine.
Renal insufficiency- MedGen UID:
- 332529
- •Concept ID:
- C1565489
- •
- Disease or Syndrome
A reduction in the level of performance of the kidneys in areas of function comprising the concentration of urine, removal of wastes, the maintenance of electrolyte balance, homeostasis of blood pressure, and calcium metabolism.
Glomerular crescent formation- MedGen UID:
- 1785072
- •Concept ID:
- C5539893
- •
- Finding
Glomerular crescent refers hyperplastic lesions involving 10% or more of the circumference of Bowman's capsule. Crescents can be composed of a variable mixture of epithelial/leukocyte hypercellularity, fibrous matrix, and fibrin.
Pulmonary hemorrhage- MedGen UID:
- 57732
- •Concept ID:
- C0151701
- •
- Pathologic Function
Pulmonary hemorrhage is a bleeding within the lungs. Older children and adults may spit blood or bloody sputum. Neonates, infants and young children usually do not spit up blood. Anemia, pulmonary infiltrates, increasingling bloody return on BAL and the presence of hemosiderin-laden macrophages in broncho-alveolar lavage (BAL) fluid or lung biopsy can diagnose lung bleeding. Alveolar macrophages contain phagocytosed red blood cells and stain positive for hemosiderin, a product of hemoglobin degradation, after about 48-72 hours following pulmonary hemorraghe. Previous or recurrent bleeding can thus be distinguished from fresh events. A differentiation into local or diffuse is of importance. Also differentiate if pulmonary hemorrhage is due to a primary lung disorder or a manifestation of a systemic disease.
Weight loss- MedGen UID:
- 853198
- •Concept ID:
- C1262477
- •
- Finding
Reduction of total body weight.
Anemia- MedGen UID:
- 1526
- •Concept ID:
- C0002871
- •
- Disease or Syndrome
A reduction in erythrocytes volume or hemoglobin concentration.
Cough- MedGen UID:
- 41325
- •Concept ID:
- C0010200
- •
- Sign or Symptom
A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation.
Hemoptysis- MedGen UID:
- 5502
- •Concept ID:
- C0019079
- •
- Sign or Symptom
Coughing up (expectoration) of blood or blood-streaked sputum from the larynx, trachea, bronchi, or lungs.
Crackles- MedGen UID:
- 11118
- •Concept ID:
- C0034642
- •
- Finding
Crackles are discontinuous, explosive, and nonmusical adventitious lung sounds normally heard in inspiration and sometimes during expiration. Crackles are usually classified as fine and coarse crackles based on their duration, loudness, pitch, timing in the respiratory cycle, and relationship to coughing and changing body position.
Exertional dyspnea- MedGen UID:
- 68549
- •Concept ID:
- C0231807
- •
- Sign or Symptom
Perceived difficulty to breathe that occurs with exercise or exertion and improves with rest.
Tachypnea- MedGen UID:
- 66669
- •Concept ID:
- C0231835
- •
- Finding
Very rapid breathing.
Pulmonary infiltrates- MedGen UID:
- 116009
- •Concept ID:
- C0235896
- •
- Finding
A finding indicating the presence of an inflammatory or neoplastic cellular infiltrate in the lung parenchyma.
Restrictive ventilatory defect- MedGen UID:
- 478856
- •Concept ID:
- C3277226
- •
- Finding
A functional defect characterized by reduced total lung capacity (TLC) not associated with abnormalities of expiratory airflow or airway resistance. Spirometrically, a restrictive defect is defined as FEV1 (forced expiratory volume in 1 second) and FVC (forced vital capacity) less than 80 per cent. Restrictive lung disease may be caused by alterations in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus.
Increased DLCO- MedGen UID:
- 893148
- •Concept ID:
- C4073174
- •
- Finding
Increased ability of the lungs to transfer gas from inspired air to the bloodstream as measured by the diffusing capacity of the lungs for carbon monoxide (DLCO) test.
Reticular pattern on pulmonary HRCT- MedGen UID:
- 1386432
- •Concept ID:
- C4476748
- •
- Finding
On pulmonary high-resolution computed tomography, reticular pattern is characterized by innumerable interlacing shadows suggesting a mesh.
