| Time After Starting | Therapy | ALT (U/L) | Alk P (U/L) | Bilirubin (mg/dL) | HCV RNA (IU/mL) | Other |
|---|---|---|---|---|---|---|
| - 8 weeks | 204 | 91 | -0.9 | 1,420,000 | IgG 2130 mg/dL, ANA neg | |
| - 4 weeks | 185 | 83 | 0.7 | 2,890,000 | ||
| Peginterferon (180 µg/week) started | ||||||
| 0 | 203 | 92 | 0.4 | 2,130,000 | ||
| 2 weeks | Peginterferon | 329 | 102 | 0.4 | 587,000 | |
| 4 weeks | Peginterferon | 1093 | 133 | 0.9 | <100 | |
| 6 weeks | Peg & Rbv | 1002 | 162 | 8.0 | <10 | IgG 2910, ANA neg, LKM pos |
| 7 weeks | None | 1206 | 147 | 15.8 | <10 | |
| Prednisone started (20 mg daily) | ||||||
| 8 weeks | Pred 20 mg | 1110 | 136 | 5.3 | <10 | |
| 10 weeks | Pred 20 mg | 784 | 117 | 2.1 | 212,000 | |
| 5 mo | Pred 10 mg | 165 | 66 | 0.6 | ||
| 9 mo | Pred 5 mg | 134 | 85 | 0.6 | 1,350,000 | |
| Prednisone stopped | ||||||
| 18 mo | None | 216 | 98 | 0.4 | 3,645,000 | |
| 25 mo | None | 348 | 121 | 0.8 | 2,656,800 | |
| Prednisone (20 mg daily) restarted with azathioprine | ||||||
| 29 mo | Pred 20 & Az | 54 | 100 | 0.8 | 7,452,000 | |
| 40 mo | Pred 5 & Az | 30 | 62 | 0.4 | ||
| Prednisone stopped and azathioprine continued (100 mg daily) | ||||||
| 4 years | Az 100 | 26 | 86 | 0.8 | 11,529,000 | |
| 5 years | Az 100 | 35 | 118 | 0.5 | 20,682,000 | |
| 10 years | Az 50 | 38 | 47 | 0.4 | 28,300,000 | |
| Normal Values | <42 | <115 | <1.2 | |||
From: Alpha Interferon
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