Osteocalcin

Osteocalcin was measured on serum which was drawn of Framingham Offspring participants from 7/30/1997 to 5/20/1999. These draw dates span Offspring exams 6 and 7. Specimens were frozen at -80C until testing. Osteocalcin assay was performed in the Vitamin K laboratory at the Human Nutrition Research Center of Tufts University, under the direction of Dr. Sarah Booth.

In 1948, researchers recruited men and women from the town of Framingham, Massachusetts, beginning the first round of extensive physical examinations and lifestyle interviews that would later be analyzed for common patterns related to CVD development.

Initially, the Framingham Heart Study enrolled 5,209 men and women from the Framingham area who were between the ages of 28 and 62 years. Beginning in 1971, the Framingham Heart Study enrolled 5,124 men and women, who were either offspring of the original cohort or spouses of those offspring. In 2002, 4,095 third generation participants (men and women) were enrolled.

During each clinic exam cycle, the participants undergo a detailed examination including physical examination, medical history, laboratory testing, and electrocardiogram. Over the years, other tests (that may not be performed at every exam cycle) have included pulmonary function, lifestyle, physical function, cognitive function questionnaires, and various noninvasive cardiovascular tests including echocardiograms. The content of each exam cycle differs for Original, Offspring and Generation 3 cohorts and can be found in the Exam Cycle Protocol Manuals.

• Study Weblinks:
  • The Framingham Heart Study
• Study Design:
  • Prospective Longitudinal Cohort
• Study Type:
  • Longitudinal
• Total number of consented subjects: 1960
• Subject Sample Telemetry Report (SSTR)

Offspring cohort from exam 6 and 7 were examined between the dates of 7/30/1997 and 5/20/1999.

The Original cohort began Exam 1 in 1948 (9/1948 - 4/1953) and has continued with biennial examinations to the present. Exam 29 was performed from 4/2006 - 12/2007.

The Offspring cohort began Exam 1 in 1971 (8/1971 - 9/1975) and has on average been examined every 3 to 4 years since enrollment. However, there was an eight year window between Exam 1 and Exam 2. Exam 8 was performed from 3/2005 - 1/25/2008.

The Generation 3 cohort Exam 1 was performed 4/2002 - 7/2005.

Examination of all three cohorts is ongoing.

• Primary Phenotype: Cardiovascular System

• Principal Investigator
  • Sarah Booth, PhD. Tufts University, Human Nutrition Research Center (HNRC), Boston, MA, USA.
• Co-Investigator
  • Peter Wilson, MD. Framingham Heart Study, Framingham, MA, USA.