Nodular pattern on pulmonary HRCT- MedGen UID:
- 1380219
- •Concept ID:
- C4476750
- •
- Finding
A nodular pattern is characterized on pulmonary high-resolution computed tomography by the presence of numerous rounded opacities that range from 2 mm to 1 cm in diameter, with micronodules defined as smaller than 3 mm in diameter.
Parenchymal consolidation- MedGen UID:
- 1687071
- •Concept ID:
- C5139174
- •
- Finding
Consolidation refers to an exudate or other product of disease that replaces alveolar air, rendering the lung solid (as in infective pneumonia).
Hemosiderin-laden macrophages in bronchoalveolar fluid- MedGen UID:
- 1717924
- •Concept ID:
- C5397971
- •
- Finding
Hemosiderin-laden macrophages (HLM) in bronchoalveolar lavage (BAL) fluid were originally known as adiagnostic biomarker of alveolar hemorrhage, but have also been observed in idiopathic pulmonary fibrosis (IPF) with histopathological pattern of usual interstitial pneumonia (UIP).
Bloody bronchoalveolar lavage fluid- MedGen UID:
- 1724345
- •Concept ID:
- C5421662
- •
- Finding
Return of lavage fluid characteristically has a bloody appearance in pulmonary alveolar hemorrhage. This is due to admixture of blood, which typically increases with each consecutive lavage portion. Microscopically erythrocytes can be seen. After 24 to 48 h macrophages contain phagocytosed erythrocytes, indicating previous bleeding.
Ground-glass opacification- MedGen UID:
- 1779663
- •Concept ID:
- C5539411
- •
- Finding
On chest radiographs, ground-glass opacity appears as an area of hazy increased lung opacity, usually extensive, within which margins of pulmonary vessels may be indistinct. On CT scans, it appears as hazy increased opacity of lung, with preservation of bronchial and vascular margins. It is caused by partial filling of airspaces, interstitial thickening (due to fluid, cells, and/or fibrosis), partial collapse of alveoli, increased capillary blood volume, or a combination of these, the common factor being the partial displacement of air. Ground-glass opacity is less opaque than consolidation, in which bronchovascular margins are obscured.
Glomerulonephritis- MedGen UID:
- 6616
- •Concept ID:
- C0017658
- •
- Disease or Syndrome
Inflammation of the renal glomeruli.
Cytoplasmic antineutrophil antibody positivity- MedGen UID:
- 1690999
- •Concept ID:
- C5139210
- •
- Finding
The presence of autoantibodies in the serum that react against proteins predominantly expressed in cytoplasmic granules of neutrophils.
Anti-glomerular basement membrane-antibody positivity- MedGen UID:
- 1747042
- •Concept ID:
- C5421560
- •
- Laboratory or Test Result
The presence of autoantibodies in the serum that react to the glomerular basement membrane.
Anti-myeloperoxidase antibody positivity- MedGen UID:
- 1784416
- •Concept ID:
- C5539684
- •
- Laboratory or Test Result
The presence of autoantibodies in the blood circulation that react against myeloperoxidase.
Fever- MedGen UID:
- 5169
- •Concept ID:
- C0015967
- •
- Sign or Symptom
Body temperature elevated above the normal range.
Increased blood urea nitrogen- MedGen UID:
- 760252
- •Concept ID:
- C0151539
- •
- Finding
An increased amount of nitrogen in the form of urea in the blood.
Cyanosis- MedGen UID:
- 1189
- •Concept ID:
- C0010520
- •
- Sign or Symptom
Bluish discoloration of the skin and mucosa due to poor circulation or inadequate oxygenation of arterial or capillary blood.
Pallor- MedGen UID:
- 10547
- •Concept ID:
- C0030232
- •
- Finding
Abnormally pale skin.
- Abnormality of blood and blood-forming tissues
- Abnormality of metabolism/homeostasis
- Abnormality of the cardiovascular system
- Abnormality of the genitourinary system
- Abnormality of the immune system
- Abnormality of the integument
- Abnormality of the respiratory system
- Constitutional symptom
- Growth abnormality